Sepijmber 9, 1947

     X aa looking forward to seeing you next month, sometiti
betusen the 10th and 28th of October,  I rqhdl plan to oorae to xsdiebn-
apolis, fur twa or three dsrgra, ir mme that this Is satiafac-tory with
3-U*  It rfll ba a plaersure "a mm how the work in the Lilly Laborator-
ies has been gokra; on*

     One idea that X have had, #and would Uke to try out BOPB-
tiiue if posasiblr, i% that of :x&fag 88 imesti.gatfon of the fate of
1amU.n in the body.  It seeuia 8urprIsfng to me that insulin retains
its a&tivity ia the blood strem For auoh a short while after injec-
tfon or release.  There ir, of courm, a sound physfologfcal reasm
for this, in nomuaL healthl, butt if it were possible to rh4.a the
activity for a longer period a patient Bight well be` able, by i~etiting
at mailer suitable intervala, to mke a given amount of inlritlin la&
very much lower than at premmt.  In view of what you and Dr. Clowsa
told 1~19 a few lgontha ago,
gatedr         this possfbLlity should, X t-hi&, be inp~esti-

     One Yuggsstion that I have to mike, euJtd which f thiaicr hither
you or we Bight fDllow up, is to attempt to change the inmalin molecule
la such a way 8s to oause it to retti ite activity but. +vc be stabilfaed,
so that it remin@ active in the blood etreaia far a lmger the. X
would suggest that insulin be treated with various reagents - ketenfs,
qartm aubotids, eta, - in or?er to Cind out whether such ciz~&cal
treatmmt can be carried oat wtiithou% destro$ng the aotivi!ty of the
instUn, and what th? effect of the ohmiod treataent is or& the
periad of activity. There hs a chance - & s,na3;1 chmce, it is true -
that a chemioally treated inmlfa &ght be aamafactured that would