SURGEON GENERAL'S WORKSHOP Health Promotion and Aging Backgmund Papers Edited by: DEP SG Faye G. Abdellah SR PHARM Steven K. Moore DEPARTMENT OF HEALTH & HUMAN SERVICES -. Public Health Service The Surgeon General of the Public Health Service Rockville MD 20857 November 23. 1987 Dear Workshop Participant, Change often offers opportunity! As our society changes and we have an older population, age has traditionally been equated with diminished capacity and ability. This does not necessarily have to be the expected outcome. The combined expertise of the scientific community, the interest of the aging network, and the will of older individuals to modify their way of living to accommodate healthful lifestyles, can allow later life to be both meaningful and active. At my request, individuals ;Jho have expertise in various aspects of health pro.notion and aging have compiled a series of papers that seek to document what we know about health promotion research and activities. These papers are thus provided to you in preparation for the deliberation of the Workshop participants on Health Promotion and Aging. Though they may not offer answers, the papers will hopefully provide an overview of what is knoun and provoke thought on the topic areas prior to the meeting. In the same manner, the papers do not seek to provide answers, for in many instances we do not necessarily have these answers yet. We do have indicators and Mith the proper emphasis and encouragement, we hope to move forrrard into the arena of preventive activities and healthful lifestyles. Please consider these papers as starting points for your further thought and deliberation, and more importantly, for our joint action in the application of health promotion to our aging society. Surgeon General Surgeon General's Workshop Health Promotion and Aging Background Papers TABLE OF CONTENTS -- _---- topic area - -- Alcohol Dental Health Exercise Injury Prevention Medications Mental Health Nutrition Preventive Health Services Smoking Cessation cage A-l B-l c - 1 D- 1 E-l F- 1 G - 1 H -1 I - 1 Health Promotion and Aging "Alcohol" Erma Polly Williams, M-R-E. Continuing Education Faculty, Rutgers Center of Alcohol Studies Consultant to the New Jersey State Division on Aging Consultant to the New Jersey State Division on Alcoholism Alcohol is here to stay. Older people probably have a better sense of the meaning of that statement than younger people since anyone over the age of 55 lived part of their life under Prohibition. Anyone over the age of 65 probably remembers at least fragments of the "roaring twenties", and anyone over seventy probably recalls Temperance slogans, speeches and rallies. Older people are also here to stay. With people over 65 representing approximately 12% of the population, they are the fastest growing segment of the society, and include many more people of increasingly advanced age. As the quality of life for these older people is strongly tied to the maintenance of health, it is appropriate that there should be a consideration of the relationship of age and alcohol from a health perspective. Interest and concern about the incidence of alcohol use and abuse by the older portion of the population have increased dramatically over the last 20 years. This increase is evident in the core of alcohol literature, as well as in the publications of many disciplines, reflecting the multidisciplinary dimensions of the phenomenon. It is being addressed in professional journals, giving evidence that the problem is being encountered by the many systems and agencies that provide services to older people. Y?t despite this tide of attention, the area of study and the level of response to the need do not seem to gain much headway. In view of all the needs of older people in our society, problems related to alcohol are relegated to a low place on the priority list. And in the alcohol field, the aged do not appear to generate the excitement and involvement of other population groups. The society is becoming increasingly sensitive to the presence of elderly people. By sheer weight of numbers, it is becoming more imperative that issues related to their health and well-being be addressed. The pervasiveness of the use of alcohol as a societal practice, and the types of impact that this use can have on the indjviduals and the resources of the society, require that it be one of the areas addressed in relation to the older segment of the society- BAZTC DEMOGRAPHIC AND POPULATION DATA Extent of drinking ~-~ In considering the data available that indicates the nature and the extent of the problem, it should be noted that the designaticns of the older we and the designations rzlaterl to alcohol use and abuse arit specific to the individual study, and become relative terms when used to discuss several studies that may not have the same specific criteria. Cross sectional studies of the use of alcohol have provided information that, when compared to younger age groups, the rates of abstainers increase and the A-l percentage of drinkers decrease in the older age groups. Cahalan et al. (19691, using national household survey data, reported the percentage abstainers by age group: age 40-49, 29%; age 50-59, 40%; and age 60+, 47%. The proporticn of heavy drinkers for the same age groups were 15%, 10% and 6%, respectively. For men, Cahalan reported that more than half of the men o;`er 65 were not regular drinkers (54% being either abstinent or infrequent drinkers) and the lowest percentage of heavy drinkers were found in this age group. In the age group of 60-64, 20% were classified as heavy drinkers, representing 35% of those that drank. At age 65, this figure dropped to 7%, cr 11% of those that drank. In the same study, for women, there was similar decline but evidenced at age 50. Two thirds of women aged 50 to 64 did not drink at all or infrequently . After age fifty, the percentage of heavy drinkers among women became inconsequential. Similar tendencies were reported by Barnes (19791 from a general population survey in western New York state, by Christcpherson et al. (1984) from a survey in rural Arizona, and by Meyers et al. (1981) from a household survey in Boston. Barnes noted that while the regional rates of heavy drinking are significantly higher than the national rates, the trends holds. Rates cf abstinence increased from 13% for those age 50-59, to 31% for age 60-96. In addition, Barnes refined the age group of 60+ and reported that 24% 3f males age 60-69 were hEaiTy drinkers; for those age 70-96, 6% were in that category. Among females, heavy drinkers accounted for none of those age 60-69, but ;I% of those age 70-30. The reasons for the decrease in the proportion of drinkers from the younger to the older age categories has been considered by sereral researchers _ Items were included in several studies that inquired about previous drinking patterns or problems. Responses frequently mentioned concerns for health or health problems that were experienced as a reason to temper the quantity and/or the frequency of drinking _ Other responses rsng,,d from eccnomic reasons, changing social opportunities, and changing response to the substance. Gnmberg (1982) has summarized possible explanations for the decrease in social drinking as economic (decrease in drinking may result from lower income). physiolcgy (change in obtained blood alcohol levels with physical aging), effects of alcohol (resulting impacts and behaviors are no longer worth th:: cost:, life cycle differences (decrease a natural occurrence 3s cohorts ages), unique historical aspects (drinking habits of current generation influenced by Prohibition, Depression), and medical problems (health status, with increased medical problems, cause older pecple to limit or eliminate drinking! _ J Two additional items shculd be kept in. :ilind when considering this data. The cohorts of older people that are repcrted in each of these studies are products af the social and historical influences of their time: xhich are then intertwined with an array of unique individual experiences. Subsequent generations of older pccple will, in inany r2spects, b;. very different from the ,:1der people of these studies. Specifically, it should bt remembered that cross sectional studies present data that evidence a lower percentage of abstainers and an increase in the level of drinking in the younger age groups. There is also evidence in surveys that drinking practices remain consistent overtime with some people. Christophorson (1984) has presented data that there is a tendency for people to carry drinking patterns into old age as long as circumstan::Fs and health permit. Data frsrr, th2 Normative Drinking Study confirms this (Glynn et 31. 1984) - ?l?ri, originally surveyed in their IO's and 50's, ten years later reported consistent drinking habits. It would aPpear that future generations Of older people would present a larger proportion of drinkers and a potential of more people who continue to drink at higher levels into old age. Problems w$.JJ drinking Evidence of problems related to alcohol use among older people comes from several types of sources with a range of criteria for the designation of a problem. Cahalan (1970) utilized the self reporting of eleven typzs of problems, including quantity/frequency and pattern of drinking, elements of physical and psychological dependency, and interpersonal, social, health, economic and legal problems. He reported that 12% of men age 60-69 had a current problem score of 7+. For age 70+, it was 1%. For women age 60-69, 1% had a current problem score of 7+; age 70+, less than one-half percent. These figures do represent a tapering off of drinking problems fcr men after age 50 but continuing until age 70. Further analysis involved the development of a social-psychological risk score which included attitude toward drinking, environmental support for heavy drinking, alienation and maladjustment, impnlsivity and ncn-conformity, looseness of social controls, and unfavorable expectations. Data indicates that men 60t of highest risk sccre show almost the same problem score as those of younger age groups. A second community sur:Iey source of infcrmation on problems related to drinking is the Epidemiologic Catchment Area Study which utilizes the WIMH Diagnostic Interview Schedule. This schedule provides for assessment of alcohol abuse and dependence based on the American Psychiatric Association's Diagnostic and Statistical Manual, DSM-III (Ameri'can Psychiatric Association 1980). Three sites of the five in the study have presented information related to alcohol abuse and dependence. The lowest rates of alcohol abuse and alcchol dependency were among those 65+, ranging from 4% to 8% at sometime in their life. In terms of the recent occurrence of problems (within the last 6 months!, 3% of males reported a problem, 1% of females. Similar rates were found for blacks and whites, and social class did not appear to have a large effect (Robins, 1994). Warheit and Auth (19841, investigating concurrent alcohol and mental health problems, found similar rates for alcohol problems within the older population. In looking at the correlation between mental health concerns and alcohol use, an alcohol risk score was developed and the sample divided into high and lcw alcohol risk groups. Items included were drinking in general, intoxication, problems related to drinking (personal, social the frequency of and family), self- perceptionS regarding the appropriateness of alcohol use, and the use of alcohol to face daily problems. For the older segment of the sample, age 50t, the high risk group generally gave more indications of poor mental and physical health than the low alcohol risk group of the same age _ Advancing ag? bras highly associated the increasing feelings of helplessness among the high risk group. Self perception of pcor health was more common in the alcohol high risk grcup. In reporting their present mental health, 39% of the high risk group responded fair or poor; among the low alcohol risk group, only 22.1% reported fair or poor mental health. Almost half (46.3%) of the high risk alcohol group reported at least one hospital stay in the last three years, 14.6% had three or m?re inpatient stays. This is contrasted with the low risk group that reported 28.7% had one or two stays, 4.7% had three or more. Generally, Warhei t and Auth concluded that alcchol use rather than age alone seemed to a better predictor of the kinds of health problems that necessitate hospitalization. A-3 Studies that report on the older population within institutions and medical settings provide additional information. McCusker et al. (1971) conducted a prevalence study of newly admitted patients to the medical wards of a Nen York City hospital serving a high proportion of blacks and Hispanics. Questionnaires were utilized to gather information to rate alcohol related problems over the past year. The moderate level of the scale, identified as the threshold for the diagnosis of alcoholic, identifed frequent intcxication up to cne or two times per week and/or significant impairment in social, family, or occupational functioning, or evidence of physical impairment related to alcohol. In the age group 50-69, 63% of the males and 35% of the females met this criteria. A study of 113 consecutive male admissions to acute medical wards was made by Schuckit and Miller (1976) in a Veterans Administration Hospital. Interviews established the patient's psychiatric diagnosis, organicity tests determined the presence of organic impairments, chart reviews provided basic demographic information, past and present physical and mental status, medication and drug and alcohol history. A resource person validated the patient information. Of these admissions, 18% (20) were diagnosed as alcoholic, with 55% (11) of these considered inactive, or having had no alcohol related problem in the 6 months prior to hospitalization, although 3 of the I1 still drank. Data from psychiatric services provides other evidence: of 534 first admissions of patients age 60+, 28% had serious drinking problems (Simon et al. 1968); in an outpatient psychiatric program in Harlem Hospital, 12% of the elderly were noted as having a drinking problem (Zimberg 1369); in a county psychiatric screening ward, among 100 consecutive admissions of persons 60+, 44% were alcoholic (Gaitz and Baer 1971); and in a medical home care program, 13% of the elderly patients requiring psychiatric consultation were diagnosed as alcoholic (Zimberg 19711. Although it is not possible to determine the actual prevalence, the fact remains that a sizable proportion of the elderly do evident? alcoholism and problem drinking. While recognizing that older people do drink less, an estimate of the prevalence of alcoholism among those whc do drink approximates that cf ether adults, nearly 8% (Nate 1984). Estimated rates in clinical practice with older people ranges from 10 to 20% with a higher proportion among the elderly who are hospitalized and institutionalized (Schuckit and pastor 1379, Zimberg 1982). Ufferent types of presentation - As early as 1968, there were attempts to dr:ielop a classification system of older alcoholics. It was recognized that there are sub-groups who presented similar histories and symptoms. Simon et al. (1968) reported that among a uroup of first admission psychiatric patients with serious drinking problems, age 60 and older, about l/3 had become alcoholic after age 60, while about 2/3 had been a?coholic before age 60 and had a long history of alcohol abuse. He also noted that a little over l/3 had chronic brain syndrome, but this diagnosis was not excl?;sive to either group. The proportion of :I! late life and 2/3 long standing was confirmed by Rosin and Glat t (1971) from studies of psychiatric home consultations and admissions :0 alcoholism units and hospital geriatric units. Schuckit and Miller (1976) also made a distinction betrreen early-onset and late on-set, using age 40 as the demarcation. Among the Ferscns ages 65t being admitted to a medical ward, using this designation, the groups was almcst equally A - 4 divided- Carruth et al. (1973) noted three distinct types: individuals with no history of problem drinking until one developed in response to age related stress, a second group that had at times experienced problems but only developed severe and persistent problematic drinking in old age, and a third group who had a long history of alcoholism and continued to drink into old age. Gomberg (1982) also recognized three groups, the survivors: alcoholic persons who have grown older; those with intermittent histories of heavy drinking in response to severe stress; and the reactive problem drinkers who are responding to the stresses and losses of aging by drinking heavily. The generally accepted division is that of early-onset and late-onset without a specific age of onset. The distribution of 2/3 early-onset vs. l/3 late onset is generally confirmed by personnel in the field. Different terms are at times used. Geriatric alcoholics (early-onset) are the stereotypic chronic alcohol abusers who have continued to drink while aging, and geriatric problem drinkers (late-onset) include those who had no history of a problem and those who occasionally experienced problems, all of whom develop abusive patterns in response to the stresses of aging (Dupree and Zimberg, 1984). Recognizing this general classification facilitates the process of identification and treatment. General characteristics of the early-onset individual include a medical history that indicates extended severe drinking, mental pathologies and personality characteristics related to chronic alcohol use, a social history that indicates the impact of alcohol, such as a poor work history, a disrupted or stressed social and family history, poor relationship skills, and fewer economic resources. Late-onset characteristics generally include alcohol related medical problems that may be acute but of.shorter duration, better problem solving and relationship skills, and more stable job, family and social histories. Problems in these areas are usually of recent origin and of shorter duration. Psychological problems are generally more focused upon issues related to age, such as loneliness, depression, grief, boredom and pain. The hidden older Foblem drinker Observations have been made by several researchers that older problem drinkers are a hidden population. The high percentage of alcoholics among the older populations in acute medical and psychiatric institutions is probably more reflective of the debilitating and/or long term impact of alcohol on an older person than it is of the sensitivity of the intervention mechanisms that exist. Perceptions of service providers indicate that the older person is underrepresented in the alcohol treatment network. Many reasons are given for the inadequate level of identification. There is a more subtle presentation of symptoms of problem drinking and alcoholism in older people. Presenting symptoms are inaccurately identified as -being related solely to medical or psychological problems associated with the aging process. Care providers, including medical personnel, are reluctant to become involved in the identific3tion/intervention process. The elderly themselves may have a lack of awareness about the effects of alcohol and are reluctant to self discbose. Denial and enabling may exist within family units. Due to the life stage, there is a lack of social and occupational identifiers- Finally, significant others and care providers may have the inaccurate perception that the drinking is a rational choice of A - 5 behavior, and further, may believe that it is logical given the age of the person. ALCOHOL, ALCOHOL USE AND HEALTH The impact of alcohol and alcohol use on the health and well being of any one older person has many dimensions. Of primary importance is the quantity and the frequency of the drinking experiences. How much alcohol is taken into the system and how frequently these occasions occur generally provide information that allows for the description of light, moderate or heavy drinker. A second consideration is the pattern and the duration of the drinking history. Movement along the continuum of type of drinker at different periods in the life span provides a variable to the current impact. Cultural and social norms that influence the designation of appropriate drinking occasions, such as with meals, or at drinking oriented events, may ameliorate or exacerbate the effect of the alcohol on any one occasion, and cumulatively, the effect of the use of alcohol on the entire system. General physical condition, and all the elements that support that condition, such as genetic factors, nutrition, the balance of rest and physical activity, are important. The presence of chronic and acute medical conditions plays a role, as does the existence of drug regimens, whether monitored by a physician or self-prescribed. Generally, the more intense and prolonged the use of alcoholic beverages, the greater the impact the substance ethanol will have upon the health of the individual. The general process of aging brings its own contribution to health implications for alcohol use. Response to the aging process is highly individual, in terms of persons and all of the components of each person. But there are general principles that apply. Advancing age witnesses a gradual lowering of the level of the homeostatic state. This is accompanied by a lessening of the physical reserve of the entire system and each of its parts. All body systems and organs tend to decrease in efficiency of operation and to loose resiliency. Stress, whether physical, emotional or environmental, has a greater impact upon the system and each of its parts. Returning to the pre-stress state or finding a new level of balance is more gradual, taking a longer period of time than when younger. Vulnerability to disease states increases with age and is compounded by stress _ Disease states also increase the vulnerability of older people to the impact of alcohol. It is `particularly important to remember that, as an individual ages, there are greater mutual effects that operate between the physical, social and emotional health of an individual. The older age stage of life brings unique developmental tasks, stresses and age related life crises. In responding to these tasks, stresses and crises, the totality of the person is affected. Of specific importance to. the use of alcohol and other chemical substances are general physiological changes. with age there is a decrease in the lean body mass and an increase in fat storing tissue. Alcohol, being water soluble, is distributed through less lean tissue, resulting in higher concentrations within organs _ Generally, when compared to younger people of equal weight and drinking the same amount, older people may be espected to evidence a higher blood alcohol level _ Time and rate are also affected. Age has a tendency to slow both the process of metabolism and of elimination. The blood alcohol level may be held for a longer period of time. In addition, the elimination process may be A-6 particularly affected by the presence of medications. The liver, being the principal organ involved, may be operating at a less efficient level and may be required to process multiple substances at the same time. All of these have impact upon the tolerance level, which is generally characterized as decreasing with age (Schuckit 1980, 1982, and Bosmann 1984). There are medical and health and safety areas that need particular emphasis in the concern of health and alcohol use as related to older people. It must be emphasized that, although there is a wealth of material that addresses the relationships that exist between specific areas and alcohol, the particular emphasis upon the older person frequently has been inferred from other studies or has been inconclusively explored to date. It should also be noted that biomedical research has not thoroughly explored health problems in the older age group, or among segments witbin that group. The cardiovascular system The implications of alcohol use for cardiovascular disease are particularly important in relation to older people as hypertension and heart conditions account for two of the four most common chronic conditions of non- institutionalized elderly. Although the exact relationship between alcohol consumption and the development of cardiovascular diseases has not been determined, there are areas that are important to consider. Generally, alcohol can have a direct effect on the heart muscle leading to an increase in the cardiac rate and output. In older people this may produce stress on the organ itself and on the rest of the cardiovascular system because of a reduced level of physiological reserve. In individuals with impaired cardiac functioning, this may have the ultimate effect of decreased cardiac output and diminished efficiency of the system. Alcohol can directly affect the heart as a cardiac toxin and the cardiovascular system by increasing blood pressure. Excessive amounts of alcohol have been strongly linked with the development of hypertension, stroke, myocardial degeneration, arrhythmia, and cardiac failure. Alcohol can also mask the symptoms of a disease state, such as angina pectoris. Individuals frequently do not feel the associated pain in the chest while drinking but the medical indications are that the affected tissue continues to suffer from the lack of blood flow. Continued or increased activity may increase the stress level although no pain is felt. (Gambert et al. 1984, Hermos et al. 1984, Kannel 1986, Schuckit 1982.) J There is, however, evidence of lower rates of congestive heart disease in association with moderate alcohol intake. Regular use of alcohol appears to have the effect of increasing high density lipoprotein cholesterol which may retard the development of coronary artery disease (Barboriak et al. 1983, Kannel 1986). Non-drinkers had higher mortality rates than those who drank lightly (in reference to the Normative Aging Study) and non-drinkers had higher blood pressures than those who drank in small amounts (in reference to the Framingham Study) (Gordon 1984.) The central nervous system The relationship of the health of the central nervous system in the maintenance of autonomy and independence makes it a particularly sensitive area to consider A-7 in relation to alcohol use and aging. There are changes that do take place with age that result in variations in functioning compared to the time when the individual was younger. But for healthy older people these changes do not necessarily have to exert a deleterious effect on the ability tc manage their life or to cope with their environment. Age frequently brings an increase in reaction time and in the time needed to retrieve something from memory. With age, there is also an increased tendency to exhibit confusion when under physical, emotional or social stress. Cognitive processes may be slowed but seldom become impossible tasks for healthy older people. Educational gerontology has contributed much to the affirmation of the ability of older people to perform learning tasks provided that the information is well organized, presented in a way that compensates for sensory changes, that the stress of the learning situation is reduced, and the risks associated with performing incorrectly are minimized- Ethanol affects the central nervous system. It may have the short-term effect of acting as a stimulant. However, the long-term effects are as a depressant. This may result in respiratory depression, sedative-hypnotic effect, ataxia, pronounced disinhibition, impaired motor skills, neuropathy, and unconsciousness. Age related metabolic changes are generally accompanied by an apparent increase in the sensitivity of the brain to all central nervous system depressing drugs, including alcohol. Very small amounts of alcohol can produce symptoms that are commonly identified as age-related mental decrements, or may exacerbate age related phenomenon. The mis-reading of the presentation of an older person is frequently responsible for non-identification of alcohol problems (Bosmann 1984, Schuckit 1982). Much research has been conducted on the effect of alcohol upon the central nervous system. A prominent theme' in that research is the question of accelerated or premature aging as an effect of alcohol use. Functional changes that are related to aging and functional changes that are the result of alcohol use are frequently very similar in their presentation. The processes of aging and of alcohol intoxication have much in common in the way that they affect memory, learning, recognition and organizational processes. In a "worst scenario" of the aging process or from long and intense use of alcohol, similar organic changes may take place in the brain and disease states occur. Current research outcomes do not seem to support the theory of premature aging. Although chronic alcoholic drinking appears to increase the behavior defects that accomp'any aging, as yet, a common pathology,has not been identified. Alcohol use is responsible for some brain dysfunction, but the effects seem to be independent of and parallel to the effects of normal aging. Studies do suggest that people who use alcohol to excess appear to run an additional risk of neuropsychological impairment beyond what might be expected from the aging process. Further, since some of the deficits related to alcohol use are at least partially reversible, continued research may illicit some value in terms of therapies for age related problems. (Blusewicz 1982, Bosman 1984, Lowe 1985, Parsons and Leber 1982, Russell 1984.) Medications and over-the-counter drugs The use of alcohol combined with a regimen of overTthe-counter or prescribed medications is a common but potentially lethal occurrence. As one grows older, the number of drugs one takes usually increase. A figure commonly cited is that A - 8 older people who are 12% of the population are using approximately 25% of the prescribed medications. Further, it has been estimated that over-the-counter preparati0nS account for approximately 90% of all drugs taken by the elderly (Baker 1985). The problem of drug use and misuse has many dimensions and is compounded when drugs are used with alcohol. Alcohol interacts adversely with many drugs, a situation that is particularly significant with other central nervous system depressants. Polypharmacy is not uncommon among older people. Frequently, the medical regimens are being prescribed by more than one physician, and older people often have difficulty in correctly self-administering the medications. The potential for drug interactions and adverse drug reactions is great under such circumstances, particularly in view of the changing physiology with age. ~11 of these situations are intensified with the use of alcohol. Adverse drug and alcohol interactions can be potentially life threatening to older people because of the decrease in reserve in vital organs. Many older people have poor or incorrect conceptualizations of how their bodies handle substances and need education in order to practice healthful habits. Further, many professionals and para-professionals who work with older people are unaware of the seriousness or the extent of the problem. (Atkinson 1984, Glantz 1983, Schuckit 1980.) Nutrition Healthful nutritional practices among older people have been a concern of many who work and have contact with the elderly. Nutritional practices are affected by the totality of the life circumstances of older people. Social, psychological, economic and physical factors are important to consider, Changing circumstances within the family unit, such as the loss of a spouse, may affect the pattern of food preparation and may precipitate all but minimal attention to the activity- Depression, social isolation and physical incapacity can- intensify and make insurmountable the problems related to the maintenance of a good diet. Life-long dietary practices, which may not have seemed problematic at a youn$er age, now become detrimental and debilitating. Physical changes that are age related, coupled with the use of medications, may require modification of these practices. The ability to make such changes may be limited by a lack of information, minimal economic resources or lack of access to appropriate facilities for shopping, storage or preparation of food. Malnutrition has been long recognized as being caused by chronic alcohol use. The impact of the use of alcohol on nutrition is seen as a result of a change in ability to function as well as affecting the appetite, absorption, metabolism and excretion of nutrients. When compounded with physiological aging, with the reduction of functional reserves ,' the effect may be particularly detrimental. It is widely recognized that the elderly user is much more susceptible to the nutritional consequences of alcoholism. It is not as widely recognized that there may be nutritional consequences for the more social user, particularly if there are acute or chronic diseases present and medical drugs are being taken. There are many specific nutrition-alcohol interrelationships that should be kept in mind both in the maintenance of healthful practices and in the treatment of alcoholism in elderly people. One will illustrate the weight of the area of consideration. The cwurse of normal aging brings a reduction in bone mass as well as reduction of the capacity of the gastrointesinal tract to absorb calcium. A-9 The presence of metabolic acidosis, a common result of consuming alcoholic beverages, may further aggravate a negative calcium balance. The development of osteoporosis, a frequently identified condition in older people, particularly women, may be aggravated by alcohol use. Adequate calcium levels are also required to maintain the transmission of nerve impulses at appropriate levels. These processes are also negatively affected by age and by the presence of ethanol, and may be subjected to a compounded effect. (Gambert 1984, Mishara and Kastenbaum 1980, Russell 1985.) Carcinoma The question of the carcinogenic effects of alcohol use have been of concern for several years. It does appear that there is a tendency for the chronic alcoholic to develop squamous cell carcinoma in the region of the pharynx. Carcinoma of the esophagus is frequently detected in those who are diagnosed as alcoholic, representing over half of all cases of esophageal cancer. There is some evidence that alcohol abuse may also be associated in the development of carcinoma in the mouth. However, there are methodological problems in the research in this area. It becomes extremely difficult to distinguish between the effects of alcohol and other factors that are frequently present, such as smoking, exposure to pollutants and malnutrition. It has been estimated that approximately 90% of alcoholics are also smokers, and the role of smoking to the development of some kinds of carcinoma has been well documented. Research has also indicated that there may be carcinogenic implications related to the way cells respond to ethanol. It does not appear, however, that alcohol has an equal role in the development of all types of cancer, and where there does appear to be a relationship, additional research is still desired. (Bosmann 1984, Bambert 1984, Mishara and Kastenbaum 1980.) Safety Problems related to safety and alcohol use are many, from pedestrian accidents to the interference of an alcohol-induced state in performing simple chores in the kitchen. Stress for older people who are injured in accidents has the same ripple effect on their health and mental outlook as disease states. Older people seem paPticularly susceptible to falls. Hingson and Howland (1987) report figures from the Center for Disease Control, indicating that each year 200,000 older Americans experience hip fractures associated with falls. Older people are also disproportionately represented in deaths from falls, over one-half of fatal falls involve persons over 75 years of age. There is a strong link between the use of alcohol and falls. In fact, one of the items frequently included in a list of clues of a drinking problem is the experience of falling. Although there is substantial evidence that alcohol increases the risk of falls, studies have not yet provided information that is specific to the elderly. However, from a perspective of maintaining safe practices, the potential effect of the use of alcohol on the incidence of falls among older people should not be neglected (Hingson and Howland 1987). In discussing burns of older persons, Anous and Heimback (1986) noted that frequently burns tend to be deeper because of delayed reaction times, impaired A - 10 senses and the fact that many older burn patients live alone. The reduced capacity of the older physical system has special import in dealing with the stress related to the burn experience as well as affecting the process and time of healing. It was also noted that older cases with documented alcohol problems tended to be loners and to have a higher percent TBSA (Total Body Surface Area) burn. (Anous and Heimbach 1986.) Benefits from alcohol use The beneficial use of alcohol with older persons has been a recurring theme in the literature that relates to aging and alcohol. Stories of the prescribing of spiritus frumenti have been documented in many case histories and in studies of practices within care facilities for older people. Common conditions that are addressed in this manner are loss of appetite, as an aid to digestion, as a nutritional supplement, as a relaxant, sedative and a sleeping aid. Most studies of the use of alcohol generally conclude that there is a therapeutic value to the serving of alcoholic beverages in institutional settings. Some note that, under such conditions, the medication levels may be reduced. In many of the studies, there was an effort to provide a varied or special setting for the events of drinking, as well as there being additional staff and others present who were involved in exchanges with the .residents of the facility. These factors make it difficult to identify the exact source of the benefits observed (Mishara and Kastenbaum, 1980). In reporting on their own research, Mishara et al. (1975) stated that the amount of alcohol that was consumed was small and that there was an effect of the social setting that supported drinking. There was evidence of psychological benefits in terms of morale, improved sleep and a general sense of improved well-being. It was particularly noted that the participation in the study was voluntary and that a physician's approval had been obtained for each participant. Other studies have been conducted with non-institutionalized older people. In his study, Kastenbaum reported on the effects of the use of one or two 3 ounce servings of wine on self-sufficient older people living in the community. It was noted that the changes, both those that were subjective and self-reported, and those that were determined by psychological assessment procedures, were generally in the positive direction. On the subjective items, participants reported improved subjective status in terms of morale, improved sleeping patterns, reduced chronic fatigue, anxiety and depression. In objective tests, there was a tendency for those with relatively better functioning to show improvement in behaviors dnd performances that have strong cognitive components. (Mishara and Kastenbaum 1980.1 Health issues in treatment ___- _____ For the older person, entry into the treatment syst,em is frequently through a health care agency, usually the acute care hospital. Compared to younger people the older person often presents in a more debilitated condition. Because of the number of pathological conditions that may develop as a ;esulP of long term alcohol use, it is not infrequent that the older persons enter the system for treatment of other diagnosed conditions, and then in the process of medical treatment, are encouraged to confront the reality of the relationship that alcohol use has to the current condition and to the prognosis for recovery. A - 11 While recognizing that all systems of the body are affected by the use of alcohol and have the potential of reacting adversely, there are certain medical conditions that are indicative of long term use. Cirrhosis of the liver, gastritis, chronic or acute pancreatitis, with accompanying abdominal pain, weight loss and diabetes are significant risks of long term use. Other conditions frequently associated are atrophy and weakness of the muscles, polyneuropathy, the inability of the body to fend off infections or to support healing, malnutrition and dehydration. Pneumonia and pulmonary tuberculosis also occur more frequently among alcoholics. In advanced cases, sever neurological damage may be seen as Korsakoff's psychosis and Wernicke's disease (Mishara and Kastenbaum, 1980). Generally, the late-onset individual presents with fewer and less severe medical complications, although Schuckit and Miller (1386) do point out that this type drinking is during the medically vulnerable years and may cause disproportionate medical problems. Because of the greater likelihood of the older person entering treatment for related health conditions before entering alcoholism rehabilitation programs, the role of the health care professional in identification and intervention must be recognized. Most older people trust medical personnel and hold them in high regard. Being able to accurately access the situation, to interpret the presenting symptoms correctly and to use the medical record to facilitate breaking through the denial make the health