TABLE Al&--Ezperimenta conccmng the elfect of the inhalation of cigarette smoke or it8 conalituenls upon the respiratory tract of ani7nuls (cont.) (Figurn In parenthun rcprercnt total number murvivon in opecific f~roup) Author. ye.*. C0Unlt-Y. rffrrenec Donlenwill and Golden hamsters. A. Chamber. Number of DLliIU Wicbeckc. c. - B. ur, to , cigarcttca animal4 ovcrogf 11166. E. 320 per dsy for up dead at crpoaurc Germrny lo 2 ye.rIl. 510 dnya (ciuar~llcr) (771. C. Cigarette smoke. 40 ...I . . . . . . . . . . 1 40 . . . . . . . . . . . . t, 2 80 . . . . l-2 MET des = drsqusma- Htitoiogic live mctaplusin. findinoa in MET branch = Irron- drnd animalr chini pnpillnry 81 40 MET dea mclaylasio. 8/ 40 MET drs PAP trach = trschrnl 44/ 80 MET de3 (3 hIET popillomals or branch. 2 PAP trach) lntensc truchenl b7/143 MET dn (13 MET mctnvlaaia. branch. 8 PAP trach) Lcuchtenberrer CF, mice. A. Chamber. and B. Up lo 1,000 hours. Leuchtcn. C. Cigarette smoke. Marked aauamovr bcrger 1966. exvrxurt lo in- ccl1 mclaplnaio Switzerland nuenra virus (percent) (160. (PM). Cunlrol, (100) : Male ,. ,. - Fcmnlr ,..., - Smoke en~osd (S.9) : Mule ., - Frmnle - Vinw exr>ascd (59, : hlalc 11.0 Fwnt~le ,,... - Smoke snd virus exposed (68) : >lulr 9.0 w Femnle 29.0 - - 6.0 - 21.0 43.0 64.0 - - 3.0 - 13.0 5.0 113.0 133.0 -~ Hsri i> and C57BL mice: A. Chamber. Nearun~. c. 200. II. Smuke-12 ciga- 1967. E. 1,437. rcttes per `20 Pnalnnd mice fur I2 (121). minutes every uthrr dny for lifetime. C. CiKnrelte smoke, influenza virus ae1.,,1u1, bcnr- "Yrene c.ertrsol. Author, yefar. c0""tl-i. rrferencr A. Type 01 expos"re B. Duration C. Material Kcsults Comment8 Wyndcr Cl al.. Male C57BL6 A. Chamber. Conclusions: t tRcvuit3 not prub id4 186s. mice: B. UP to 315 No squamous ccl1 respiratory cancer noted. This is attributed in tabular form. U S.A. tJ.`l). C. snd E.- ciR.alettes. to the limitation 01 inhalation time (CO and nicotine acute more than 40. C. Cigarette smoke. e!Tccts) and to the ~nuton~w~lly and ahysiologicolly intricotc nitrogen dioxide, nasnl prss!aue dclenw system. volntiic acids ktxpusure to c!gu~~`tte smoke. N02. or volatile acide snd aldr and aldehydes hydes lead:, to reactive hypcrplnria and metaplasia, both of fuund in ciua- which WPVC noted to be reversible. rette smoke. Swine inl~uenru virus exposure produced hyperplsstic and swine influenza mctnplastic cflccts which could not be enhanced by aubrc- \.il.US, qurnt ~XPOSUI'C tu ciunrrttr smoke. cc, cu 0 .---- huthur. TABLE AZl.-01rlhc of .wO.ospcc1itv shtdies of tobacco ILSC and cancc~ O/ tile larpz _. Y4'kT, CDScl "`~,`\1,)`. - ----_- rt,l,,rcnrc St,\ Numhcr hlcthod ul aclcctiun - _..... .--- ___-.__-_ _._---.-~ M.-F i!?C Clinic wticntn with canecr of the Jup/u: 108 Clinic nuticnts of ~nrne BIC P~DUD with Medical hiaturv and QUCI- TABLE A21.