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KW: recombination; commonplace book;**; The note dated July 5 1945 is one of the earliest allusions to the concept of the E. coli crossing experiment. There are many other divers remarks about mutation and heterokaryosis in Neurospora. Some of these are inspired by the Beadle Coonradt paper in Genetics, and by Beadle's Harvey lecture on 2/15/45. jl 10/3/98