professional a vital link in the network of treatment. The value that many older people place on their health often facilitates and provides motivation for engaging in the process. (Mishara and Kastenbaum 1980, Schuckit 1982, Sherouse 1983.) There are many medical and health issues that need to be considered in the course of treatment, There is no agreement on the use of medications in the process of treatment, with particular concern focusing on minor tranquilizers and sedatives (Gomberg, 1982). Monitoring the physical conditions and the medication regimen is an ongoing process. In the course of treatment, with medical care, good nutrition including vitamin therapy, and appropriate rest, there is frequently an improvement in the physical well-being of the older person, and specific medical conditions may abate in their severity- However, a parallel situation may also develop. Conditions whose presence and pain are masked by the anesthetic quality of the alcohol become evident. After the alcohol is out cf the system, dental problems, urinary tract infections, venereal disease and other conditions may be identified in the course of rehabilitation. Because of `poor physical condition and lack of reserve, older people may require more direct nursing care and help with meals, bathing and personal care. The daily schedule of the treatment program may tax their strength and endurance, and the requirements may have to be modified to allow for more rest. Attendence to medical needs, perhaps even readmittance to an acute care facility, may interrupt the treatment schedule and necessitat? decisions.or adjustments in administrative policies. The need for a wheel chair, crutches, or assistance in movement affects the participation of the client and requires additional concern on the part of the staff. Attention to hearing aids, teeth, eye glasses, and similar devices, facilitates the recovery process in terms of participation, self-image, and the development of good health habits (Williams 1985). Other relevant treatment issues -__- A - 12 The issue Of the responsibility of providing treatment services for the older alcoholic generally focuses on the questions of which service system, age or alcohol treatment, should carry primary responsibility, and whether there should be specialized programs within existing systems. Little has been done to evaluate the effectiveness of different systems or different treatment modalities with older People. Treating within the alcohol service system has been the general approach, with the recommendation that there be some adaptations and a specialized outreach program to reach the older person (Janik and Dunham 1983)- Emphasis upon social supports and peer groups appears to increase positive outcomes (Kofoed et al. 1987, Zimberg 1982). Payment for treatment requires that there be an appropriate mesh between the treatment needs of the individual, the types of alcoholism services that are available and acceptable to that person, and the regulations that govern the resources that may be tapped, whether Medicare, Medicaid, private third party, veterans benefits or others. Uorking with an older person in need of treatment often requires unusual orchestration abilities on the part of the service provider in order that access to all phases of treatment becomes financially available. Prevention opportunities for prevention programs do exist. Two excellent possibilities exist through the development of self-help groups for older people and the preretirement and retirement planning groups that are often a part of personnel services in industry and business, labor and professional groups and organizations (Gomberg, 1982). Such programs would be of primary benefit to individuals who.may at be at risk for the development of late-onset problems. Self-help groups could be developed in the community under the sponsorship of senior centers, community mental health programs, voluntary organization and others. These groups would have the advantage of being holistic in their approach, providing life-coping skills and support systems. BY including substance use within their concerns, but avoiding the label, these groups would be more appealing to older people who frequently feel stigmatized by the words problem drinker or alcoholic. Secondary prevention services could be provided by the development of programs that would-sensitize and .provide skills .to service providers of older people, whether in medical or social services. Intervention at the earliest possible stage precludes the further exacerbation of medical, psychological and social problems, optimizing the possibilities of successful treatment within the context of continuing support systems. Tertiary prevention is an integral part of treatment, targeted to the successful completion of treatment and the prevention of future problems. This approach must also include the development of life skills to help the older alcoholic successfully adjust to the realities of his/her life stage. There are many programs that have been developed to address prevention issues on all levels. Only a few examples will be sited. The Senior Alcohol Services of Vancouver, Washington, provides community training and information as well as treatment that includes aftercare, couples' counseling and family groups- The Kassachusetts Housing Finance Agency through its Tenant Assistant Program (TAP) A - 13 provides education, information and referral services in a program that concentrates'on outreach to improve the quality of life of the tenants. Elements of the program address all three levels of prevention. The Michigan Office of Substance Abuse Services and the Michigan Office of Services to the Aging sponsored the development of a three volume guide, Older Adult Substance Abuse, designed to foster a team approach to prevention. The three volumes are A Resource Manual, Prevention Program Development, and Medications Information. (Resch and Christensen, 1983.) The Wisconsin Department of Health and Social Services issued a planning guide, Examination of Problems and Solutions Related to the Chronic "Revolvinq Door" Alcohol Abuser _ The final report contains 26 -- recommendations to break the cycle and to provide for meaningful alternatives. (Wisconsin Department of Health and Social Services 1981) The AAA Foundation for Traffic Safety of Falls Church, VA, has developed a film with guide, Senior ____ Adults, Traffic Safety and Alcohol, which provides information for older people about the substance and the effects of alcohol and problems that it may generate. A SAMPLE OF NATIONAL EFFORTS There have been efforts by several agencies and groups to address the concern of aging and alcohol use on a national level. The four that are mentioned are by no means the only efforts, but do illustrate the variety of the efforts that have been made, representing a public policy effort, research, and a treatment related project _ Blue Ribbon Study Commission on Alcoholism and Aging -- - The Blue Ribbon Study Commission on Alcoholism and Aging, sponsored by the National Council on Alcoholism, was convened in the fall of 1979 with the Honorable Wilbur D. Mills as chairperson. The Commission was composed of a broad range of representatives from government, academia, voluntary organizations and the health and social service sectors. The stated goals of the Commission were: 1. to gather and evaluate present knowledge concerning alcoholism and aging: 2. to identify and analyze the information needed for thorough understanding of the problem through defining specific issues; 3. to identify and evaluate the options open as to what can be done to resolve these issues successfully; and 4. to disseminate the information gathered to the American public and to groups and individuals directly involved in the policy and implementation process. (News release! of the National Council on Alcoholism, February 22, 1980.) The outcomes of the Commission are three. 1. The Commission sponsored a two day tract, The Aging and Alcohol Abuse, at the 1980 National Alcoholism Forum of the National Council on Alcoholism. 2. It organized and sponsored a Mini-Conference on Aging and Alcoholism, held at Wingspread, Racine, WI, in conjunction with the 1981 White House Conference on Aging. 3. It prepared a report, with recommendations, to be included in the proceedings of the 1981 White House Conference on Aging. Six categories of recommendations were included: research and development, education and training, increasing the utilization of services, ensuring and improving the effectiveness of treatment, increasing the availability and access of services and protection of patients' rights. A - 14 Research center on aging and alcohol established In December 1982, the National Institute on Alcohol Abuse and Alcoholism funded the Alcohol Research Center at the University on Gainesville, one of nine national research centers. This center is specifically designated to conduct research into the causes and the consequences of alcohol use and abuse by the elderly - As a interdisciplinary center, the research agenda includes a multi- faceted approach to the subject. An extensive educational program for a broad spectrum of health professionals is a major component of the activities. kesearch conference In November, 1983, a national research conference was convened on The Nature and Extent of Alcohol Problems Among the Elderly. The conference was sponsored by the National Institute on Alcohol Abuse and Alcoholism in collaboration with the National Institute of Mental Health and the National Institute on Aging. The conference produced a monograph by the same title, edited by George Maddox, Ph.D., Lee N.,Robins, Ph.D., and Nathan Rosenberg, Ph.D.. In the preface it is stated that "the workshop at Washington University was intended as a beginning point in a systematic NIAAA effort to stimulate research interest and activity in the alcohol-aging area." (p. v-1 The keynote address of the conference by Robert Straus (pp.7-28) focused on factors of change as related to both aging and alcohol, the need to develop a biomedical perspective in relation to the topic, and stated that both alcohol studies and gerontology were entering a biobehavioral era of scientific thought and activity. The conference was organized to present key issues and current evidence of mental health and social correlates of alcohol use, presented from research of the Alcohol Research Center of the University of Gainesville, FL, longitudinal data of alcohol problems among the aged from studies in St. Louis and from the Normative Aging Project of the Veterans Administration, and research data from the Epidemiological Catchment Area Studies. Future research needs were addressed by most participant in the course of their papers, emphasizing the need for more current and more extensive research that is specific to the older population. & demonstration project related to treatment The Health Care Financing Administration Alcoholism Project was a three year demonstration project targeted to evaluate the cost effectiveness of reimbursement under Medicare of treatment in non-hospital settings. Of the six states involved in the project, most also included the provision of reimbursement under the state funded medical assistance program or Medicaid. Because of the source of the reimbursement funds, in most agencies, there was the added benefit of stimulating the entry of the elderly into treatment. In addition to collecting data related to the reimbursement effect, agencies who participated increased and expanded their experiences with the elderly, and developed and adapted treatment modalities `to meet the need of this population. A report on this additional benefit of the project was prepared by the Rutgers University Center of Alcohol Studies, New Brunswick, New Jersey. The evaluation of the data related to the reimbursement study has not yet been completed. A - 15 The identification of "what needs to be done" frequently has the quality of confused time sequence. Research of the problem area should precede the development of policy which would in turn give impetus to program development. But it is impossible to begin again. The reality is that movement on all fronts is needed and must proceed as best possible. The relationship of research in the field of aging and alcohol to the development of public policy has been addressed by Stall (1987). Stall proposes a particular value of long-term perspective research as an integrative and interpretive tool for reassessing the data from both retrospective and cross sectional studies. Such research would make it possible to test and evaluate the hypotheses that have been advanced to explain the data, and would provide direction for the development of public policy. Ruben (1986) points out that elements of incongruence are present between public policy and what we do know about the nature and the scope of the problem, Future development of policy would benefit from consideration of these observations. In relation to health and aging, there are many avenues of research that have been opened but not fully addressed. Enumeration of specific areas is repetitive and more adequately done by those whose expertise is within the specific areas of study. However, in reviewing studies, it becomes very evident that much of what we understand is based on studies that are not we and/or alcohol specific. Whereas, there is justification for applying the results of such research to the aged or to alcohol problems, additional studies that are focused on the problem area would provide a firmer foundation for the development of policy and the implementation of programs of prevention and treatment. Programs, and ultimately people, who are coping with the problems of aging and alcohol abuse, are impacted by policies in the fields of aging, alcohol treatment, health, social services, housing, transportation, and innumerable other areas of governmental responsibility. How these policies intermesh is a prime concern for the issue of aging and alcohol. The perspective from the field frequently is that policies interact in ways that are more prohibitive than facilitating. In considering what policies should be enacted, this concern should be addressed. For example, these questions might be discussed: Whaf weight should be given to current epidemiological projections in the consideration of policies related to the development of programs of prevention and treatment? What effect do current health care policies, such as the DRG's, have upon the provision of the level and the extent of medical care needed by the older person who may have multiple and extensive needs related to alcohol abuse? What policies would facilitate the development of primary prevention programs in the arenas that are most utilized by those at high risk? What incentives might be offered to encourage the private sector to be involved in the provision of prevention programs related to late-onset alcoholism? In what areas should policies be developed to address the high cost of providing institutional care for those severely disabled by alcohol? Are A - 16 other options possible tnat would allow for a more optimal quality of life? What policy provisions are possible that would encourage and support linkages between alcoholism treatment and age services to actualize the concept of continuity of care? Based on evaluative research of treatment modalities, what policy decisions should be considered to support specialized components to provide treatment for older persons? Are federally sponsored programs for volunteer service appropriate avenues for involving older people in the process of addressing the need for education and prevention in relation to alcohol use and health? The range of exploration is limitless. And the time is now. REFERENCES Anous, M-M., and Heimbach, D.M. Causes of death and predictors in burned patients more than 60 years of age. J Trauma 26: 135-139, 1986. Atkinson, R.M. Alcohol and Drug Abuse in Old As. -__ Washington, D.C.: American Psychiatric Press, Inc., 1984. Baker, W-W. Psychopharmacology of aging: Use, misuse and abuse of psychotropic drugs. In Gottheil, E. et al., ed. The Combined Problems of Alcoholism, w -- Addiction and Aging. Pp.150-163. Springfield, IL: Charles C Thomas, 1985, Barboriak, J-J.; Anderson, A-J.; Rimm, A.A. et al. Alcohol and coronary arteries. Clin Exp Research 3: 29-31, 1979. Barnes, G.M. Alcohol use among older persons: Findings from a western New York state general population survey- J Am Ger Sot 27: 244-250, 1979. Barnes, G.M.; Abel, E-L-; and Ernst, C.A.S. Alcoholism and the Elderly: A __ __ Comprehensive Bibliography. Westport, CT: Greenwood Press, 1980. Blusewicz, M-J.; Cannon, W-G.; and Dustman, R.E. Alcoholism and aging: Similarities and differences in neuropsychological performances. In Wood, W-G., and Elias, M-F.. ed. Alcoholism and.Aginp: Advances in Research. - Pp. 47-60. Boca Raton, FL: CRC Press, Inc.: 1982. Bosmann, H.B. Pharmacology of alcoholism and aging. In Hartford, J-T., and Samorajski, T., ed. Alcoholism_ in w Elderly: Social and Biomedical Issues. II___ Pp. 161-174. New York: Raven Press, 1984- Cahalan, D. Problem Drinkers. San Francisco: Jossey-Bass Inc., 1970. Cahalan, D.; Cisin, I.H. ; and Crossley, H.M. American Drinking Practices. New Brunswick, NJ: Rutgers Center of Alcohol Studies, 1969. Carruth, B.; Williams, E-P.; Boudreaux, L. et al. Alcoholism and Problem Drinking Among Older Persons. U.S. Department of Health, Education and Welfare, A - 17 Administration on Aging, Grant No. PHS-SRS-93-P-75146/2-02. New Brunswick, NJ: Rutgers Center of Alcohol Studies, Rutgers University, 1973; and Springfield, VA: NTIS, 1973. Christopherson, V-A.; Escher, M.C.; and Bainton, B-R. Reasons for drinking among the elderly in rural Arizona. J Stud Alcohol 45: 417-423, 1984. Gaitz, C-M., and Baer, P.E. Characteristics of elderly patients with alcoholism. Arch Gen Psychiatry 24: 372-378, 1971. Gambert, S-R.; Newton, M.; and Duthie, E.H. Medical issues in alcoholism in the elderly. Elderly: 1984. Glantz, M.D.; Research In Hartford, J-T., and Samorajski, T., ed. Alcoholism in the -__ Social and Biomedical Issues. Pp. 175-191. New York: Raven Press, ~ - Petersen, D-H.; and Whittington, P.J. Drugs and the Elderly Adult. ~ __ Issues 32. Rockville, MD: National Institute on Drug Abuse, 1983. Glynn, R-J.; Bouchard, G-R.; LoCastro, J-S,; and Hermos, J.A. Changes in alcohol consumption among men in the Normative Aging Study. In Maddox, G. et al., ed. Nature and Extent of Alcohol Problems Among the Elderly. Research Monograph No.14. Pp. 101-116. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1984. Gomberg, E-S-L. Alcohol use and alcohol problems among the elderly. In Special Population Issue. Alcohol and Health Monograph No.4. Pp. 263-290. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1982. Gordon, T. Discussion: Session I. In Maddox, G. et al., ed. Nature and Extent of ~-~_ Alcohol Problems Among the Elderly. Research Monograph No.14. Pp. 134-138. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1984. Gottheil, E.; Druley, K-A.; Skoloda, T.E.; and Waxman, H-M. The Combined Problems of Alcoholism, 1385. Drug Addiction and Aging. Springfield, IL: Charles C Thomas, Hermos, J.A.; LoCastro, J-S.; Bouchard, G-R.; and Glynn, R.J. Influence of cardiovascular disease on alcohol consumption among men in the Normative Aging Study, In Maddox, G. et al., ed. Nature and Extent of Alcohol Problems ~-___- Among the Elderly. Research Monograph No.14. Pp.117-132. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1984. Hingson, R., and Howland, J. Alcohol as a risk factor for injury or death resulting from accidental falls: A review of the literature- J Stud Alcohol, -- 48(3): 212-219, 1987. Janik, S-W., and Dunham, R.G. A nationwide examination of the need for specific alcoholism treatment programs for the elderly, J Stud Alcohol 44: 307-317, -- 1983. Kannel, W.B. Nutritional contributors to cardiovascular disease in the elderly. J Am Ger Sot 34:27-36, 1986, --- Kofoed, L-L.; Tolson, R-L.; Atkinson, R-M. et al. Treatment compliance of older A - 18 alcoholics: An elder-specific approach is superior to "mainstreaming". J @ Alcohol 48: 47-51, 1987. Lowe, G. Alcohol and memory processes: Implications for the elderly alcoholic. Proceedings of Dependence. Pp. 34th International Congress on Alcoholism gx& Drug 27-28. Alberta, Canada: Alberta Alcohol and Drug Abuse Commission, 1985. Naddox, G.; Robins, L-N.; and Rosenberg, N., editors. Nature and Extent of ---- Alcohol Problems Among the Elderly. Research Monograph No.14, Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1984. McCusker, J.; Cherubin, C-F.; and Zimberg, S. Prevalence of alcoholism in a general municipal hospital population. Ny State J Med 71: 751-754, 1971. Meyers, A-R.: Goldman, E.; Hingson, R.; and Scotch, N. Evidence for cohort or generational differences in the drinking behavior of older adults. Int'l J Aging Human Dev 14: 31-44, 1981. Mishara, B-L., and Kastenbaum, R.: Alcohol and Old As. New York: Grune and Stratton, Inc., 1980. Mishara, B-L.; Kastenbaum, R.; Baker, F, et al .: Alcohol benefits in old age: An experimental investigation. Sot Sci Med 9:535-547, 1975. Nate, E.P. Epidemiology of alcoholism and prospects for treatment. Ann Rev Med I_ __ __ 35: 293-309, 1984. Parsons, O-A., and Leber, W.R. Premature aging, alcoholism and recovery. In Wood, W-G., and Elias, M-F., ed. Alcoholism and Aging: Advances in Research. Pp. - 79-92. Boca Raton, FL: CRC Press, 1982. Resch, J-E., and Christensen, J-M.: Older Adult Substance Abuse, Volumes I_, II and III - -- Lansing, MI: Michigan Office of Substance Abuse Services and Michigan Office of Services to the Aging, 1983. Robins, L-N. Introduction to the ECA Project as a source of epidemiological data on alcohol problems. In Maddox, G. et al., ed. Nature and Extent of Alcohol ___-___- Problems Among the Elderly. Research Monograph No.14, Pp. 201-216. Rocll'ville, MD: National Institute on Alcohol Abuse and Alcoholism, 1984. Rosin, A-J., and Glatt, M.M. Alcohol excess in the elderly. Q J Stud Alcohol -___ 32:53-59, 1971. Ruben, D.H. The elderly alcoholic: Some current dimensions. Adv Alcohol Substance Abuse 5: 59-70, 1986. Russell, J-F. et al. Veterans Administration supports research on alcohol and the elderly. Alcohol Health Res World 8(3): 16-23, 1984. ~-- Russell, R.M. A discussion of ethanol-nutriant interactions in the elderly. Drug-Nutrient Interactions 4: 165-170, 1985. Schuckit, M.A. Clinical review of alcohol, alcoholism, and the elderly patient. J A - 19 Clin Psychiatry 43(10): 396-399, 1982. Schuckit, H.A. Phenomenology and treatment of alcoholism in the elderly. In Farm, W-E.; Karacan. I.; Pokorny, A.D. et al., ed. Phenomenology and Treatment of - Alcoholism. Pp. 167-179. New York: Medical and Scientific Books, 1980. Schuckit, M.A., and Miller, P.L. Alcoholism in elderly men: A survey of a general medical ward. Ann NY Acad Sci 273: 558-571, 1976. Schuckit, M-A., and Pastor, P.A. Alcohol-related psychopathology in the aged. In Eaplaa, O-J., ed. Psychopathology of Aging. Pp. 211-227. New York: Academic Press, 1979. Sherouse, D.L. Professional's Handbook on Geriatric Alcoholism. - Springfield, IL: Charles C Thomas, 1983. Simon, A.; Epstein, L-Y.; and Reynolds, L. Alcoholism in the geriatric mentally ill. Geriatrics 23(10): 125-131, 1968. Stall, R .: Research issues concerning alcohol consumption among aging populations. Drug and Alcohol Depend 19: 195-213, 1987. Warheit, G-J., and Auth, J.B. The mental health and social correlates of alcohol use among differing life cycle groups. In Maddox, G. et al., ed. Nature and Extent of Alcohol Problems Among the Elderly. Research Monograph No.14, Pp. 29-82. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism, 1984. Williams, E-P.: Older Alcoholics in Treatment. New Jersey Department of Health, Division of Alcoholism. New Jersey Health Service Contract No. 85-274-ALC. New Brunswick, NJ: Rutgers Center of Alcohol Studies, Rutgers University, 1985. Wisconsin Department of Health and Social Services. Examination of Problems and - Solutions Related to the Chronic "Revolving Door" Alcohol Abuser. -__ Planning Guideline #l. Madison, HI: Department of Health and Social Services, 1981. Wood, W-G., and Elias, M.F., Editors. Alcoholism and Aging: Advances in Research. - Ijoca Raton, FL: CRC Press. Inc., 1982. Zimberg, S. Outpatient geriatric psychiatry in an urban ghetto with non- professional workers. & J Psychiatry 125: 1697-1702, 1969. Zimberg, S. Psychosocial treatment of elderly alcoholics. In Zimberg, S.; Wallace, J.; and Blume, S-B., ed. Practical Approaches to Alcoholism Psychotherapy. Pp. 347-363. New York: Plenum Press, 1985. Zimberg, S. The psychiatrist and medical home care: Geriatric psychiatry in the Harlem community. Am J Psychiatry 127: 1062-1066, 1971. -- A - 20 Health Promotion and Aging "Oral Health" Helen C. Gift, Ph.D. Epidemiology and Oral Disease Prevention Program National Lnstitute of Dental Research National Institutes of Health 1. BACKGROUND There is a growing interest in the oral health needs of older persons, particularly as the size of the population age 65 and older increases and as the composition of th increase in population is occurring in the oldest-old-age 85 and over B t age group changes. The largest -a group for which little is known regarding oral health. Historically, older adults have had fewer financial and social resources than have other age groups, but evidence suggests that the picture is changing. For example, in 1984, 91 percent of older adults received Social Security benefits; 24 9 ercent received income from private pensions, and 68 percent received income from private assets. These represent considerable improvements over the past two decades. Furthermore, it is projected that improvements in the socioeconomic status of older individuals will continue over the next several decades. This does not mean, however, that all older Americans will be financially able to secure the necessary benefits from health care. Even considering these improvements, general health and medical expenditures are sizable. While older Americans represent nearly 12 percent of the population, they account 2fy 27 percent of all health expenditures and purchase 25 percent of all medications sold in this country. In the most comprehensive, published data-the National Medical Care Expenditure Study (NMCES)-it was reported that three percent of the per capita health expenditure for those 65 and older went for dental care in 1977. Modest increases were observed in mean dental expenditure per older person between 1970 and 1977-from $31 to $40 (1977 dollars)5 Traditionally, dental care for older persons has been an out-of-pocket expense. In 1981, nineteen percent of tkose ages 65-74 had some dental insurance, while 10 percent of those age 75 and older had some coverage. @elf-reported dental insurance is often at a high- er level for this age group.) In spite of major successes in dental research, treatment and prevention over the past several decades, oral diseases of all kinds remain among the most costly health prob ms prevalent in the United States, adding up to a national bill of $22.7 billion for dental services in 1986. 3p Older Americans traditionally have accounted for large proportions of less advantaged categories and are more likely to be without major support systems, judged by sociodemographic and access measures. For example, there are high proportions who 1) live alone and are widowed, 2) have few ye r are below the poverty level, 4) are not in the labor force, or 5) live in non-urban areas. f 8 g\eiJy~ytion, 3) > Improvements in oral health status and dentally-related. behaviors of the older age group have been observed over the past several decades. Continued improvements in oral health status, oral hygiene practices and dental service utilizatipy ~5 e projected as upcoming cohorts continue to become better ~~e~s~sdrPlo~!l e ffluent and dentate, yet, the older individual will continue to be at risk for oral There is no research evidence to suggest that tooth loss or specific oral diseases are a necessary concomitant of the aging process, nor do al in terms of oral health or dentally-related behaviors. {persons over age 65 fall into one descriptive group Rather, it appears that there is a great deal of heterogeneity in the older population.15 k&a ise, there is no evidence that older persons are, by definition, in poor general or oral health. The combination of genetic predisposition, lifestyle and socioeconomic environment, exposure to fluorides, oral hygiene at home and dental-visit behaviors lifetime, contribute to the state of oral health, or lack thereof, in later Maintaining quality of life through retention of the dentition requires the prevention and/or treatment of oral diseases beginning at younger ages and continuing throughout the lifetime. Preventive activities for B -1 all ages include professional and self-care. Professional preventive activities include examination of the dentition, supporting structures and muscosal tissue for decay, attrition, abrasion, periodontitis, recession, oral cancers and evidence of oral symptoms of systemic diseases, as well as oral hygiene education and regimens such as prophylaxis and fluoride applications. Appropriate restorative tBatment of observed conditions is accepted as preventing further destruction of oral structures. The prescription for maintaining optimal oral health through self-care is the same for the older person as it is for the younger one: daily toothbrushing with a fluoride toothpaste, use of a fluoride and/or antimicrobial rinses, interdental cleaning, dental visits at least once a year and observation of a balanced diet and food intake pattern. Some oral conditions may be prevented or retarded by a change in behaviors including stopping ~"4" of tobacco, improving toothbrushing technique or abandoning inappropriate chewing behaviors. Other oral conditions and appropriate treatments may be controlled through careful monitoring of systemic conditions and medications. The overall quality of life of any individ articularly an older one, can be enhanced through oral diseases prevention and health promotion. Y'b'a~ The health of the oral cavity--teeth, oral soft tissues, underlying bone, neural apparatus, immune system and glandular mechanisms-is critical to chewing, tast- ing, swallowing and speech, as well as adaptation to dentures if they are worn. Health of the oral cavity also contributes to nutrition, facial esthetics and protection from systemic infection and injury. Most older Americans are relatively healthy and functionally independent. They can be expected to cont- inue to follow habitual patterns of oral hygiene behavior and use of dental services. Still, an estimated 40 percent of older Americans are 4s ejected to constitute a special-needs category based on complex health problems and functional status. These include: emotional and physical stresses associated with the aging process; physical an mental disabilities resulting from chronic diseases and physical and financial barriers to access to care. 86 IL ORAL HEALTH STATUS-OUTCOMES OF ORAL HEALTH PROMOTION A. Data Sources Descriptions of the oral health and related behaviors of older Americans are available from a number of national and local sources. National data are the most readily available, but rziany of these studies placed an upper limit on age in the sample. Furthermore, those studies which do include older individuals typically have not focused on this age group, thus the ability to analyze the data may be iimited by the number of older individuals in the subsample. The weakness in all surveys conducted to date is the near absence of a comprehensive data set on older individuals--including attitudes, knowledge, behaviors, environmental/structural conditions, as well as clinically-determined oral health status. The major surveys which include both interview and clinical examination data on older Americans are the National Health and Nutrition Examination Survey (NHANES I), Hispanic Health and Nutrition Examination Survey (HHANES), and A St d with depaid Dental Care: 1981 # sff Dental Health Related and Process Outcomes Associated (HRSA). A National Institute of Dental Research (NIDR) study- National Suivey of Oral Health in U.S. Employed Adults and Seniors: 1985~86-contains complete clin' al but minimal self-reported data on a sample of 5686 older Americans who attended 208 Senior Centers. 8 Most other national studies do not include clinical examination and are based on data collected by interview, including information on dentally-related behaviors, attitudes and knowledge. An example is the National Health Interview Survey (NHIS) conducted by the National Center for Health Statistics. Dental health questions have not been a routine part of the core questionnaire since 1981, but issues related to dental health have been included regularly in supplements. Other examples are the 1980 NCHS Personal and Preventive Practices Survey; NHANES I Epidemiologic Followup Study; the National Medical Care Expenditure Survey, 1977; the National Medical Care Utilization and Expenditure Survey (NMCUES), 1980; and Center for Health Administration Studies and National Opinion Medical Expenditures and Use of Health Services: 1953,1958,1963,1964,1970. p$?e$bch Center Surveys of Descriptions provided in this manuscript are based on reported correlations between selected measures of predisposing and enabling factors, perceived r,eed and oral health variables which, most often, have not B-2 been analyzed in combination as part of any predictive model. Emphasis has been placed on national probability samples and verified data over convenience samples or self-reported data. In some cases, reports may appear inconsistent, as recent analyses are providing more in-depth understanding of issues than was available when earlier research was published; for example, separation of the dentate and edentulous groups in the analysis of dental expenditures, visits and oral hygiene behaviors. B. Oral Health Status 1. Fdentulousness (Absence of Teeth) Traditionally, the primary measure of oral health status of older populations has been the extent of eden- tulousness. It appears now that each succeeding gener t'o li more individuals are retaining their teeth as they age. fghas improved compared to older cohorts and Based on NHIS data, in 1958, 67 percent of persons over age 74 reported being edentulous. The proportion of edentulous persons in this age category has decreased over the years to 60 percent in 1971 and 45 percent in 1983. Decreases also have been seen in populations as they reach the age group 65-74, with 55 percent being edent 98 us in 1958, 45 percent in 1971 and 34 percent in 1983. Declines were seen among both females and males. Edentulousness is rn$&e prevalent among older persons below the poverty level and among those with fewer years of education. One fourth (27%) of those ages 65 and older who attended senior centers in 1985-86 had 20 teeth or more, while 17 percent had 1-12 teeth. The average number of teeth decrea average being 18.1 at age 65 and 15.1 for the age category age 80 and over. j%d steadily with age, with the Presence of teeth appears to be related to socioeconomic status and race. Among the Baltimore Longitudinal Study panel members, a primarily healthy, middle-socioeconomic, well-educated, volunteer, older, study group-the averag?plder person has 70 percent of natural dentition (20 of 28 teeth&and only 4 percent wear full dentures. Data from a North Carolina study, encompassing 15 yeas? indicate a decrease in mean number of missing teeth in succeeding cohorts of whites, but not in blacks. The functional adequacy of dentition is further reflected in the measured treatment needs for prosthetic services: in the 65 and older age group in 1981, 8 percent needed bridge unit(s); 19 percent needed partial denture(s); 9 percent needed full denture(sL6 Based on self-report in 1983, approximately one-fourth of ~~~on~~~,s~~~~~~~~~~eeded new dentures. This proportion increased to over one-third among those 2. Caries Caries in older adults is exhibited mostly as recurrent caries surrounding failing restorations, cervical caries associated with plaque accumulation at the gingival margin, root caries Y-f? ciated with gingival recession or as a side effect of medical conditions or pharmaceutical challenges. Research in$jcates that a small portion of individuals account for most of the restorative treatment needs for caries. In 1985-86, older adults attending Senior Centers had an a faces. About 92 percent of these surfaces being increase in the prevalence of root s Yaf r aces caries. ii YP rage of 20 decayed or filled coronal tooth sur- 1 . 35 Additionally, as individuals age, there is an Well over one-half (63%) of the indivi Ill uals over age 65 have root surface caries. Only about one-half (54%) of these root surfaces are filled. Prevention of root caries is particularly important, since there is insufficient knowledge of optimal ther- apeutic approaches for root caries, making restoration difficult. While fluoride traditionally has been associated with prevention of decay in children, a recent study in Canada showed that the occurrence of root decay in adults with lifelong histories o 1493 tjoridated water consumption was approximately 60 percent less than it was in nonfluoridated areas. 3. Periodontal Diseases Periodontal disease is a frequent self-reported chronic condition in persons ag hypertension, hearing loss, heart conditions, vision impairments and diabetes. B-3 older persons including gingivitis, periodontitis, gingival recession and 1985-86, over one half (53%) of older adults attending Senior Centers had or more, 23 percent had supragingival calculus and 66 percent had subgingival and supragingival calculus-prevalence rates greater than younger adults. Appl$ximately 22 percent of older individuals have loss of attachment of 4 mm or greater at one or more site. The prevalence of periodontal diseases appears to increase with age." l3 36 The higher prevalence and, severity of periodontal diseases among older persons may not rather, may reflect the accumulation of disease over time. 5E suit from enhanced susceptibility, but If periodontitis is defined as mild pocketing, there may not be greater proportions of older adults with disease. With the increasing numbers of adults in this age group, however, this remains a considerable disease issue. The number of teeth lost due to periodontal diseases is not f~ 1y , o n but the number of teeth which need to be extracted from periodontal disease increases with age. Whether periodontal diseases are episodic or steadily progressive is still undecided, but evidence suggests that those persons who have retained their teeth to old age have a type of periodontitis that, at any given site, usually progresses slowly. 4. Oral Cancer The prevalence of oral cancer is greater among men tha ch women and increases with age, with the great majority of cases occurring in people over t ln 1987, 29,800 new cases of oral cancer were discovered and 9400 deaths were estimated. $5 age of 40. In a series of screenings conducted between 1957 and 1972 among older white adults in Minnesota, IO percent had at least one oral lesion unusual e recorded. Leukoplakia had a prevalence of 29.1/1000 and oral cancer a prevalence of .9/1000. YY$Jap~ gressive impact of smoking, drinking and use of smokeless tobacco on the condition of teeth and develop- ment of soft tissues lesions-specifically oral cancer-is more apparent in older individuals. Use of roducts and alcohol, both individually and in combination, is associated with denture-rel ed Also, lower educational levels and infrequent dental visits are associated with oral lesions. $3 5. Other oral conditions Other oral conditions are reported more often in older than younger adults. These include oral motor function and sensori-motor problems, such as difficulties in chewing, tasting or swallowing, oral effects of systemic diseases, acute and chronic pain, among others. No real evidence exists that a generalized deterioration in oral motor function or performance occurs with aging, but selected oral conditions-alteration of lip posture, masticatory muscle function, increasing dysfunction of the tongue and suspensory musculature-appear to be related to aging. Functional problems which might result from these conditions include labial spill of saliva, inability to prepare food for swallowing, altered speech, dysphagia, traumatic bite injury, increased mouth breathing. Very serious dysftf ctions in oral motor function can lead to fatal choking, laryngeal food &netrat-lon and regurgitation. Certain diseases of the salivary glatis are more common in older adults, specifically local inflammatory diseases and Sjogren's syndrome. Acute suppurative sialadenitis, as well as chronic recurrent sialadenitis, is more common in elderly, seriously ill, debilitated patients. The prevalence of Sjogren's syndrome-lymphoepithelial lesions-is second only to rheumatoid arthritis among the connective tissue diseases and a typical onset is age 40-60. In addition, there i& some indication that submandibular saliva and possibly minor gland secretions may be affected by aging. Evidence suggests that there is a decline in bone mass so that by age 70, the total is only about 60 percent of the peak. These changes can be observed in the oral cavity, can be exacerbate disease processes and can contribute to functional problems, such as poorly fitting dentures. If ?"qEertain Some oral conditions have become stereotypic of agingaiminution of stimulated parotid fluid output, structural changes in epithelium, atrophic change in oral mucosa, and generalized decreases in taste acuity and perception--but research has led increasingly to a lack of consensuc on these conditions. Evidence suggests that other factors, such as polypharmacy, inadequate nutrition, or systemic diseases, B-4 may be the precursors of these conditions and not age, per se. l4 41 42 43 Other age-reIated change- `1 taste and oral sensation, e.g. touch, temperature, and pressure sensibility, have been observ,d b,t :. I well described or documented. 