The Martin Rodbell Papers

Title:

Signal Transduction: A Twenty Year History of G-Proteins

Description:

In this portion of an unpublished manuscript, Rodbell briefly detailed how scientific knowledge evolved from studies on the regulation of adenylyl cyclase by hormones into recognition that sets of membrane receptors are linked to proteins that bind and degrade GTP (guanosine triphosphate).

Number of Image Pages:

5 (465,541 Bytes)

Date Supplied:

ca. 1990

Creator:

Rodbell, Martin

Rights:

Reproduced with permission of Martin Rodbell.

Subject:

Medical Subject Headings (MeSH):: Adenylate Cyclase; GTP-Binding Proteins; History of Medicine; History, 20th Century; Hormones

Exhibit Category:

Cells as "Programmable Messengers," 1981-1994

Relation:

Fig[ure]. 1: 1967 Conceptualization of an Hormone-Sensitive Adenylyl Cyclase [ca. 1990]

Fig[ure]. 2: 1969 Conceptualization of Adenylyl Cyclase System Stimulated by Multiple Hormones [ca. 1990]

Fig[ure]. 3: Early 1970 Representation of the Hormone Sensitive Adenylyl Cyclase As a System Formed of Three Functional Elements: Discriminator, Transducer, and Amplifier [ca. 1990]

[Figure 4: Late 1970 Model of the Glucagon-Sensitive Liver Membrane Adenylyl Cyclase As an Information Transfer System] [ca. 1990]

Fig[ure]. 5: 1977 Model of Hormonal Stimulation of an Adenylyl Cyclase System [ca. 1990]

Fig[ure]. 6: 1984 Model of Adenylyl Cyclase System Susceptible to Both Stimulatory and Inhibitory Regulation [ca. 1990]

Box Number: 20

Folder Number: 5

Unique Identifier:

GGAABN

Document Type:

Essays

Language:

English

Format:

application/pdf

image/tif

Series: Laboratory Work and Research Publications, 1965-1997

SubSeries: Reprints

Folder: "Selective effects of organic mercurials on the GTP-regulatory proteins of adenylate cyclase systems" (1980) TO "Signal transduction: A twenty year history of G-proteins" (no date)

Metadata Last Modified Date:

2006-02-28

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