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The Marshall W. Nirenberg Papers

Title:
The Dependence of Cell-Free Protein Synthesis in E. Coli Upon Naturally Occuring or Synthetic Polyribonucleotides pdf (1,644,825 Bytes) ocr (31,215 Bytes)
Description:
In this landmark essay, published in conjunction with "Characteristics and Stabilization of DNAase-Sensitive Protein Synthesis in E. coli Extracts," the authors present the same conclusions revealed in Nirenberg's address at the now famous International Congress of Biochemistry in Moscow during August 1961. Adding an artificial form of RNA, polyuridylic acid, consisting of the base uracil, to the E. coli extract resulted in the production of an unnatural protein composed entirely of the amino acid phenylalanine. The experiment showed that UUU was the codon for phenylalanine and that messenger RNA, which transcribes genetic information from DNA, directs protein synthesis. This provided a route to base compositions of codons and the exploration of the general nature of the code.
Number of Image Pages:
15 (1,644,825 Bytes)
Date:
1961-10 (October 1961)
Creator:
Nirenberg, Marshall W.
Matthaei, J. Heinrich
Source:
Periodical: Nirenberg, Marshall W., and J. Heinrich Matthaei. "The Dependence of Cell-Free Protein Synthesis in E. Coli Upon Naturally Occuring or Synthetic Polyribonucleotides." Proceedings of the National Academy of Sciences 47, 10 (October 1961): 1588-1602. Article. 15 Images.
Publisher:
National Academy of Sciences
Rights:
Reproduced with permission of Marshall W. Nirenberg.
Subject:
Medical Subject Headings (MeSH):
RNA
RNA, Ribosomal
Escherichia coli
RNA, Messenger
Exhibit Category:
Synthetic RNA and the Poly-U Experiments, 1959-1962
Relation:
Metadata Record Characteristics and Stabilization of DNAase-Sensitive Protein Synthesis in E. Coli Extracts (October 1961)
Unique Identifier:
JJBBDK
Accession Number:
2001-009
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Metadata Last Modified Date:
2006-06-12
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
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