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The Martin Rodbell Papers

Title:
The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity pdf (1,971,973 Bytes) ocr (63,171 Bytes)
Description:
The third in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, Rodbell established that the glucagon receptor is involved in the activation of the enzyme adenyl cyclase and that intracellular signaling is achieved through specific GTP-binding heterotrimeric G-proteins.
Number of Image Pages:
11 (1,971,973 Bytes)
Date:
1971-03-25 (March 25, 1971)
Creator:
Rodbell, Martin
Krans, Hendrik Michiel Jan
Pohl, Stephen L.
Birnbaumer, Lutz
Source:
Periodical: Rodbell, Martin, Hendrik Michiel Jan Krans, Stephen L. Pohl, and Lutz Birnbaumer. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity." Journal of Biological Chemistry 246, 6 (25 March 1971): 1861-1871. Article. 11 Images.
Publisher:
American Society for Biochemistry and Molecular Biology
Rights:
Reproduced with permission of The American Society for Biochemistry and Molecular Biology.
Subject:
Medical Subject Headings (MeSH):
Adenylate Cyclase
Binding Sites
Cell Membrane
Enzymes
Glucagon
Pharmacology
Exhibit Category:
Signal Transduction and the Discovery of G-Proteins, 1969-1980
Relation:
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties (March 25, 1971)
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities (March 25, 1971)
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon (March 25, 1971)
Metadata Record The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action (March 25, 1971)
Box Number: 19
Folder Number: 10
Unique Identifier:
GGAAAY
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Series: Laboratory Work and Research Publications, 1965-1997
SubSeries: Reprints
Folder: "Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase" (1979) TO "The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon" (1971)
Metadata Last Modified Date:
2006-04-06
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
USA.gov, Copyright, Privacy, Accessibility
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