4

Dr. krren %mer
Tha xoakafellw FoImdutloa
49 Ueclt 49th strwt
lkv York a, bv T4rk

     Ii we6 YeTy &AA to rw8iTe your ietter of septelnber 21, end to
knov,that you are dntersetsd in the prupoeal mdr, in my letter of August &L

     I bite buen thlnkislg about the point8 vhich you refrad, and, in
4%UCOdtUK?U tdth ~OUI' 63&@36tiQl% that tiub 4OST%~OXUhiM bs AQt dd&yOd, 1
would have anrvend after a fw dayu, o xcagt that for over a vwk X haps bees%
anthuriarti4aily %lawaebigrstfq$ a 6wMlod for obt&iaing tnfvmetma ab4nt the
rtnaatw of protsias vhbh, tithough not WV, her nutur before been wed
affeatirely.  This method oosslists in the detemlrtethos of the aAwrptio8
ieothermo of vat%r mqor cm the protetiso.  I hme found that thu data o$ tti
lit-erature, S-U&I as) those publirhed remmtly by Elsnry 3ml1, can be mbJectsd
t0 a th@oratfecPt &$f&d.y6it uhioh 16ad6 Pi0 wry &finite COAUb6iOA6 abOUt th,
vay la vh&tUs %iM amho add residttss llnte~ct with vatar molecules.  tt seerno
clrur th& more prwire eiqwriaental data wuldt with this method of Lnterpse-
tabioa, yield wry lrtteresting infanaatfoa abut tha rtructurq of pmtrsinr,
rupphwntiag that obtahd by other methods.

     I agrw with your statement thut tkmrcs pap veil be sore dessmd far
veil trained yam& scfentlrtr tlllam rcianti&o to fill the jobs aftar the v&r*
On ths other hand, T baliete that 10 ~411 be possible for IXB to find 9 number
of sneretic and Eatrls yaung mnn who are auffiaiemtly intererted in the fxsnde-
aemtal problarm C? 6ui6,ncre to b glad to hervrr the qpportwdty of &king -JKSX%
i8 a ~~6e8rch prO&4t which p.~8isO6 t0 yield mmy ii+pOrtti%At UtX.&ribUth?%6 t0
sol.sa4e.  There my `be moma difftclnltg ta balk&lag up a resasorah grmp,
bea~ues of the demtmd of unirsrsit~ teaahisg and bdurtrical reueereh; Z think,
howewr'. that the wriod at the errd of the WFAI will be BL wry good one far
forming thir &map, becaw.6 of the fad that we 8lpb EOW guttinlg augwaintrsd vlth
a lerge xnmlmr of young mew, and v% should bar able to make a reap good wleatian
fr6m rupong them, prorUed that w ere able to attract them iato thir ast$Vity.

     Dr. &my aaA f half43 fhf ty youA& wri ernd w8@n WQrlcing on our XDEG
projsut.  Of theses, fifteen or tvemty have the gropertiss deslr&ls fer
employment on the proposed program of fuadamtciX research, iaad a nIuB)Nr of
thsss alght br, intersotsd in panrticipati!&g ia thir pmgxvm. Sow of the
workerr would prssuppebly be obtained fro8 othar pro&et8 and other inrtltutbna.

     If it tUX'A6 out that tfr6r.a i6 130 Our@6 of trained inrrati@.on
ataflabI* after the var. it Eoight be tim to plan ta carry ost the pxvgmw
outlined in q mrlier lsttetr over a period of about @ix years, rather them
three yeare.


Pr. Weman Wmwer

-29

actol3er 5, 1944

     The teahniqusa have boon dmmpsb to aauh s pa&t that the uu*
could, f balieve, be pushed forvard at (I mather rapid rat!, tithout lorr of
efZtuisnq.  If the work wre to ba qmad ovar six or eight year6 r&ml:
than to ?m Oonrnurtr~teA into thma or four yam6 the total fund6 sxpcmdrd
might k rued ronwhat mm affroOin4.  &nrmw, 1 wrxld prefer to bw the
vork bona 16 r&d&y 86 poruiblrs; ? ?? o nihasfartia be biWA tha PLIauWI ioo
the M6t hltOrU8ttng qWM3tbXM pCW%d ftlr 91 by &tbpre, &?&d f am &W%d fhhab
tualrrr a verg intonrlre attack la mde oa these problemr the mmrem say sot
?.m found daring oar llietirar.

     t&era may bs en sr&ummt ;Ln favor of an intonaive afta&, b;v w
miWmde, on th protein prob&u,  f do aat, be1 ien thiit my otw tebthsd of
iaY*ati~tlon will aloao proyi& the rolutiooa of thi6 probl#a;r.  Instead it
ia, X think, probable that hfntr about tb+ wlutioa UfIl br giwm bJr thm
mdtr of n8Ry llPbthod6 of innrt~~tlon, and that the fin01 6jath6S%u Of
there hlatlr will be medt~ by vWksrr imo pm famkllar with sll of the aothubs
aXid di Of tb MI(Xlt6.  `Ehir rooomplidwient may thea be crrpwtcd oz&y ubb
(L bread am well PI iatoneito rttmk oa the problem io beixw mdb.

     Tb inatituttanal aooper~tion VRidr my be o xpeatod vmkd m~@sm,
X think, tho ranleo~ of T)r. 3Wmt II. Oarry, Dr. Corner hhtmbr, aad myseW
08 ptiaaipal inr*rt2g&8tor,* ud iam mm 00 $+j,Ow uur9rlly (for mol*oular
rtrwtum reoaiwdn) which ha6 bean protidaci Q oh8 h6titUt6 4arb$ tEu part
080 ywrr.  we have laboratory #p&a. aAd feoll~tier for fiflm investigBterr,
vithout orwdla& Zn rdd%~lo~~ to tho umtbeiptad ntmbm of #reAuate rtudentr
and other nomid rtmborah 88a.

     The derelopm6nt of our Irrabrr6taadhg of the fwda8ental pCyreimbX
iad ahamioml `&air of pbgriolo(laa& pro0e680#, for vhlah there ir suoh 89
im6mAbto llaara need, will, I baltsre, promo8 vit& a rapidity lnctmpmd&y
#rester after iualt a pro&ma OS that propowA hat boa rzarrfsd to 8~ a-waae~s-
ful oonalu8ion th8n vitho%&t the remAt 6f ,thi, pro@wl.

IE roll look fomw6 to your letter.

Siaaarely ymw8,