The Marshall W. Nirenberg Papers

Title:

Laboratory project: "Regulation of Adenylate Cyclase by Alpha-Adrenergic Receptors"

Description:

Summary of work on this project as indicated in the report: "The role of the cyclic nucleotides adenosine 3':5' monophosphate (cyclic AMP) and guanosine 3':5' monophosphate (cyclic GMP) in synaptic transmission is under study using cultured cells of neural origin. The topics of interest during the current year have been the following: 1) The alpha-receptor-mediated inhibition of adenylate cyclase activity by norepinephrine in neuroblastoma x glioma hybrid cells; and 2) characterization of a compensatory increase in adeylate cyclase activity in cells treated for 10 hours or longer with norepinephrine and study of the mechanism of this increase, which results in cell tolerance to and dependence on norepinephrine with respect to cyclic AMP synthesis."

Item is a photocopy.

Number of Image Pages:

3 (220,481 Bytes)

Date:

1977-09 (September 1977)

Creator:

Nirenberg, Marshall W.

Sabol, Steven L.

Ayukawa, Saburo

National Heart, Lung, and Blood Institute. Laboratory of Biochemical Genetics

Rights:

This item is in the public domain. It may be used without permission.

Exhibit Category:

From Neuroblastoma to Homeobox Genes, 1976-1992

Relation:

Annual Report of the Laboratory of Biochemical Genetics, July 1, 1976 - September 1, 1977 (September 1977)

Box Number: 13

Folder Number: 35

Unique Identifier:

JJBBQS

Document Type:

Reports

Excerpts

Language:

English

Format:

application/pdf

image/tif

Physical Condition:

Good

Metadata Last Modified Date:

2002-12-06

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