The Oswald T. Avery Collection

Title:: Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IV. The Synthesis of the p-Aminobenzyl Ether of the Soluble Specific Substance of Type III Pneumococcus and Its Coupling with Protein
Description:: The fourth of a long series of studies on efforts by Avery's lab to chemically couple the type-II and type-III pneumonia polysaccharides to protein. Although Avery oversaw most of these experiments, their principle investigator was Goebel, who in 1939, independently demonstrated that the specificity of the type-III polysaccharide is inherent in the structure of the disaccharide, glucose-glucuronic acid. When the disaccharide was coupled with the protein, it yielded a synthetic antigen that induced the formation of antibodies reactive with the intact polysaccharide. These antibodies could protect laboratory animals against type-III infection.; Item is a photocopy.
Number of Image Pages:: 6 (511,064 Bytes)
Date:: 1931-08 (August 1931)
Creator:: Goebel, Walther F.; Avery, Oswald T.
Source:: Periodical: Goebel, Walther F., and Oswald T. Avery. "Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IV. The Synthesis of the p-Aminobenzyl Ether of the Soluble Specific Substance of Type III Pneumococcus and Its Coupling with Protein." Journal of Experimental Medicine 54, 3 (August 1931): 431-436. Article. 6 Images.
Publisher:: Rockefeller University Press
Rights:: Reproduced from the Journal of Experimental Medicine, 1931, 54, 431-436, by copyright permission of the Rockefeller University Press.
Exhibit Categories:: The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929; Shifting Focus: Early Work on Bacterial Transformation, 1928-1940
Relation:: Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: I. The Synthesis of p-Aminophenol beta-Glucoside, p-Aminophenol beta-Galactoside, and Their Coupling with Serum Globulin (October 1929); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: II. Immunological Specificity of Synthetic Sugar-Protein Antigens (October 1929); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: III. Active and Passive Anaphylaxis with Synthetic Sugar-Proteins (November 1929); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: V. The Immunological Specificity of an Antigen Prepared by Combining the Capsular Polysaccharide of Type III Pneumococcus with Foreign Protein (August 1931); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VI. The Synthesis of p-Aminophenol alpha-Glucoside and Its Coupling with Protein (May 1932); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VII. Immunological Specificity of Antigens Prepared by Combining alpha- and beta-Glucosides of Glucose with Proteins (May 1932); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VIII. The Influence of the Acetyl Group on the Specificity of Hexoside-Protein Antigens (July 1934); Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IX. The Specificity of Antigens Prepared by Combining the p-Aminophenol Glycosides of Disaccharides with Protein (November 1934)
Unique Identifier:: CCGMCP
Document Type:: Articles
Language:: English
Format:: application/pdf; image/tif
Physical Condition:: Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:: 2005-04-21

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