The Julius Axelrod Papers

Title:

The Enzymatic Deamination of Amphetamine (Benzedrine)

Description:

Part of long series of research articles on the role played in the body by sympathetic amines, in this paper, Axelrod compared the transformation of amphetamine in rabbits to rats, dogs, and guinea pigs. The subject of the article originated in Axelrod's curiosity as to why when amphetamine was administered to rabbits it disappeared entirely. Axelrod found in this article that one or several enzymes in a rabbit's liver deaminated amphetamine, leading to the formation of phenylacetone and ammonia. He also determined that ephedrine was similarly demethylated to norephedrine and formaldehyde by the microsomal drug metabolizing enzymes.

Number of Image Pages:

12 (987,525 Bytes)

Date:

1955-06 (June 1955)

Creator:

Axelrod, Julius

Source:

Periodical: Axelrod, Julius. "The Enzymatic Deamination of Amphetamine (Benzedrine)." Journal of Biological Chemistry 214, 2 (June 1955): 753-763. Article. 12 Images.

Publisher:

American Society for Biochemistry and Molecular Biology

Rights:

Reprinted with permission of the American Society for Biochemistry and Molecular Biology.

Subject:

Medical Subject Headings (MeSH):: Microsomes; Amphetamine; Deamination

Exhibit Category:

Work on the Sympathomimetic Amines, 1946-1958

Relation:

Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine (September 1953)

Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine (March 1954)

Box Number: 22

Folder Number: 7

Unique Identifier:

HHAAAI

Document Type:

Articles

Language:

English

Format:

application/pdf

image/tif

Series: Writings and Publications, 1910-2003

SubSeries: Articles by Axelrod

SubSubSeries: Loose Reprints

Folder: Articles 1-280, 1948-1969

Metadata Last Modified Date:

2006-07-19

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