The Julius Axelrod Papers

Title:

Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine

Description:

This article was the first in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure. Through a variety of tests on several animals, Axelrod found two primary processes, demethylation and hydroxylation, that metabolically transformed ephedrine. He also noted that various animal species showed considerable differences in the relative importance of the two metabolic routes.

Number of Image Pages:

12 (1,063,369 Bytes)

Date:

1953-09 (September 1953)

Creator:

Axelrod, Julius

Source:

Periodical: Axelrod, Julius. "Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine." Journal of Pharmacology and Experimental Therapeutics 109, 1 (September 1953): 62-73. Article. 12 Images.

Publisher:

American Society for Pharmacology and Experimental Therapeutics

Rights:

Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics.

URL: http://www.aspet.org/

Subject:

Medical Subject Headings (MeSH):: Biotransformation; Sympathomimetics

Exhibit Category:

Work on the Sympathomimetic Amines, 1946-1958

Relation:

Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine (March 1954)

The Enzymatic Deamination of Amphetamine (Benzedrine) (June 1955)

Box Number: 22