The Fat Cell Adenylate Cyclase System: Characterization and Manipulation of Its Biomodal Regulation by GTP
Description:
The second of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.
Number of Image Pages:
5 (637,611 Bytes)
Date:
1979-09-25 (September 25, 1979)
Creator:
Cooper, Dermot M. F.
Schlegel, Werner
Lin, Michael C.
Rodbell, Martin
Source:
Periodical: Cooper, Dermot M. F., Werner Schlegel, Michael C. Lin, and Martin Rodbell. "The Fat Cell Adenylate Cyclase System: Characterization and Manipulation of Its Biomodal Regulation by GTP." Journal of Biological Chemistry 254, 18 (25 September 1979): 8927-8931. Article. 5 Images.
Publisher:
American Society for Biochemistry and Molecular Biology
Rights:
Reproduced with permission of The American Society for Biochemistry and Molecular Biology.
Subject:
Medical Subject Headings (MeSH):
Adenylate Cyclase
Cell Membrane
Guanosine Triphosphate
Exhibit Category:
Signal Transduction and the Discovery of G-Proteins, 1969-1980
Relation:
Letter from Joshua Lederberg to Michael Doudoroff (April 4, 1949) (in The Joshua Lederberg Papers)
Letter from Joshua Lederberg to Michael Doudoroff (April 4, 1949) (in The Joshua Lederberg Papers)