-Outline of sehxspcc~ivc sludies of tobacco use and cancer 01 the laqmz (cont.) Cn3-3 Controls Collwtion of data SC% Number Method of selection Number Method of selection hl. 241 Clinic patients with enncer of Inrynx: 200 Patients wi!h no laryngeal disease: Personal history taken In Wyndcr ct al.. hl. 209 White mnie inpatiente hlemorinl Cancer 200 Paticnta with other than epidcrmoid TraIned lay inlervtcwera. 1056. Research Center during 1952 to 1954. cnnccr, individually matched controls U.S.A. (512). with benign or malignant epidermoid in wme institutions: tumors of larynx: Prrccnl Pcrcrnl Nonsmokers I. .,. I,. 0.6 Nonsmokers ,. . ..*..... 10.6 Cigarettes ,,. .,, ,,, 86.0 Cigarettes .,, .,, ,. ._, 13.7 Cigars ,. ,. ,,, ,. ., ,, 7.6 Cigars .,.. . 10.1 PiDM .I.. ,. I., 6.0 ripea ,...... ......II.,..... 3.8 CigRts/pipCS ., ., .I., ,. 1.0 Clynla/plpc3 I. . . . . ,. ,. 1.9 Wynder et al.. hl. 60 Patients at Rndiumhrmmst with squam- 1957, ous-cell etlncer of larynx. from 1952 Sweden (~2). through 1'355: PCrCCllt Nonsmokers . . . . . . ._ 6 CiKnrettee ., ,, 41 Cimrs ,, ., ,, 17 ripes ,, 16 Mixed .., ., ,, 17 Wynder et al.. hl. 142 Clinic yntients in Havann during 1956.67. 220 Same IOUTCC nnd time: aooarentlv DLL- Interview of Dntirnts 384 1.1 14 12.1 II.4 1 ,I 11.2 4.5 I .`J -- 2 1.7 - 0 - - 0 - - v - - . 0 -. 04 100.0 125 100.0 :1:9 100.0 130 I 1.1 I .H 0 - 0 4 43 25 20 0 ` 1.2 0 50 63.0 54 432 Xl 26.4 21 23 24.5 21 II; n IIG 35.3 ib 0 0.G 1 1.2 44 13.4 33 2.1 2 1.6 I !I 6.H II 1 1.1 0 -- 5 I G 0 :oo 0 ..-. - I'(, I I TAELE A24.-Number and percent distribution, 611 highest number of cell TOWS in the basal layer of the true vocal cord, of men classi/icd Ly smoking cutcgoty T<>lal . . . , . . . . HH 100.0 116 100.0 04 100.0 125 100.0 329 100.0 190 100.0 Lcr. than 5 ccl1 row, . . . ,,,.I . 311 34.1 7 6.0 4 4.3 3 2.4 1 0.3 0 5 cell rows ,. . 2'J 33.0 21 23.9 20 21.3 27 21.6 9.8 11.6 20 10.6 6 cc,, rows , , . . ,,, .,, , x 9.1 15 12.9 15 6.0 25 20.0 61 IS.4 24 12.6 7 cell rows . . ., . . . . 6 6.8 12 10.3 IR 19.1 12 9.6 39 11.6 19 10 0 n cell r"wB . . . *. . , , . ,, . 6 9.1 la 12.1 9 9.6 13 10.4 30 9.1 23 12.1 3 cell rows . . ,. ,. 1 1.1 7 6.0 7 7.4 6 4.8 ZG 7.9 I4 1.4 10 or m"re cell row3 . . . . . 6 6.R 34 29.4 ?I 22.3 39 31.2 146 44.1 90 47.4 - Source: Auerbnch, 0. et al. (9). ---- -. .-_- -_.-.- ____-.---- TABLE A28.-&lhc of retrospective studies of tolmcco use and cancer of the oral cavils (cont.) (Data~oblsincd from patient interview and otbrr auurce.) Author, year. CO"ntTy, refercncc CllWS Co"trob Commcnlc SC% Number Melbod ol selwtlon Number bletbod of selection Sbsnta and Xl. 662 Patient> with oral and phnryngenl cancer 300 Krisbnwnurthi, F. 20t (unsure of conflrmstion) : 100 1964. PerCCtlt India (~66). Buccal At1teriOT Posteri.Jr MtllCll: LiJJ nLllcod* touguc tongue No tobacco habit . . - 2.0 7.2 2.0 