Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid
Description:
Early twentieth-century scientists had long been attempting to treat trypanosomiasis, or African Sleeping Sickness, with arsenic-based compounds. Unfortunately, these compounds were largely ineffective and highly toxic. In light of this, Heidelberger and Walter Jacobs began work to formulate an alternate treatment for the disease. This article describes the pair's successful creation of a simple, non-toxic, and easily made arsenic compound to treat sleeping sickness, which Simon Flexner, director of the Rockefeller Institute, named "tryparasamide."
Item is a photocopy.
Number of Image Pages:
5 (393,427 Bytes)
Date:
1919-10 (October 1919)
Creator:
Jacobs, Walter A.
Heidelberger, Michael
Source:
Periodical: Jacobs, Walter A., and Michael Heidelberger. "Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid." Journal of Experimental Medicine 30, 5 (October 1919): 411-415. Article.
Publisher:
[Rockefeller Institute for Medical Research]
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Drug Therapy
Spirochaetales
Exhibit Category:
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
