The Martin Rodbell Papers

Title:

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action

Description:

The fifth in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In the last two articles of this series, Rodbell demonstrated that GTP affected the binding of glucagon to its receptors and was necessary for glucagon to activate adenyl cyclase, an important component of some intracellular signaling pathways.

Number of Image Pages:

6 (892,231 Bytes)

Date:

1971-03-25 (March 25, 1971)

Creator:

Rodbell, Martin

Birnbaumer, Lutz

Pohl, Stephen L.

Krans, Hendrik Michiel Jan

Source:

Periodical: Rodbell, Martin, Lutz Birnbaumer, Stephen L. Pohl, and Hendrik Michiel Jan Krans. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action." Journal of Biological Chemistry 246, 6 (25 March 1971): 1877-1882. Article. 6 Images.

Publisher:

American Society for Biochemistry and Molecular Biology

Rights:

Reproduced with permission of The American Society for Biochemistry and Molecular Biology.

Subject:

Medical Subject Headings (MeSH):: Adenylate Cyclase; Binding Sites; Cell Membrane; Guanine Nucleotides

Exhibit Category:

Signal Transduction and the Discovery of G-Proteins, 1969-1980

Relation:

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: I. Properties (March 25, 1971)

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities (March 25, 1971)

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity (March 25, 1971)

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon (March 25, 1971)

Box Number: 19

Folder Number: 11

Unique Identifier:

GGAABA

Document Type:

Articles

Language:

English

Format:

application/pdf

image/tif

Series: Laboratory Work and Research Publications, 1965-1997

SubSeries: Reprints

Folder: "The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role" (1971) TO "G-proteins have characteristics of cytoskeletal proteins: A basis for the programmable messenger theory" (1988)

Metadata Last Modified Date:

2006-04-06

U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
USA.gov, Copyright, Privacy, Accessibility
Comments, Viewers, Acknowledgments