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The Martin Rodbell Papers

Title:
The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities pdf (501,891 Bytes) ocr (16,814 Bytes)
Description:
The second in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, he suggested that glucagon and inorganic fluoride activate the enzyme adenyl cyclase, an important component of some intracellular signaling pathways, by different mechanisms and possibly through different molecular entities, which indicated more than one mode of signal transduction.
Number of Image Pages:
4 (501,891 Bytes)
Date:
1971-03-25 (March 25, 1971)
Creator:
Birnbaumer, Lutz
Pohl, Stephen L.
Rodbell, Martin
Source:
Periodical: Birnbaumer, Lutz, Stephen L. Pohl, and Martin Rodbell. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities." Journal of Biological Chemistry 246, 6 (25 March 1971): 1857-1860. Article. 4 Images.
Publisher:
American Society for Biochemistry and Molecular Biology
Rights:
Reproduced with permission of The American Society for Biochemistry and Molecular Biology.
Subject:
Medical Subject Headings (MeSH):
Adenylate Cyclase
Cell Membrane
Enzymes
Fluorides
Glucagon
Pharmacology
Exhibit Category:
Signal Transduction and the Discovery of G-Proteins, 1969-1980
Relation:
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties (March 25, 1971)
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity (March 25, 1971)
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon (March 25, 1971)
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action (March 25, 1971)
Box Number: 19
Folder Number: 10
Unique Identifier:
GGAAAX
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Series: Laboratory Work and Research Publications, 1965-1997
SubSeries: Reprints
Folder: "Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase" (1979) TO "The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon" (1971)
Metadata Last Modified Date:
2006-04-06
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
USA.gov, Copyright, Privacy, Accessibility
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