Heidelberger's work on the antigenic properties of pneumococcus polysaccharides was met with skepticism at first. Critics charged that his solutions had been tainted with proteins or protein-like substances, and that these were responsible for the observed antigenic effect. Heidelberger methodically responded to these charges in articles such as this, in which he presented the results of many different experiments that showed that the specific antigenic substance was not a protein, but a structurally unique polysaccharide.
Item is a photocopy.
Number of Image Pages:
22 (2,093,222 Bytes)
Date:
1927
Creator:
Heidelberger, Michael
Source:
Periodical: Heidelberger, Michael. "The Chemical Nature of Immune Substances." Physiological Reviews 7, 1 (1927): 107-128. Article.
Publisher:
[American Physiological Society]
Rights:
Reproduced with permission of the American Physiological Society.
Subject:
Medical Subject Headings (MeSH):
Allergy and Immunology
Exhibit Category:
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