111. AREAS OF PARTICULAR CONCERN A. Concomitant Medical Conditions, Pharmacological Challenges and Oral Conditions 1. Nature of Problem There are approximately 120 physical or mental diseases which manifest symptoms in the oral cavity or affect ab `ty to perform dentally-related behaviors. with age." The prevalence of most of these conditions increase For example: o Slower movements, less agility, impaired vision and hearing, urinary dysfunction, vascular insufficiency, among other things, may affect the ability to follow recomm and may make it impossible for an older individual to visit a dental office; zidations for self-care o The oral symptoms which result from hypofunctional or nonfunctional salivary glands are unpleasant and painful and affect vital functions such as speech, taste, chewing and swallowing. Xerostomia is highly associated with prescribed radiation or medications. It ma~~~e~n~i~r~~~~~~~~~ibility infections-both oral and systemic-and have an impact on nutrition to caries and periodontal diseases; o Cancer in the head, neck and oral cavity increases with age; o Aging diabetic patients are vulnerable to oral i nfi ections and impaired healing which may lead to periodontal diseases and related oral problems; o Psychoses, affective disorders and sleep disturbances may affect the patient's willingness or ability to perform appropriate r health, speaking or swallowing?' 1 hygiene or seeking of dental services, thus affecting oral o Neurological problems, including stroke and Parkinson's disease, can adversely affect oral functions. Dementing conditions such as Alzheimer's disease increase with age. Traditional education, training or compliance methods might be 5tf effective in changing any inappropriate dental health beliefs or behaviors for such patients. o Chronic and acute pain can adversely affect oral functions and the provision of dental care. Oral health Status also can affect general health status. Examples include the impact of missing teeth, inadequate restorations or poorly fitting dentures on food intake which ultimately might affect nutrition. Mso, .untreated o# infections can result in serious systemic complications, especially in immunocompromised patients. Medications for age-related systemic conditions--e.g. congestive heart failure, diabetes, depression, sleep disturbances, chronic pain--influence the oral conditions observed, cpytribute to the cause of some oral conditions, and affect the kinds of treatment which can be provided. More than 75 percent of a rural Iowa population age 65 and older took medications that could affect oral health or dental treatment. About one-half of the older individuals in the Iowa study took drugs which may cause xerostomia, e.g. antihypertensives, antihistamines, decongestants, diuretics, pain killers and tranquilizers. Other commonly used drugs affect blood clotting and cause oral ulcerations or sloughing of soft tissue. About one-fourth of these older adults took muscle relaxants and medications for anxiety, which can interact adversely with drugs commonly used in dental surgery for sedation and pain relief. Drugs used commonly for cardiac conditions by older persons can interact adversely with local anesthetics containing epinephrine. Broad spectrum antibiotics, medications for diabetes, systemic corticosteroids, phenytojn for convulsions, nifedipine used for cardiovascular disease, medications for angina and congestive heart B-5 failure and antipsychotic medications each may be associated with abnormal healing, predisposition to infection, overgrowth o &' mgival tissue, inability to tolerate long, stressful appointments and/or abnormal oral-facial movements. Also, dental visits create anxiety for many older individuals, a condition which may be heightened by some drugs. 2. Mechanisms and Interventions Established To Deal With Problem Health education and promotion efforts have been used to increase the awareness of older adults or care- takers regarding systemic conditions and medications which relate to oral health. Examples include:, Radiation, Chemotherapy, and Dental Health, Detection and Prevention of Periodontal Disease in; Diabetes and NIDR Fact Sheet: Dry Mouth (Xerostomia). Health care providers can play an active role in early diagnosis of systemic and oral conditions, assisting the patient and each other in limiting the progressio dentist, pharmacist and physician is very important. ivYi diseases. Emphasis on the interaction among the Education for dentists, physicians, nurses and pharmacists, both in basic training and continuing education, should provide increased attention to medical conditions and pharmacologica challenges exhibiting symptoms in the oral cavity. Increased emphasis should be given to recording, routine monitor- ing and clinical application of medical histories, particularly those specific to changes since the most recent visit. Review of related medical conditions involves recording medications whichthe individual is taking. This is particularly important for patients who are taking multiple medications." Dentists should be knowledgeable regarding alternate treatment approaches for compromised patients. For example, the removal of oral infection and employment of antibiotic therapy is especially critical for patients undergoing cardiac or joint-replacement surgery. Where discontinuing medication with negative oral side effects or substituting less harmful agents is not possible, a protective regimen for the oral environment can be instituted. This could include sugar-free chewing gum or candy, artificial saliva, con- trolled-release devices and specific plaque control programs to reduce bacterial burden. The National Foundation of Dentistry for the Handicapped and the American Society for Geriatric Dentistry encourage programs which address the needs of older individuals. They encourage dentists to consider the style of furniture, positioning of the patient, office lighting, staff assistance and other aspects of practice to improve the ease and comfort of the delivery of services to the older patient. Hearing and sight limitations have been acknow!edged in some dental disease prevention programs for the impaired older adult. The American Denal Association (ADA) is developing hospital protocols for twelve medical/surgical con- ditions, including head and neck radiation therapy, cardiovascular disorders, cancer chemotherapy and end-stage renal diseases. These protocols, will assist physicians and hospital-based dentists in understanding oral complications of diseases, why they are important and what to do about them. The Veterans Administration (VA) has established guidelines for the oral health of medically compromised patients in long-term care facilities to assist the health care team. The American Society of Hospital Pharmacists sponsors a project through affiliated state c&ptefs which distributes materials to educate older consumers on appropriate drug use and compliance. Similarly, the American Pharmaceutical Association, in collaboration with state pharmacy associations, has encour- aged the use of Medication and Self-Medication Awareness Tests and Health Check Test to de onstrate to older consumers the importance of having information about medicines and how to use them. i% "Share the Health", a National Pharmaceutical Council project provides education and T-8 istance for older adults regarding medication identification and purpose through "Operation Brown Bag". 3. Apparent Deficiencies More basic research and health professional education is needed to clarify the linkages among systemic conditions, medications and oral problems seen in o!der individuals. More health services research is needed to develop, evaluate and demonstrate ways to improve: 1) interaction among the dentist, B-6 physician, pharmacist and patient regarding health care, * 2) clinical applications of information on medical histories in the practices of dental and medical professionals; and 3) the routine updating of medical his- tories in the practices of health care providers; 4) oral health care of medically compromised patients in long-term care facilities. B. Orientation toward Oral Health and Oral Hygiene 1. Nature of Problem The importance attached to oral health is a key factor dete IF ining actual oral health status and the behaviors which influence its attainment among older adults. A range of attitudinal, behavioral and socioeconomic factors over a lifetime interact to form that orientation. In turn, these factors affect an individual's performance of oral hygiene practices, dental visit behaviors, and compliance with recommended regimens. Attitudes, knowledge and beliefs appear to have the dentally-related behaviors among older adults as they do among younger adults. gjrne correlations with As current middle- aged adults become older, it is assumed that they will keep appropriate levels of knowledge and attitudes thus creating a more informed older sector in the future. Perceived oral health status, as measured by the self-reported presence of conditions, has be investigated in several research projects and is often a key explanatory variable for visiting a dentist. 22 In a study of older rural Minnesota residents regarding perceived overall health status and presence of common health problems, dental (or denture) problems were frequently mentioned conditions along with vision problems, arthritis, hypertension and obesity. There were no differences in self-reported dental problems when the age group 60-74 was compared to that 75 and older. Other stu ws have shown that dental problems receive less mention than other chronic conditions of older persons. 4; ln a 1981 national survey, only 18 percent of dentate individuals age 65 and older--compared to 28 percent of younger adults-reported two or more oral problems (e.g. broken tooth, bleeding gums, sensitive to hot and cold, canker6sores, toothache, sensitive to sweets), while only 10 percent reported problems with chewing and biting. In a study of older Massachusetts health care panel study members, perceived need for care was best explained by perceived oral health status, dentate status and previous dental utilization. Age*ger se, was not significantly related to perceived need and socioeconomic indicators were not predictive. Perceived oral health status is not always a reflection of actual clinical conditions.45 47 48 For example, in a recent study of older patients scheduled for periodontal treatment `4'1p nly 18 percent were aware before arriving at the dental school that they had periodontal disease. In another study, it was estimated that 70 percent of older adults need treat "48 nt, 25-40 percent of older adults perceive that need, and 20-35 percent of older adults seek treatment. Lack af perceived need has been a primary reason for not seeking dental care. 8 24 53 55 62 63 64 Addi- tionally, a low re Al tive priority usually is assigned to dental care in comparison to other health and func- tional activities. Survey research indicates that the combination of perceived need and attitudes toward oral healqk gp d e is y as considerable predictive power in explaining the use of dental services by older adults. 6Q gi & 6l$ For example, in a sample of older individuals in senior centers in the Seattle area, those who attributed greater importance to oral health, believed they needed dental had more teeth, and had more positive dentally-related beliefs, were more likely to seek dental care. we7 Older Americans seem to be resigned to accepting their oral health status, yet express positive attitudes regarding oral health. Fifty seven percent of adults ages 65 to 74 believe nothing can be done to change oral health, while 70 percent of those age 75 and older believe this. Only 32 percent of older adults strongly agree that some people have good teeth and other have bad teeth no matter what they do, while 9 percent strongly agree that people lose their teeth anyway. The majority of dentate older individuals never expect to lose all of their teeth. It appears that if individuals reaches age 65 and if they have not lost their teeth already, they do not expect to. fied with the way their teeth look.6 Interestingly, 80 percent of dentate older adults are satis- As expected, most older individuals believe t a care is often too high; but, most indicate that cost of care is not a barrier for them, 8 i @e cost of dental B-7 Information regarding appropriate dentally-related behaviors may never have been learned or may change over time. Today's older people are more likely not to have been exposed to a preventive orientation early in life and/or may remember outdated information. Their early exposure to dentistry may have predated the acceptance of self-efficacy measures for oral health status. Older adults today have received a large amount of conflicting health information over a lifetime. Misinforma&n and confusion often discourages older persons from changing behaviors or seeking preventive services. The cognitive skills of older individuals as reflected by attention and recall may be somewhat diminished compared to younger individuals. This may require special attention to methods of communication, including message structuring, repetition and reinforcement, shorter limitations, active participation and multiple modes of presentation. ?f ssion length, information Research projects are demonstrating that established attitudes and beliefs can be altered or used to the advantage of oral health. For example, the generalized belief that people can take responsibility for their own health has been shown to be associated with reduction in plaque levels. Conversely, older persons who look to others for control and believe that dental prophylaxis &, important are more likely to avail themselves of diagnostic, preventive and therapeutic dental care. Orientation toward oral health is evident also in attitudes, knowledge and behaviors known to affect oral health status. Approximately three-fourths of older adults believe smoking increases risk of cancers in the throat-a lower proportion than in younger adults. Slightly over a third of older adults believe&avy drinking increases risks of mouth arid throat cancers, a higher percentage than adults of other ages. Health professionals may hold inappropriate beliefs which compound the problems faced by the older indi- vidual. For example, beliefs that older persons cannot learn, will forget quickly what il@.tEhtl that it is too late for them anyway may interfere with effective practitioner-patient interaction. Smce phys- icians have more contact with older adults than dentists, their attitudes toward oral health issues are important to monitor and change as appropriate. Social and psychological risks are not easily quantified, yet need serious consideration in understanding the promotion of oral health. Significant improvements in oral health may be achieved only when the gap need and perceived need-as reflected in numerous attitudinal variables--is 2. Mechanisms and Interventions Established to Deal With Problem Not only should dental practitioners understand normal and pathological aging, they also should have excellent interpersonal skills. Dental practice provides an opportunity to educate and change the attitudes of the patient through examination and communication. For example, when the dentist or dental hygienist cleans teeth, self-care can be discussed. Additionally, when dentists and other health 0";;; ,","Pl,`gai screen for oral cancer, they can educate patients on the relation of tobacco, alcohol and Precancerous lesions and conditions'predisposing to cancer that can be detected and treated early result in less mutilation and increased survival rates. Cognitive behavioral methods that emphasize a strategy of changing an individual's inaccurate beliefs are believed to be effective in oral health promotion. Educational and oral health promotion sessions can be conducted in private practice, but probably can reach more people, at lower cost, if provided in other settings, especially where older persons gather. It has been demonstrated that some preventive dental and educational sessions, in which motivation to %% hieve oral health is significantly enhanced with regular feedback, can be conducted by paraprofessionals. Oral health promotion to improve attitudes and change behaviors can relate to and build on the current lifestyle of the older individual. For example, research demonstrates that older people watch more telev- ie5;on~;;l~;~~~; ;;ews~~~rs regularly. In addition, their use of other media can be targeted and used Non-dental organizations that already have access to older adults can facili- tate changes in oral health attitudes and behaviors. The American Association of Retired Persons (AARP) and the American Red Cross work together to keep members informed regarding health B-8 ::.toy;; topics through -resource manuals, slide/tape programs and articles in publications. activities. &, these organizations have established demonstration projects to encourage health promotion Educational materiaIs to improve orientation toward oral conditions and appropriate self-care and professionally-provided services are available from several sources. Some of these are specific to older adults-emphasizing problems which are more prevalent in later years or prepared with the older person in mind, e.g. the use of large print. Others addressing general adult problems also are useful to older persons. The Federal gover ment , state public health departments, professional associations, and universities are active in producing oral health education audiovisual and print materials to be used with individuals or in community or institutional settings. Examples include `Keeping Your Smile in Later Years" (ADA brochure), radio spots on special care for older persons and "Prescription for Periodontal Health" (NIDR film). m May, 1987, as part of the Congressionally proclaimed "Older American Month", the ADA established a National Senior Smile Week. The theme was "A Healthy Smile Can Last a Lifetime" and the purpose of the campaign was to heighten awareness on the part of the general public of the importance of dental care and the availability of dental services for the older adult. The kit, provided to state and local dental societies, included a planning guide, program ideas, a slide and script for television, a cassette for radio and sample advertising copy, as well as posters and other visual aids. The effort was designed to encourage media, special community activities and dental practice programs. Communities were encouraged to work with pharmacists, hospitals, health fairs and nutritional counseling services. The pro- gram also encouraged the involvement of more dentists in the provision of appropriate care for older aduIts. This program will continue on an annual basis. The American Dents1 Hygienists Association (ADHA) has developed a national campaign-"A Beautiful Smile is AgelesstL-to increase older adults' access to oral health information and services. The nationai organization developed a `program &ifr for use in promoting oral health care that has been adopted by 349 local chapters of the organization. 3. Apparent Deficiencies The 1980s have shown an increase in efforts to improve attitudes and knowledge of oral health for older adults, yet the efforts have not been widespread, sustained or evaluated. Many have been demonstration projects at the local level. More directed efforts are needed to encourage: 1) positive attitudes regarding the oral health of older persons on the part of both the health practitioners and the public; 2) educational materials for older dentate individuals; 3) education on lifestyle including the oral implications of tobacco use, alcohol consumption and polypharmacy. C, Oral Hygiene Behaviors 1. Nature of Problem Appropriate toothbrushing with fluoride toothpaste, interdental cleaning and rinsing with fluorides or antimicrobial products are useful methods to keep the oral cavity clean to prevent caries and periodontal diseases. In addition to preventing further oral disease, appropriate oral hygiene behaviors can result in improved physiological and psychological wellbeing. Plaque retention is a major problem in older adults, exacerbated by existing restorations, rough root surface topology, and inability to brush correctly. Diminished manual dexterity, in addition to more severe functional limitations associated with serious conditions frequently seen in older persons--such abilities to use a toothbrush and interdental devices. 2f s stroke, arthritis, Parkinson's disease-decrease Also, the motivation to prevent diseases and learn ~g$yIi?l ques may be less than for a younger adult, and for some people, self-care may not be physically . Most (70%) dentate older Americans believe that brushing is the most iv ortant preventive measure for dental problems. This is reflected in their dentally-related behaviors. The great majority (88%) of B-V deptate older adults report brushing at least once a day-front and back of teeth and over one fourth (27%) of older dentate individuals report flossing at least four lmes a week. Frequent snacking h reported by less than one third (30%) of adults, age 65 and older. 8' Wh'l over two-thirds of dentate older adults report using a fluoride dentifrice. 620 less than for younger adults, 2. Mechanisms and interventions Established to Deal With Problem Availability of appropriate oral hygiene aids, instruction on how to use them and continuation of lifetime oral hygiene activities address this issue. These may be accomplished through maintenance of activities from younger ages or established through special training sessions. Physical limitations of certain older adults may require oral hygiene measures such as fluoride and antimicrobial rinses. Also, toothbrushes and other oral hygiene aids are being developed with better`grips and other specifications to improve ability to clean the entire oral cavity. The VA has developed an oral hygiene in-service manual which has been used since 1985. It is provided to nursing unit administrators and is designed for periodic updating. Additionally, hands-on in-service training is offered. Researchers at the University of Washington have demonstrated, using several different groups of older individuals, that oral hygie 31 e can be improved and maintained through behavior management based on contingency reinforcement. Research suggests that older persons benefit most from a combin program of regular oral examinations by a dentist and interactive educational sessions for home care. 59 An interactive educational approach with a self-management focus can improve oral health by increasing the individual's personal responsibility for health, perception of general health and self-esteem. A focus on 1) prevention of further disease, 2) control of iatrogenic disease, 3) prescribed regimens for medical conditions, 4) maximizatio3p f oral functions, such as mastication and speech, has been successful in these educational sessions. Trained paraprofessionals and peers have been used to instruct older individuals using such behavioral techniques. A combination of traditional educational booklets, videotapes, modeling, one-on-one interaction with the instructor, self-monitoring, reporting and refining of home-care behaviors and repetitive interventions have resulted in better plaque scores over time as well as improvements in25dental behaviors, perceived overall health, morale and beliefs about the importance of oral health. Demonstration projects with older persons are in place in several major communities, for example, an `Elders Take Charge' program in Denver. Such programs need to be identified and oral health education and training should be incorporated into these general health efforts. Commercial manufacturing can encourage oral hygiene behaviors through advertising of products. 3. $pparent Deficiencies The importance of oral hygiene for all ages needs to be emphasized more by dental and medical personnel and the media. Other forums which have ready access to older people, e.g., retirement homes, consumer advocacy groups, Visiting Nurses Association, could be encouraged to promote oral hygiene. For those people for whom self-care is not possible, caretakers who provide necessary oral health regimens are essential. The lack of acceptance by caretakers of this responsibility is a glaring deficiency. D. Professionally-Provided Dental Care 1. Nature of Problem Use of dental services has increased over the past two decades among older adults.50 51 The percent of lder visiting a dentist during the past year increased from 21 percent in 1964 The 1983 data show that older people have an average of 1.5 visits to the B - 10 dentist during the past yef[, in contrast to 2.0 visits for those age 45-64. never been to the dentist and Less than one percent ha85 38 percent have received no dental services in the past five years. Only 31 percent of older adults, 75 years of age and older, have been to the dentist during the past year. Older white individuals ar about twice as likely to have gone to a dentist during the past year than black individuals (40% VS. 19%) f0 As i sd he case among younger adults, having a dental visit during the past year js directly related to income. It appears that the dental visit pattern of the dentate older person is very $T#aq;tg2the younger adult, while it is the edentulous older adult who is less likely to visit the dentist. Over one-half of dentate older Americans reported visiting the dentis\Sdurmg- the past 12 months in 1983, compared to approximately IO percent of edentulous older adults. Slmrlar data af& reported from the 1986 NIDR National Survey of Oral Health in the U.S. Employed Adults and Seniors. At the other extreme, in 1986 two-thirds of edentulous older adults reported that it had been three years or longer since they we t to a dentist, while only 19-20 percent of the younger adults or dentate older adults had this visit 32 pattern. Reasons for visiting a dentist are similar for younger adults and dentate o de 6 16 !!!I ults, with `prevention and checkup' being the primary reason followed by `something being wrong'. Edentulous oldfb el#g cite `something wrong' or `prosthodontic care' as the reason for their most recent dental visit. Some evidence suggests that level of education influences the reason for visit more than does the number of visits e-r er se. As with younger adults, older a$u@ are more likely to give no need (dentate) or no teeth (edentulous as reasons for not visiting a dentist. Most older individuals report having reasonable access to a dentist, yet, access to care is not easy for some older adults, particularly frail and medically compromised individuals. Access problems may include actual availability of dentists, perceived barriers to medical care, immobility, i % at ion, problems with meeting expenses, functional impairments or the need for assistance in daily living. The evidence of the extent to which finances and isolation are problems is inconsistent. For example, the best predictors of the use of dental services in a study of older individuals in Massachusetts were presence of teeth and perceived need for care. Once these people reached age 75, dentate status a perceived need outweighed education and liquid assets in differentiating a dental user from nonuser. `4i! Income and other socioeconomic variables appear to be associated with the priority and relative value attached to oral health. These priorities and preferences (relative values) develop from many sociocultural influences which occur over a lifetime and are not overcome by provision of money, per se. Expenditures for dental services as well as utilization of dental services and oral hygiene behaviors among older persons traditionally are reported to be less than for younger adults. Absence of visits and lower levels of oral hygiene behaviors have been shown to be related to social and economic factors--such as lower level of education, rural residence, and inability to pay-which are characteristics common among older ad&s. Some research has demonstrated that Medicaid, reduced-fee and free care have not increased use of dental services in a t ay; yet little was done in analysis to differentiate dentate and edentulous older persons. lY6TiF!P&% n g-oT;, g&get6 `itB t dental visits and expenditures among dentate older adults are similar to . Historically, the large percent of older adults who were edentulous appears to be associated with the lower expenditure and visit level. With an increasing number of dentate older adults, the issue of finances may need special consideration. With the need for complex restorations and the lack of insurance, the influence of cost of care among the older person may be considerable. Having a regular source of care is highly correlated with the use of preventive health services. In fact, having a regular source of care may predict the use of preventive dental serv'c 6 74 far better than do perceived need, enabling or predisposing characteristics of older individuals. While preventive services are generally less expensive than are restorative services, the absence of insurance or prepayment for most older individuals or the failure of may4 reimbursement systems to acknowledge pre- ventive services may create a barrier for their regular use. B - 11 2. Mechanisms and Interventions Established to Deal With Problem Improvements in financial capabilities, such as availability of dental insurance and reduced-fee program5 address this problem for older adults. The ADA is working actively to encourage the coverage of dental care in Medicare and is encouraging corporations and insurance companies to extend dental benefits to retired and older Americans. National and local efforts established to improve access for older adults who have financial, disability, 01 geographical barriers to dental care address this issue. For example, during the late 1970's, the ADA and its constituent and component societies began a directed effort to improve the use of appropriate dental services by addressing the issues of convenience and available r E ources in Prevention and Control of Dental Disease Through Improved Access to Comprehensive Care. Through this program, over 119 state and local dental societies provide a toll-free number for referrals to local dentists. Seventy percent of the programs offer a full range of dental services, nine percent denture services only. Over 70 percent of- the programs are directed toward older adults and over 80 percent are reduced fee py5grams. Transport- ation or portable equipment are available through 10 percent of the access programs. In 1988, the ADA plans to encourage the component and constituent societies to re-emphasize the access programs, Additionally, the ADA contributes funds to help sustain the activities of the National Foundation of Dentistry for the Handicapped and endorses the dental degree program--Disabled Dental Services- promoted by the Association of Geriatric Dentistry. Through the ADHAs nationwide geriatric outreach project--"A Beautiful Smile is Ageless"--nygienists- work on a voluntary basis in oral health care programs. The programs provide dental screening and on- site visits to long-term care facilities, senior group settings and individual homes. Improving access to residents of nursing homes has been an objective of other projects. As part of their teaching programs, some dental schools work with nursing homes. Many provide slide/tape materials tom assist nurses in looking for oral health problems in patients, health education materials for patients and preventive treatment prescriptions along with a recall program for residents. Some dentists throughout the United States have begun to provide care to homebound an& institutionalized older Americans. Using vans furnished with portable dental equipment, dentists carr screen a large number of older individuals and provide appropriate care to those who need it. These dentists, working with nursing home administrations, coopera t ingl s ith caretakers and attending to records, are making the provision of services in institutions a reality. 3. Apparent Deficiencies Except for the VA, most of the programs mentioned above have been developed on a local and voluntary basis, resulting in inconsistent availability of care for many older adults. More directed efforts are neede,d to assure adequate oral health care for indigent, institutionalized and homebound older adults. Few programs exist in combination with non-dental organizations, e.g. Visiting Nursing Association. Con- tinued effotts are needed to encourage payment assistance, e.g. dental insurance or Medicare for retired adults, as well as reduced-fee programs or improved medicaid for dental services for those unable to pay. Much of the dental care system, as it exists today, is passive-individuals must seek out care. Some efforts have been made to accommodate the service delivery system to the needs of the older adults, but- more consistent attention needs to be given to reaching out and meeting needs where they exist- community, senior centers, nursing homes or individual residences. E. Oral Health of the Edentulous 1. Nature of the Problem Edentulousness, while decreasing in the overall older population, is highly associated with level of education. Beyond this, its prevalence among older people reflects a predominant form of dental practice and patient expectation that existed when these people were younger. To continue the decrease in- B - 12 edentuloUnesS, individuals must perceive the value of retaining their teeth. Also, dentists, as well as other health care prOfeSSiOnalS, must encourage and reinforce the value of retention of teeth. Appropriate oral health care changes after an individual receives dentUres.6 24 Self-care usually involves cleaning dentures to prevent bad breath and oral infections as well as to preserve healthy tissues for denture Support- Regular visits to the dentist are important for instruction on appropriate home care, detection of soft tissue lesions, refityfg of dentures to accommodate changing bone structure and repairing ill-fitting or broken dentures. Although approximately 3 million denture wearers experience denture retention problems because of alveolar ridge deterioration, dental visits after receipt 0f6c&tures are low, on average. Most denture wearers believe that they need never again g0 to the dentist. 2, Mechanisms and Interventions Established to Deal with Problem Professionally-developed educational tools as well as mass media have been used to encourage denture wearers to maintain adequate oral hygiene and to visit the dentist regularly. The ADA Access Program encourages denture wearers to visit the dentist regularly at reduced fees. 3. Apparent Deficiencies Even with a decreasing proportion of edentulousness in the older population, the number of denture wearers will remain substantial and increased efForts to improve the oral health of these individuals are needed. Efforts to educate denture wearers must counter a strongly held traditional belief that routine dental care is not needed. F. Professional Training for Research, Teaching and Patient Care 1. Nature of Problem Evidence suggests that dental, medical, pharmacy, and gerontology professionals have acl pack/day of cigarettes and systolic hypertension (1). Physical exercise also is associated with a lower risk factor profile (lower lipids, better blood pressure and glucose tolerance, elevated high density lipoprotein cholesterol) for coronary artery disease (2). The interaction among- diseases, lifestyle variables, and putative aging makes it difficult to assesf" the effects of each of these processes on the overall functional capacity of the aging human being unless the influence of all the factors on functional capacity are delineated or controlled while the physiologic effects of one single process are measured. This is not always feasib1.e because change in one usually alters the others, thereby limiting the ability to distinguish the physiological effects of each process independently. One approach to studying the effects of extrinsic variables on age-related declines in organ function might be to first differentiate the effects of disease from those of biological aging. To identify the effects of one disease is not difficult when clinical signs and symptoms of other diseases are not present; however, the effects of asymptomatic disease can be easily overlooked and may cause substantial functional impairments. Furthermore, the effects of several diseases on functional capacity can be synergistic. Arteriosclerosis is the main disease process which correlates directly with biological age, and has the greatest impact on cardiovascular function and longterm survival in the elderly (3). Asymptomatic coronary disease was probably responsible for the decline in the peak exercise ejection fraction below resting levels in 72% of apparently healthy volunteers over 60 yrs of age (4). The coexistence of wall motion abnormalities in 50% of individuals older than 70 years of age with an abnormal ejection fraction response to exercise suggests that regional ischemia was indeed present. In contrast, during maximal cycle exercise there was neither a decline in the ejection fraction below resting levels nor were there regional wall motion abnormalities in normotensive older c- 2 subjects intensively screened for coronary artery disease by exercise thallium scintigraphy (5). This suggests that biological aging per se does not reduce cardiac function in older individuals who are properly screen for cardiovascular disease. Hypertensive disease also has, a substantial effect on cardiac performance by increasing arterial stiffness and pressure, pulse wave velocity and left ventricular wall thickness, decreasing the early diastolic filling rate and prolonging ventricular relaxation (6). There is a 25% increase in left ventricular wall thickness and a 50% reduction in early diastolic filling rate at rest between the third and ninth decades in clinically normotensive individuals (7,8); thus, hypertension might accelerate age-related changes in cardiac function. This would increase after-load in the aging heart, alter the pulsatile component of external cardiac work, reduce arterial distensibility and raise systolic arterial blood pressure, pulse wave velocity and peripheral vascular resistance. Physical conditioning modestly lowers both systolic and diastolic blood pressure, and reduces peripheral vascular resistance in hypertensive middle-aged patients (9), and increases stroke volume, cardiac output and left ventricular wall thickness without changing peripheral vascular resistance in normotensive younger subjects (10). Whether exercise training would increase arterial distensibility and reduce pulse wave velocity and systolic arterial pressure in older subjects is not known; but lower pulse wave velocity and systolic arterial pressure are common in cultures where levels of physical activity are high and the sodium content of diets are low (II). Rigorous screening for silent ischemia and hypertension at rest and by maximal treadmill exercise testing with electrocardiography and thallium scanning (12) can provide individuals free from coronary artery and other asymptomatic cardiovascular disease in which to study the physiological effects of exercise training, independent of disease, on cardiovascular and endocrine-metabolic functions in aging man. Using these techniques the prevalence of coronary artery disease in subjects over the age of 70 years was estimated to approach the post- mortem finding of greater than 70% narrowing of at least one major coronary artery in 40-60% of unselected hearts (13). Similarly, screening the older individuals for diabetes with the glucose tolerance test by the criteria of the National Diabetes Data Group (14,15) and for hyperlipidemia using criteria from the Lipid Research Clinics Prevalence Study (16,17) allows detection and exclusion of older people with generally accepted abnormalities in glucose and lipoprotein lipid metabolism who may be at high risk for asymptomatic disease or organ dysfunction. While disease causes demonstrable and clearly significant impairments in functional capacity, increased physical activity by raising aerobic capacity, lean body mass and energy level and reducing body fat can have a substantial impact on the functional status of the aging human being. Physical Activitv and Maintenance of Functional Reserve Capacity An emphasis on maintenance or improvement in functional capacity with advancing age has not been a major focus of gerontologic research. A substantial amount of information regarding the effects of aging on physiologic function is derived from cross-sectional studies which report declines in performance among different age groups. In the analysis of measurements of the various functional status within group data, there is substantial heterogeneity in the physiologic function of individuals within the various age groups. While mean data