The Marshall W. Nirenberg Papers

Title:: Laboratory project: "Acetylcholine Receptor-Mediated Regulation of Adenylate Cyclase in Hybrid Cells"
Description:: Summary of work on this project as indicated on the report: "The activity of adenylate cyclase in neuroblastoma x glioma hybrid NG108-15 cells is regulated by the interaction of acetylcholine and its analogues with the muscarinic acetylcholine receptors of the cells. Addition of the acetylcholine analogue carbamylcholine inhibits adenylate cyclase activity. However, growth of cells with carbachol results in a prolonged increase in adenylate cyclase activity. Adenylate cyclase activity increases slowly and after 18-24 hours is 1.5-3 times higher than control values. Intracellular cAMP is also 1.5-3 -fold times higher in carbachol-grown cells than in controls. These changes are maintained for at least three days in the presence of carbachol, but the activity returns to control values if carbachol is removed."; Item is a photocopy.
Number of Image Pages:: 2 (137,322 Bytes)
Date:: 1976-09 (September 1976)
Creator:: Nirenberg, Marshall W.; Nathanson, Neil M.; National Heart and Lung Institute. Laboratory of Biochemical Genetics
Rights:: This item is in the public domain. It may be used without permission.
Exhibit Categories:: From Neuroblastoma to Homeobox Genes, 1976-1992; Neuroblastoma Research, 1967-1976
Relation:: Annual Report of the Laboratory of Biochemical Genetics, October 1, 1975 - September 30, 1976 (September 1976)
Box Number:: 31 of 31
Unique Identifier:: JJBBNX
Accession Number:: 2001-020
Document Type:: Reports; Excerpts
Language:: English
Format:: application/pdf; image/tif
Physical Condition:: Good
Metadata Last Modified Date:: 2002-12-06

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