Smokcw 60.0 46.7 66.6 76.0 Numberofcwcs ,,., (12) (213) (69) (481 Femnlca: No tobncco habit , a, , 14.3 11.0 33.3 - Smokers . ., ,, . . - 4.7 - Number of eaws . (7) (162) (0 Controls residing in ~&me area matched for age, vex, and ClilBa: Phat-unz Nlolta 6.3 99.1 72.8 62.7 (130) (300) FRndCI 40.0 RR.8 8.8 (26) (100) Wnhi et al., 1965. lndla (302). hl. F. IA0 Pnticnts with oral and pharvngeal car- 689 Patients matched for age, sex. religion. 232 Cl"Ol"a: 232 and wcial class. PeTCCTlL PC7CC7ll Nonsmokers . . . . . . . . . . . 9.62 C6.6 Smokers . . . . . . . . . . . . . . . . . . . 17.05 21.2 Chewers (Betel nut) . ., , 35.44 6.9 Hirayama. 1966. Central and South East Asia (124). Both I . . . . ,.. ,. . . 37.88 6.4 Bl 3c9 Patients with oral and pharyngenl cnrci- 277 Patients with other (unspecified) dls- Found only a suggnllve F. 176 noma: 163 eases: association between PCTCCTlt PCrCCVlt hlcohol-drinking and Malt Fcmolc Malt Fcmalc oral crlnccr In non- Nonusers . . . . . ,. 1.~ 2.6 11.0 33.0 chcwcm only. Smokers . . . 17.1 2.6 23.8 1.2 t UN-Iletcl nut. Smokers, tBN nnd tobncco chewers . . . 46.7 6.6 24.9 1.6 TABLE AZ&-Outline of retrospective studies o/ tobacco me ad cancer o/ the oral cauilu (cont.) (Datr obtalnrd from patient interview and other sources) Author, yerr. CUCU controla country, Comments reference Sex Number Method of aelection Number Method of selectlo" Keller, M 4on Patienta with s~usmous cell carclnomn al 408 Next mule patient admitted to same hos- Excessive ulcohol LO"- 1967. oral cavity and orophsrynx connrmed pit01 within 6 year hw range. aumotiun noted lur U.S.A. (I40). hiatolonieally. Three New York Cite VA cbscs invulving flour. PIrCCnt 14.2 56.4 (Du) (IO shu\%cd h>wr- co"de"sate. kerntosis). D>lBA in 0.6% DMBA . . . . . . . . . . . . . . ,a,...,, . . . . . . . . . . ..a.. 0.8 14/21 microscopic cancers (at 00 daya) petrolatum. (invaaivc ~puatnous conccr 0riKinntinz in the skjn at Ihc WIED of the vouch). Salley. 19c3, U.S.A. (239). CAFI strain mice. A. Ultraviolet light exjmsure to nnd pninting of lips. B. 3 ~)er week for 08 weckr. c. D(8)P in ncetone Cigarette smoke WV llnht. Uock et al.. 1CR Swiss A. Pointing mouse 1864. mice. skin. U.S.A. D. See results 36 wwka. (JO). C. Various extract3 of Trentmrnt: unburned t&am, DhlBA once then: DhlBA. Acetone benzene extmct Conccntratnl na(OH)pextroct .,. Diiuteil Un(Oll)Zcxtrnct ,.. ,,,,, DMllA only Aectnnc bvnzene EXtl'sCt Concentrnctcd Un(OH), ~xtrrict ., Diluted Bn(OIil 2 cxtrnct None ,. :. 5 0 h.matera.' 07ipind Aforlolify Number utilh wlh Treatment: number rn1c animals 1umorr CL?"CO DhlUA Alcohol Smoke 2'J 41.0 II 100.0 60.0 DMnA Alcohol . . , 29 6G.0 10 60.0 40.0 DhlllA ,. Smoke 29 42.0 14 100.0 10.0 DMIlh . , ., . . . . . 28 4R.O 16 100.0 80.0 . . . . . . Alcohol Smoke 29 42.0 14 . . . , . . . , . . Smoke 28 42.0 14 - -