Bldg. 10, Room 9N-119

March 26, 1970

Dr. Draska Seman
B ioloski Ins ti tu t
Medicinskog Fakulteta Sveucilista
:agreb 1, Salata 3
Yugoslavia

Dear Drasko:

lJas it really November when I received your letter?

The winter has,

fortunately, sped by. Fortunately, because it is a miserable season--damp
and cold.
been--parents and children.  The busy schedules, as well as the cold, were
interrclpted by a delightful two weeks on the island of Curacao, 40 miles
north of Venezuela. Needless to say, the days were spent in the sea. There
are beautiful coral reefs there and the children seem to love it as much as
we do.
to snorkel a mile and a half!

The speed of itis passing is related to how busy we have all

\<e are most pleased with David, who dives well and manggdd one day

The winter was brightened some by Paul's arrival in the States  late

November, to work Cor six months in Chicago.  I say "brightened same" because
we have seen almost nothing of him.
shortly after his arrival, but all our efforts to get him here have cune to
nought.
most of things. His family did not come and that, coupled with the painfully
cold Chicago winter has made things unpleasant.
very interesting; and has gone reasonably well.
polymer formed from NAD, by loss of the nicotinamide--a polymer of adenosine
diphosphoribose, that appears to attach to histones.

I managed a brief visit in Chicago

He is working 7 days a week--hours and hours, trying to make the

                       Fortunately, the work is
                        He is working on the interesting

Have you finished your writing and gotten back to research--I hope so.

Writing is a terrible chore!
should be available shortly and I will send them.

I managed to write 3 papers this fall.

Reprints

   I had myself noticed that bit in the paper by Britten and Davidson.
also vaguely recall something relevant this winter in nature, but do not have
the reference.
enjoy-by Calvin, on chemical Evolution. I hope it arrives shortly.

I

Also, Dan and I sent off a copy of a book we thaught you might

-2 -

If you can recall your letter--I would agree that an idea of the

immediacey of the events seen on electrophorograrns is of interest, but
really only as a tool in detennining which of the bands may be most
interesting for further characterization.  This question is really
related to your point number 2, that is changing patterns in human
arganogenesis, together will go a long way toward helping decide the
direction of the future work. Obviously, it is a long term project. I
think I would feel smewhat more confortable about such an undertaking
if there were some way to follow something functional. Baaed on the
literature, is it possible to make some guesses aa to what $me oE the
proteins might be?

I haven't forgotten your request for a photograph of the children

but we need to have sane prints made.
slides lately.  I have, from Charles Cantor, a lovely photo of you, Paul,
and Linda Cantor, sitting about a table on the beach, (other side of
Spetses, near the cave)

Dan has taken little except color

The table is piled high with watemelon rinds.

f see I scribbled on your letter something about a paper regarding

evolution, by ti;oese, January 1968, Proc. Nat. Acad. Sei., U.S.A.

Very best from the Singer family to the Sennan family.

Yours,

Maxine Singer

m:vt