CALIFORNIA INSTITUTE OF TECHNOLOGY

               PASADENA 4

To;     Rofessor c. w. Beadle

l?HOMl    J. H. Sturdivant

S~CTI Space requirements

     I e&mate below the gross spac3e whioh is needed to oare
adequately for certain existing acrtivities in chemistry which are
related to medioine or bidogy. In mat amas these activities
need double the space now available to them, even without
expansionof the researohprograms.  If they cxa be given the
space they need in a new building, that which they free in
Gates and Crellin can bo used to grecst adverntbb- by other existing
aQtiVities.

     The various needs for space are taken up in order of
decreasing urgency,

    1. The izu83unochemistry group directed bp kofeseors
Linus Pauling and D, H. Campbell is most inadequately housed at
prssent.  The group progrsm includes investigations of hemoglobin
in relation to disease in human bsings; of sqpcLlyg&l.atin, a
plasma extender developd by the group; and of allergy, the processes
of sensitisakion, and the nature of entigen-antibody reactions.
A wide variety of chemiual and physical instrumental methods must
be employed, including electron microscopy, analysis in the
ultra.oentrifuge, electrophoreais, ultrtisonlos, light scattering,
radioactive tracer techinques, snd magnetic methods; oonsequently
the demands for space are especially heavy. The group now occupies
74UC sq, ft. in Gates snd Crellin; they need 15rOOQ sq. ft.

      2.  Professor Rauling, who should have office and
ldxwhtary spase near the immunochemistry group and related grouts,
ocoupios 1000 sq. ft. in Crellin, and needs 1500 8q. ft.

      3.  The small analytical snr? ;;reparative group headed "~Y,J:
Dr. Sohroeder, and directed generally by Professor Corey, ~~~G-s-KB
itself with the problem of deternining the order of amino acid
residues in iz polypeptide chain. They are now attempting the
analysis of gelatin, a protein of great v~3dical and physiological
importance.  This program complements from the fundmen+kl side the
more pxd&xil studies of gelatin s.nd modified galatius as plasma
extenders.  If suoussafl it will dso fmiah the -be&L2 infor~tiuw
necessary before a detailed determination of the stru&tirs of the
gelatin moleculs by x-ray diffractian can be attez@ed.


This group, one which is only a few years old, is hampered by the
limited apace available, 1250 sq. ft.; they need 3QOO sq. ft.

     4. Frofemwr EUemann heads a large group whiah ilp
carrying out a penetrating study of the nature of enzymes and the
meuhani8m of their aotion in relation to their structure,
especrially the enaymes whic& degrade proteins into smino acids in
the animal body.  This group orzoupies 3OOC sq* ft., end crould use
effectively 4500 sq. ft.

     5. The large x-ray diffractti&n group headed by
Professor Pauling and Prof8ssor Corey began about 16 years ago a
long-range attack on the problem of the struoture of proteins.
Muuh of the groundwork has been completed; the interatomic
distanoes, bond angles, and other structural features in many
amino acids and polypeptides have been measured. A number of
aaaeptable ways of ooiling the @ypeptide ohain have been
proposed, and now detailed ucmparieons of the proposed models
with the evidence from diffraation studies are under wa,y. This
group omupies 6000 sq, ft. It needs l2,OOC sq, ft.

    6, To serve the five groups above a variety of
special utility rooms would be necessary, such as balance rooms,
dark rooms, speotrophotometric laboratories, a oaloulating
room, a seminar room, etu.  Roughly 2OOC sq. ft. would be needed
here.

The foregoing spaae requirements are tabulated below.

I.. Immunochemistry        15,ooo sq. ft.
2. Professor Pauling        1,500
3. Protein analysis
4. EnzyDle &emietry    ::iz
5. x-ray llxd.eoular struoture l2,ooo
6. therail                2,.CW

          Total       38&00 sq, .n. grose3

     As I have told you, these are not quite al.1 of the
pressing needs for spaoe for chemistry.

    Three proposals for a new chemistry building have been
prepared in reoent years with the advicre of Mr. Hertenstein. I
believe that the following costs for 8paae for ohemieal activities,
with quality and facilities equal to Crellin Iaboratory to-day,
are r8alistio.  Paoh item should be multiplied by the gross area
ooeupied.


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For construction, including architects' fees,
   Ughting, ventilation, and utilities

$25 per we ft.

For uhemiual furnltur8, including f&m
   hoods,uhemiual dsaks,mdreagent
    ShelVeS

For office furniture

For mmhanical assistance in nroving end
   iastalling apparatus and facilities,
   and for materials of Installation

Total

6 per sq. ft.

1 per sq. ft.

lwr sq. ft.

3 pr 8q. ft.

JHsrnt