Room 9N-119, Bldg. 10 January 15, 1973 James J. Castles, M.D. Ass is tant Professor of Medicine The University of Chicago 950 East 59th Street Chicago, IL 60637 Dear Jim: It wasn't clear from your Letter whether you had a firm, but informal, appointment at Davis or whether there was still a real question. I assume, from the fact you spoke of a real choice that it is the former. I'm really delighted. Chicago was an error. You'll be glad to know that in the various letters I've written for YOU over the years, that situation was always pointed out, with an attempt to give a balanced picture of your own role in the collaboration. More or less, I think yoa're right in feeling The situation is dreadful all over. Morale is very low over the firing of Marston. And people who previously threw all job offers in the round file are now seriously looking. There is not even a rumor about who will replace Marston. worse before they get better . Even NIH is quaking for real now. Things will get Meanwhile we (myself and two new hard working but not yet proved fellows) have our monkey cells growing, SV40 growing, various substrates prepared, and are actually starting experiments. I am very pleased by the progress these few months, though it's just boling up until the last week or so. Therefore it's 8 bad time to be going off to India for three weeks, but I'm going. Resettling both at lab and home has been a drag, and I can't quite manage the 20-hour days any more (shades of Leon Heppel and complaints on aging). Actually it's bad for other reasons, mainly, I'm tired. All else is well--keep me posted. Yours, Maxine Singer MS : peg