may show a decline in the functional reserve capacity among the elderly, there are older individuals with either minimal or no loss, and sometimes equal or even better functional capacity than that of the average younger person. This information has come to the forefront in evaluating the physiologic effects of factors extrinsic to c-3 primary biologic aging, such as regular, intense physical activity, on functional reserve capacity. In master athletes, individuals over the age of 50 years who are very physically active, highly conditioned and compete regularly in athletic events, there is minimal loss in cardiovascular function with advancing age, and glucose tolerance, insulin sensitivity, and lipoprotein lipids are comparable to those of younger athletes (18-21). Master athletes, and other older individuals without specific pathologic linked losses in function commonly associated with disease, who have maintained functional reserve capacity comparable to younger counterparts might constitute that category of non-diseased elderly who have aged successfully (22). This suggests there are more important determinants of health than biological (as opposed to functional) age in disease-free older people. The role of these extrinsic factors or lifestyle behaviors, especially physical activity habits, as significant modulators of physiologic function in the elderly requires further evaluation. A profound effect of physical exercise training on cardiovascular, endocrine- metabolic and musculoskeletal function in younger individuals is now well recognized, and it is likely that many changes in functional reserve capacity that have been previously attributed to an "aging process" are in part due to the sedentary lifestyle and dietary indiscretion that accompanies advancing age. It is not known how much of an improvement in physiological function can be expected in response to varying levels of physical exercise in sedentary elderly subjects, nor is it known to what extent and under what conditions medically unsupervised physical activity can be recommended for healthy or disease-afflicted elderly. Further investigation is needed to understand the mechanisms by which aging affects physiologic responses to acute and long-term physical activity and to define the roles that physical conditioning can play in the promotion and maintenance of health and the prevention of diseases attributed to biological aging. The perspective gained in this area of gerontologic investigation will be limited if only cross-sectional data are examined, especially when all that is reported are mean data. Only through longitudinal investigations of medically defined, carefully selected cohorts can the impact of physical activity on the functional reserve capacity of aging humans be distinguished from other extrinsic factors, disease and biological aging itself. Several longitudinal studies examining the potential of exercise training to slow age-related declines in cardiovascular, musculoskeletal, bone-mineral, and glucose and lipoprotein lipid metabolism are currently supported by the National Institute on Aging. There are also studies in progre'ss to investigate the mechanisms by which physical exercise may improve the functional reserve capacity and the medical condition of elderly people afflicted with diseases such as coronary artery disease, hypertension, type II diabetes mellitus and osteoporosis. If the results of these studies are to provide insight into the efficacy of aerobic exercise as a therapeutic modality to improve the well-being of the rapidly expanding population of older people, the common experimental problems distinguishing confounding effects of aging, cohort, secular and time effects on the experimental measures must be considered and may require an age-time matrix type of study design (23). DEFINITION OF THE ISSUES The specific contributions of physical inactivity and deconditioning to the commonly observed declines in the functional reserve capacity of major organ systems with aging have not been thoroughly delineated. The maintenance of physical activity and conditioning status measured as maximal aerobic capacity C -4 (the ability of the cardiovascular system to deliver blood and oxygen to working muscles and of exercising muscles to utilize the oxygen and energy substrate to perform work in response to a maximal exercise stimulus) (24) into older age may have substantial health and socioeconomic benefits for the elderly. The fact that high levels of maximal aerobic capacity (VO max) observed in selected master athletes are associated with improved metabolic f unction and the maintenance of a high level Of functional reserve capacity compared to their sedentary peers suggests that this is the case. Although maximal aerobic capacity is probably the best measure of physical work capacity and fitness in younger individuals, it may not be the only measure of organ performance or necessarily the best measure of functional reserve capacity in the elderly. Energy expenditure, measured as oxygen consumed, or other physiologic responses (hemodynamic, muscular, hormonal, cognitive-motor or otherwise) to submaximal isotonic work on a bicycle or treadmill, to an isometric (weight) stimulus, or to environmental and mental stressors are also important, useful measures of human performance. The goal of remaining physically active with advancing age is to delay the declines in functional capacity with aging. Not only does regular aerobic exercise maintain muscle strength, coordination, speed, endurance and agility, but it reduces body fat and other risk factors for coronary artery disease, heightens mental acuity, maintains self esteem and enhances quality of lifestyle. The rehabilitative capacity of regularly performed aerobic exercise also is demonstrated in human disease. Physical activity has improved physiological function and overall performance in some patients with ischemic coronary artery disease, hypertension, endstage renal disease, diabetes mellitus, weakness due to muscle wasting and depression. The salutary effects of physical conditioning on behavior include enhanced motivation, increased confidence in the ability to perform daily tasks and activities, successful return to a regular work schedule, and a heightened level of energy for activity; all presumed due to increased aerobic capacity. Such improvements could maintain the functional capacity of older people afflicted with disease, in spite of concomitant physical limitations. This suggests that regular physical activity may be a suitable mode of rehabilitation for older individuals with limited function due to disease and for maintaining the functional reserve capacity of the healthy elderly. If physical conditioning status is maintained by regular exercise, can age- associated declines in functional capacity be avoided? Can vigorous exercise successfully restore the declines in organ function and vulnerability to diseases and st,resses associated with aging? If so, how much exercise is needed? How often and at what intensity? Is there a threshold for activity or set point for V02max at which beneficial adaptations will occur or deteriorations ensue? Can the observations in master athletes with high levels of maximal aerobic capacity or in disease-afflicted individuals who regain functional capacity through regular physical activity be solely ascribed to exercise? Many questions need be answered regarding the potential for physical exercise to promote successful, healthy aging and to restore the functional capacity of those afflicted with disease. Substantial research is needed to understand the relationship of regular physical exercise and the maintenance of heightened aerobic capacity to the functional status of the aging human being. Major Areas Which Require Investiqation Evaluation of the potential role for regularly performed physical exercise in the prevention and/or reduction in the extent of age-related diseases and disorders in humans, and the determination of the exercise c-5 prescription (type, frequency, intensity and duration) and magnitude of the increase in aerobic capacity required to produce these effects. Assessment as to whether or not there is a threshold for the increase in maximal aerobic exercise capacity required to achieve a specific functional reserve capacity. Are there different benefits for different degrees of exercise intensity? Investigation of the mechanisms by which regularly performed exercise increases cardiovascular, endocrine-metabolic, cerebral, and other organ function, maximal aerobic capacity, and the ability to work and function independently, and reduces risk factors for disease in the elderly. Measurement of the biological adaptations to increased exercise/physical activity in man in vivo at functional levels ranging from the whole body to the specific organ systems, tissues and to the cellular and molecular level, and the determination of the influences of advancing age onthese processes. Evaluation of whether or not maximal aerobic capacity (V02max) is the best measure of physical conditioning status, cardiovascular function and overall functional reserve capacity in the elderly. Determination whether functional declines with short- and long-term deconditioning are more rapid and of greater magnitude in older active individuals than in comparably conditioned younger individuals, and an assessment as to whether or not deconditioned older individuals are capable of rehabilitation to previous levels of performance after deconditioning. Assessment whether the recommendation for increased physical activity in older individuals is medically safe for healthy as well as disease- afflicted elderly. If affirmative, then studies are needed to develop guidelines for baseline medical evaluations and appropriate prescriptions (type, frequency, duration and intensity of activity) for exercise training older people that maximize the benefits of exercise while preventing injury. THE ELDERLY BE PHYSICALLY CONDITIONED? ; of'the longitudinal studies documenting improvements in functional reserve icity with aerobic conditioning are in younger and middle-aged individuals; is-sectional comparisons in epidemiologic studies provide most of the Jrmation on the potential of physical exercise training to increase aerobic icity and improve functional reserve capacity in the elderly (2, 25-27). In few longitudinal studies examining the effects of exercise training on :ntary people over the age of 60 years, the training stimulus was of short ition and low intensity, and sample sizes were small. As a result, a ;tantial change in maximal aerobic capacity was documented in some (28-30), not in other studies (31-33). These inconsistencies have limited the ability -each a conclusion about the trainability of older individuals (34). However, physiological results of longitudinal studies in which high intensity -cise was used to condition older individuals (30,35), the benefits achieved middle-aged and older patients with coronary artery disease (36), type II letes (37,38) and chronic renal disease (39) with participation in vigorous C-6 aerobic exercise programs, and the observations in master athletes (18-21) support the view that exercise has the potential to improve functional capacity and prevent disease in the elderly. Several studies have attempted to determine the training intensity required to raise V02max substantially in older individuals. In an early study (28), 60% of people aged 60-79 yrs increased their aerobic capacity an average of 7% after participation in a 6 week walking and jogging program at an intensity of 40-50% of heart rate reserve. In another study, there were comparable increases in the peak VO max 4 of 60-70 year olds after 9 weeks of exercise at an intensity of either 7 or 70% Of VO2max (29). The most comprehensive study to date involved, a 6 month program of walking at 40% of heart rate reserve which increased V02max by 12% in 11 healthy subjects ages 65-+3 years (30,35); however, in spite of the rise in V02max during the lower intensity exercise, glucose and lipoprotein lipid metabolism did not improve. Subsequently, higher intensity exercise at 80-85% heart rate reserve for 6 months raised V02max an additional 18% and substantially improved hemodynamic, metabolic and pulmonary responses (30,35,40,41). It is not clear whether it was the duration or the intensity of the training stimulus which limited the improvement in the functional reserve capacity of these older subjects. Although the older individuals increased their VO max an additional 18% in response to the vigorous aerobic exercise program, t e lower intensity i training stimulus was sufficient to improve cardiac performance, but not the metabolic function of these individuals. subjects at these lower intensities, While V02max increased in older higher intensity training programs and a more significant rise in maximal aerobic capacity over a longer time period might be required for older subjects to achieve .the metabolic improvements observed in younger and middle-aged subjects after endurance training (42-45). The high VO max 6 and associated cardiovascular and metabolic benefits achieved by master at letes who have trained intensely for a long period of time lends credence to this hypothesis (18-21,46,47). In some older subjects, the cardiovascular and metabolic adaptations to exercise programs may be significantly less than in younger individuals. This may reflect the presence of asymptomatic disease or irreversible changes in cardiac, respiratory and/or skeletal muscle structure and function in older subjects which limits the ability of the exercise stimulus to produce physiologic adaptations in the function of various organs comparable to those observed in healthy younger subjects (48,491. The suggestion that enhanced muscular adaptations, rather than increased cardiac output may be responsible for the greater oxygen extraction at maximal exercise in master athletes suggests that peripheral, not central adaptations are primarily responsible for their elevated VO max f (49). These changes in skeletal muscle structure and function may take onger to occur in older individuals. Whether or not endurance exercise can induce these peripheral adaptations in sedentary older individuals and raise their V02max to levels comparable to those found in younger individuals may require longterm longitudinal studies. The ability of master athletes to maintain high levels of VO2max and have glucose tolerance, insulin sensitivity, and plasma lipoprotein lipid levels comparable to those found in younger active individuals (18-21) suggests that maintenance of a high level of physical activity into older age can slow the decline in the functional reserve capacity of the cardiovascular and endocrine-metabolic systems previously attributed to biological aging (48). Preliminary results in several highly conditioned master athletes who began intensive physical exercise training in their 6th decade of life and in one who deconditioned for 10 weeks (V02max c -7 declined from 53 to 39 ml/kg*min) suggest that these cardiovascular and metabolic adaptations are probably not inherited (50). In studies examining the effect of regular chronic wheel exercise on cardiac function in sedentary adult rats there was a mild augmentation in cardiac oxidative enzyme capacity and an attenuation of the age-related decline in myocardial calcium activated actomyosin ATPase activity. This indicates that exercise conditioning can partially reverse the decline in cardiac muscle oxidative capacity observed in aging sedentary rats (51), suggesting that the relative efficacy of chronic exercise to modulate myocardial performance is possible into older age, and apparent age-related declines in myocardial function, at least in rodents, can be reversed by physical conditioning. It is possible that the vigorous high intensity training program required to test the hypothesis that physical exercise will improve functional reserve capacity in the elderly may not be possible in all older individuals. The ability to condition some older individuals may be limited by obesity or coexistent diseas or other medical conditions. Obesity, defined as a body mass index >30 Kg/m 5 (52) . associated arterio:Zlerosis (53) with hypertension, diabetes, hyperlipidemia and and an increased mortality from coronary heart disease (54). Thus, overweibht individuals are at increased risk for complications during exercise training and require careful screening for overt and asymptomatic disease prior to onset of exercise training. Furthermore, oxygen consumption and cardiac work are increased in overweight individuals during exercise (55), increasing risk for cardiovascular complications. Weight reduction prior to participation in a physical exercise program may reduce risk for complications during training and enhance the ability of overweight individuals to raise their maximal aerobic capacity. Simultaneous programs of weight reduction by hypocaloric feeding and behavior modification combined w'th physical exercise may be even more beneficial, since increased energy expenditure during exercise will enhance the caloric deficit produced by hypocaloric feeding (55,56). Preliminary results in healthy overweight, middle-aged and older men screened for occult coronary disease by maximal treadmill stress testing suggests that such a combined intervention promotes a greater reduction in adipose tissue mass than achieved either by hypocaloric feeding or exercise alone (57). Such an approach seems attractive if confounding extrinsic factors such as disease do not limit the exercise capacity of these sedentary, overweight individuals or place them at risk for injury. Thus, prior screening for disease, especially symptomatic and asymptomatic coronary artery disease by careful medical exam and exercise stress testing'with electrocardiography and thallium scans would provide a healthy population of older individuals at low risk for exercise-induced complications in which to test whether prolonged, intensive physical exercise in elderly individuals will cause cardiovascular, metabolic and other physiologic adaptations comparable to those seen in younger individuals. ARE AGE-RELATED DECLINES IN CARDIOVASCULAR FUNCTION MODIFIABLE BY PHYSICAL EXERCISE' The most effective test to evaluate the maximal functional capacity of the cardiovascular system is to measure maximal oxygen uptake during strenuous exercise. This test determines the capacity of the cardiovascular system to deliver oxygen to working muscles and for exercising muscles to utilize the oxygen to perform the work (24). Most of the studies examining the effects of aging on V02max are cross-sectional comparisons of the changes in physiologic responses to maximal exercise stress with age in active, but non-athletic men. They report a rather uniform average 10% per decade or 0.45 ml/kg*min per year C- 8 mean &cl master at ine in V02max from age 25-80 years (25,58). However, in highly trai;;: rate Of .hletes there was a decline in VO2max of only 5% per decade (18). decline in heterogeneous, VO max with advancing age in longitudinal studies is and depen ent on the physical activity status of the population 5 studied. In subjects aged 40-72 years divided into active and inactive categories, the V02max of active men who jogged an average of 3 miles/week declined by much less rapidly than that of sedentary men (59). In men aged 40-60 yrs old who ran an average of 25 km/week, there was no decline in V02max over a 10 year period of follow-up (60). In a recent longitudinal study there was a decline in VO max of less than 2% per decade in highly conditioned master athletes aged 5 O-82 yrs who remained competitive and a significant 12% decline per decade in the V02max of those who ceased competition but remained highly active during the 10 year period (19). In that study, maximal heart rate and fat free mass decreased and percent body fat increased comparable amounts in both groups, suggesting that the competitive group either increased arteriovenous oxygen difference (i.e., muscular adaptations occurred) or raised stroke volume (i.e., cardiac adaptations occurred since maximal heart rate decreased) during the 10 year period of intensive training. Thus, while maximal heart rate declines with advancing age, it appears that highly conditioned elderly subjects without evidence cardiovascular disease can maintain their aerobic capacity by increasing muscle oxidative capacity (arteriovenous oxygen difference) and by increasing stroke volume and diastolic filling (Frank Starling mechanism) to compensate for the progressive decline in maximal heart rate with advancing age (46-49). In addition to the physiologic adaptations observed with regular high intensity endurance exercise in healthy conditioned older athletes, long term, high intensity aerobic training produces both cardiac and peripheral adaptations in middle-aged patients with ischemic heart disease (36,61,62). In these patients the peripheral adaptations also may be of greater significance then central (cardiac) ones, since left ventricular wall thickness, contractility and function during systole did not change (46). Thus, while maximal aerobic capacity declines with advancing age, this decline can be attenuated by central and peripheral circulatory adaptations. In highly conditioned master athletes there is a decline in V02max with advancing age that can be attributed to a decline in maximal cardiac output caused by the well- documented age-related decline in maximal heart rate (46-48). However, this can be attenuated by continued high intensity aerobic training (19). Thus, because of variability in lifestyle habits there may be diversity in VO2max and cardiac hemodynamics in elderly individuals such that some older individuals have a V02max'comparable to that of younger individuals. In addition to differences in the disease status, physical activity habits and body composition of older subjects, studies in disease-free older subjects indicate that there are at least three significant age-associated alterations in cardiac structure and function. These are a mild increase in left ventricular wall thickness (8,48), slowed and delayed ventricular relaxation (6,8), and diminished contractile performance during physical exercise (46,48). The first two age-related changes probably reflect a compensatory response to the increased workload imposed by vascular changes (increased peripheral vascular resistance), which increase pulse wave velocity and afterload. This increases the pulsatile component of external cardiac work and raises systolic arterial pressure (11). These changes are magnified in individuals with hypertension (6) and are an independent risk factor for cardiovascular mortality (63). The clinical relevance of the left ventricular hypertrophy observed with advancing age is not clear, but under conditions of acute volume overload or exercise stress may raise c -9 ventricular and pulmonary pressures and increase shortness of breath. Physical conditioning profoundly affects the circulatory system in younger individuals by increasing stroke volume, decreasing peripheral vascular resistance, and increasing left ventricular mass (10,48); in older subjects it might also increase arterial distensibility, reduce pulse wave velocity and lower systolic blood pressure. The effects of physical conditioning on these processes are not known in older people. The third age-related change in cardiovascular function, a decline in maximal aerobic capacity, defined by the Fick equation as the product of cardiac output and arteriovenous oxygen difference during maximal exercise stress is dependent on the population studied, and age-related changes in the peripheral and central circulation (46-48). In disease-free individuals cardiac output, measured at peak oxygen consumption using the gated blood pool scan technique during cycle exercise to exhaustion, was maintained with advancing age (5,12). However, neither arteriovenous oxygen difference nor cardiac output or their determinants have been measured at VOZmax; and in preliminary studies evaluating the mechanisms regulating aerobic capacity in master athletes and sedentary older subjects, peripheral and not central adaptations seem responsible for the higher levels of V02max in highly conditioned master athletes (49). Other possible reasons for differences in V02max among older individuals may be the inappropriate normalization of oxygen consumption during maximal exercise stress to total body mass rather than to lean body mass since muscle mass decreases with advancing age (64,65) and the additive effects of the age-associated decline in blood flow to muscle during maximal exercise in elderly subjects (66). While there is a progressive decline in pulmonary function with advancing age that may be caused by effects of biological aging or environmental exposures and lifestyle (67,681, they do not seem to limit. exercise capacity in individuals without evidence of pulmonary disease because maximal ventilatory capacity is rarely achieved at V02max. Hence, the pulmonary system is usually not rate-limiting in exercise performance, although oxygen exchange in the lung may hinder performance during prolonged exercise. Thus, the health status and lifestyle habits of the individuals studied seem to have the most profound affect on cardiovascular performance during maximal exercise stress testing. Coronary artery disease, whether overt or asymptomatic has the most significant impact on cardiac function and screening out individuals with cardiovascular disease especially in older populations, dramatically alters cardiac performance (5,12,48). In healthy older individuals, screened for coronary>artery disease, differences in cardiac function may be primarily due to physical conditioning status. In the only study addressing this issue, both cardiac output and end diastolic volume were higher at the same level of exercise intensity after a 12 week aerobic training program, but end systolic volume did not change (69). The extent to which the peripheral (muscle mass, blood flow and oxygen extraction) and central (ventricular function, cardiac output, and oxygen exchange) factors determining maximal aerobic capacity (Fick Equation) differ among healthy elderly subjects with varied physical activity habits, and the effects of physical conditioning on these parameters is not known. ARE GLUCOSE AND LIPID METABOLISM MODIFIABLE BY PHYSICAL EXERCISE IN THE ELDERLY? Some of the alterations in glucose and lipoprotein metabolism which occur with advancing age predispose older people to *diabetes mellitus and hyperlipidemia U5,W, major risk factors for coronary artery disease, the leading cause of death in older Americans (3). If physical inactivity and a reduced aerobic c -10 capacity are maJor determinants of the decline in metabolic function and increase in adiposity which predispose older individuals to develop atherosclerosis, then interventions which improve physical conditioning status and V02max should improve metabolism, reduce risk factors for atherosclerosis and decrease cardiovascular complications during stress. A better understanding of the effects of change in lifestyle habits on glucose and lipid metabolism with advancing age might have important health implications for reducing the prevalence of coronary artery disease and prolonging the survival of older individuals. A beneficial effect of physical conditioning on glucose and lipoprotein metabolism and body composition is recognized in younger and middle-aged individuals (2,26,27,42-45) and several studies indicate that similar changes occur in older subjects (28-30). The longitudinal studies in older individuals are few in number and most are descriptive, not mechanistic. Furthermore, changes in body fat and diet during training, the duration and intensity of the exercise, and the timing of the last exercise session relative to the performance of the research tests affect glucose and lipoprotein metabolism and may limit the ability to distinguish effects of physical conditioning per se from those of other extrinsic factors affecting metabolism. Declines in metabolic function with advancing age are highly variable, and in a substantial percentage of older subjects measures of lipoprotein lipids, glucose metabolism and body composition are comparable to those in younger subjects. The reduction in overall muscle mass and blood flow to muscle in elderly individuals contributes to the decline in metabolic function by decreasing muscle structure and function and reducing the peripheral utilization of substrates. Thus, while glucose utilization and lipoprotein turnover traditionally have been normalized to body weight or the pool size of a substrate, it may be appropriate to normalize these parameters for lean body mass and organ function in older individuals. Glucose Metabolism with Advancinq Aqe The 5 mg/dl deterioration in glucose tolerance per decade observed with advancing age is primarily caused by peripheral tissue resistance to the action of insulin (14,15). Studies using the glucose clamp technique indicate that at submaximal insulin concentrations both glucose disposal and the suppressibility of hepatic glucosg production by insulin on the average are reduced in older subjects despite normal insulin receptor binding (70-72). This raises plasma insulin levels and reduces glucose tolerance, both of which increase risk for accelerated atherosclerosis (73). Tissue responsiveness to insulin, defined as the glucose disposal rate at maximal insulin concentration, is normal in some and reduced in other elderly subjects depending on their degree of hyperinsulinemia and glucose intolerance. This suggests that in some older people there may be a post- insulin receptor defect in insulin action, yet this has not been examined directly at the cellular level. Other mechanisms, such as reduced insulin secretion (74) and increased levels of norepinephrine resulting in impaired insulin secretion and action (75), also may worsen glucose metabolism in older individuals. Cross-sectional data in master athletes (20) and sedentary younger and older individuals (38,42,43) suggest that the maintenance of high levels of physical activity into older age protects against the age-related deterioration in glucose tolerance and insulin sensitivity. In only one study examining the effects of c -11 aging on glucose metabolism was VOzmax and percent body fat of the subjects measured directly (21); and there are no longitudinal studies of the effects of change in physical conditioning status and body fat on the mechanisms regulating glucose metabolism in older individuals. Thus, the relationship of physical conditioning status to glucose metabolism in older individuals, independent from hereditary factors and other extrinsic variables, is not known. Liooprotein Lipid Metabolism with Advancinq Ase The finding of elevated levels of high density lipoprotein cholesterol (HDL-C) and lower triglyceride and low density lipoprotein cholesterol (LDL-C) levels in master athletes that are comparable to those in athletic younger individuals suggests that physical conditioning may improve lipoprotein lipid metabolism and reduce risk for coronary artery disease in older individuals. There is little known about the regulation of lipoprotein metabolism in elderly subjects, but the impact of extrinsic factors, genetics and disease on metabolic function is substantial (76). For example, obesity and diets high in cholesterol and saturated fat lower HDL-C, raise LDL-C and increase plasma triglyceride levels (77,78). Alcohol intake (79), medications (80) and chronic diseases also have substantial effects on lipoprotein lipids, most of them undesirable. Chronic diseases, such as diabetes, renal and liver disease, common in elderly populations lower HDL-C and raise plasma LDL-C and triglyceride levels. These abnormalities in lipoproteins are associated with increased risk for atherosclerosis and coronary artery disease (16,76). If the presence of these conditions is undetected, lipoprotein lipid profiles will be altered independent of biological aging. Thus, the accurate study of the effects of physical activity on lipoprotein metabolism in older individuals requires rigorous screening to select healthy people of comparable body weight and diet without evidence of disease or genetic factors which affect lipoprotein metabolism. Such a design would distinguish the metabolic effects of exercise capacity from those erroneously attributed to biological aging per se. Studies of this type have not been performed in the elderly and might provide insight into the role of physical exercise programs in reducing risk for coronary artery disease in seniors. CAN AGE-RELATED LOSS OF BONE DENSITY BE PREVENTED BY PHYSICAL EXERCISE?. There is a progressive decline in bone density in both males and females with advancing age. These losses may be so severe in elderly females to result in fractures causing progressive disability, limited activity and substantial declines in functional capacity (81). Although biological aging is considered a major factor in the loss of skeletal bone, the effects of estrogen and vitamin D deficiency, physical inactivity, cigarette smoking and excessive alcohol also contribute to the development of osteoporosis in the elderly (81-84). In postmenopausal females the rate of loss in skeletal mass and bone density is greatly accelerated due to estrogen deficiency; however, this decline can be accelerated by the present of the aforementioned additional extrinsic risk factors which enhance osteopenia. Physical inactivity is one potentially modifiable factor contributing to the loss of skeletal integrity and bone density. A number of cross-sectional studies suggest that bone loss can be attenuated by physical exercise (84-86); thereby slowing the emergence of osteoporosis and reducing the heightened risk of bone fracture in the elderly. If estrogen is replaced in the postmenopausal female, c =12 bone resorption will decrease; simultaneous weight bearing exercise may further augment bone accretion and increase bone mass (87). Estrogen administration (in the postmenopausal female), cessation of cigarette smoking, reduction in alcohol intake, dietary supplementation with vitamin D (and perhaps calcium) and other extrinsic factors may be additive with the effects of exercise to reduce the progression of osteopenia in the elderly. Although supplemental calcium administration alone or with estrogen does not increase bone density (88), its effects when administered during exercise are not known. The increase in muscle mass and strength, and enhancement of agility associated with physical exercise may substantially reduce the vulnerability of older individuals, especially postmenopausal women, to risks of bone fracture. While the 1984 Consensus Conference on Osteoporosis (89) recommended modest weight bearing exercise for the possible prevention of bone loss, closer inspection of the literature indicates that more information is needed (90). If it is decided which older individuals might benefit from physical activity, it will be necessary to determine the type, intensity and duration of the exercise program best suited to increase bone density; assess whether there are additional requirements for supplemental hormones, vitamins and minerals to maximize the effects of exercise; and develop measures of bone density and aerobic capacity to accurately evaluate the effects of exercise on bone-mineral metabolism. Many factors can affect the progression/remission of osteoporosis; hence the selection of subjects, size of the sample studied and method of randomization to treatment will be critical. ARE ADAPTATIONS TO ENVIRONMENTAL STRESS IMPROVED BY PHYSICAL EXERCISE? The ability to adapt to changes or stresses in the environment declines with advancing age. Older individuals are on the average less tolerant to extremes of temperature (91,92), more prone to orthostatic hypotension after rapid positional change (93) and more often remain tachycardic, hypertensive and fatigued after physical exertion than younger people (94). Tolerance to temperature and recovery from exhaustive exercise are improved in younger and middle-aged individuals after physical conditioning (95-97), but the results of exercise training on these responses are not known in the elderly. Paradoxically, exercise training worsens orthostatic tolerance in younger subjects (98,99), but the effects in older sedentary individuals with impaired baseline orthost;,tic tolerance are not known. Blood volume, blood flow and thermoregulation (swea ing and shivering) affect responses to these environmental conditions; tt,ese parameters have neither been measured in healthy older individuals nor related to maximal aerobic capacity, body.composition or diet. One would suspect that more physically active older individuals would be more tolerant to these stresses, but this requires investigation. SUMMARY AND FUTURE PROSPECTS There is evidence that regularly performed exercise may improve the quality of life and protect against the development of disease in elderly subjects. Several studies have shown that the functional reserve capacity of the cardiovascular, endocrine-metabolic and musculoskeletal systems can be maintained and/or improved by regular exercise in healthy, elderly subjects. Controlled longitudinal studies have shown that regularly performed exercise is associated with fewer risk factors for arteriosclerosis and coronary artery disease in middle-aged men and women and a few studies have documented similar effects in older subjects. Results in master athletes and in patients with disease support the hypothesis c - 13 that physical activity will improve the functional capacity of older people. More information is needed to determine the extent to which physical conditioning will benefit the elderly and type and quantity of regular exercise which should be prescribed for older populations. This can be achieved both by large scale longitudinal studies as well as by small short and long term evaluations in healthy and disease afflicted older subjects of the mechanisms by which exercise training improves functional capacity, reduces risk factors for arteriosclerosis and improves the quality of life. If it can be documented that exercise training slows or prevents the age-related deterioration in functional capacity and makes it easier for the elderly to complete activities of daily living with more energy and less fatigue, then regular exercise could be incorporated into programs of public health and preventive medicine as a means by which the productivity, independence, and active lifestyle of the aging population can be prolonged. In studying the effects of exercise on the functional reserve capacity of the elderly it will be important to determine the age, gender and clinical characteristics of the older subjects most likely to benefit. Guidelines for medical screening and baseline evaluations of functional reserve capacity will be needed to determine the exercise prescription most likely to achieve the desired physiologic result without risking injury to the older participant. This will require determination of the type, intensity, duration and frequency of exercise for each functional decline and risk factor which develops with advancing age. Standardized methods will be required to monitor physiologic responses to exercise, determine the rate of progression to higher levels of exercise and document the physiologic effects of the exercise program. Safeguards will be needed to maintain diet, drugs and other lifestyle habits constant to permit accurate assessment of the physiological effects of physical exercise. Progress in this area of investigation will require support for centers of excellence to perform large scale exercise studies to document the physiological effects of physical exercise, and its role in the prevention of disease, reduction in the utilization of health resources and improvement in the mental health and the quality of life of elderly populations (100). Longitudinal studies of this type would ultimately have sufficient data to determine the impact of exercise training on morbidity and mortality in the elderly and establish the relationship of physical activity to survival in healthy and disease-affected older individuals. REFERENBES 1. Morbidity Mortality World Reports, Progress in Chronic Disease Prevention: Protective Effect of Physical Activity on Coronary Heart Disease 1987; 36:426-429. 2. Leon, AS. Physical Activity Levels and Coronary Heart Disease. Analysis of Epidemiologic and supporting studies. Med Clinics North America 1985; 69:3-20. 3. Levy RI. Declining mortality in coronary artery disease. Arterio- sclerosis 1981; 1:312-325. 4. Port S, Cobb FR, Coleman RE, et al. Effect of age on the response of the left ventricular ejection fraction to exercise. New Eng J Med 1980; 303:1133-1137. 5. Rodeheffer RJ, Gerstenblith' C, Becker LC, et al. Exercise cardiac output is maintained with advancing age in healthy human subjects: Cardiac dilation in increased stroke volume compensate for a diminished heart C - 14 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. rate. Circul. 1984; 69:203-213. Lakatta EG. Do hypertension and aging have a similar effect on the myocardium? Circul. 1987; 75:69-77. Fleg JL. Alterations in Cardiovascular Structure and Function with Advancing Age. Am J Cardiol 1986; 57:33-44. Gerstenblith G, Frederiksen J, Yin FCP, et al. Echocardiographic assessment of a normal adult aging population. Circ 1977; 56:273-278. Seals DR, Hagberg JM. The effect of exercise training on human hypertension: a review. Med and Sci in Sports and Exercise 1984; 16:207- 215. Blomqvist CG. Cardiovascular Adaptations to Physical Training. Ann Rev Physiol 1983; 45:169-189. Avolio AP, Fa-Quan D, We-Qiang L, et al. Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: Comparison between urban and rural communities in China. Circul. 1985; 71:202-210. Lakatta EG. Health, disease and cardiovascular aging. In: Health in an Older Society: Institute of Medicine and National Research Council, Committee on an Aging Society, The National Academy Press, Washington, DC, 1985. pp: 73-104. Elveback L, Lie JT. Combined high incidence of coronary artery disease at autopsy in Olmstead County, Minnesota, 1950-1979. Circul. 1984; 70:345- 349. Davidson MB. The effect of aging on carbohydrate metabolism: A review of the English literature and a practical approach to the diagnosis of diabetes in the elderly. Metabolism 1979; 28:688-705. Goldberg AP, Andres R, Bierman EL: Diabetes mellitus in the elderly. b: Principles of Geriatric Medicine, (eds. R Andres, EL Bierman, WR Hazzard), New York: McGraw Hill Inc., N.Y., 1985. pp. 750-763. Hazzard WR. Disorders of lipoprotein metabolism in aging. In: Principles of Geriatric Medicine, (eds. R Andres, EL Bierman, WR Hazzard), New York: McGraw Hill, Inc., 1985. pp. 764-775. LaRosa JC, Chambless LE, Criqui MH, et al. Patterns of dyslipoproteinemia in selected North American populations. Circul. 1986; 73:1-12. Heath GW, Hagberg JM, Ehsani AA, et al. A physiological comparison of young and older endurance athletes. J Appl Physiol 1981; 51:634-640. Pollock ML, Foster C, Knap D, et al. Effect of age and training on aerobic capacity and body composition of master athletes. J Appl Physiol 1987; 62:725-731. Seals DR, Allen WK, Hurley BF, et al. Elevated high-density lipoprotein cholesterol levels in older endurance athletes. Am J Cardiol 1984; 54:390-393. Seals DR, Hagberg JM, Allen WK, et al. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol 1984; 56:1521-1525. Rowe JW, Kahn RL. Human aging: Usual and successful. Science 1987; 237:143-149. Elahi VK, Elahi D, Andres R, et al. A Longitudinal Study of Nutritional Intake in Men. J Gerontology 1983; 38:162-180. Astrand PO, Rodahl K. Textbook of work physiology. McGraw Hill, St. Louis, 1977. Buskirk ER, Hodgson JL. Age and aerobic power: the rate of change in men and women. Fed Proc 1987; 46:1824-1829. Kannel WM, Sorlie P. Some health benefits of physical activity: The Framingham Study. Arch Intern Med 1979; 139:857-861. c- 15 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. Paffenberger RS, Hyde RT, Jung DL et al. Coronary Hear t Disease. Epidemiology of Exercise and Clinics In Sports Medicine 1984; 3:297-318. DeVries, HA. Physiological effects of an exercise training regimen upon men aged 52-88. J Gerontol 1970; 25:325-336. Badenhop DT, Cleary PA, Schaal P, et al. Physiological adjustments to higher-or lower-intensity exercise in elders. Med Sci Sports Exercise 1983; 15:496-502. Seals DR, Hagberg JM, Hurley BF, et al. Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. Jour Amer Med Assoc 1984; 252:645-649. Benested, AM. Trainability of old men. Acta Med Stand 1965; 178:321-327. Saltin B, Hartley LH, Kilbom A, et al. Physical training in sedentary middle-aged and older men. II. Oxygen uptake, heart rate, and blood lactate concentration at submaximal and maximal exercise. Stand J Clin Lab Invest 1969; 24:323-334. Suominen H, Heikkinen E, Liesen H, et al. Effects of 8 week's endurance training on skeletal muscle metabolism in 56-70 year old sedentary men. Eur J Appl Physiol 1977; 37:173-180. Holloszy JO. Exercise, health, and aging: a need for more information. Med Sci Sports Exer 1983; 15:1-5. Seals DR, Hagberg JM, Hurley BJ, et al. Endurance training in older men and women. I. Cardiovascular response to exercise. J Appl Physiol 1984; 57:1024-1029. Ehsani AA, Heath GW, Hagberg JM, et al. Effects of twelve months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease. Circul. 1981; 64:116-1124. Goldberg AP, Phair RD, Krauss R, et al. Dyslipoproteinemia in type II diabetes: Metabolic effects of exercise training. J Amer Co11 Nutr 1985; 4(3):308-309. Koivisto VA, Yki-Jarvinen, DeFronzo, RA. Physical Training and Insulin Sensitivity. Diabetes/Metabolism Reviews 1986; 1:445-482. Goldberg AP, Geltman EM, Hagberg JM, et al. The therapeutic benefits of exercise training for hemodialysis patients. Kidney Intl 1983; 24:S303- 309. Seals DR, Hurley BF, Schultz J, et al. Endurance training in older men and women II. Blood lactate response to submaximal exercise. J APP~ Physiol: 1984; 57:1030-1033. Yerg JE, Seals DR, Hagberg JM, et al. The effect of endurance exercise training on ventilatory function in older individuals. J Appl Physiol 1985; 58:791-794. Rdsenthal M, Haskell WL, Solomon R, et al. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes 1983; 32:408-412. Hollenbeck CB, Haskell W, Rosenthal M, et al. Effect of Habitual Physical Activity on Regulation of Insulin Stimulated Glucose Disposal in Older Males. 3 Amer Ger Sot 1985; 33:273-277. Wood PD, Haskell WL. The effect of exercise on plasma high density lipoproteins. Lipids 1979; 14:417-427. Wood PD, Haskell WL, Blair SN, et al. Increased exercise level and plasma lipprotein concentrations: A one year, randomized controlled study in sedentary, middle-aged men. Metabolism 1983; 32:31-39. Ehsani, AA. Cardiovascular adaptations to exercise training in the elderly. Fed Proc 1987; 46:1840-1843. Hagberg, JM. Effect of training on the decline of V02max with aging. Fed Proc 1987; 46:1830-1833. c -16 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. Gerstenblith G, Renlund DG, Lakatta EG. Cardiovascular response to exercise in younger and older men. Fed Proc 1987; 46:1834-1839. Fleg J, Gerstenblith G, Lakatta E, et al. Personal Communication. Busby J, Drinkwater D, Goldberg A, et al. Personal Communciation. Lakatta EG, Spurgeon HA. Effect of Exercise on cardiac muscle perfoi%dnce in aged rats. Fed Proc 1987; 46:1844-1849. Bray, GA. Definition, measurement, and classification of the syndromes of obesity. Int J Obesity 1978; 2:99-112. Van Itallie, TB. Health implications of overweight and obesity in the United States. Ann Intern Med 1985; 103:983-988. Hubert HB, Feinleib M, McNamara PM, et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circul. 1983; 67:968-977. Bray, GA. The Energetics of Obesity. Med Sci Sports 1983; 15:32-40. Gwinup, G. Effect of Exercise Alone on the Weight of Obese Women. Arch Int Med 1975; 135:676-680. Drinkwater D, Bleecker E, Meyers D, et al. Personal Communication. Hodgson JL, Buskirk ER. Physical fitness and age, with emphasis on cardiovascular function in the elderly. J Am Geriatr Sot 1877; 25:385- 392. Dehn MM, Bruce RA. Longitudinal variations in maximal oxygen intake with age and activity. J Appl Physiol 1972; 33:805-807. Kasch FW, Wallace JP. Physiological variables during 10 years of endurance exercise. Med Sci Sports 1976; 8~5-8. Ehsani AA, Heath GW, Martin WH III, et al. Effects of intense training on plasma catecholamines in coronary patients. J Appl Physiol 1984; 57:154- 159. Ehsani AA, Martin WH III, Heath GW, et al. Cardiac effects of prolonged and intense exercise training in patients with coronary artery disease. Am J Cardiol 1982; 50:246-253. Kannel, WB. Prevalence and natural history of electrocardiographic left ventricular hypertrophy. Amer Jour Med 1983; 25:4-11. Borkan GA, Hults DE, Gerzof AF, et al. Age changes in body composition revealed by computed tomography. J Gerontol 1983; 38:673-677. Tzankoff SP, Norris HA. Effect of muscle mass decrease on age-related BMR changes. J Appl Physiol 1977; 43:1001-1006. Allwood MJ. Blood flow in the foot and calf of the elderly; a comparison with that in young adults. Clin Sci 1958; 17:331-338. Permutt S, Martini HB. Stasis pressure-volume characteristics of lungs in not-ma1 males. J Appl Physiol 1960; 15:819-825. Shepherd RJ. Physical Activity and Aging. London: Crown Helm Ltd, 1978. Schocken DD, Blumenthal JA, Port S, et al. Physical conditioning and left ventricular performance in the elderly: Assessment by radionuclide angiocardiography. Am J Cardiol 1983;52:359-364. DeFronzo, RA. Glucose Into1 erance and Aging: Evidence for tissue insensitivity to insulin. Diabetes 1979; 28:1095-1101. Rowe JW, Minaker KL, Palotta JA, et al. Characterization of the insulin resistance of aging. 3 Clin Invest 1983; 71:1581-1587. Fink RI, Kolterman OG, Griffin J. et al. Mechanisms of insulin resistance in aging. J Clin Invest 1983; 71:1523-1534. Stout, RW. Insulin and Atheroma - An Update. Lancet 1987; 1:1077-1079. Chen M, Bergman RN, Pacini G, et al. Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased B-cell function. J Clin Endocrinol Metab 1985; 60:13-20. Rowe JW, Troen BR. Sympathetic nervous system and aging in man. Endocr c -17 76. 77. 78. 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. 95. 96. 97. Rev 1980; 1:167-179. Brunzell, JD. Pathophysiologic approach to hyperlipidemia In: Yearbook of Endocrinology 1984, (eds. Schwartz TB, Ryan WG), Yearbook Medical Publishers, Inca., Chicago 1984. pp. 11-30. Zimmerman J, Kaufman N, Fainaru M, et al. Effect of Weight loss in Moderate Obesity on Plasma Lipoprotein and Apolipoprotein levels and on High Density Lipoprotein Composition. Arteriosclerosis 1984; 4:115-123. Goldberg AP, Schonfeld G. Effects of diet on lipoprotein metabolism. Ann Rev Nutrition 1985; 5:195-212. Taskinen MR, Nikkila EA, Valimaki M, et al. Alcohol Induced changes in serum lipoproteins and in their metabolism. Amer Heart J 1987; 113:458- 463. Wallace RB, Hunninghake DB, Chambless LE, et al. A screening survey of dyslipoproteinemias associated with prescription drug use. The Lipid Reserch Clinics Program Prevalence Study. Circul. 1986; 73:70-79. Riggs BL, Melton LJ. Involutional Osteoporosis. New Eng J Med 1986; 314:1676-1696. Williams AR, Weiss NS, Ure CL, et al. Effect of weight, smoking and estrogen use on the risk of hip and forearm fractures in post menopausal women. Obstet Gynecol 1982; 60:695-699. Bilke DD, Genant HK, Cann C, et al. Bone Disease and Alcohol Abuse. Ann Int Med 1985; 103:42-48. Krolner B, Toft B, Nielsen SP, et al. Physical exercise as prophylaxis against involutional vertebral bone loss: A controlled trial. Clin Sci 1983; 64:541-546. Smith EL, Reddan W, Smith PE. Physical activity and calcium: modalities for bone mineral increase in -aged women. Med Sci Sports Exert 1981; 13:60-64. Aloia JF, Cohn SH, Babu T, et al. Skeletal mass and body composition in marathon runners. Metabolism 1978; 27:1793-1796. Aloia JF. Estrogen and exercise in prevention and treatment of osteoporosis. Geriatrics 1982; 37:81-85. Ettinger B, Genant HK, Cann CE. Postmenopausal bone loss is prevented by treatment with low dose estrogen with calcium. Ann Int Med 1987; 106:40- 45. Osteoporosis, Consensus Conference. JAMA 1984; X2:799-802. Block JE, Smith R, Black D, et al. Does exercise prevent osteoporosis? JAMA 1987; 257:3115-3117. Collins KJ, Dore C, Exton-Smith AN, et al. Accidental hypothemia and , impaired temperature homeostasis in the elderly. Brit Med J 1977; 1:353- 356. Drinkwater BL, Horvath SM. Heat tolerance and aging. Med Sci Sports 1979; 11:49-55. MacLennan WJ, MRP Hass, Timothy JI. Postural hypotension in old age: is it a disorder of the nervous system or of blood vessels? Age and Ageing 1980; 9:25-32. Montoye HJ, Willis PW, Cunningham DJ. Heart rate response to submaximal exercise: Relation to age and sex. J Gerontol 1968; 23:127-133. Roberts MF, Wenger CB, Stolwijk JAJ, et al. Skin blood flow and sweating changes following exercise training and heat acclimation. J Appl Physiol: 1977; 43:133-137. Brooks GA, Fahey TD. Exercise in the heat and the cold. In: Exercise Physiology: Human Bioenergetic and its applications. Macmillan Publishing Company, New York, 1985. pp. 443-469. Hartley LH, Saltin B. Reduction of stroke volume and increase in heart C -18 rate after a previous heavier submaximal work load. Stand 3 Clin Lab Invest 1968; 22~217-223. 98. Stegemann, Busert JA, Brock 0. Influence of fitness on the blood pressure control system in man. Aerosp Med 1974; 45:45-48. 99. Greenleaf JE, Bosco JS, Jr., Matter M. Orthostatic tolerance in dehydrated, heat-acclimated men following exercise in the heat. Aerosp Med 1974; 45:491-497. 100. Rowe J, Beck JC, et al. Report of the Institute of Medicine: Academic Geriatrics for the Year 2000. J Amer Ger Sot 1987; 35:773-791. c -19 Health Promotion and Aging "Injury Prevention" Richard W. Sattin, M.D. Chief, Unintentional Injuries Section Division of Injury Epidemiology and Control Center3 for Disease Control, Atlanta Michael C. Nevitt, Ph.D. Adjunct Assistant Professor of Medicine and Epidemiology University of California, San Francisco Patricia F. Wallet, Ph.D. Director, Injury Prevention Research Center University of North Carolina, Chapel Hill Richard H. Seiden, Ph.D., M.P.H. The Glendon Association Los Angeles, California THE FREQWENCY AND IMPACT OF' FALLING IN THE ELDERLY Falls (IO-9 codes E880-E888) are the leading cause of death from injury in per- sons over the age of 65. Approximately two-thirds of reported injury-related deaths of persons 85 years of age and older are due to falls (1). Of the 8200 fatal falls that occurred in the United States in 1985 for persons aged 65 years or older, 59% were those that occurred in the home. This large number of fatal falls listed on death certificates, however, may understate by one-half the num- ber of deaths in which falls are contributing causes (2). Approximately 250,000 hip fractures per year among persons ages 45 and over result from falls, with an annual medical cost exceeding $7 billion (3). There may also be six times as many fractures of other bones as there are hip frac- tures in persons over the age of 65 (4), most of which are attributable to falls (5) . The majority of falls in the elderly result in minor physical injury (6), with only a small percentage of falls causing severe injury, such as a fracture. Es- timates of the proportion of falls causing a fracture range from four to six percent in ambulatory populations, with one percent or less resulting in hip fractures (6,7). Slightly higher rates of hip fractures per fall have been reported among institutionalized populations (8,9,10). Most falls, however, go unreported and are not medically attended. Respondents to the 1984 U.S. Health Interview Survey (HIS) Supplement on Aging were asked about also cause a much younger person to take a spill (slippery surfaces or un- seen obstacles). However, the older person may be influenced by more subtle en- vironmental factors, such as lighting and visual and spatial design. The multifaceted, multifactorial nature of falls has prompted attempt3 to develop a typology of falls (22-25). These typologies focus on the circumstances of falls and provide information about the probable etiologic factors that guide inter- vention efforts (24). In addition, greater specificity about outcome3 would en- hance understanding of risk relationships by allowing researchers to link specific risk factor3 or biologic measurements to specific types of fall. Some examples of these typologies follow: . unexplained falls versus falls with a self-evident etiology (i.e. syncope, seizure, stroke) . falls due to host (intrinsic) factors versus falls due to environmental (ex- trinsic) factor3 o pattern or recurrent falls versus occasional or isolated falls D-2 falls occurring in the sick or older elderly (age 75 and over) versus $hose occurring in the healthy or younger elderly (ages 60-74). Unfortunately, work on classifying falls is still developmental and may be of limited value in understanding and preventing falls for the following reasons: a. It is sometimes difficult or impossible to obtain valid information about the circumstances of a fall. b. Syncopal falls may have an etiology similar to many "unexplained falls" which do not progress to full loss of consciousness but do involve the effects of decreased cerebral perfusion on muscle tone and balance (26,27). c. Most falls probably have a mixed etiology, involving both host and environ- ment as contributing factors. d. Trips and slips involving a definite hazard may also implicate 1) age-related changes in gait (28), and 2) decline in the speed and organization of dynamic postural responses to external displacement (29) I blurring the distinction between environmental and balance falls. e. What constitutes an environmental hazard depends on the individual's func- tional capacity. With functional decline, features of the environment which were once negotiated without difficulty can become major barriers. f. The same individual can fall for different reasons on different occasions. This makes it difficult to classify individuals as one type of faller or another. g. Persons at risk for falls because of abnormalities of gait or balance may SC restrict their activities that they fall infrequently over the near-term. Such "adaptations" to diminished capacities may be dysfunctional over the long-term, accelerating loss of function and leading to multiple falls. Prevention of falls must address a large number of risk factors. At present, we know very little about the interaction between risk factors which will be neces- sary in the development of effective prevention efforts. 3. PROBLEMS ARISING FROM THE UNCERTAIN SIGNIFICANCE OF ANY FALL Because the etiology of falling is complex, the significance of any individual fall is difficult to determine, both for health care professionals and for the person who falls. This may lead to inappropriate actions at several extremes, including: extensive medical work-ups which have little yield; dismissal of the fall as of no consequence; inappropriate reductions in mobility and activities, including use of physical and chemical restraints (30); or extreme fear of fall- ing again. In someJ persons, a fall or series of falls signals serious acute illness, precipitous functional decline and, possibly,.imminent death (7,31,32). For these reasons, any fall must be taken seriously by clinicians. However, most falls in the elderly do not carry this meaning. Falling is an ubiquitous experience throughout life, usually resulting in no or only very minor injury. Though the circumstances of falls appear, on average, to change with age (12,33), the most frequent fall in the elderly is a consequence of persons with diminished functional capacity attempting to meet the intrinsic and external demands of mo- bility within specific environments. For the relatively fit and functionally able, mobility entails constant exposure to and successful negotiation of a wide range of physical environments. Risk of fall is spread over many diverse situa- tions and environments. As function declines, success in mobility focuses in- creasingly on basic movements, such as transfer, short walks and quiet standing within a familiar environment. These basic movements then become the focus of exposure to fall risk. The behavioral response t0 falling and postural instability affects the trans- D-3 lation of physical decline into reduced mobility (34). A fall or a near fall provides information about activities and circumstances which place a particular person with a given set of capacities at risk as well as information about a mismatch between the external and intrinsic demands of mobility and individual competence (35). This information may motivate a reduction in mobility, in turn resulting in reduced exposure to the risk of falling by decreasing the range of environmental exposures and by decreasing the time at risk while walking, trans- ferring and standing. Indeed, persons who do not adjust their activities to declining capacities may be at especially high risk (12,36). Clearly, however, adjustments in activity and mobility in response to falls are neither universally appropriate nor sufficient to eliminate the risk of fall- ing. 1) Fear and excessive restrictions in activity may reduce exposure to the risk of falling in the short term, but only increase the long-term risk by un- dermining self-confidence and physical conditioning. 2) For the elderly whose functional capacity is severely compromised, maintenance of even a minimum of independent mobility may entail substantial risk- 3) Some risk of falling is probably unavoidable if mobility and independence are to be maintained in the presence of functional decline. The goals of prevention should be realistic and based on our best understanding of the problem. It is realistic to aim for modest reductions in the frequency of falls and perhaps to prevent a recurrence of falling in some individuals. It is not realistic, given our current understanding, to eliminate falls as a fea- ture of aging. Even if every fall does have a set of causes, there will remain a random element in many falls beyond our ability tomodel, predict or anticipate. Equally important, prevention efforts must strike a balance between protection from risk and the maintenance of mobility, function, personal autonomy and an acceptable quality of life. To optimize the latter, it may be necessary to ac- cept a certain level of risk. Prevention should focus on modifying risk factors that reduce that level of risk as much as possible while impinging on inde- pendence and autonomy as little as possible. Prevention efforts would benefit from an increased understanding of behavioral and psychological responses to the onset of instability and falls. The nature of this response may have important implications for the individual's short-term and long-term risk. Fear and excessive activity restrictions may only increase risk in the long run. On the other hand, failure to make some behavioral accom- modation to aging and disease may also increase risk in the near term. Adapta- tions to diminished function, while perhaps inevitable, should be appropriate to the threat and emphasize and strengthen residual capacities. In addition, re- search is needed on what constitutes "risk-taking behavior" in the context of speci$ic functional disabilities. Finally, preventing the adverse consequences of falls, including injury, fear and the "long lie," may be as important a goal as preventing falls. Severe in- jury may precipitate maladaptive behavioral responses as well as lead directly to physical deconditioning and further falls. REVIEW OF HOST AND BEHAVIORAL FACTORS The following risk factors are limited to controlled studies in which comparisons were made between "failers" and "nonfallers." Specific study designs vary con- siderably. Nearly all of the associations between risk factors and falls reported here are univariate and do not control for confounding. 1. GENERAL RISK FACTORS Age and Sex. These variables may contribute to identifying persons at risk, but tell us little about actual causes of falls or where to intervene to reduce risk. D-4 There is substantial variation in risk within age groups. Biologic and function- al variability within age groups may be more important determinants of fall risk than age-dependent variations. History Of Previous Falls and Dizziness. It is not known how the risk of injury is related to the frequency of falling. The ratio of injuries prevented per fall prevented may vary considerably between frequent and infrequent failers. For ex- ample, those who fall frequently may do so in a way that has a low risk of in- jury or learn to protect themselves from injury. Research is needed on how the mechanics of falling affect the risk of injury (5). Certain interventions may be less effective after a person has fallen. For example, extreme fear Of fall- ing may reduce acceptance of exercise programs to improve neuromuscular func- tion. Health Status, Mobility Limitation and Functional Disability. General health variables appear valuable in identifying elderly at increased risk of falling because their association may reflect a common origin in underlying diseases and conditions. However, mobility limitations and functional disability may also have a direct bearing on prevention to the extent that they indicate a mismatch between the external and intrinsic demands of mobility and personal competence increasing the risk associated with routine activities (35). Residual capacities may be enhanced by environmental modifications that reduce the demands placed on the individual. However, it is not known whether environmental and behavioral interventions that improve function also reduce fall risk. Moreover, the relationship between mobility and fall risk is complex and not well understood. Mental Status, Psychological Status, and Psychosocial Factors. Cognitive, psychosocial and psychological risk factors for falls in the elderly are not well understood, but are being evaluated in ongoing prospective studies. Neurological disorders affecting cognitive function are often clinically as- sociated with neuromuscular deficits and falls in the elderly, but it is not known if the association is causal (18,37-39). The causal relationships are potentially complex (40). Confusion, impaired judgement, distraction, agitation, depression and lack of awareness may increase exposure to hazardous situations. Associated gait and balance deficits and psychomotor depression may increase the chance that a fall will result. Depression, in turn, may result from falls, in- jury or physical illness. Antidepressant and sedative medication may increase the risk of falls (41,42). The behavioral aspects of depression that affect fall risk are not well understood. There are no studies of the effect of cognitive or psychological factors on the coping strategies and adaptations of elderly in response to falls and instability. Physic&Activity. Longitudinal studies of physical activity and falls are needed since reduced activity levels may result from previous falls, fear of falling or gait and balance problems. Moreover, increased physical activity could in- crease exposure to environmental hazards. lbrironwmtal Hazards. Environmental hazards include such factors as stairway design and disrepair, inadequate lighting, slippery floors, unsecured mats and rugs, and lack of non-slip surfaces in bathtubs, among others. These factors have been implicated in about one-third to one-half of all falls or falls in- juries in the home (43-45). Most studies that deal with home environmental hazards are difficult to interpret, however, because of differences in case selection criteria, information collected, and presentation of data. Definitions, espe- cially those of environmental hazards, were not provided, making valid com- parisons difficult. Only two investigators who studied the environment used a referrent group of nonfallers for comparison: one of case-control and one of cohort design (31,45). However, these investigators described the environment only for cases and not D-5 for the referrant group, and the environment was not assessed visually. In- stead,persons were interviewed to determine what-the respondents felt were the causes of their falls. Few studies actually defined the environment or an en- vironmental hazard, and none provided a uniform approach to assessing the en- vironment. Despite indication3 that several potential risk factor3 might be interrelated, only one study explored the possibility of such interaction3 in a limited way (45). More analytic studies need to focus on where falls occur in the home and on the prevalence of various home hazards. The risk attributable to each of these home hazards, especially in relation to a person's time at risk to these exposures, is criticalto the design of prevention strategies. Moreover, the definitions of a room, dwelling unit, and home hazard need to be clearly stated, reproducible and valid. The use of analytic techniques that determine risk factor3 for diseases, such as the determination of the interaction of host factor3 and the environment,will be key to the etiology of falls and fall in- juries. Intervention strategies would then be based on sound epidemiologic prin- ciples hnd would take into account acute and chronic health problem3 as well as contributing environmental factors. 2. COMMON INTERMEDIATE PATHWAYS: NEUROMUSCULAR FUNCTION Gait and Balance. Clinical and laboratory assessment of gait and balance is in- creasingly sophisticated and show3 significant promise as a method of assessing fall risk. Important research issue3 remain, however, including 1) identifica- tion of the modifiable causes of gait and balance abnormalities, 2) the relation- ship of clinical assessments of balance and gait to laboratory measurement of the biological mechanism3 of balance and gait, 3) the utility of computerized gait analysis for fall risk assessment and research, 4) the utility of gait and balance measures a3 intermediate outcome measures for risk factor modification studies, and 5) the relationship of falling to the determinant3 of total motor reaction time (46) - In addition, the relationship between balance and gait is not well understood. For example, slowed walking speed may be caused by balance problems, fear of falling, or both, or it may be due to pathology not directly related to balance (47). The effect of musculoskeletal condition3 on gait and balance performance is not well understood. The ability to influence corrective and protective response through training and learning should be investigated (46). Finally, an understanding of how specific gait and balance problems transform environmental features into "fall hazards" would help focus environmental intervention ef- forts. FACTORS AFFECTING NEUROMUSCULAR FUNCTION AND OTHER SPECIFIC RISK FACTORS Muscle Strength. The effect of improvements inmuscle strength on gait or balance, or on 106.Seiden RB. Mellowing with Age: Factors Influencing the Nonwhite Suicide Rate. Int J Aging Human Develop 1981;13(4): 265-284. 107.Messer U. Race Differences in Selected Attitudinal Dimensions of the Elderly. Gerontologist 1968;8(4):245-449. 108.Robina L, West P, Murphy G. The High Rate of Suicide in Older White Men. Sot Psych 1977;12:1- 20. lOP.Wylie FM. Attitudes Toward Aging and the Aged Among Black Americans: Some Historical Perspec- tives. Aging and Human Development 1971;2:66-70. llO.Allen N. Homicides in the Elderly. Unpublished research report, U.C.L.A. Neuropsychiatric In- stitute, 1985. lll.Pedrick-Cornell c, Gellee RJ. Elder Abuse: The State of Current Knowledge. Family Relations 1982;31:457-465. 112.Powell S, Berg RC. When the Elderly Are Abused: Characteristics and Intervention. Ed Gerontol 1987;13:71-83. 113.Wolfgang ME, Ferracuti F. Subculture of Violence--A Psychological Theory. In: Wolfgang ME (ed). Studies in Homicide. New York: Harper and Row, 1967, pp. 271-280. 114.Kastenbaum R, Aisenberq R. The Psychology of Death. New York: Springer, 1972. D-20 Health Promotion and Aging "MEDICATIONS AND GERIATRICS" Charles C. Puliiam, MS. Pharm. Associate Director, U.N.C. Center for Health Promotion and Disease Prevention, and Assistant Professor of Pharmacy, School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Joseph T. Haalon, M.S. Pharm. Coordinator of Pharmacogeriatrics, Division of Geriatrics and the Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina. SR PHARM Steven R. Moore Division of Drug Advertising and Labeling, Food and Drug Administration, Rockville, Maryland. I. Introduction and General Overview Health promotion and disease prevention in the elderly is both appealing and worthy of our attention. While old age is not preventable, much of the disease and disability which is common in late life is preventable.' The rational use of medications, at both the policy and clinical level, has an important, place in achieving this end, providing an important component in a health promotion strategy for healthy aging. Rowe and Kahn have cautioned against a "gerontology of the usual."' The focus on typical aging as "normal" ignores the enormous heterogeneity in this population. This may mislead scientists and policy makers to view what is "usual" as a reasonable health objective for older Americans. II. Basic Demographics and Population Data In 1987, about 12% of the U.S. population is 65-years or older. By 1990, the 65 and older group will reach 12.7% of the population; by 2000 the percentage rises to 13.1; and by 2020, to 17.3%. By the year 2020, the 65 and over population will have increased by 102%, compared to the 31% growth for the entire U.S. population for the same 40 year period.s Changes will also be taking place within the elderly population itself. Not onIy wiIl there be more citizens over 65 years of age, both in absolute number and percentage, but individuals within this age group will be living longer and, on the average, may tend to be more frail, and possibly in greater need of medical care. The older age groups, especially those over 75, will increase most dramatically. The current number of persons over 85 (2.7 million) will double by the end of the century. Conservative estimates to the year 2050 indicate that at least 50% of Americans will survive to their 85th birthday, with the 85 years and older population constituting at least 15 million people.' , III. Health Characteristics Three general health characteristics of older U.S. residents are reievant to medications and geriatrics. First, the pattern of health service utilization influences the opportunities for receiving a prescription; second, the epidemiology of disease (especially chronic disease) influences the duration of treatment; and third, drug activity in the aging body influences therapeutic-safety and efficacy. A. Utilization of Health Services. Prescription drugs are prescribed for the elderly primarily as outpatients making physician office visits, as inpatients in long-term care facilities, and as hospitalized patients, as well as upon discharge from health care institutions. Persons 65 and older account for 20.5% of physician office visits in 1985.5 And while most elderly are not in nursing homes, they did occupy 88% of the available nursing home beds in 1985.6 And in 1986 persons 65 and older accounted for more than 40%. of the hospitalizations in this country, staying an average 8.5 days compared to 6.8 days for 45-64 years of age.' "In the near future, the majority of all users of health and health related services with the exception of obstetrics and pediatrics will be persons over 65."s E-l B. The Epidemiology of Disease. As briefly discussed above, the elderly in America are more likely to use health services than are younger age groups.8 This is explained in part by the fact that in spite of fewer acute illnesses, their recovery time is often longer; the fact that they are nearly twice as likely to suffer from a chronic illness; and the possibility that they may overuse services relative to true need.`?`* In view of this reality the health care system's response requires strategies that are often quite different than those for younger persons because of the following: the prevalence of chronic disease. Eighty percent of persons 65 years and older have one or more chronic diseases. Certain of these diseases are largely age dependent, such as coronary artery disease and dementia of the Alzheimer's type; other diseases, such as most cancers, are considered age related." multiple pathology. The existence of several simultaneously active conditions is much more prevalent in the aged than in those younger. ?zonspecific presentatiorr of disease. Several diseases which occur at all ages have a different natural history in the elderly. Almost any of the classic signs or symptoms of disease are present in the elderly in uncharacteristic ways. Instead of usually anticipated presentations, diseases often give rise to nonspecific problems which may be incorrectly identified as due to aging rather than due to disease. These nonspecific problems include falling, dizziness, acute confusion, new incontinence, weight loss, failure to thrive, etc. silent presmtatiorl of disease. Especially likely to be obscured in the elderly are pulmonary embolism, pneumonia, cancer, acute surgical abdomen, thyrotoxicosis, depression, drug intoxication, myxedema, myocardial infarction, alcoholism.`2J'3 C. Pharmacokinetics and Pharmacodynamics of Drugs. Drug disposition in the body of an elderly patient may be quite different than in a similar patient forty years younger. Although these changes may not necessarily occur, when present they are largely the result of age related changes in body composition, renal and hepatic function, and concurrent disease states. In addition, an older patient may not respond to a given drug concentration in the same manner as a younger individual.`4y'5 Age related physiologic changes in older patients dictate that while the standard guidelines for applying pharmacokinetic principles often apply, they must be approached with caution because some of the usual assumptions may not be valid. In particular, the clinician must more carefuhy consider possible changes in body composition and vital organ function. ABSORPTlON / A number of aging-related physiologic changes occur in the gastrointestinal tract (GI) which increase the possibility of altered drug absorption. With advancing age intestinal blood flow may decrease; muscle tone and motor activity in the GI tract may decline; and mucosal cells may have atrophied, reducing both gastric secretory and absorptive function. The elderly demonstrate prolonged and widely variable gastric emptying times when compared to younger groups.r6 In addition, thf, pH of GI fluid is increased in the elderly, a change that may effect the absorption of calcium. In spite of these demonstrated and theoretical GI changes, altered absorption does not appear to be a clinically important factor in dosage calculations for older patients.r8 DISTRIBUTION / Body composition undergoes noteworthy changes over a lifetime of 70+ years. Body fat increases, muscle mass decreases, and total body water decreases. By age 70 greater than 30 percent of body weight in a given individual may be fat. On the other hand, muscle mass contributes a smaller proportion of body weight, declining by an estimated 25 to 30 percent by age 70. Total body water decreases in the elderly from 13 to 18 percent.`g'20 These changes can have a clinically significant impact on the distribution of both water soluble and lipid soluble drugs. As a rule, with substantially increased age, water soluble drugs will have decreased distribution, while lipid soluble medication will have increased distribution. The plasma protein binding of drugs in the elderly may be altered.21 The two major plasma proteins are albumin and alpha- l-acid glycoprotein. Older patients often have a lower than normal serum albumin level, usually the result of decreased albumin production. Also, an E-Z increased level of alpha- l-acid glycoprotein has been associated with advanced age.2' The potential significance of these changes are either an increased free fraction of drugs bound to ..Jbu&l (e.g. warfarin, phenytoin) or decreased free fraction of drugs bound to aipha-l-acid glycoprotein (e.g. lidocaine, propranolol). These alterations in binding may lead to the erroneous clinical judgments based on misinterpretation of serum blood levels. METABOLISM / Phase I oxidative metabolism can be impaired in the elderIy patient due to decreased microsomal enzyme activity. Also, the metabolism of dru s extraction ratios can be impaired due to a decrease in hepatic blood flow. 2f with high hepatic This is particularly important when prescribing certain drugs such as diazepam, quinidine, theophylline, propranolol, and imipramine. Easily estimating the extent of impaired metabolic function is not currently possible; consequently, dosage adjustments necessitated by metabolic impairment are, at best, estimates based on investigational and clinical experience. Hepatk Phase I1 metabolism via conjugation is not meaningfully altered with advancing age. Consequently age related changes in clearance of drugs metabolized by glucuronidation clearance have not been reported. For example, oxazepam, lorazepam, and temazepam doses need not be reduced in older patients on the basis of hepatic function alone. ELIMINATION / Glomerular filtration rate (GFR) declines steadily with increasing age. Because of the typical decline of muscle mass with advancing age, production of creatinine also declines. This produces serum creatinine levels usually considered normal for younger persons, but unreliable as an indicator of renal function in the older person. Thus, a calculated creatinine clearance is recommended when considering the proper dose of such drugs as digoxin, cimetidine, many antibiotics, and active metabolites such as N-acetylprocainamide and normeperidine. 