/    [COPY COURTESY OF THE

UNIVERSITY OF CAMBRIDGE

kiDICAL RESEARCH COUNCIL    SCHOOL OF BIOCHEMISTRY
ARCHIVES, 19851
File 203612

Telephone: CAMBRIDGE 1461
deference:  3c31'12 7

WC.
               SIR W 'ILLIAM DUNN INSTITUTE,

          .-\ r \I          TENNIS COURT ROAD,

I have now been back from the States one week and

i-,ave much to tell you but I will bepin with the item which needs

your active assistance.

PL rather ;romieirq yourq man,bne Dr. Tarr from

Y.'ontreaJ,has turned UD to work in this Department on problems

of bacterial meta~olism.Ris ofin hish is to investigate

-Lio?,iie~ica.llg  We difference in   two strains of tLe same

owanisu  ex::ibitine rough and smooth type colonies espec-

ially where such t:rues show a difference in gathoeenicity.

I t;ucfested to him t1lat it would be interesting to adopt for

ti_ie pur;)ose the ha.eiYiOljrtiC  streps associated with puerperal

fever in view of the fact t2;at the 3.R. C was inaugurating an

attack on this, disease , and that therefore material and

COKO eration might be forthcominp and we miF,ht also hope

to p,ather results which r;ibyht be of use in characterization

of strair.s.%e Y ounc man in question fell In very readily

with this pro:;osal;will you let me know if it strikes

you as a feasible Iilan .and if so help ua to Eet in touch with

the ri,rht bacteriologist to su;~~ly &s with straine.

I had a marvellous time in America both as regards

holiday and work.As reg,ards the latter,on the technical side


.
  [COPY COURTESY OF THE     UNIVERSITY OF CAMBRIDGE
  MEDICAL RESEARCH COUNCIL
  ARCHIVES, 19851         SCHOOL OF BIOCHEMISTRY

  File # 203612

rekphone: CAMBRIDGE 1461
fieference :

SIR WILLIAM DUNN INSTITUTE,
       TENNIS COURT ROAD,
                   CAMBRIDGE.

I WDrked first in ti;e Be~nrtr;;srLt of Prof, Robert Chazbers
infw asi;ir.Eton S;quyre  wi;ers I learnt the use of his micro-disse

tion aFpra'ttl;s  and then T was _nassed on to Dr, Liorton Kahn

of Cornell wlio is an expert in the application of the apparatus

to the isolation of the single k#%%  bacterial cell. In both

tijese Departments I received an incredible lot of kindness

.Tnd invluable help.1 am now encaged in tr_vinE to acquire the

(ratYLer ~x~;ensive)~p!,aratus from Leitz.

From Dr. Cakin I cot introductions to Avery and

-<eidel;~erger nnd from these I was enabled to eet   a most

valua~sle insight into the methods by which  chemical problens

of inrjunoloF7 ?re belnp attacked and  a view of the rapidity wi

with wilich tkiis subject is advancin over there;in fact

I got the idea the: along tLese lines the iz,ost significant

c.ov e in Biochemistry is now beiq made .Ihe subject is
b,eiq- a..pproached from so many angles by so many workers(al1
quite read)- to spend time telling one all about itjthat
                                                  .
one firally comes awa:T with. a vwry vivid idea of the

lines on which things are orocressing.
Eowever I can't tell you all in a letter 60 I Will stop

right now.

Yours sincerely,
                     ,
   Pb OV "I/ $4 hews-.