The Martin Rodbell Papers

Title:

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon

Description:

The fourth in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In the last two articles of this series, Rodbell demonstrated that GTP affected the binding of glucagon to its receptors and was necessary for glucagon to activate adenyl cyclase, an important component of some intracellular signaling pathways.

Number of Image Pages:

5 (927,809 Bytes)

Date:

1971-03-25 (March 25, 1971)

Creator:

Rodbell, Martin

Krans, Hendrik Michiel Jan

Pohl, Stephen L.

Birnbaumer, Lutz

Source:

Periodical: Rodbell, Martin, Hendrik Michiel Jan Krans, Stephen L. Pohl, and Lutz Birnbaumer. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon." Journal of Biological Chemistry 246, 6 (25 March 1971): 1872-1876. Article. 5 Images.

Publisher:

American Society for Biochemistry and Molecular Biology

Rights:

Reproduced with permission of The American Society for Biochemistry and Molecular Biology.

Subject:

Medical Subject Headings (MeSH):: Adenylate Cyclase; Binding Sites; Iodine Isotopes; Glucagon; Guanine Nucleotides; Pharmacology

Exhibit Category:

Signal Transduction and the Discovery of G-Proteins, 1969-1980

Relation:

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties (March 25, 1971)

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities (March 25, 1971)

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity (March 25, 1971)

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action (March 25, 1971)

Box Number: 19

Folder Number: 10

Unique Identifier:

GGAAAZ

Document Type:

Articles

Language:

English

Format:

application/pdf

image/tif

Series: Laboratory Work and Research Publications, 1965-1997

SubSeries: Reprints

Folder: "Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase" (1979) TO "The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon" (1971)

Metadata Last Modified Date:

2006-04-06

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