Br. Donald S. Fredrickson
Named Heart Institute's
Dir. Intramural Research

Dr. Donald S. Fredrickson was
rcxcently named Director of Jntra-
mural Research, National Heart
Institute.  Dr. Theodore Cooper,
Director of NIII. announced the
appointment.

Dr. Fredrickson will be charged
with overall planning, direction
and coordination of the Heart In-
stitute's intramural cardiovascular
research programs. He will con-
tinue as chief of the Molecular
Disease Branch.

Left Post for Research

A member of the NH1 scientific
staff since 1953, he served as Di-
rector of the Heart Institute from
1966 until 1968: he left this post
in order to devote more time to
research.

Dr. Fredrickson's research at
NH1 has earned him international
recognition as an authority on fat
transport in the circulation and on
the diseases of lipid metabolism.

He has conducted and directed
laboratory and clinical research on
the structure of plasma lipopro-
teins, their role in fat transport,
and on gcnetir factors that rcgu-
late lipoprotein metabolism.

His studies of heritable diseases
of fat storage and metabolism in-
cluded the discovery of the lipopro-
tein deficiency state, Tangier dis-
east, and establishment of its mode
of inheritance.


DR. FREDRICKSON

(Continued from Page 1)

Recently, Dr. Fredrickson and
his colleagues introduced a new
system for using plasma lipopro-
tein patterns to identify and class-
ify excesses of blood cholesterol
and other fats.

With it they have demonstrated
several new syndromes not previ-
ously recognized as separate dis-
eases.

Employing  s i m p 1 e,  low-cost
methods, this system is coming in-
to wide clinicjal use as a basis for
the di#agnosis, treatment, and fol-
lowup of patients with elevated
blood lipids.

The system establishes the prev-
alence of these diseases which are
frequently associated with accel-
erabd development of atheroscle-
rosis.

Dr. Fredrickson received his B.S.
and M.D. degrees at the University
of Michigan. He did postgraduate
work at Peter Bent Brigham Hos-
pital, Massachusetts General Hos-
pital, and Harvard Medical School.

He joined the NH1 staff as a
clinical associate in 1953. He was
certified by the American Board of
Internal Medicine in 1957.