The Oswald T. Avery Collection

Title:

The Transformation In Vitro of R Pneumococci into S Forms of Different Specific Types by the Use of Filtered Pneumococcus Extracts

Description:

Alloway published this article shortly after he joined Avery's lab. In it, Alloway demonstrated that by dissolving certain living pneumococci cells in sodium dexoycholate one could bring about transformation in vitro, rather than in laboratory mice as had previously been demonstrated. Through the process described here, he yielded the first soluble preparation of DNA, although it was not to be identified as such for 10 more years.

Number of Image Pages:

9 (711,828 Bytes)

Date:

1932-01-01 (January 1, 1932)

Creator:

Alloway, J. Lionel

Source:

Periodical: Alloway, J. Lionel. "The Transformation In Vitro of R Pneumococci into S Forms of Different Specific Types by the Use of Filtered Pneumococcus Extracts." Journal of Experimental Medicine 55, 1 (1 January 1932): 91-99. Article. 9 Images.

Publisher:

Rockefeller University Press

Rights:

Reproduced with permission of the Rockefeller University Press.

Subject:

Medical Subject Headings (MeSH):: Transformation, Genetic; Research Design

Exhibit Category:

Shifting Focus: Early Work on Bacterial Transformation, 1928-1940

Relation:

Beitrage zur Variabilitat der Pneumokokken (1928)

The Interconvertibility of 'R' and 'S' Forms of Pneumococcus (April 1, 1928)

The Transformation of Pneumococcal Types In Vitro (1930)

Further Observations on the Use of Pneumococcus Extracts in Effecting Transformation of Type In Vitro (February 1, 1933)

Box Number: 1

Folder Number: 5

Unique Identifier:

CCAAAI

Document Type:

Articles

Language:

English

Format:

application/pdf

image/tif

Physical Condition:

Good

Series: Research and Discovery of the Transforming Principle, 1912-1999

SubSeries: Preliminary Research

Folder: Scientific Articles, 1928-1937, 1966, 1980-1984

Metadata Last Modified Date:

2006-12-11

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