23,24 PHARMACODYNAMICS / The term pharmacodynamics usually refers to the magnitude of pharmacological effect that results from the interaction of drugs with receptors at the site of action. There is little information about the pharmacodynamics of drugs in the elderly, but an increased "sensitivity' to a number of drugs has been reported.20126 Perhaps the most widely reported is the enhanced pharmacological effect of narcotic analgesics in the elderly.2612' In a study by Kaiko it ws found that elderly cancer patients, who received intramuscular morphine post-operatively, had significantly greater total pain relief and duration of pain relief than their younger counterparts. No information regarding adverse effects was reported.28 This study confirmed similar findings reported in an earlier study by Bellville, et al.2g Demonstrating decreased pharmacodynamic sensitivity, Vestal et al. have reported a reduction in response to both beta adrenergic agonist and antagonist drugs in the elderly." From these and similar reports there is some evidence that age-related pharmacodynamic changes can occur. For the most part whether these alterations are due to diminished homeostatic mechanisms, chronic disease, or changes at the receptor or post-receptor remains to be determined.20p26 IV. Areas of Particular Interest Medications are &ually beneficial, sometimes of no value, and on rare occasion detrimental in their contribution to the health of the elderly. Numerous areas are of particular interest with regard to drugs for older patients. The few areas discussed in this background paper are the extent and pattern of drug use among older patients; the health promoting benefits the elderly derive from medications; their susceptibility to untoward effects of drugs; the potential for new technologies to benefit the elderly; successful interventions and programs; and selected deficiencies- in current programs and services. A. The Extent of Drug Use. The elderly take prescription and non-prescription drugs to a greater extent than younger persons. This appears to be so because their greater use of health services makes them. more likely to receive prescriptions or make self-medication decisions. PRESCRIPTION DRUG USE / As previously mentioned, the elderly make up 12% of the U.S. population. It is estimated however that this group accounts for approximately 30% of all drugs prescribed in the U.S.5831 In 1982 all consumers spent $14.5 billion for prescriptions dispensed by community pharmacies." The elderly's precise proportion of that cost is not known, but if it was 30% that would be $4.35 billion. An FDA study found that those over 75 years of age E-3 received the most prescriptions in 1982, averaging almost 17 annually. The "young-old," those 65 to 74, received only 13.6 that year. These numbers are much larger than the averages of those in the 55 to 64 age group (9.3 prescriptions) and the 45 to 54 age group (6.9 prescriptions)." The 1985 National Ambulatory Medical Care Survey of office based physicians found that elderly women accounted for 12.5 percent of all visits and 17.7 percent of visits in which drugs were prescribed; elderly men accounted for 8.0 percent of visits and nearly 11 percent of visits involving drug prescription. " Overall at least one drug was prescribed or provided in over 68 percent of office visits by those 65 years of age and older. OTC DRUG USE /`Self medication as part of self-care seems to be one of the most important and frequent health maintenance actions taken by the elderly. A recent study of rural elderly found 65% of those surveyed to have used over the counter (OTC) medications in the previous two weeks, with women taking more than men." This was consistent with findings from an earlier study of an elderly population in which 64% had taken OTC medications; again, women used more than men-" Respondents in this study reported consuming in a one day period an average of 1.74 prescription drugs and 1.13 over-the-counter drugs." B. Patterns of Drug Use. Drug use patterns in the elderly vary according to the populations in which data is collected. The best defined data comes from ambulatory elderly populations. Two ongoing programs, the Dunedin Program in Florida and the N.I.A.`s Established Populations for Epidemiologic Studies of the Elderly (EPESE), provide the most extensive and detailed information about both prescribed and OTC medications in a controlled study population or cohort. The Dunedin Program which has screened approximately 3,000 elderly each year since 1978 for undetected medical disorders, has also collected patient-recorded information about prescribed and OTC medication. Over a five-year period 93% of patients in that population took some medication, with a mean of 3.7 medications at the time of interview. The study also found women to be consuming more than men, and drug use increasing with advancing age.36 The most common therapeutic indications for all drugs were antihypertensives, non-narcotic analgesics, antirheumatics, various vitamins and cathartics. Striking changes over the five year period include an increase in mean drug use (from 3.2 medications) and a considerable increase in nutritional supplement use." The EPESE project, a community-based surveillance program funded by the National Institute of Aging, is being conducted at four research sites; New Haven (Yale University), East Boston (Harvard University), rural Iowa (University of Iowa), and the Piedmont area of North Carolina (Duke University). Extensive information regarding both prescription and OTC medication use is being collected as part of these in-home surveys of between 3,000 to 4,500 community elderly. The first published report of medication use in an EPESE population was from Iowa where 88% of patients took some medication, with the mean bej;g 2.87 drugs. In this population medication use increased with age and was greater in women. The most common therapeutic indications for drugs were .cardiovascular, analgesics, products a&l CNS agents. vitamins and nutritional supplements, gastrointestinal Analgesics, vitamins, and GI agents (e.g., laxatives) were the most frequently taken over-the-counter therapeutic categories in Iowa among rural elderly.34 In fact, products classified as "analgesics and antipyretics" constituted over 39% of the reported OTC drug use; and three most frequently mentioned categories accounted for more than 94.1% of this use. While the Dunedin and Iowa populations and methods are not comparable, the most distinguishing difference is the apparently greater use of drugs seen in the Florida population. Additional -information about commonly prescribed medications for ambulatory elderly comes from a variety of sources. The most recent information (1986) is from two electronic data bases: IMS America Ltd. (Ambler, PA), and Pharmaceutical Data Services [PDS] (Scottsdale, AZ).37V98 The top five therapeutic classes prescribed for the elderly according to the IMS data were digitalis preparations, diuretics, beta-blockers, nitrates, and antiarthritics. The PDS data, reflecting prescription drugs dispensed, showed the top five drugs for the elderly to be hydrochlorothiazide and triamterene, digoxin, potassium chloride, nitroglycerin, and furosemide. Drug use patterns from institutional settings are less well defined. A 1976 survey of long-term care facilities found that most patients received between 4 and 7 medications with the mean being 6.1 drugs." The most common therapeutic indications were cathartics, analgesics, E-4 tranquilizers, sedative/hypnotics, and vitamins. According to PDS, the top five drug products dispensed to elderly nursing home resignts in 1986 were digoxin, furosemide, potassium chloride, dipyridamole, and nitroglycerin. This pattern reasonably reflected the frequency of use these products had among non-institutionalized elderly that year. In alarming contrast, the sixth and seventh ranking drugs among elderly nursing home residents were haloperjdol and thioridazine HC 1; among non-institutionalized elderly these same agents ranked 99th and 90th respectively." This report also revealed that during the first quarter of 1986, 59.2% of the elderly in the nursing homes received 4 or more prescriptions, compared to 35% of the non- jnstitutionaljzed elderly. Drug usage in hospitalized elderly is available from a variety of sources. A drug use surveillance project on a geriatric specialty unit found 500 of 521 patients to be given medications. Patients observed during the study period were given an average of 6.1 medications. In order, the most frequently used drugs were diuretics, antibiotics, bronchodilators, and analgesics."' Another study of 56 hospitalized elderly patients reported the mean drug use to be 4.1 medications prescribed for chronic use with the most common therapeutic indications being cathartics, analgesics, vitamins, diuretics, and cardiac drugs." c. Health Promotion Benefits of Drug Therapy. Health promotion strategies, particularly in older populations, must clearly rely on both social-behavioral and medjcal strategies. Many maladies of old age can be traced to health risk behaviors of young adulthood, and as a result .prevention is often viewed as having little value as a health strategy after 65 years of age. Kannel and Gordon have suggested "that because of the relatively high incidence of mortality in the elderly the absolute impact of preventive measures short-term may actually be greater in the elderly than the younger despite a lesser reIative impact."42 Since that suggestion, made in 1977, the preventive value of treating diastolic-systolic hypertension in the elderly has been demonstrated. The V.A. cooperative study demonstrated a 54 percent reduction in fatal and nonfatal cardiovascular events in the 60 years and over age group.43 The Hypertension Detection and Follow-up Program found that older patients receiving drug therapy according to structured guidelines (otherwise termed "stepped-care") had lower incidence of stroke and lower mortality than age matched controIs referred to their usual "regular care" for management." And, results from the European Working Party on High Blood Pressure in the Elderly Trial have shown dramatic reductions in morbidity and mortality among drug treatment subjects over a seven year period.46 Of course the importance of attentive monitoring during treatment cannot be over emphasized; anti-hypertensive medications are among the most widely implicated contributors to adverse drug reactions in the elderly [reviewed later in this wwl. The efficacy of influenza vaccine was evaluated in nursing homes of Genesee County, Michigan, during the winter of 1982-83. Investigators found the use of influenza vaccine to reduce both incidence and severity of infIuenza virus infections among the elderly." A positive cost- effectiveness analysis of influenza vaccination programs for the elderly was reported comparing medical costs and health effects between vaccinated and unvaccinated elderly from 1971- 1972 through 1977- 1978." Despite belief in the preventive value of the vaccine, medical compliance with recommendations for its use has been poor; institutional policy appears to be the best means for accomplishing wide spread immunjzation.48 Disability and immobility are associated with fractures in older persons; and fractures are associated tiith low bone mass." The N.I.H. estimates that about 1.3 million fractures a year can be attributed to osteoporosis in people aged 45 years and older." As one of the most prevalent afflictions of advancing age, osteoporosis-related vertebral fractures burden one-third of women by age 65. By age 81 hip fractures, usually associated with osteoporosis, will have stricken one- third of the women." An effective means of preventing the loss of bone mass in postmenopausal women is re ular use of estrogen therapy, particularly when combined with calcium supplements. 5 52, 3,64 The FDA recently acknowledged this preventive indication to be an effective use of estrogens when taken for 21 or every 28 days and combined with calcium supplements and exercise. E-5 A variety of useful but less well documented preventive and protective actions of drugs have been reported. For example, a case-control study of 300 cataract a protective effect from long-term use of aspirin-like analgesics. 2 atients and 609 controls found Such findings clearly require methodologic scrutiny and additional investigation. But they also ought to encourage the continuing search for agents with potential for preventive/protective impact on common disabling conditions of advanced years. D. Health Risks and Problems Associated With Medications. The major areas of concern with regard to health risks and problems associated with geriatric drug therapy can be organized as &o-medical, behavioral, economic, and health policy/health services. Conversely, these areas also represent important targets for drug oriented health promotion interventions. In general, issues reviewed independently in this background paper (e.g. adverse drug reactions, compliance, costs, access, a6d attitudes) are very much interdependent, and an integrated approach to solutions is recommended. DRUG RELATED BIO-MEDICAL ISSUES / Aging is associated with a variety of physical changes and health problems. Adverse drug reactions also present in a wide variety of symptoms throughout the body. A major challenge for the clinician is to distinguish between symptoms of aging and those associated with drug therapy. Mental disturbances, fatigue, depression, and syncope ate examples of complaints that are associated with commonly encountered conditions as well as frequently prescribed medications.66 1. THE EPIDEMIOLOGY OF ADRs. Just as drug use patterns vary with populations, incidence and prevalence data for adverse drug reactions (ADRs) is quite dependent on data collection methods and settings in which studies have been conducted. Multicenter collaborative drug surveillance programs, voluntary repotting to FDA, cohort surveillance, the control phase of intervention demonstrations, institutional or population specific prevalence surveys, and computerized record linkage of secondary data sets have provided the most enlightening perspective on ADRs in the elderly thus far. The Boston Collaborative Drug Surveillance Program (BCDSP) formalized and standardized clinical data collection on medication use and effects in a consortium of hospitals. Routine screening procedures have been used by BCDSP to correlate patient factors and drug response. From this effort dozens of adverse effects associated with drug therapy have been identified. advanced age has been an important variable in several instances (e.g. heparin in older women sf and high dose flurazepam in older patients'*). The FDA has been collecting reports of suspected and known adverse drug reactions (ADR's) since 1968. The data has limitations because of the spontaneous and voluntary nature of the reporting system. Nevertheless, the value of summary information from this data set to alert researchers and clinicians to drugs worthy of more careful attention should not be overlooked. Recently FDA data from the 15 year period 1968-82 was tabulated to identify medications which may cause,the older patient untoward effects." From this analysis the five generic drug classes with the highest reported adverse drug reactions were identified. These were, in order, antiparkinsonian drugs, antibiotics, antiarthritics, antiarrhythmics and diuretics. The most recent data from FDA spontaneous reporting indicates an overall rate of 8.5 ADR reports per 100,000 population; the rate among those 65 and older is nearly double that.60 Drug induced admissions to hospital were examined along with other iatrogenic causes of hospitalization at a 769-bed urban teaching hospitaL6' In that institution 4.2% of admissions during two -summer months were attributed to medication; half of which were considered by the investigators to be potentially avoidable. Medications accounted for 77% of all iatrogenic admissions. The average age among all iatrogenic admissions was 55 years. Another report of 293 admissions to a family medicine inpatient service found 15.4% to be drug-related with almost one-half occurring in patients 60 years of age or oldet.62 The occurrence of ADRs during hospital stays provides another perspective. During March and April of 1981 records for all admissions to Denve?s VA Medical Center were reviewed.63 In this study the occurrence of hospital associated iatrogenic complications for veterans aged 65 and older was compared with younger patients. The younger group had no complications caused by E-6 drug reactions while 17.7 percent of the older group experienced an ADR. This rate is consistent with those reported in other studies.64'66 The differences between hospitals are perhaps due to the use of different criteria for determining a drug reaction. Growing awareness of aging has stimulated an increasing number of investigators to use large computerized data sets to focus on drugs for their possible etiologic part in common problems of old age. Two examples for illustrative purposes are included. (1) An association between psychotropic drug use and hip fractures has been identified using computerized Medicaid files; dementia as a confounding variable did not appear to influence the tesults.66 (2) A slightly increased risk of hospitalization because of gastrointestinal bleeding has been noted among elderly Cooperative of Puget Sound.67 users of nonsteroidal anti-inflammatory drugs compared to nonusers at the Group Health 2. FACTORS CONTRIBUTING TO ADI&. It's estimated that at least 60 percent of adverse drug reactions are an extension of normal pharmacologic action.68*6g Because most adverse effects are pharmacologic and usually well-known minor reactions, many should be preventable with more careful prescribing, monitoring, and patient education. Elderly patients are at a higher risk of developing drug reactions than the general population. Several factors are known to predispose older persons to this excess risk. The first, and perhaps strongest factor is multiple drug use. Perhaps the first approach to preventing adverse drug reactions is to limit the number of drugs. This would not on1 reduce the chances of side effects & occurring, but also reduce the possibility of drug interactions. Polypharmacy . . . The incidence of polypharmacy or multiple medication use in the elderly is substantial.34'36 One of the major associated problems is adverse drug reactions.70 Williamson and Chopin found an increasing prevalence of ADRs as the number of prescribed drugs increased, occurring in 10.8% of those taking one drug and 27.0% of those taking six.71 Another study of ambulatory elderly with dementia also found an increased incidence at ADR's with an increased number of medications.72 A number of factors contribute to the problem of polypharmacy.73 Patients who use multiple physicians and pharmacies run the risk of receiving drugs that are therapeutic duplicates 2nd drugs that interact since the health care professionals they see may not be completely informed about other prescriptions. In addition, there is a greater risk of medication errors and/or noncompliance due to polyphatmacy.74 Pharmacokinetic and Pharmacodynamic Changes . . . As previously mentioned, there are a number of possibly age-related physiological changes that may effect the pharmacokinetics of drugs in the elderly. There is a possibility of adverse drug reactions occurring when total body clearance of drugs is reduced either due to decreased hepatic metabolism or renal excretion. This risk is increased because the higher resulting plasma concentration should correlate with higher concentrations at the receptor site with an accompanying chance of enhanced pharmacological effects. In addition, regardless of pharmacokinetic changes, the elderly may experience enhanced pharmacodynamic response to drugs. Often, however, it is difficult to determine which mechanisms, if not both, sjmuJtaneousJy contribute to adverse drug reactions. For example, a study from the Boston Collaborative Group has shown that at high doses of flurazepa$ (= or > 30mg) 39% of patients 70 years of age or older, experienced adverse drug reactions. This compared to an incidence of 2% in the same group taking 15mg/day of flurazepam. A later study of flurazepam kinetics found a prolongation of its half-iife in elderly men.75 However, there are several studies of similar benzodiazepines in which the elderly had greater central nervous system sensitivity than younger subjects despite having the same drug plasma concentrations.76y77 Drug Interactions . . . Traditionally, the term drug interaction (DI) has been defined as the effect -- either favorable or unfavorable -- that the administration of one drug has on another drug. Only a few studies examining DI's in the elderly have been reported. In a study of 573 ~;;;it;fg~c;~~;~Jyi . 2 16% of prescriptions written during their hospitalization produced potential The investigators classified 78.2% of those interactions as avoidable or probably avoidable. Drug interactions in a 1975 nursing home survey of 562 patients were found in 5.8% of medication orders.7g Another study of 132 nursing homes and 11,173 patients found E-7 that 2.7% of patients had clinically significant drug interactions occurring." The occurrence of drug interactions among 1,094 ambulatory elderly was found to be much greater than that in the institutional populations ( 15%).8' It is not clear what proportion of potential drug-drug interactions are actually of clinical significance. For example, in one study 80% of the patients only required close patient monitoring as opposed to dosage reduction or drug discontinuance.80 Still, the elderly are at an apparently increased risk for drug interactions as a consequence of the prevalence of polypharmacy. Also, in individual elderly patients who have altered homeostatic mechanisms and limited functional reserves, drug interactions may cause significant morbidity. There are two major types of drug-drug interactions: pharmacokinetic and pharmacodynamic. Pharmacokinetic drug interactions occur when one drug alters the absorption, distribution, metabolism, or elimination of another drug. Interactions with the greatest potential for adverse drug reactions are those involving a decrease in the total body clearance of drugs with a narrow therapeutic index. For example, cimetidine has been shown to decrease the clearance of antipyrine, a marker of oxidative liver metabolism.82 Pharmacodynamic drug interactions occur when one drug either enhances or diminishes the pharmacological effect of the other drug. This usually involves an interaction at the site of action or the receptor level. Of particular importance in the elderly is the cumulative effect of drugs with different desired pharmacological effects but similar side effects. For example, alcohol is reported to significantly contribute to sedation experienced by patients taking dru s with central nervous system depression side effects such as antihypertensives of psychotropics. 8f Drug interactions in an even broader context include their adverse interactions with disease processes, foods, or laboratory tests. Drug-disease interactions, although less common than dru - drug interactions, have a greater potential to produce clinically meanirrrful adverse effects.78* ' 5 Information about drug-food (drug-nutrient) interactions is increasing. It is well known that some foods can alter the pharmacokinetics of drugs, but drugs can alter appetite and/or cause vitamin deficiencies as well.84 An area of current research interest is the effect of nutritional deficiencies on hepatic function and drug metabolism.e5 Drug-lab interactions (drug induced alterations of laboratory values) require careful evaluation and interpretation. They may indicate drug-induced illness or statistically significant, but clinically insignificant changes in laboratory test values. With growing interest in self-care and the in-vitro home diagnostic market, it will be imperative that patients and health care professionals understand that drugs may interfere with test results.86 3. BIO-EQUIVALENCE AND GENERICS. Generic prescription products provide a potential cost savings for the elderly. However, this potential has not been fully realized. The older consumer has shown reluctance to request generics in spite of potential savings. Reasons include perceived safety, efficacy, and financial risks; preference for the known product; and uncertainty about quality.87~88~8g There is a considerable debate about the use of generic drugs." Since the passage of the 1984 Drug Price Competition and Patient Term Restoration Act, there has been an increasing number of generic products approved by the FDA.`l One potential benefit of generics is that they are usually less expensive than brand name drugs. This should translate to cost savings for elderly patients. A recent study, however, questioned the cost savings of generic drugs and found wide variations in the prices of generic and brand name drugs." Some have used this data to conclude that "it is not unusual for a generic drug to cost more than a brand name drug."" It is important to point out that in this study the consumer usually paid less for generics. Also, the study was conducted during 1984 before the new law took full effect. Concerns have also been raised about the efficacy of generic drugs in the elderly.Q4Yg6 This may stem from the fact that prior to approval for marketing, the studies required to prove bioequivalence are single-dose bioavailability studies of only 20-30 young health male volunteers. In addition, statistical variations as great as a 30oh difference in generic vs. brand name drugs are acceptable.ae Although the question of how this information specifically relates to the elderly patient is not fully answered, it is important to note that since 1984 there has not been a documented report to the FDA of a serious problem with a generic product.s`s E-8 B~~AVIGRAL ISSIJES / The elderly appear to be particularly vulnerable to their own attitudes toward taking medications and the attitudes of others providing care. Straus has reviewed the complexity of behavioral issues as a risk factor in geriatric drug usesg7 Issues of compliance and attitudes provide a useful background to the larger topic. 1. COMPLIANCE. Assuming that a certain prescribed or OTC medication is beneficial, medication compliance or adherence is imperative to achieve therapeutic success. Numerous studies have shown, however, that whenever self administration or discretionary action is involved, patients frequently fail to take their medication as prescribed.g8*W~100~1a1 Patient noncompliance to prescribed therapies can have serious consequences. First and foremost, noncompliance can neutralize any therapeutic benefits of medical care rendered. Second, medication errors and/or medication noncompliance can lead to adverse drug reactions. Third, it has been associated with higher rates of hospitalization, longer length of stay in the hospital, and increased ambulatory visits, resulting in additional and unnecessary diagnostic and treatment procedures that generate avoidable costs.102~1037104 There is considerable controversy whether the elderly are less compliant with medications than younger patients. Two studies among noninstitutionalized elderly conducted 24 years apart reported an approximately similar medication error rate (59% and 50%).743g8 Also, when the elderly were compared to a younger population, compliance rates were again similar. 105,106 Indeed, noncompliance seems to be associated with an increasing number of drugs rather than an increasing number of years."' An added dimension compounding the problem at the clinical level is the fact that physicians tend to overestimate their patients' compliance with prescribed regimensms Patient factors implicated as contributors to noncompliance include behavioral, social, and personal considerations. There is difficulty attributing health related behaviors, such as compliance, to the aging process. Not only are there methodological constraints (prevalence data vs. life course incidence data), but health behavior is also related to the social circumstances and historical context of an individual's life-log Nonetheless, an individual's perception and response to illness clearly influence his/her drug-taking behavior."' Eraker et al. have proposed a model for patient behavior which combines components Becker's earlier Health Belief Model and patient preferences."' This thoughtful approach to the issues of compliance contends that the matter is one of shared responsibility between physician and patient. One premise of this model is that the physician's responsibility is inversely related to the degree of patient participation; thus, the less responsible the patient, the more so must be the physician. Social isolation has been found to play a significant roll in noncompliance."2 A large proportion of oIder Americans live alone, increasing their likelihood of having compliance problems. In addition, one-third of the approximately 20 million Americans classified as illiterate are 60 years of age and older"s about therapy."' compounding the potential risk of misunderstandings or lack of knowledge Other patient factors include personal impairments such as difficulties with vision or nlemor Y or learning disabilities,"6Y*r6 and physical limitations imposed by arthritis or other handicaps. " intentiona1118 There is also evidence that some nonadherence in the elderly may be and perhaps represent intelligent noncompliance."' In addition, it appears that economic issues play a role in noncompliance among older persons. A 1986 AARP telephone survey of a population (sample size not available) 45 years and older found 13% of those deciding against having prescription filled doing so because of costgl 2. ATTITUDES. Provider attitudes may place the elderly, especially the poor elderly, at an increased for substandard medical care.l*' In spite of more prescriptions per office visit for older patients,6 office practice encounter time with older patients is apparently less than with younger patientsl'l Perhaps this results from a perpetuation of the agism myths which Surgeon General Koop sees as self-fulfilling prophecies.`22 WetIe has suggested that this may partially be attributed to misapplication of population-based data."' Applying average life expectancy data in making individual management decisions deprives the patient of credit for surviving to the moment of care; the more appropriate issue is the life expectancy beyond this encounter for the individual patient. E-9 ECONOMIC ISSUES / More than 30% of the national health care budget is spent on care for older Americans3 Nevertheless, this does not come close to covering the full expense of health needs of the elderly. Beyond this, out-of-pocket payments and third-party payors account for additional health expenses. 1. PERSONAL EXPENSES. A high rate of use and the large out-of-pocket expenditure for drugs place economic concerns on a par with safety and efficacy as important medication issues to be faced by the elderly. There are more elderly, and more of them are using more expensive drugs. Prescription prices in the U.S. rose 56% from January 1981 to June 1985; this far out-paced the Consumer Price Index which grew 23% over the same period. National telephone surveys by AARP in 1985 and 1986 found 62% of the elderly to be taking prescription drugs on a regular basis, with just less than half (45%) receiving some assistance from insurance or other health coverage. Among those without assistance the number of older patients paying more than $40 each month increased from 24% to 34h. O " The extent of poverty (12.4% in 1986) among older Americans has remained at or near current levels for several years.`24 Currently, Medicare coverage for outpatient medications moving through legal hurdles and final implementation. Overall, the potential cost of drugs under Medicare depends on the number of participants, the number of units per participant, and the unit cost of medications prescribed. Each factor is rising. In 1967 less than 78Oh of Medicare beneficiaries were taking medications; by 1980 the proportion had grown to more than 80%. Over that same period the average number of prescriptions per beneficiary grew from 10.4 to 12.1 annually. Because prescription size (doses dispensed) has increased over that same period the growth curves cannot be compared, but the average prescription cost more than doubled going from $4.00 in 1967 to $8.05 in 1980; in 1984 the cost for Medicare beneficiaries was over $10.00 per prescription.`25 Although there are some state pharmaceutical assistance programs,`26 Medicare does not pay for outpatient drugs at this time. They will, however, reimburse for drugs administered as part of an office visit, with the notable omission of influenza vaccination. Perhaps Medicare use of health maintenance organizations in the future may change this policy.127 For elderly patients that fall below a certain income level, Medicaid coverage of medications is available. In 1986 an estimated 6.6 percent of the elderly were covered by Medicaid insurance.128 A recent study analyzing different Medicdid cost-saving programs found that the elderly had less access to "essential" medications [as determined by an expert panel (e.g., digoxin)].`2Q insulin, thiazides, furosemide, The use of generic drugs may be an approach for patients and third parties to reduce medication costs. New factors in understanding the cost of prescriptions are encountered each year. An estimated 5% of physicians are now dispensing drugs they prescribe, with nearly one-third of office-based MD's expected to do so "within a few years." 3o It's probably too early to appreciate the full impact of physician dispensing on drug costs for the elderly, but analysis by the Pennsylvania Department of Aging in the fourth quarter of 1986 found that elderly patients paid nearly $2.00 more per wescription when doctors dispensed the medication. The report did not indicate whether wholesale cost or quantity dispensed had been controlled in the analysis.131 2. PAYMENT AND REIMBURSEMENT. A major activity now under legislative consideration and enactment is the reimbursement of outpatient drugs for Medicare beneficiaries. Regardless of the exact outcome of this activity by the current Congress, this area will `be of major interest for health economists and government officials for years to come. Although the primary concern of Medicare beneficiaries is the substantial out-of-pocket costs associated with prescription drugs, the primary concern of government officials is the cost of such a provision.`26 Given the finite dollars that Congress envisions for this benefit and the demographics of this benefit as a dramatic growth area, further refinement and adjustment will almost certainly occur with the introduction of the benefit. At the request of the Health Subcommittee of the Senate Finance Committee, the Office of Technology Assessment (OTA) has submitted an examination cost containment strategies and possible approaches appropriate to drug coverage under Medicare.`26 Some (but not all) of the specialized cost-containment mechanisms offered for further exploration by OTA include various forms of price setting, provider and patient incentive programs, beneficiary cost-sharing E - 10 programs,' Federal grants to state pharmaceutical assistance programs, and developing a federal restrictive formulary. Options for defining drug coverage under Medicare are limited. Comprehensive coverage, acknowledged by OTA to be the most expensive, might include all prescription drugs or all drugs prescribed for documented chronic diseases. Over-the-counter medications could be a component of this program. A limited coverage approach, on the other hand, could finance only selected therapeutic categories or targeted sub-populations (e.g., poor elderly or nursing home residents). Some options for specifying drug groups for coverage included determination of "life-sustaining" drugs by medical consensus, identifying drugs likely to prevent hospitalization with its associated costs, and approval only for drugs (or drug products) for which the manufacturer can demonstrate specific evidence of efficacy and safety when used by elderly patients. A third option available under Medicare is "phased-in" implementation drug coverage. This approach could allow for administrative consideration of changes in clinical practice standards, and benefit from accumulated prbgram experience.`26 HEALTH POLICY AND HEALTH SERVICE ISSUES / The delivery of health services and the implementation of health policy are indicators of society's expectations for health promotion. The drug component of a larger strategy is reflected in these selected examples. 1. MEDICAID. Although only 6.6% of the elderly were covered by Medicaid insurance in 1986, these were by definition among the least able to afford out-of-pocket health expenses.12' Efforts to reduce costs and focus benefits under Medicaid have been a dominating health policy issue at the state level for several years. An analysis of the effects of a $1.00 copayment compared to a monthly limitation of 3 prescriptions found Medjcajd's monthly savings under the two systems to be comparable.12D However, the proportion of "essential" medications [see pg. E-101 obtained by recipients was greater under the copayment arrangement. One approach has been the adoption of a generic formulary for Medicaid recipients by Alabama. Under that State's provisions, reimbursement for brand name drugs will not be made when generic equivalents are available. In another tack coverage of most anti-anxiety drugs was discontinued by Kansas; while coverage of psychotherapeutic drugs has been added by Arizona."' Recently three states (Florida, lowa, and North Carolina) adopted Medicaid service programs that are preventive in nature, but none of the three were directed at drugs or targeted the elderly. In 1985 Michigan adopted a therapeutic drug utilization program to identify Medicaid recipients at risk f&r drug induced illness.`32 In view of the higher rate of ADRs among the elderly, successes in this program ought to have greatest benefit for older recipients of Medicaid. In view of the the increased general use of medjcatjons38~3Q~`33 (and psychotropic drugs jn particula?), preadmission screening of applicants for nursing homes may shield some from overmedication while perhaps leading to more appropriate therapy for those admitted. Minnesota recently adopted a nursing home applicant screening program, and Massachusetts was considering the same ip mid- 19X5.1s2 2. MEDICAFZE. An average 17% annual increase in Medicare expenditures between 1967 and 1983 prompted the shift to a prospective payment system based on diagnostic related groups (DRG's). This change in the reimbursement system was accompanied by increased rates of hospitalization for elderly Medicaid nursing home residents in Wisconsin."' Higher drug usage is usualiy associated with hospitalization; whether this occurred in this population is not known. In spite of changes since 1983 Medicare costs continue to rise; and rising health care costs have financial impact on the elderly. In dealing with the issue the 100th Congress seems to favor an approach which will limit out-of-pocket health expenses to $2000 annually.13' Proposals to expand Part B to include outpatient prescription coverage received wider support in 1987 than in previous years. Under consideration is a requirement that participating pharmacies would consent to offer medication counseling to all eligible program participants. Prescription drug assistance under Medicare could include policy features designed to improve overall drug therapy. The OTA background paper on options for drug coverage by the Medicare Program included several policy features that might accomplish this end.lz6 Among the options E - 11 outlined were concepts of periodic professional review of drug regimens, limiting the number of prescriptions that can be funded, requiring a single dispensing pharmacy site, rewarding safety and toxicity studies targeted at elderly patients, and providing incentives for user-friendly packaging and labeling as well as patient education services. 3. HEALTH MAINTENANCE ORGANIZATIONS. Medicare recipients have been able to join an HMO since April 1985. During the two years following enactment of the legislation allowing this choice, slightly more than 900,000 (5.5%) of the eligible Medicare recipients had done so.lz7 However, serious questions have been raised about the long term feasibility of a prepaid capitation system of providing health services for the elderly.`36J'37 In some instances the actuarial basis for capitation payments does not reflect the population served; also, if treatments are influenced by financial self-interests the patient may suffer. In addition, a few early providers have allegedly devised enrollment campaigns which made access to enrollment sites difficult for frail or handicaped elderly. It is ciearly in the interest of HMOs to promote health and prevent disease among their members; whether medications become an important facet of their strategy remains to be seen. There is some evidence that annual prescriptions per person is approximately unchanged in older subscribers but declines among younger subscribers following enrollment in prepaid health plans.`38 4. PHARMACY SERVICES. Interest in mail-order prescription services has increased in recent years. Although its advantages and disadvantages have been debated in hearings and editorials, rigorous evaluation of the risks and benefits is lacking. Costs, counseling, error rates, convenience and access are the usual issues addressed. Proponents cite advantages that include savings due to an economy of scale, better ability to monitor therapy because of less "switching" between pharmacies, and convenience for less mobile patients.13g Detractors claim higher error rates, less personal counseling,"' and even higher costs. In 1985 an Arizona based study reported that a 4% savings in unit costs was offset by a 9% higher utilization by mail-order users. 141 It reported that changes in therapy for older users brought about more frequent ordering and increased wastage. Labeling and packaging of prescriptions for older patients ought to take into account the possibility of visual impairments and confusion about products of similar size and color.