The Christian B. Anfinsen Papers

Title:

The Amino Acid Sequence of an Extracellular Nuclease of Staphylococcus aureus: II. The Amino Acid Sequences of Tryptic and Chymotryptic Peptides

Description:

Throughout the late 1960s, the primary concern of Anfinsen's laboratory was to understand the relationship between structure and function in staphylococcal nuclease. Anfinsen chose to study this enzyme because it was relatively small, with only 149 amino acids, and because it appeared to be entirely dependent on noncovalent binding for the maintenance of an ordered catalytically active structure. In this series of three articles, authored by Anfinsen and Taniuchi, but based primarily on research conducted by the latter, the two scientists presented the first analysis of the primary sequence of the enzyme.

Number of Image Pages:

16 (2,556,979 Bytes)

Date:

1967-10-25 (October 25, 1967)

Creator:

Taniuchi, Horoshi

Anfinsen, Christian B.

Sodja, Ann

Source:

Periodical: Taniuchi, Horoshi, Christian B. Anfinsen, and Ann Sodja. "The Amino Acid Sequence of an Extracellular Nuclease of Staphylococcus aureus: II. The Amino Acid Sequences of Tryptic and Chymotryptic Peptides." Journal of Biological Chemistry 242, 20 (25 October 1967): 4736-4751. Article. 16 Images.

Publisher:

American Society for Biochemistry and Molecular Biology

Rights:

Reproduced with permission of the American Society for Biochemistry and Molecular Biology.

URL: http://www.jbc.org/

Subject:

Medical Subject Headings (MeSH):: Amino Acid Sequence; Peptides; Micrococcal Nuclease; Research Design

Exhibit Category:

Molecular Engineering and Affinity Chromatography, 1959-1972

Relation:

The Amino Acid Sequence of an Extracellular Nuclease of Staphylococcus aureus: I. Linear Order of the Fragments Produced by Cleavage with Cyanogen Bromide (October 10, 1966)

The Amino Acid Sequence of an Extracellular Nuclease of Staphylococcus aureus: III. Complete Amino Acid Sequence (October 25, 1967)

Box Number: 27