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The Michael Heidelberger Papers

Title:
The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus pdf (1,024,388 Bytes) ocr (28,303 Bytes)
Description:
Throughout the 1920s the scientific community remained skeptical of Avery and Heidelberger's work on the unique antigenic polysaccharides in type II and type III pneumococcus. Echoing prevailing beliefs among scientists that only proteins could act as antigens, critics contended that Heidelberger and Avery's polysaccharide solutions had been contaminated by proteins, and that these, not the polysaccharides, were causing the antigenic reactions. As a result, the two approached Walther Goebel, an organic chemist, in order to more specifically determine the nature of these polysaccharides and their antigenic properties. This article details their findings as to the structure and composition of the polysaccharide capsule of type III pneumococcus.
Item is a photocopy.
Number of Image Pages:
12 (1,024,388 Bytes)
Date:
1926-11-02 (November 2, 1926)
Creator:
Heidelberger, Michael
Goebel, Walther F.
Source:
Periodical: Heidelberger, Michael, and Walther F. Goebel. "The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus." Journal of Biological Chemistry 70, 3 (1 November 1926): 613-624. Article.
Publisher:
[American Society for Biochemistry and Molecular Biology]
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Streptococcus pneumoniae
Pneumococcal Infections
Polysaccharides
Exhibit Categories:
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929
Relation:
Metadata Record The Soluble Specific Substance of Pneumococcus (June 1923) (in The Oswald T. Avery Collection)
Metadata Record The Soluble Specific Substance of Pneumococcus: Second Paper (August 1924) (in The Oswald T. Avery Collection)
Metadata Record The Soluble Specific Substance of Pneumococcus: Third Paper (October 1925)
Metadata Record The Soluble Specific Substance of Pneumococcus: V. On the Chemical Nature of the Aldobionic Acid from the Specific Polysaccharide of Type III Pneumococcus (September 1, 1927)
Unique Identifier:
DHBBBH
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-06-21
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
USA.gov, Copyright, Privacy, Accessibility
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