`42 Many pharmacists use special services and "senior discounts" to attract the older patients. If such programs succeed in establishing client loyalty, the opportunity for regular counseling and ADR monitoring should benefit the older patient. "Brown Bag" projects are programs in which elderly are encouraged to bring medications to a convenient location for review and counseling. Their focus is the ambulatory older population, and their purpose is to detect potential medication problems and correct those that need attention. One program has reported approximately 88% of participants need reinforcement, clarification, education, or health provider follow-up.143 6. FRAUD. The elderly seem to be less suspicious of medications that do not produce their promoted Jar expected results.`44 Among 172 older respondents (age 60 or older) to a 1984 survey, one-half reported purchasing a health product that did not work and just over one-half of those (53%) suspected it to be quack medicine. While appropriate cautions regarding interpretation were stated, the authors pointed out that the elderly are particularly vulnerable to fraud and the consequences of quackery because they are more likely to suffer from conditions for which many quack medications are promoted. 6. ADVEPTISING. The claims that OTC as well as prescription drugs portray, either directly or indirectly, to the elderly are an area of continuing concern. Surveillance of the prescription drug claims relating to the elderly that are made directly to consumers or through health practitioners, will continue to share an area of high interest and surveillance by FDA. E. Developing Technologies. New technologies in information management, drug products, and health service delivery bode well for improvements in drug therapy for the elderly. As computerized expert diagnostic systems become more user-friendly, the power of knowledge previously available only through years of experience should make extensive information available to all that care for elderly patients.`45 Public awareness of the special needs of older E - 12 citizens has served to stimulate the application of new technologies in areas which benefit the elderly. 1n the future, advances in technology are expected to result in the development of new dosage forms and new drug entities that will be more convenient for older patients as well as more specific and efficacious in their pharmacologic effects.`461"7 A number of novel drug delivery systems are currently being developed."6 For example, transdermal delivery systems can extend a drug's duration of effect, and therefore should assist in improving compliance. Biotechnology advances are also expected to result in the development of numerous new therapeutic entities."7'148 A number of pharmaceutical firms are currently working to develop new drugs that might reverse congnitive losses in Alzheimer patients."' Geriatric assessment units have been referred to as examgles of "new technologies" in health services, and have grown in number and scope since 1979.' ' A 1985 survey of 104 units found that nearly half had begun operation during the previous two years, and two-thirds of the others increased their capacity during that time. Most (approx. 60%) are outpatient units, and 27% of those reported "improvement in drug regimens" to be either their 1st or 2nd most important effect. F. Successful Interventions and Programs. Drug related problems in the elderly do not usually occur in isolation. The several successful interventions reviewed here gave emphasis to a particular outcome (e.g., compliance, polypharmacy, adverse drug reactions, cost savings), but in most instance: the intervention required multidisciplinary effort and cooperation, and effected more than one area of need. COMPLIANCE / The success of drug-related health promotion patient interventions depends on relevance, individualization, feedback, reinforcement, and facilitation.151 Ten strategies for reducing drug errors in the elderly were reviewed by Green et al. in 1986.152 These investigators found facilitation to be the most common technique, with no more than half incorporating relevancy or individualizing intervention, and even fewer using feedback or reinforcement. They concluded that interventions combining interpersonal communication methods, visual materials and memory-aids had been shown to be effective means of reducing drug errors as well as related clinical symptoms in the elderly. Several of these studies compared the effectiveness of different strategies on medication compliance and errors. MacDonald, et al., found no significant difference between medication counseling and counseling with a medication calendar. Both strategies significantly improved compliance in comparison to controIs.153 Color-coded weekly medication packaging significantly reduced medication errors when compared to color-coded s conventionally dispensed medications, medication counseling, and no intervention.`54 Another study compared verbal medication counseling alone and in combination with either written information, a medication calendar, or a seven day medication package.15' Attitudes, knowledge, and compliance in an elderly ambulatory population were assessed. Drug knowledge was most favorable effected by verbal instruction alone or combined with a medication calendar. In contrast, patient deported compliance was improved only by the combined intervention of verbal medication counseling and use of a seven day medication package. In general 18 atients felt the interventions were useful with the notable exception of the medication calendar. EDUCATION FOR PRESCRIBING / There is some evidence that physician peer education can have positive impact on prescribing in general. Studies by Ray and Schaffner have shown that the prescribin 6 of antibiotics and diazepam improves after receiving education visits from a physicianw15-6~' 1158 Also, pharmacist provided drug information can favorably impact on the prescribing of specific drugs or therapeutic classes of drugs.15g~`60~`61 Avorn found improvement in the prescribing of cerebral and peripheral vasodilators, oral cephalosporins and propoxyphene after education visits by a clinical pharmacist. in a 14% reduction in utilization."' The program, involving 400 physicians, resulted Hanlon, et al., found the prescribing of the above mentioned medications and the number of medications prescribed per patient to be lower than national prescribin data in a family medicine residency program with an active clinical pharmacy K program. " Finally, a controlled study showed that global prescribing practices were favorably impacted by continuing education provided by clinical pharmacists and pharmacologists.161 E- 13 ADR REDUCTION and SAVINGS / Interventions by clinical pharmacists as consultants in long- term care facilities (LTCFs) have been documented as being effective. One study of feedback from the LTCF clinical pharmacist consultant reduced the incidence of medication errors, the number of inappropriate or unnecessary drugs, and the incidence of adverse drug reactions, thereby reducing medication and hospitalization costs.133 In a long-term study evaluating the initiation, termination, and reinstitution of a consultant clinical pharmacist, it was found that there was lower drug-use, admission, discharge, and death rates during the time the consultant was with the facility.16' A recent paper examining the cost-benefit ratio of pharmacist- conducted drug-regimen review in LTCFs estimated a net savings of $220 million nationwide.`63 Another study monitored adverse reactions in 2,771 randomly chosen hospitalized patients during 1969-1976. Medications as well as indications for starting and stopping therapy were tabulated, and records for the 1969-72 period were compared with those for the 1973-76 period. An active surveillance and ADR reporting program during the second period resulted in a 61% reduction in the number of patients affected by reactions to dru E therapy; with the greatest reductions in the two age bands over 70 years of age (69% and 89%)' ' A novel study evaluating the pharmacist as a prescriber of drugs to previously diagnosed LTCF patients, found them to be more effective than physicians in terms of number of drugs prescribed lower number of deaths, and increased number of patients discharged to lower levels of care.16' The significance of this study may not be the role of the pharmacist as an independent mid-level practitioner but extrapolating this information to include the pharmacist as an integral part of a multidisciplinary team. MULTIDISCIPLINARY COOPERATION / Nursing initiative at one teaching nursing home has targeted reduction in cathartic drug use as a priority.`66 In nursing homes conflicting schedules limit opportunities for personal contact and direct dialogue among professionals. Although drug regimen reviews conducted by nursing personnel in Iowa intermediate care facilities have identified a variety of problems, widely variable physician responsiveness to reports and recommendations has been reported.16' In Georgia Longe et al. found that written recommendations of' consultant pharmacists_ in skilled nursing facilities were usually effective, with 72% of drug-dosage recommendations and 80% of laboratory test recommendations being accepted.lea In North Carolina an interdisciplinary team review approach to drug therapy recommendations resulted in a reduction in the number of medications at one long-term care facility.16' V. Priorities and Recommended Programs to Address Areas of Concern THE AGING PROCESS and DRUG DEVELOPMENT / Basic research into the aging process and the diseases of aging is needed. not possible in many instances."' Distinction between aging processes and disease processes is Investigation into the physiology of aging will contribute to needed understanding of pharmacodynamic changes and guide drug development specifically beneficial to older patients. Health promotion and disease prevention initiatives should benefit from this basic research and, perhaps lead to the development of products that will enhance the quality of life in later years. DRUG TESTING / In the past, there have been few carefully carried out geriatric clinical drug trials that investigated the pharmacokinetics and pharmacodynamics of drugs in older patient samples.`71 However, in recent years there has been a steady increase in information about these areas of interest."* FDA labeling guidelines were revised in 1979. These guidelines directed that prescription drug labeling feature special age group indications or precautjons.`73 It is now common for FDA new drug applications to include analyses relating age with drug responses."' Evidently Phase III clinical trials are now less likely to have excluded subjects on the basis of advanced age. At FDA, Dr. Temple expects to have a formal drug testing proposal in place in 1987."' Although there are some disagreements about the specifics of the proposal,176 a number of professional groups are encouraged by the FDA's requiring the inclusion of formal testing of new drugs in the elderly and improved labeling of such information. Once a drug testing regulation is approved, the clear need will be for more studies of currently marketed drugs (Phase IV) in older patients. E - 14 clinical drug trials in which subjects are stratified on age and factors known to alter drug disposition are controlled. These studies are needed in order to identify agents for which pharmacokinetic changes are truly age-dependent. This approach to testing would provide e]der]y patients with maximum benefit at minimum risk and allow companies developing new drugs to inform prescribers of true factors effecting dose. POST-MARKETING DRUG SURVEILLANCE / The field of pharmacoepidemiology, or the stody r$ drug use and drug effects using specific epidemiological methods has emerged in recent years. Interest in post-marketing surveillance (PMS) of drugs and their effects is evident in several sectors, including the government, the pharmaceutical industry, and third party payors. 177 Investigations carried out once a new product has been marketed (Phase IV studies) can include careful assessment of spontaneous reports, additional clinical trials, cohort monitoring, and case control studies.`78 Two primary objectives of PMS are an assessment of efficacy and toxicity under conditions of actual clinical use, and an evaluation of the relative impact on approved indications.17' There are a number of data-bases which investigators utilize to study drug use, some of which were previously mentioned in this paper. Recently, there has been great interest regarding the effects of non-steroidal antiinflammatory drug since they are so widely used in the elderly; several studies utilizing the Medicaid Drug Event (Compass) Data Project,18' The Boston Collaborative Drug Surveillance Program,`81 The American Rheumatism Association Medical Information System (Aramis),`82 and the FDA data-base have been published.`83 In view of the evidence that older patients are at higher risk of adverse drug reactions and may exhibit atypical response to therapy, PMS in populations 65 years of age and older seems particularly advisable. Presently there are limitations due to the inherent nature of the data-bases themselves,i8' and the lack of a comprehensive national system.`85 There are, however, encouraging signs that the field of pharmacoepidemiolo important role in knowledge of drugs and the elderly.1861 KB; will continue to emerge and play an LACK OF TRAINED PROFESSIONALS / Specialized knowledge of clinically important pharmacokinetic and pharmacodynamic changes that often accompany the aging process are needed for prescribing for the elderly.`88'18g It has been persuasively argued that many problems associated with prescribing can be avoided,6g178 and yet about half the physicians delivering care in geriatric assessment units have no special training in care of the elderly,r5' Specialty training programs in gerontology and geriatrics offer one approach to imparting the specialized knowledge needed to avoid such problems. Unfortunately projections of population growth, particularly in the numbers of fraii "old-old", strongly support the contention that requirements for geriatric specialists over the next decade will not be met.190,1Q111Q2Z1Q3 At present there are 66 geriatric medicine programs and 27 geropsychiatry programs in the U.S.`Q2 A new fellowship program to train 4-6 physicians in geriatric clinical pharmacology will begin in 1988."' At a broader and more basic level, medical schools are providing only minimal training of geriatrics.lgl Federal law' mandates that a pharmacist review the drug regimens of all LTCF patients. This regulation has resulted in decreased exposure to unnecessary drugs and an associated decline in the cost of drugs in nursing homes. hospitalizations have also deciined.16s In addition adverse drug reactions and subsequent Although this role is established, there are only three accredited pharmacy residencies in geriatrics, and ten funded geriatric pharmacy fellowships jn the U.S.lQs~`gs A 1985 survey of U.S. Schools of Pharmacy found that 40 schools planned to incorporate an AACP developed text on geriatrics in their coursework.`g7 At least 10 schools indicated plans to offer geriatrics courses not previously available. The Geriatric Education Centers (GEC) Program has also stimulated expanded training in geriatric drug therapy.lg8 Whether responsibility for drug therapy management of elderly f9a atients should be a shared or independent exercised, there is agreement that neither medicine nor pharmacy1g6~`g8~200 will provide an adequate number of specialized practitioners in the near future. Interdisciplinary training programs designed to enhance cooperative relationships between physicians, pharmacists and nurse-specialists should shorten the period during which the elderly can anticipate the shortage of geriatric drug specialists. E - 15 REIMRLJRSEMENT FOR SERVICES / Among issues usually associated with Medicare reimbursement, medication for the elderly is not typically considered. However, the OPPortunity (or risk) to receive medications begins with access to the prescriber and so reimbursement policy that effects access wi]] probably effect drug utilization Patterns as We]]. The American College of Physicians has recently published a position paper on alternative payment approaches for Medicare in which it suggests that inequities in the present reimbursement system "induce physicians to provide technologic and procedural services as opposed to cognitive and interpersonal services such as history taking, preventive health care, or patient education and counseling."201 FINANCING / An immediate assessment of the probable financial consequences of ambulatory drug coverage under Medicare is needed. The potential impact of such coverage on prescribing, pharmacy services, and self-care practices has not been studied.lz6 VI. Summary Drug therapy represents an important approach to promoting health in the elderly. Rational and judicious use of medications can enhance the quality of life for older patients with chronic diseases. Wide variations in body compositon and organ system function exist among older persons. Consequently the clinical management of individual elderly patients demands caution and an appreciation of the possible variations in drug response. Respect for these nuances in drug response are essential to rational prescribing for the elderly. It appears that drug usage in the elderly is considerable in terms of medications taken and associated expenses. There are also patterns of medication use which, while easily understood, suggest the need for greater prescribing forethought in subsets of the 65 and older population. For instance, increased prescribing for and general use of medication among older women; an increase in the number of medications with advancing age continues into the ninth decade of life; and more medications ordered in settings where higher levels of care is provided. Changes in pharmacokinetics and pharmacodynamics can contribute to adverse drug reactions in the elderly. Polypharmacy (a major reason for drug interactions) and non-compliance (particularly excessive dosing) can also contribute to the incidence of ADRs. It is often difficult to predict the specific cause making advisable the use of lower initial doses with careful dose escalation titrated to therapeutic response. As new drugs designed specifically for geriatric needs are developed, as additional training programs are funded, as new technology raises health costs in general, and as the number of elderly over 75 increases, the questions of "Who pays?" and "How much?" take on even more challenging dimensions. The issues to be faced in providing affordable, safe, and effective medications for older people in the U.S. are plentiful today, but will surely be even more numerous beyond the year 2000. 1988 is not too soon to begin to address them. VII. REFERENCES: 1. Hacsard WR. creventive Gerontology: Strategies for Healthy Aging. Postgrad Med 1983.74:279-287. 2. Rowe JW and Kahn RL. Human Aging: Usual and Successful. Science 1987;237:143-149.' 3. U.S. Department of Commerce, Bureau of Census, Projections of the Population of the United States: 1982-2050 (Advance Report). Current Population Reports, Series P-25, No. 922, October 1982. Projections are middle series. 4. Siegal JS and Taeuber CM. Demographic Perspectives of the Long-lived Society. Daedalua 1986;115:72-117. 5. N.C.H.S., Koch H and Knapp DE. Highlights of Drug Utilisation in Office Practice, National Ambulatory Medical Care Survey, 1985. Advance Data From Vital and Health Statistics, No.134. DHHS Pub.No.(PHS)87-1250. Public Health Service, Hyattsville, MD., May 19, 1987. 6. N.C.H.S., Hing E. Use of Nursing Homes by the Elderly. Preliminary Data from the 1985 National Nursing Home Survey. Advance Data From Vital and Health Statistics. No.136. DHHS Pub.No.(PHS) 87-1250. Public Health Service, Hyattsville, MD., May 14, 1987. 7. N.C.H.S. 1986 Summary: National Hospital Discharge Survey. Advance Data From Vital and Health Statistics. No.145. DHHS Pub.No.(PHS) 87-1250. Pubiic Health Service, Hyattsville, MD., Sept.30, 1987. 8. Irelan LM, Motley DK, Schwab K, et al. Almost 66: Baseline from the Retirement History Study. DHEW Social Security Admin., Off& of Research & Statistics. &search Report No.49, HEW PubINo. (SSA)76-11806, 1976, pp.7-34. 9. Gruenberg EM. Patterns of Disease Among the Aged. NIA Science Writer Seminar Series, DHEW, NIH PubI.No. (PHS) 79-1407, revised July, 1979. 10. Davidson SM and Ma-mm TR. The Cost of Living Longer. Lexington, MA: D.C. Heath and Co., 1980, pp.l-9. 11. Brody JA and Schneider EL. Diseases and Disorders of Aging: An Hypothesis. J Chronic Dis 1986;11:871-876 12. WiIliams ME. Clinical Implications of Aging Physiology. Am J Med 1984;76:1049-1054. E- 16 ,3. Rowe JW. Health Care of the Elderly. N Engl J h&d l086;~12:827-836. 14. Greenblatt DJ, Sellers DM and Shader RI. Drug Disposition in Old Age. N Engl 3 Med 1982;306(18):1081-1088. l6. Rock RC. Monitoring therapeuti.c drug levels in older patients. Geriatrics 1986;40(6):76-86. l6.2~~~~ MA, &al. Gastnc Emptymg Rate in the Elderly: Implications for Drug Therapy. J Am Geriatr Sot 1981;29:2Ol- l7. Decker RR. Calcium Absorption and Achlorhydria. N Engl J Med l986;313:70-73. 18. Johnson SL, et al. Gabtrointestinal Absorption an a Function of Age: Xylose Absorption in Health Adults. Clin pharmacoi Ther 1985;S8:SSl-335. l9. Mayersohn M. Special Pharmacokinetic Considerations in the Elderly. In: Applied Pharmacokinetics, Evans WE et al. ,,dz. Spokane, WA: Applied Therapeutics 1986;pp.229-29s. 20. Pucino F, Beck CL, Seifert RL, et al. Pharmacogeristricz. Pharmacotherapy 1986;6:314-326. 21. Wallace SM and Verbeeck RK. Plasma Protein Binding of Drugz in the Elderly. Clin Pharmacokin 1987;12:41-72. 22, James OFW. Druga and the Ageing Liver. J Hepatology 1986;1:431-436. 23. Cockcroft DW and Gault MH. Prediction of Creatininc Clearance from Serum Creatinine. Nephron 1976;16:31-42. 24. Bennett WM, et al. Drug Prescribing in Renal Failure: Dosing Guideline6 for Adults. Amer J Kid Dis 1983;3:155-193. 26. O'Ma&y K, Kelly JG, Swift CG. Responsiveness to Druga. In: Clinical Pharmacology in the Elderly. CG Swift (ed) New York: Marcel Dekker, 1987 p. 83-101. 26. Hanlon JT, O'Brien JG. Pharmacological Management of the Elderly Patient with Terminal Cancer Pain. [in press] J Geriatr Drug Ther 27. Kaiko RF, Wallenztein SL, Rogerz AG, et al. Narcotics in the Elderly. Med Clin North Am 1982;66:1079-1089. 28. Kaiko RF. Age and Morphine Analgesia in Cancer Patients with Postoperative Pain. C[in Pharmacol Ther 1980;28:832- 826. 28. Bellville JW, Forreat WH, Miller E, et al. Influence of Age on Pain Relief from Analgesics. JAMA 1971;217:1836-1841. 30. Vestal RE, Wood AJJ, Shand DG. Reduced Beta-Adrenoceptor Sensitivity in the Elderly. Clin Pharmacol Ther l979;26:181-186. 31. Baum C, Kennedy DL, Forbes MB, et al. Drug Use in the United States in 1981. JAMA 1984;251:1293-1297. 32. Baum C, Kennedy DL, Forbes MB, et al. Drug Use and Expenditures in 1982. JAMA 1985;253:382-386. 33. Baum C, Kennedy DL, and Forbes MB. "Drug Utilization in the Geriatric Age Group." in Geriatric Drug Use -- Clinical and Social Perspectives, Pcrgamon Press, New York, 1985, pp.63-69. ~4. Helling DK, Len&e LH, Semla TP, et al. Medication Use Characteristics in the Elderly: The Iowa 65+ Rural Health Study. J Am Geriatr Sot 1987;35:4-12. 36. May FE, Stewart RB, Hale WE, et al. Prescribed and Nonpreecrihed Drug Use in an Ambulatory Elderly Population. South Med J 1982;76:522-528. 96. Hale WE, May FE, Marks RG, et al. Drug Use in an Ambulatory Elderly Population: A Five-Year Update. Drug Intel1 Clin Pharm 1987;21:530-635. 37. Anon.(IMS America, Ltd.) NDTI Drug Data for 66 Plus Patients - 1986 [in press] J Geriatr Drug Therapy. 38. Benson JW. Drug Utilization Patterns in Geriatric Drugs in the U.S. - 1986. [in press] J Geriatr Drug Therapy. 99. Dept.HEW. Physiciana Drug Prescribing Patterns in Nursing Homes. Waahindon, D.C., 1976. 40. Leach S and Roy SS. Adverse Drug Reactions: An Investigation on an Acute Geriatric Ward. Age Aging l986;ls:24l- 246. 41. Reynolds MD. Institutional Prescribing for the Elderly: Patterns of Prescribing in a Municipal Hospital and a Municipal Nursing Home. J Am Geriatr Sot 1984;32:640-645. 42. Kannei WB and Gordon T. Cardiovascular Risk Factors in the Aged: The Framingham Study. In: Haynes SG and Feinleib M, eds. Proceedingz of the Second Conference on the Epidemiology of Aging. Washington, D.C.: DHHS Public Health Service, 1980. NIH Pub.No.80-969. p.82. 43. V.A. Cooperative Study Group. Effects of Treatment on Morbidity in Hypertension. Circulation 1972;XLV:991-1004. 44. Hypertennion Detection and Follow-up Program Cooperative Group. Five-Year Findings of the Hypertension Detection and Follow-up Program. JAMA 1979;242:2572-2561. 45. Amery A, Brixko P, Clement D, et a[. Mortality and Morbidity Results from the European Working Party on High Blood Pressure in the Elderly Trial. Lancet 1985;1:1349-13.. 46. Patriarca PA, et al. Efficacy of Influenza Vaccine in Nursing Homes. JAMA 1985;253:1136-1139. 47. Riddiough MA, et al. Influenza Vaccination: Cost-effectivenena and Public Policy. JAh4A 1983;249:3189-3195. 48. Setia U, Serventi I and Lorenz P. Factora Affecting the Use of Influenza Vaccine in the Institutionalized Elderly. J Am Geriatr Sot 1986;33!&66-868. 49. Hui SL, et 1. A Prospective Study of Change in Bone Mass with Age in Postmenopausal Women. J Chron Dis 1982;36:716-725. 50. N.I.H. Consensus Development Panel (NIADDK). 0 t p 8 eo orosis. Jm 1984;252(6):799-802. 51. Riggs BL and Melton LJ. Involutional Osteoporosis. N Engl J Med 1986;314:1676-1684 62. Ettinger B, Genant HK and Cann CE. Postmenopausal Bone Loss is Prevented by Treatment with Low-dosage Estrogen with Calcium. Ann Intern Med 1987;106:40-45. 63. Young RL and Goldzieher JW. Current Status of Postmenopausal Oestrogen Therapy. Drugs 1987;33:96-106. 64. Stevenson JC, Townsend PT, Young 0, et al. Calcitonin and the Calcium-regulating Hormones in Poetmenopausa] Women: Effect of Oestrogens. Lancer 1981;1(8222):693-696. 56. Van Heyningen R and Harding JJ. Do Aapirin-Like Analgesics Protect Against Cataract? Lancet 1986;1:11ll-1113. 56. Pulliam CC and Stewart RB. Adverse Drug Reactions in the Elderly. In: Pharmacy for the Geriatric Patient. Carrboro, NC: Health Sciences Consortium, 1985. pp.l1/6-11/7. 57. Jick H, et al. Efficacy and Toxicity of Heparin in Relation to Age and Sex. N Engl J Med 1968;279:284-289. 58. Greenblatt DJ, Allen MD and Schader RI. Toxicity of High Dose Flurazepam In the Elderly. Clin Pharmacol Ther 1977;21:355-61. 59. Moore SR and Jones JK. "Adverze Drug Reaction Surveillance in the Geriatric Population: A Preliminary View." in Geriatric Drug Use -- Clinical and Social Pempectivee, Pergamon Press, New York, 1985,pp.70-77. 60. Tanner A, et al. Geriatric ADR Reports - FDA 1986. /in press] J Geriatr Drug Therapy, 61. Lakshmanan MC, et al. Hospital Admissions Caused by Iatrogenic Disease. Arch Intern Med 1986;146:193l-2934. 62. Ives TJ, et al. Drug-Related Admissions to a Family Medicine Inpatient Service. Arch Intern Med 1987;14:1117-1120. 63. Jahnigen D, et sl. Iatrogenic Diseacre in Hospitalized Elderly Veterans. J Am Geriatr Sot 1982:30(6):387-390. E - 17 64. Becker PM, McVey LJ, Salts CC, et al. Hospital-acquired Complications In a Randomised Controlled Clinical Trial of a Geriatric Consultation Team. JAMA 1987;267:2313-2317. 66. Levy M, Kewitt H, Aitwein W, et al. Hospital Admissions Due to Adverse Drug Reactions: A Comparative Study from Jerusalem and Berlin. Eur J Clin Pharmacol 1980;17:26-31. 66. Ray WA, et ai. Psychotropic Drug Use and the Risk of Hip Fracture. N Engl J Med 1987;916:363-369. 67. Beard K, Walker AM, Perera DR, et al. Nonsteroidal Anti-inflammatory Drugs and Hospitalisation for Gastroesophageal Bleeding in the Elderly. Arch Intern Med 1987;147:1621-1623. 68. Burnum JF. Preventability of Adverse Drug Reactions. Ann Intern Med 1976;85:80-81. 69. M&non KL. Preventable Drug Reactions: Causes and Cures. N Engl J Med 1971;284:1361-1368. 70. Klein LE, German PS, Levine DM. Adverse Drug Reactions Among the Elderly: A Reassessment. J Am Geriatr Sot 1981;29:525-530. 71. Williamson J and Chopin JM. Adverse Drug Reactions to Prescribed Drugs in the Elderly: A Multicentre Investigation Age and Aging 1980;9:73-80. 72. Larson EB, Kukull WA, Buchner D, et al. Adverse Drug Reactions Associated with Global Cognitive Impairment in Elderly Patients. Ann Intern Med 1987;107:169-173. 73. Kroenke K. Polypharrnacy: Causes, Consequences, and Cure. Am J Med 1985;79:149-152. 74. Darnell JC, et al. Medication Use by Ambulatory Elderly: An In-Home Survey. J Am Geriatr Sot 1986;34:1-4. 75. Greenblatt DJ. Divoii M, Hat-mats JS et al. Kinetics and Clinical Effects of Flurarepam in Young and Elderlv Non- insomniacs. Clin Pharm~ol Ther 1981;30:476-486. 76. Castleden CM. George CF. Marcer D et al. Increased Sensitivity to Nitracepam in Old Age. Br Med J 1977:1:10-12 , - 77. Swift CG, Ewen JM, Clarke P, et al. Responsiveness to Oral Diarepam in the Elderly: Relationship to Total and Free Plasma Concentrations. Br J Clin Pharmacol 1986;20:111-118. 78. Gosnev M and Tallis R. Prescription of Contraindicated and Interacting Drugs in Elderly Patients Admitted to Hosnital. Lance;1984;2:664-568. 79. Cooper JW, Welling I, Fish KH, et al. Frequency of Drug-Drug Interactions. JAPhA 1975;15:24-31. 80. Armstrong WA, Priever CW, Hays RL. Analysis of Drug-Drug Interactions in a Geriatric Population. Amer J HOSD Phann 1980;37:385-387. 81. Adams KRH, et al. Inappropriate Prescribing in the Elderly. J Roy Co11 Phys (London) 1987;21:39-41. 82. Feely J, Pereira L, Guy E, et al. Factors Affecting the Response to Inhibition of Drug Metabolism by Cimetidine-dose Response and Sensitivity of Elderly and Induced Subjects. Br J Clin Pharmacol 1984;17:77-81. 83. Yamanaka-Yuen NA. Ethanol and Drug Interactions. Drug Interact Newsletter 1985;6:46-48. 84. Lamy PP. The Elderly and Drug Interactions. J Am Geriatr Sot 1986;34:586-92. 86. Hathcock JN. Nutrient-Drug Interactions. Clin Geriatr Med 1987;3:297-307. 86. Gossel TA. Fecal Occult Blood Testing Kits. US Pharm 1984;(Feb):lO-16. 87. Bearden WO, Mason JB and Smith EM. Perceived Risk and Elderly Perceptions of Generic Drug Prescribing. Gerontologist 1979;19:191-196. 88. Mertr B and Stephens N. Marketing to Older American Consumers. Intl J Aging and Hum Devel 1986;23:47-58. 89. AARP. Prescription drugs: A Survey of Consumer Use, Attitudes and Behavior. Washington, DC. 1984. p.49. 90. Strom BL. Generic Drug Substitution Revisited. N Engi J Med 1987;316:1466-1462. 91. Brown J. Prescription Drug Costs for Older Americans. Issue Brief. Washington, D.C.: AARP Public Policy Institute, March. 1987. pp.l-6. 92. Bloom BS, et-al. Cost and Price of Comparable Branded and Generic Pharmaceuticals. JAMA 1986;256:2523-2630. 93. Lasauna L. The Economics of Generic Prescribing: Winners and Losers. JAMA 1986;266:2566. 94. Morgan JP, Schwarts LL, Sherman FT. A Survey of Generic Drug Legislation and Geriatric Pharmacotherapy: Opinions of Those Who Generate the Literature. J Am Geriatr Sot 1983;31:536-539. 95. Lamy PP. What Should We Know About Generics. Geriatric Medicine Today. 1986;5:25-27. 96. Faith GA, Morrison J, Dutra EV, et al. Reassurrance About Generic Drugs. N Engl J Med 1987;316:1473-1476. 97. Straus R. "Risk Factors in Geriatric Drug Use: Behavioral Issues." in: Moore SR, Teal TW eds., Geriatric Drug Use -- Clinical and Social Perspectives. Pergamon Press, New York, 1986,pp.160-167. 98. Schwartr D, Wang M, &its L, et al. Medication Errors Made by the Elderly, Chronically I11 Patients. Am J Public Health 1962;62:2018-2029. 99. Stewart RB and Cluff LE. A Review of Medication Errors and Compliance in Ambulant Patients. Clin Pharmacol Ther 1972;13:463-468. 100. Smith DL. Patient Compliance with Medication Regimens. Drug Intel1 Clin Pharm 196;10:386-393. 101. Atkins0 L, Gibson II and Andrew6 J. The Difficulties of Old People Taking Drugs. Age and Aging 1977;6:144-150. 102. Blackwe 1 B. The Drug Defaulter. Chin Pharmaco Ther 1972;13:811--823. ? 103. Hood JC and MurphyJE. Patient Noncompliance Can Lead to Hospital Readmissions. Hospitals 1978;62:79-84. 104. Haynes RB. Strategies for Improving Compliance. In: Compliance with Therapeutic Regimens. Sack&t DL and Haynes RB, eds. Baltimore: Johns Hopkins, 1976, pp.69-82. 105. German PS, Klein LE, McPhee SJ, et al. Knowledge Of and Compliance With Drug Regimens in the Elderly. J Am Geriatr Sot 1982;30:668-671. 106. Haug MR and Ory MG. Issues in Elderly Patient-Provider Interactions. Rsch on Aging 1987;9:9-44 107. German PS and Klein LE. Drug Side Effects and Doctor/Patient Relationship Among Elderly Patients. J Social and Admin Pharm 1984;2:67-73. 108. Roth HP and Caron HS. Accuracy of Doctors' Estimates and Patients'statements on Adherence to a Drug Regimen. Clin Pharmacoi Ther 1978;23:361-370. 19Q. Ory MG. Social and Behavioral Aspects of Drug Taking Regimens Among Older Persons. [in press] J Geriatr Drug Therapy. 110. Becker MH and Maiman LA. So&behavioral Determinants of Compliance with Health and Medical Care Recommendations. Medical Care 1975;13:10-21. 111. Eraker SA, Kirscht JP and Becker MH. Understanding and Improving Patient Compliance. Ann Intern Med 1984;100:258-268. 112. Blackwell 13. Drug Therapy: Patient Compliance. N Engl J Med 1973;289:249-252. 113. Irelan LM, Motley DK, Schwab K, et al. Almost 65: Baseline from the Retirement History Study. DHEW Social Security Admin., Office of Research k Statistics. Research Report No.49, HEW Publ.No. (SSA)76-11806, 1976, pp.7-84. E - 18 ll4. Fletcher SW, Fletcher RX, Thomas DC, et al. Patients' Understanding of Prescribed Drugs. J Community Health lQ79;4:183-189. ll6. Dir&x JH. Labels for prescribed drugs (letter). JAMA 1979;242:413-414. ll6, Richardson JL. Per8pectives on Compliance with Drug Regimens Among the Elderly. J Compliance Xealth Care l~86;1:33-43. ll7. Bootman JL. M ucimiring Compliance in the Elderly. In: Pharmacy Practice for the Geriatric Patient. Carrboro, NC: Health Sciences Consortium, 1986. pp.ll/B-14/12. ll8. Cooper JK, Love DW, R&foul PR. International Prescription Nonadherence (Noncompliance) by the Elderly. J Am Geriatr Sot 1982;30:329-553. 119. Weintraub M. A Different View of Patient Compliance in the Elderly. In: Vestal RE ed. Drug Treatment in the Elderly, MIS; Sydney, 1984. 120. Hellar TA, et aI. QudiCy of Ambulatory Care of the Elderly: in Analysis of Five Conditions. J Am Geriatr Sot lQ84;32:782-788. lfl. Keeler EB, et al. Effect of Patient Age on Duration of Medical Encounters with Physicians. Med Care 1982;2O:llOl-1108 122. Koop CE. Exploring the Myths and Realities of A&g and Health. Aging 1984;(Apr-May):5-9. 123. Wetle T. Age aa a Risk Factor for Inadequate Treatment. JAMA 1987;268:616 124. U.S. Department of Commerce, Money Income and Poverty Status of Families and Persons in the U.S.: 1986. (Advance Report). Current Population Reports, Se&s P-60, No.lS7 126. Anon. Some Facts About Drug-cost Burden on the Elderly from HCFA. PMA Newsletter 1986;(Jan.21):3-4. 136. OTA Project Staff (Solan G, et al.) Prescription Drugs and Elderly Americans: Ambulatory Use and Approaches to Coverage for Medicare. Health Program, Office of Technology Assessment, U.S. Congress. October, 1987. 127. Iglehart JK. Second Thoughts About HMO's for Medicare Patients. N Engl J Med 1987;316:1487-1492. 128. N.C.H.S., Rica P. Health Care Coverage by Age, Sex, Race, and Family Income: United States, 1986. .4dvance Data From Vital and Health Statistics, No.199. DHHS Pub.No.(PHS)B'I-1250. Public Health Service, Hyattevi]]e, MD., Sept.18,1987. 129. Soumerai SB, et al. Payment Restrictions for Prescription Drugs Under Medicaid. N Engl J Med 1987;317:550-556. 150. Relman AS. Doctors and The Dispensing of Drugs. N Engl J Med 1987;317:311-312. 131. Anon. Physician Dispensing Update. NARD Journal 1987;(Aug.):46. 152. Intergovernmental Health Policy Project. Major Changes in State Medicaid and Indigent Care Programa. The Ceorne Washington University. July, 1986. 153. Cheung A. Kayne R. An Application of Clinical Pharmacy Servicea in Extended Care Facilities. Calif Pharm 1975;23:32-8. _ _ 134. Sager MA, Leventhal EA and Easterling DV. The Impact of Medicare's Prospective Payment System on Wisconsin Nursing Homes. JAMA 1987;267:1762-1766. 196. Hogan GH and Abernathy GB. Effect of Catastrophic Health-Care Legislation on Hospital Pharmacy Services. Am J Hosp Ph- 2987;44:2232,2234. 136. Peck RL. Medicare-supported Hh4Os: Should Physjciana Give Up on the Frail Elderly? Geriatrics i987;42:96-96,98. 137. Gillick MR. The Impact of Health Maintenance Organizations on Geriatric Care. Ann Intern Med lQZ37;106:139-143. 138. Rabin DL, Bush PJ and Fuller NA. Drug Prescription Rates Before and After Enrollment of a Medicaid Population in an HMO. Pub1 Health Rep 1978;93:16-23 139. Konnor DD. Competitive Economics Promote Cost Consciousness. Presented at the Symposium on "The Changing Economics of Healthcare: Impact on Pharmacy in the 90'8 and Beyond." Orlando, FL, November 16, 1986. 140. Dickinson J. What Do Mail-Order Rxs Really Mean for Pharmacy. US Pharm 1987;(0ct):32,34,100. 141. Anon. Mail Order Rx Costs Are 5% Higher Than Conventional Drug Plans. The Green Sheet. F-D-C Reports, Inc., Chevy Chase, Md., September 29, 1986. 142. Waldinger CW. Drug Dispensing for the Elderly (letter]. N Engl J Med 1987;316:695. 143. Taubman AH, Truncellito M and Mattea EJ. The Brown Bag Rx Project: How It Helps Community RPhe to Provide Counseling Services. Pharm Times 1986;(Feb):73-76. 144. Morris LA and Klimberg R. A survey of the elderly's view and experiences regarding quack medicines. [in press] J Geriatr Drug Therapy. 145. Torasso P. Knowledge Based Expert Syatema for Medical Diagnosis. Stat Med 1985;4:317-325. 146. Block LH and Shukla AJ. Drug Delivery in the 1990's. US Pharm 1986;11:51-68. 147. Peck JC. Future Directions in GeriatricDrug Activities. [in press] 3 Geriatr Drug Ther. 148. Saks DF. TodaysJTrends to Spur Drug Industry Growth. US Pharm 1986;11:12-22. 149. Kataman R. Alcheimers disease. N Engl J Med 1986;314:364-375. 150. Epstein AM, Hall JA, Besdine R, et al. The Emergence of Geriatric Assessment Units: The "New Technology of Geriatrics" Ann Intern Med 1987;106:29Q-303. 161. Mullen PD and Green LW. Measuring Patient Drug Information Transfer: An Assessment of the Literature. Washington, D.C., Pharmaceutical Manufacturera Association, 1984. 152. Green LW, Mullen PD and Stainbrook GL. Programs to Reduce Drug Errora in the Elderly: Direct and Indirect Evidence From Patient Education. J Geriatr Drug Therapy 1986;1:3-18. 163. MacDonald ET, MacDonald JB, Pheonix M. Improving Compliance After Hospital Discharge. Br Med J 1977;2:618- 621. 154. Martin PC and Mead K. Reducing Medication Errors in a Geriatric Population. J Am Geriatr Sot 1982;30:258-260. 155. Ascione FJ, Shrimp LA. The Effectiveness of Four Education Strategies in the Elderly. Drug Intel1 Clin Pharm 1984;18:126-131. 156. Schafher W, Ray WA, Federspiel CP, et al. Improving Antibiotic Prescribing in OffIce Practice: A Controlled Trial of Three Educational Methods. JAMA 1983;250:1728-32. 157. Ray WA, Schaffner W, Federspiel CF. Persistence of Improvement in Antibiotic Prescribing in Office Practice. JAMA 1986;253:1774-776. 158. Ray WA, Bluer DG, Schaffner W, et al. Reducing Long-Term Diazepam Prescribing in Office Practice: A Controlled Trial of Educational Vi&s. JAMA 1986;256:2536-639. 159. Avom J and Soumerai SB. Improving Drug-Therapy Decisions Through Educational Outreach: A Randomized Controlled Trial of Academically Based "Detailing." N Engl J Med 1983;308:1457-1463. E - 19 160. Hanlon JT, Andolsek KM, Clapp-Charming NE, et al. Drug Prescribing in a Family Medicine Residency Program with a Pharmacotherapeutics Curriculum. J Med Educ 1986;61:64-67. 161. Manning PR, Lee PV, Clintworth WA, et al. Changing Prescribing Practices Through Individual Continuing Education. JAMA 1986;256:230-232. 162. Cooper JW. Effect of Initiation, Termination, and Reinitiation of Consultant Clinical Pharmacist Services in a Geriatric Long-Term Care Facility. Med Care 1985;23:84-88 163. Kidder SW. Cost-Benefit of Pharmacist-Conducted Drug-Regimen Review% Consult Pharm 1987;2:394-398. 164. Levy M, et al. Drug Utilization and Adverse Drug Reactions in Medical Patienta. Israel J Med Sci 1977;13:1065-1072. 165. Thompson JF, h&Ghan WF, Ruffalo RL. Clinical Pharmacists Prescribing Drug Therapy in a Geriatric Setting. J Am Geriatr Sot 1984;32:154-59. 166. Patterson J. Maximizing RN Potential in a Long-Tern-Care Setting. Geriatr Nursing 1987;(May/June):142-144. 167. Thomas B and Price M. Drug Reviews. J Ger Nursing 1987;13:17-21. 168. Lange RL, Martell PH, Gelbart AO, et al. Drug Therapy Communications To Family Physicians in a Nursing Home. Can Fam Physician 1986;32:2595-2598. 169. Andolsek KM, Hanlon JT, Lyons R, et al. Drug Therapy Team Review in a Long Term Care Facility. Drug Intel1 Clin Pharm 1987;21:660. 170. Williams TF. "Setting the Agenda for Geriatric Drug Research." in: Moore SR, Teal TW eds., Geriatric Drug Use -- Clinical and Social Perspectives. Pergamon Press, New York, 1985,pp.55-60. 171. World Health Organization. Health Care in the Elderly: Report on the Technical Group on Use of Medicaments by the 172. Swift CG. Trinns EJ. Clinical Pharmacokinetics in the Elderly. In: Swift CG ed. Clinical Pharmacology in the Elderly. Elderly. Drugs 19t?l;22:279-94. New York: ' M&l Dekker, P.31-82. -. 173. Millstein LG. "Issues in Geriatric Labeling Revisions." in Geriatric Drug Use -- Clinical and Social Perspectives, Pergamon Press, New York, 1985, pp.ll-21. 