The Christian B. Anfinsen Papers

Title:

Studies on the Structural Basis of Ribonuclease Activity

Description:

This brief note was the product of Anfinsen's one-year postdoctoral fellowship from the Rockefeller Foundation at the Carlsberg Laboratory in Copenhagen. It was Anfinsen's second tour at the laboratory; his first in 1939-1940 was cut short due the outbreak of World War II. Working with the Danish biochemist Kaj Linderstrom-Lang and others, Anfinsen conducted an in-depth physical analysis of the structure of ribonuclease, or Rnase. The group suggested that only a relatively small part of the Rnase molecule, the "active center," is directly involved in catalytic activity, and therefore an ordered secondary structure in a protein was unnecessary for its properties as a catalyst. This conclusion was largely disproven by Anfinsen's subsequent research into amino acid sequencing and protein folding in the 1960s.

Item is a photocopy.

Number of Image Pages:

2 (247,597 Bytes)

Date:

1955

Creator:

Anfinsen, Christian B.

Harrington, W. F.

Hvidt, Aase

Linderstrom-Lang, Kaj

Ottensen, Martin

Schellman, John

Source:

Periodical: Anfinsen, Christian B., W. F. Harrington, Aase Hvidt, Kaj Linderstrom-Lang, Martin Ottensen, and John Schellman. "Studies on the Structural Basis of Ribonuclease Activity." Biochimica et Biophysica Acta 17, (1955): 141-142. Article. 2 Images.

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