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The Marshall W. Nirenberg Papers

Title:
Laboratory project: "Regulation of Cyclic Nucleotide Biosynthesis by Neurotransmitters and Opiates" pdf (174,778 Bytes) ocr (4,552 Bytes)
Description:
Summary of work on this project as indicated on the report: "The role of the cyclic nucleotides adenosine 3'5' monophosphate and guanosine 3'5' monophosphate in synaptic transmission is under study using cultured cells of neutral origin. The topics of interest during the current year have been the following: 1) The receptor-mediated inhibition of adenylate cyclase activity by alpha-adrenergic agents in neuroblastoma x glioma hybrid cells; 2) Demonstration of a compensatory induction of adenylate cyclase activity in cells treated for one or more days with alpha-adrenergic agents, as had been previously demonstrated by others for opiates, and study of the mechanism of this compensatory induction; 3) The effect of opiates and alpha-adrenergic agents on guanosine 3'5' monophosphate levels in the hybrid cells; 4) Search for a cultured-cell system which synthesizes a peptide with opiate-like properties."
Item is a photocopy.
Number of Image Pages:
2 (174,778 Bytes)
Date:
1976-09 (September 1976)
Creator:
Nirenberg, Marshall W.
Sabol, Steven L.
National Heart and Lung Institute. Laboratory of Biochemical Genetics
Rights:
This item is in the public domain. It may be used without permission.
Exhibit Categories:
From Neuroblastoma to Homeobox Genes, 1976-1992
Neuroblastoma Research, 1967-1976
Relation:
Metadata Record Annual Report of the Laboratory of Biochemical Genetics, October 1, 1975 - September 30, 1976 (September 1976)
Box Number:
31 of 31
Unique Identifier:
JJBBPD
Accession Number:
2001-020
Document Type:
Reports
Excerpts
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Metadata Last Modified Date:
2002-12-06
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
USA.gov, Copyright, Privacy, Accessibility
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