174. Temple R. Clinical Investigation of Drugs for use by the Elderly. [in press] J Geriatr Drug Therapy 175. Ab- WB. "Development of Drugs for use by the Elderly." in: Moore SR, Teal TW eds., Geriatric Drug Use -- Clinical and Social Perspectives. Pergamon Press, New York, 1985,pp.290-205. 176. Porta MS, Hartrema AG. Contribution of Epidemiology to the Study of Drugs. Drug Intel1 Clin Pharm 1987;21:741-7. 177. Stewart RB. Pharmacoepidemiology. Drug Intel1 Clii Pharm 1987;21:121-24. 178. Jones JK. Post-marketing Surveillance, Annual Reports, Long-term Follow-up. Drug Info J 1982;(Jan-June):87-92. 179. Wardell WM. et al. Postmarketing Surveillance of New Drugs: Review of Objectives and Methodology. J Clin Pharmacol 1979;(Feb-I&):85-Q4. -_ 180. Carson JL, Strom BL, Super KA, et al. The Association of Non-Steroidal Antiinflammatory Drum and Upper Gastrointestinal Tract Bleeding. Arch Intern Med 1987;147:85-88. 181. Fox DA, lick H. Non-Steroidal Antiinflammatory Drugs and Renal Disease. JAMA 1984;251:1299-1300. 182. Grigor RR, Spitz PW, Fur& DE. Salicylate Toxicity in Elderly Patients with Rheumatoid Arthritis. J Rheumatol 1987;14:60-66. 183. Rosai AL, et al. Ulcerogenecity of Piroxicam: An Analysis of Spontaneously Reported Data. Br Med J 1987;294:147-50. 184. Jick H. Use of Automated Data-Bases to Study Drug Effects After Marketing. Pharmacotherapy 1985;5:278-279. 185. Wegner F. Post-Marketing Surveillance (PMS) and Geriatric Drug Use. in: Moore SR, Teal TW eds., Geriatric Drug Use -- Clinical and Social Perspectives. Pergamon Press, New York, 1985,pp.95-97. 186. Hart-ma AG, Porta MS, Jilson HH. Introduction to Pharmacoepidemiology. Drug Intel1 Clin Pharm 1987;21:739-40. 187. Program Announcement for the 3rd International Conference on Pharmacoepidemiology. Pharmacoepidemiology Newsletter 1987;3:2-4. 188. Ferry ME, Lamy PP, Becker LA. Physician's Knowledge of Prescribing far the Elderly; A Study of Primary Care Physicians in Pennsylvania. J Am Geriatr Sot 1985;33:616-625. 189. Vestal RE. Clinical Pharmacology. In: Andres R, Berman EC, Hazard WR, eds. Principles of Geriatric Medicine. New York: McGraw-Hill 1985:424-443. 190. Anon. Geriatrics and the USA. [editorial] Lancet 1986;1:133-134. 191. Schneider EL, Williams FF. Geriatrics and Gerontology: Imperatives in Education and Training. Ann Intern Med 1986;104:432-35. 192. Committee on Leadership for Academic Geriatric Medicine. Report of the Institute of Medicine: Academic Geriatrics for the Year 2QOO. J Am Geriatr Sot 1987;35:773-91. 193. Lamy PP. New Dimensions and Opportunities. Drug Intel1 Clin Pharm. .1985;19:399-402. 194. Program Announcement for Merck Fellowship in Geriatric Clinical Pharmacology. 195. Anon. Roster of Residents Completing ASHP Accredited Programs in Calendar Year 1987. Am J Hosp Pharm. lQ87;44:1137-42. 196. Ksul AF, et al. Post Graduate Pharmacy Fellowships (1986-1987). Drug Intell Clin Phar 1987;21:205-210. 197. Palumbo FB. Effectiveness Measures of an Established Drug Curriculum. [in press] J Geriatr Drug Therapy. 198. Gleich CS. Innovations in Geriatric Drug Training: The Experience in the Geriatric Education Centers. [in press] J Geriatr Drug Therapy. 199. Rowe J, Beck JC, Beeson PB, et al. Report of the Institute of Medicine: Academic Geriatrics for the Year 2000. J Am Geriatr Sot 1987;35:773-791. 206. Campbell WH, Chalmem R, Cohen E, et al. Pharmacy and the Elderly. Bureau of Health Manpower, DHEW Pub.No.(HRA&l-36 Washington, D.C., 1980. 201. Health and Public Policy Committee, American College of Physicians. Medicare Payment for Physician Services. Ann Internal Med lQ87;106:151-163. E - 20 HEALTH PROMOTION AND AGING "MENTAL HEALTH" Barry J. Gurland, M.D.* and Barnett S. Meyers, M.D.+ * Director and Borne Professor of Clinical Psychiatry, Center for Geriatrics, Columbia University and NYS Office Of Mental Health. + Associate Professor of Clinical Psychiatry, New York Hospital and Cornell Medical Center. Intgoduction: The emphasis in this paper is on the direction that health promotion efforts might take to enhance the mental health of the elderly by building on the established effectiveness of primary, secondary and tertiary health care interventions. This approach accepts that health promotion strategies should invoke the capacity of elderly persons to take responsibility for their health style and care decisions and should thus make available the requisite information and a social and service environment which allow8 a proper role in such decisions; and that in- dividuals at high risk for mental health problems should be tar- geted for special efforts in health promotion as well as screen- ing, risk appraisal and early intervention programs. Partly because of space limitations, this paper does not do JUS- tice to the complexity and activity of developments in this field. A supplement will be available to address two substantial limitations in the coverage of this review: 1. The set of conditions which are discussed here are not in- tended to be exhaustive: The specific mental health conditions chosen to illustrate the discussion are in the realm of dementia, delirium, schizophrenia, depression, and anxiety. Taken together, these conditions constitute the great maJority of severe mental health problems among the elderly (alcoholism is omitted because it is covered in another background paper). Notably missing are problems which lie in the range between severe conditions and normal states: Low morale, grief reactions, loneliness, diminished self-esteem, age related slowing of intellectual processes, loss of creativity and productivity, reduced social engagement and activities, lack of. friendly relationships, changes in sexual performance with aging, and the like. These are not less important or less accessible to preventive interventions than the more severe conditions which are discussed, although ar- guably, their consequences appear to be less devastating and the urgency of the need for interventions less pressing. 2. The types of interventions which are described are not restricted to classical health promotion techniques: Biomedical treatments are covered on the grounds that these are main reference points in the content of health education, in decisions on mental health care that the elderly are called upon to make, in restructuring of social emvironments to foster autonomy and self-care, in the purposes of screening and in selecting modes of early intervention. However, some widely used interventions do not receive the space they deserve in this review: Such as stress F-l management including relaxation exercises, autogenic training, biofeedback, assertiveness training and self-hypnosis; bereave- ment counselling, easing relocation stress, resocialisation, memory training, cognitive-behavioral methods of redressing self- defeating ways of responding to perceived experiences, and skills training in coping with problems; and methods of empowering the elderly through involvement in service to others, advocacy groups, resident's councils and the like. The central reasons for the omission of discussion on these and many other interventions are lack of space and (in some instances) their uncertain relevance to the severe mental conditions that serve as the focus of the paper. Severe mental health problems: Interventions aimed at promoting the mental health of the elderly should be built on an under- standing of certain characteristics of severe mental health problems among the elderly: I. The effects of age on mental health and its treatment; as an indication of what knowledge can be transferred from experience with youger persons and what is unique to old age. II. The frequencies of specific conditions and the sites at which they may be found; to show the size and distribution of the public health problem. III. The consequences of specific conditions in terms of the distress, disability and danger to the patient, and disturbance to others; as a gauge of the urgency of the need for health promotion and preventive intervention. IV. The etiology of mental health conditions; as a guide to the potential for health promotion and preventive intervention. V. The ways in which problems are amenable to prevention; with respect to the onset, relapse or consequences of disease. VI. The barriers to seizing the opportunities that may arise for intervention; and the strategies and needed resources for enhancing the chances of successful intervention. I-The effects of sue on mental health and its treatment. There are three broad groups of elderly patients with mental health problems: 1. Those who developed their problem during adult -life and have since grown old. 2. Those who have a problem which more commonly presents in adult life but in this instance is of late onset. 3. Those whose problem typically presents in old age. The fact that the person is chronologically elderly reveals very little about the circumstances surrounding a mental health problem because the elderly are a differentiated group. Only in some elderly do mental health problems acquire a distinctive 'geriatric character'; that is show the effects of age: 1. On the clinical presentation: The picture of mental illness in old age is largely similar to that in younger patients; the specific conditions should therefor be readily recognizable by professionals familiar with adult psychiatry. Exceptions to this rule are of significance to health promotion in that potentially F-2 treatable conditions may be overlooked: for example, depression in the elderly is often overshadowed by complaints of somatic symptoms, Or masked by ambiguous descriptions of distress such as complaints of emptiness, anxiety or unease. SUbJeCtiVe report8 or ObJective signs of memory impairment dominate the clinical pic- ture in about 10% of severe depressions; phobic anxiety is often disguised as disability. 2. On outcomes: There is a tendency to underestimate the poten- tially good spontaneous and treated outcomes Lhat can be obtained with most mental conditions occurring in old age; even relative to the outcomes in younger patients. For example, schizophrenic- like states which begin in old age (paranoias or paraphrenias) even if untreated are less likely to show progressive emotional deterioration, inability to express thoughts coherently, or loss of iniative than is typical for younger schizophrenics (Kay 1963) The symptoms of adult onset schizophrenia become less troublesome to the patient and others if the patient survives to old age. However, some aspects of mental illness become more severe with agei suicidal efforts are more determined, delusional depression is frequently a serious problem (Meyers and Greenberg 1986). Paranoia tends to respond well to pharmacological treatment if the compliance of the patient is maintained (Post 1984b3); the proportions of elderly with depressions who return to normal and symptom free function after treatment are not substantially less than in younger patients (Georgotas et al 1985; Godber et al 1987). While it is true that the prognosis for the primary demen- tias is generally gaurded at the present, a small but importamt proportion of suspected cases turn out to be treatable and re- versible conditions. The successfulness of intervention in the elderly may sometimes be obscured and overlooked because of the complexity of adequate treatment and the care required in its administration. Compared with younger cases, depressions in the elderly maybe somewhat more difficult to treat because of physical complications which frequently accompany it and the age associated adJustments required in medication regimes. 3. On pharmacological treatment: Pharmacological interventions for elderly patients are given in a context of geater complexity than for younger patients. The elderly patient frequently has multiple conditions and correspondingly is often found to be on four, five or more medications; probably from more than one prescriber and several other sources such as over-the-counter and stocks of hoarded medications. There age related alterations in metabolism, protein binding, distribution, and sensitivity to and excretion of psychotropic medications which demand greater care and special experience with administration of medications. The elderly are particularly vulnerable to anticholinergic side ef- fects of psychotropics and to medication induced delirium. With certain medications (e.g. tertiary tricyclic antidepressants) it takes longer than in younger patients to achieve a steady state of the blood levels of the parent medication and its active meta- bolites, and smaller daily doses are needed to obtain therapeutic blood levels. It is not surprising that there is a higher risk of F-3 drug interactions and side-effects in the elderly: toxic or in- teractive side effects are relatively common. Accordingly, dosage and administration of psychotropic medica- tions must be adJusted to allow for age related changes. Usual practice is to start low and increase dosage slowly but the clinician must avoid falling over backwards through giving overly cautious treatment. Although there are a few studies suggesting that moderate dosages may be effective, a high rate of therapeutic success will depend upon a willingness to pursue treatment with intensity and duration where necessary; the cooperation of the patient (and in many cases the family or other caregiver) is crucial to the success of such treatment. 4. On service patterns: The elderly may be reluctant to bring their incipient mental health problems to sites offering expert treatment (for example, community mental health centers). To address rather than overwhelm these resistances, the services need to reconsider their own organization, attitudes, procedures and location as well as channels for better informing the elderly about the resources and benefits which are being offered. Since many elderly patients with mental health problems have mui- tiple conditions which cut across disciplinary boundaries, their use of services differs from that in younger patients. Mental health problems are likely to present in medical and social serv- ice settings: psychiatrists may have to expand their skills to include primary medical care and conversely, primary care physicians may have to acquire psychiatric skills; bridges be- tween social and medical settings are vital. The elderly patient will on average require the spending of con- siderable time for screening, comprehensive or multidisciplinary evaluation of their problems, the eliciting of appropriate com- munity resources, and the arranging of referrals as necessary. Coordination of services (case management) becomes important in order that the patient does not become lost or receive redundant and possibly deleteriously interacting treatments. 5, On the base rates of specific psychiatric disorders. Preven- tive services to the elderly must be matched to the age specific probamlities of specific mental health problems. The dementias and deliria become much more common with advancing age while schizophrenic syndromes decrease. The rates of depression remain considerable in clinical populations but despite stereotypes about the adversities of old age there is not an excessively high rate of maJor depression and nor other types of depression (Robins et al. 1984) among the general elderly population; it is clear that it is not normal for the elderly to be depressed and the goals of health promotion should take this into account. 6. On the person's support system. Most elderly are women, tradi- tionally the heaviest users of mental health services at all ages. Very old women are likely to be widowed; they can be dif- ficult, to reach with health promotion information or to draw into treatment and maintain in the community, especially if there is no family to act as a line of communication or to replace the F-4 care and attention formerly given by the spouse. However, about two thirds of the elderly live with someone else in the household and around 80% have a family member or friend who is willing to help look after them. Thus there is usually an opportunity for health promotion efforts to draw upon the assistance of the in- formal support network. Nevertheless, there is a call for ex- traordinary determination on the part of health promotion and prevention services to reach the needy segment of the elderly who are truely isolated. Comment: Age induced alterations in mental health and its treat- ment are sometimes for the better, not always for the worse; either way they require new understanding of the biolcgical, psychological and social processes of aging in order to adequately plan for health promotion and preventive interven- tions. Some older patients are like younger patients and some are different; it is these latter who require special geriatric ap- proaches. The principles of geriatric interventions to improve mental health are modifications of those governing adult mental heath strategies. Mental health professionals who are interested in reaching the elderly must master an additional knowledge base and set of skills, and expand the organization of their referral network for health promotion, screening, consultation, community services and relocation; and will need a deep interest in, and empathy with, the problems of the aged. There is no Justification for setting the goals of treatment at a lower level for the elderly than for younger patients; either be- cause of a presumed lesser ability to respond to treatment or the even more dubious grounds that they have a briefer life expec- tancy or less need to be optimally functional. II. The frequencies of specific conditions and the sites at which they may be found. DEMENTIAS AND DELIRIA: The dementias are a set of typically chronic syndromes in which the most striking features involve deterioration of memory, orientation, general intellectual and specific Cognitive capacities and social functioning; occurring in clear consciousness and arising usually after intellectual maturity has been reached. Among dementias in the general elderly population about 60% or more are Alzheimer's disease type, 10% or less are a relatively pure multi-infarct (or other cerebra-vascular) type and 1.5% a mixture of the last two; the remaining 15% are secondary to neurological diseases such as Huntington's Chorea or Parkin- sonism, or a so-called reversible secondary dementia arising from such causes a6 intracranial lesions, normal pressure hydrocephalua, a systemic condition or depression. Persons with primary or secondary dementia who reside in the com- munity constitute about 5% of the elderly (i.e. 65 years and over) population; persons with these dementias who reside in long F-5 stay institutions are a further 2 l/2% of the elderly population (although they constitute up to 50% of the long stay residents) (Gurland and Cross 1982). Therefore, most dementias live outside institutions. Rates of dementia rise steeply with age and reach 20% over age 80. Incidence varies from less than 1% annually at age 70 to around 4% at age 85. The lifetime risk of dementia is around 1 in 3 for males who survive to 85 years. Women are probably not more prone to develop dementia but many more of them survive to ex- treme old age where the risk is highest. The dementias must be distinguished from the deliria (acute con- fusional states), which share some of the main symptoms of demen- tia but are relatively acute in onset and course, and show a clouded or hyperaroused alteration of consciousness. Deliria typically result from systemic disorders arising outside the cranium. Deliria are frequent in medical settings, especially where the prevailing physical illnesses are acute and severe; some level of cognitive impairment (not necessarily meeting criteria for delirium) has been reported in as much as 25% or more of elderly patients in such settings (McCartney and Palmateer 1985). SCHIZOPHRENIA: Symptoms of schizophrenia occur in old age in two main contexts: 1. As a result of the aging of schizophrenics whose condition began prior to old age. 2. As part of a late on- set primary psychiatric disorder known as late-life paraphrenia in European psychiatry and as paranoia in DSM-III. Up to half the long stay patients in large psychiatric centers are elderly (Goodman and Siegel, 1986) and about half of these are-schizophrenics of earlier onset who have grown old; many of these aged schizophrenics are placed in nursing homes, especially if chronic medical problems have supervened. Paranoia is chronic but not progressive, has a predominance of paranoid delusions and often hallucinations and leads to supris- ingly little impairment of affect, volition or intellect. Among psychiatric first admissions with symptoms of schizophrenia, 10% or mor'e begin after middle age (Rabin,s 1984, Volavka and Cancro 1986 1. Paranoia is found in about 10% of psychiatric first admis- sions after the age of 60; in upwards of 3% of elderly nursing home residents and less than 2% of the community residing elderly population. Paranoia is predominantly a disorder of women, partly because this gender is the maJority group in the elderly popula- tion but also because of a much higher risk for this disorder in elderly women than in elderly men; in contrast to the gender risk for adult schizophrenia. DEPRESSION: The cluster of depressions of all types, major depression, dysthymia, cyclothymic disorder and atypical depres- sion but including also dysphorias considered to be of clinical interest, is in the region of 13% of the general elderly population; with maJor depressions accounting for l-2%. In in- patient settings the depressions of all types usually constitute F-6 about half the admissions, with maJor depressions the predominant type- Depressions of clinical interest are also frequent in out- patient psychiatry and in primary medical care; in the latter site the maJor depressions are a minority of cases (Sireling et al. 1985) while masked and atypical depressions are common. ANXIETY: It is perfectly reasonable to expect that the elderly would suffer high rates of anxiety given the frequency with which their life situations appear precarious. Nevertheless, the prevalence of anxiety disorders in the general population is around 10% of elderly women with the maJority of these being phobias, especially agoraphobias (Turnbull and Turnbull 1985) ; prevalence in males is around half that in females. Anxiety dis- orders in the elderly are seen more frequently in primary care practice than in psychiatric settings; reflecting the observation that sedatives and hypnotics are widely dispensed by primary care physicians. III. The consequences of specific conditions in terms of the distress, disability and danqer to the patient, and disturbance to others. DEMENTIA AND DELIRIUM: The primary dementias are invariably disa- bling as the disorder involves first the higher order tasks such as work, handling finances, finding the way in public places, shopping or doing household chores; at a later stage, the simple self care tasks such as bathing, dressing, use of toilet, mobility, continence and feeding. Dependence on others for assis- tance and supervision increases over time. Parietal dysfunction (difficulties in naming or understanding the use of common ObJects) obtrudes as the disease advances and, in the closing stages, seizures, spasticity, profound weight loss, intercurrent infections and coma. Life expectancy is considerably shortened by dementia unless assiduous nursing and medical care keep the com- plications (e.g. undernutrition, aspiration of food, infections and other overlooked medical illness, contractures, bedsores, overmedication, and falls) under control. Disturbing behaviors are very frequent: Aggression, nocturnal restlessness, wandering, and incontinence are particularly dis- ruptive a6d add to the heavy demands on the caregiver's time and energy. The family may be devastated also by a profound erosion of the patient's personality, a dropping of standards of decency and a patient's apparent indifference to the caregiving. Family members are more often depressed than is the patient (Gurland and Birkett 1983). The consequences of deliria depend on whether the condition is recognized and the underlying cause promptly identified and ap- propriately treated. If so, the delterious consequences are usually limited and transient; if not, the mortality rate is high, and avoidable morbidity may arise as a result of the patient's confusion (e.g. falls and fractures). SCHIZOPHRENIA: The maJority of adult onset schizophrenics achieve old age. About one third of the survivors to old age have F-7 recovered virtually completely but the remainder are left with impaired functioning; including around a third of the whole cohort who have chronic or relapsing symptoms (Ciompi 1985). With age and the passage of time the person tends to become quieter and easier to supervise or live with. Nevertheless, although patients may have few troublesome symptoms, poor social function- ing or supports may make living in the community or discharge from hospital difficult; the promotion of health among this de- pendent population can be facilitated by access to enriched al- ternative environments in the community such as group homes. The onset of paranoia is usually fairly slow. The person is preoccupied by experiences of harassment, assault, and intrusion of privacy; and eventually responds to the psychotic phenomena with vigor, making persistent complaints to authorities, striking back at neighbors because of imagined grievances, trying desperately to escape through flight or suicidal actions, or en- tering a state of withdrawn siege. Emaciation, shouting at hal- lucinations, pacing and moving furniture around an apartment, furtive nocturnal sorties and eccentric appearance may arouse the concern of others; leading to hospitalization or eviction which swells the ranks of the homeless. DEPRESSION: The distress of a depressive disorder is worse by an order of magnitude than that of normal depression. Other mood changes that accompany depression, such as irritability, apathy and loss of interest in social roles may damage the interpersonal and supportive relationships which are vital to the patient's tenure in the community. The consequential costs are not only to be measured in human terms; there are also expenditures due to increased and inappropriate use of physicians services. A prolonged episode of depression can lead to undernourishment, dehydration, inactivity and self neglect; with serious undermin- ing of the patient's physical health. Mortality rates are in- creased by depression in excess of that explainable by suicide and declines in health behaviors; one possible mechanism being an alteration of immune mechanisms. There are exceptionally high rates of suicide among elderly white males. This is a generational (cohort) phenomenon and not due to aging,(Gurland and Cross 1982); future groups of elderly white males will probably have lower rates as do current cohorts of females, and non whites. Nevertheless, the elderly tend to be deadly serious in their suicidal actions (their first attempt is likely to be their last). Behaviors which are potentially harmful to the self (eg. non compliance with medical regimes, failing to report warning symptoms of illness, neglect of diet, fighting, or falling) may sometimes be analagous to suicide attempts. These behaviors are seen quite often among the elderly in nursing homes and call for a search for an underlying depression. ANXIETY: Anxiety disorder has both an emotional component (e. g. fear, tension, dread, irritability and worried apprehension), a behavioral component (e.g. distractibility, complaints and reas- surance seeking), and, especially in the elderly a somatic com- ponent. The somatic symptoms of anxiety are both SubJective (e.g. F-8 feelings of respiratory restriction, palpitations, feeling shaky, dizziness and headache or chest pains ) and ObJective (e.g. sigh- ing and rapid breathing, trembling, diarrhea, vomiting, coughing, rapid pulse, and sweating). These'symptoms are not only distress- ing but also can be disabling and exhausting. Self medication or inappropriate presribing for relief of symptoms can lead to drug dependence and other serious side effects. Unnecessary and even harmful hospitalization may be precipitated by the presentaion of the anxiety symptoms in the guise of an acute medical (e.g. cardiac) crisis. IV. The etiology of mental health conditions. DEMENTIA AND DELIRIUM: In Alzheimer's Disease the frequency of microscopically visible senile plaques around nerve terminals and neurofibrillary tangles inside neurones in the cerebral cortex (parietal, temporal and occipital regions especially) and hip- pocampal region of the limbic system, is increased beyond age norms (Blessed et al. 1968, Katzman et al 1983 1 i dendritic processes and spines waste away. There is still uncertainty as to whether these neuropathological changes are the cause or result of brain dysfunction, and whether they are reversible up to a point. The locus coeruleus and Nucleus Basalis of Meynert are par- ticularly affected by Alzheimer changes, and through their proJections, large areas of the cerebral cortex. There is degeneration of cholinergic neurotransmitter pathways essential to memory processes; choline acetyl transferase is decreased and the production of the neurotransmitter acetylcholine is presumably reduced. The muscarinic receptors situated after the neural Juncture (post-synaptic) are not affected. There are other relevant structural and neurotransmitter changes but this basic model provides a rationale for the efforts to develop treatments which would enhance acetylcholine neural transmission in dementia through use of precursors (e. g. choline), extenders (e. g. physostigmine) and agonists (i.e. substitutes such as arecoline) (Lauter 1985). The fundgmental cause of Alzheimer's Disease is not known, and there is probably more than one. In surveys of precursors, head trauma occurs more often than expected by chance. The presence of amyloid and immunoglobulins in plaques in the brain has led to the suggestion of a brain tissue autoimmune disease; changes in brain antibody levels and the HLA histocompatibility System have given some support to this avenue of research. Possibly a break- down in the blood brain barrier allows access to damaging sub- stances such as aluminum along the lines of dialysis dementia; however the latter differs in important respects including the neuropathology. A transmissible slow virus has been sought but found consistently only in kuru and Creutzfeldt-Jacob disease. A familial pattern consistent with an autosomal dominant mode of inheritance has been reported particularly in the severe and younger cases and those with focal signs; penetrance increases with age but may be complete by the age of 90. There are also clues that there may be a link with Down's syndrome (Heston and F-9 Maatri 1977) leukemia and an older age of the mother (and perhaps tbe father) at time of the patient's birth; abnormal microfila- ments may be implicated in this triad of disorders. Recent studies have linked one form of familial patterning with trisomy and a subsection abnormality on chromosome 21; thus adding to the genetic and neuropathological overlap with Down's syndrome (Delabar 1987). Multi infarct dementia is characterized by arteriosclerosis of the blood vessels supplying the brain and numerous, usually small cerebral infarcts. Cognitive impairment rather than stroke is the predominant presentation. Presumably, the well known predisposi- tions to arteriosclerosis may play a role in multi infarct demen- tia as well. The causes of the reversible secondary dementias and of deliria are to some extent overlapping: intracranial lesions such as hematomata (trauma induced pockets of blood pressing on the brain) or tumors, systemic conditions such as pernicious anemia, or metabolic and endocrine disturbance. Deliria may additionally arise from toxic states, septic agents, drug side effects, anoxia, or an intracranial infection. Reversible dementias can further be due to normal pressure hydrocephalus (enlargement of the cerebral ventricles probably due to inadequate reabsorption of cerebrospinal fluid). or even depression. Dementias may also be secondary to alcoholism, Parkinson's disease, Huntington's chorea, Creutzfeldt-Jacob disease (caused by a transmissible agent that can be carried in transplanted tissue) and repeated head trauma. Neurosyphilis is currently still a possibility and the AIDS virus may one day increase its attack on the older age groups. SCHIZOPHRENIA: Among families of elderly patients with paranoia, the risk of a schizophrenia is raised but not as high as in families of earlier onset schizophrenics (Funding 1961, Kay 1963). The risk among relatives is raised for both adult and late onset types but with some loading towards the latter (Bridge and Wyatt 1980b). It has also been suggested that the mode of trans- mission is recessive. Women are particularly vulnerable to paranoia. The life long personality is usually abnormal: Unso- ciable, cold hearted and prone to take offense; isolated, single or divorced, or with few sibs and few children (Kay et al. 1976). .J In spite of an abnormal personality, patients with paranoia main- tain competence in the running of their own lives until the onset of the illness in old age. Socially evident deafness precedes the psychosis in a higher proportion of cases than for depressive disorder; a severe degree of hearing loss (as indicated by audiometric tests and social function) occurs more frequently than in depressives or the general elderly population (Cooper et al. 1976). The deafness usually dates back several decades and is of the type (conductive or mixed) caused by chronic middle ear disease and not by aging. DEPRESSION: There appears to be a spectrum of association between old age depression and neuropathology; with the majority of depressive disorders in old age being Just as functional as in F-10 younger persons. The neurotransmitter (biogenic amine) hypothesis is as valid for the elderly as for younger depressions; moreover, there are age related changes increasing monoamine oxidase ac- tivity (leading to increased break down of the biogenic amines) and decreasing the activity of tyrosine hydroxylase (with reduced production of biogenic amines) which reinforce the rationale for biological treatment of some of the depressions in old age. Life events are variably related to the precipitation of depres- sion among the elderly. Most depressive episodes in old age are noted to be preceded by a negative life event, generally bereave- ment or physical illness and disability; depression and physical illness occur together in the elderly at a far higher rate than is expected by chance. The absence of a confidante predisposes to depression in the face of a severe adverse life event. These facts seem in accordance with the widely held view that in old age depression is often a consequence of isolation and losses of close persons, health, material resources and status, as are likely to occur at this phase of life. A wide variety of medications may be depressogenic in elderly patients: especially the benzodiazepines, barbiturates, an- tihypertensives, digitalis, L-dopa, or anticonvulsants (Ouslander 1982). ANXIETY: Cases of anxiety disorder in the elderly (with persist- ence of symptoms for at least a month) may fall into any of the following broad classes: Panic states with or without agoraphobia, other specific phobic states, generalized anxiety disorder, or adJustment disorder with anxious mood. These diag- nostic classes and their etiologies are usually identical to those found in younger groups of patients. V. The ways in which problems are amenable to prevention. 1. Prevention of onset. DEMENTIA AND DELIRIA: Community resources which can be applied to supporting the family have been mentioned as a means of prevent- ing the onset of reactive mental illness and demoralization among these ca?egivers. Patients with dementia are at risk for superim- posed delirium, the symptoms of which may be incorrectly dis- missed as an advance in the dementia process; cases of dementia should be kept in mind for active preventive efforts. Many of the potential causes of deliria can be avoided or treated prior to their provoking the state of delirium. Mostly this in- volves providing good~primary medical care and the early treat- ment of such conditions as pernicious anemia, thyroid abnor- malities (e.g. hypothyroidism, apathetic hyperthyroidism), occult infections, malnutrition and dehydration. Attention must be given to controlling medications, especially those with anticholinergic properties, and coordinating prescriptions from all sources in- cluding multiple service providers, self medication and over-the- counter drugs. F-11 SCHIZOPHRENIA: The role of deafness in precipitating paranoia can be understood as a paradigm for the effect of poor social com- munication and lack of opportunity for reality testing in vul- nerable individuals. Other causes of poor communication such as the development of increased isolation in old age may explain the late precipitation of paranoia. The long latent interval between deafness, isolation and the onset of paranoia suggests that there are opportunities for preventive intervention aimed at improving hearing impairments and social interaction. DEPRESSION: Key life events are markers of vulnerability to depression in the elderly person: bereavement, the onset of physical disability or illness, and relocation to a venue that is perceived as undesirable. These are opportunities for counseling, and shoring up social networks; especially involving or sub- stituting for a confidante, preparation for relocation (e.g. to a nursing home) so as to inform and involve the entrant as a par- ticipant in making choices, and help with adJustment after bereavement. Among other external depressogenic agents, medica- tions rank high and should be kept to a minimum routinely. ANXIETY: The exercise of abilites which lead to experience of mastery may help to allay general anxiety; continuation of social activities may prevent the onset of restrictive agoraphobias. 2. Prevention of consequences. 2.1 THROUGH EARLY RECOGNITION: Given the highly effective treat- ments now available for a wide range of mental health problems of the elderly, it is important that remediable conditions be recog- nized and treated early. Many consequences of mental illness can thus be averted: The deterioration of the patient's health if deliria are not noticed and investigated so that the underlying condition can be reversed; the dislocation of the paranoid patient from the community and the breakdown of the patient's trust in the treatment team; the loss of independence, risk of suicide, emaciation and deleterious effects on concomitant physi- cal disorders in the patient with depression; the social isola- tion and drug dependency that can emerge when anxiety is uncontrolled; and especially the unnecessary distress that may be inflicted on the patient. In primary dementia as well, early recog'nition and intervention can prevent a rift between the patient and supporting family and the damage resulting from in- discretions, and can permit the patient and family to become edu- cated about the contingencies for which they must plan. The difficulties that must be overcome to achieve the early recognition that paves the way to early intervention involve the unfamiliarity of many practitioners with geriatric presentations of mental disorder, the mixed and atypical symptom patterns among the elderly that may make differential diagnosis complex, lack of adequate testing and investigatory techniques, insufficient time given over to taking a history from the patient and family mem- bers, and reluctance of patients to report their symptoms early or to consult specialists where advisable. DEMENTIA AND DELIRIUM: Efforts at early recognition in dementia F-12 should first be directed at the identification of reversible con- ditions, which are found in up to 20% of investigated cases (Cummings 1983, NIA Task Force 1980). The first priority in assessing patients for possible dementia is a history and a specific inquiry for symptoms of depression or delirium. Next steps are a physical examination and review of medications as causes of deliria, and a search for neurological signs or a condition associated with secondary dementia. The clinical recognition or exclusion of dementia is assisted by brief clinically feasible tests (e.g. the Mental Status Question- naire or Mini Mental Status Examination) together with other clinical information. An extensive range of widely accessible technical investigations of blood, urine, chest and heart are es- sential to detect hidden causes of deliria; and so is some form of brain imaging (usually computerized axial tomography) to help rule out an intracranial mass or normal pressure hydrocephalus, or to show up brain infarcts. Neuropsychological batteries can help to confirm a diagnosis of dementia; regional blood flow studies or electroencephalograms can assist the identification of the subtype of dementia. SCHIZOPHRENIA: The onset of paranoia almost invariably arises out of a previously abnormal asociable personality, after a long prodrome. There may be signs of an impending episode: The patient appears at first to be merely embattled and aggrieved; the victim of an unfriendly environment. An increase of complaints and rest- lessness may be noticeable. As frankly paranoid symptoms emerge the condition must be distinguished from organic and depressive syndromes. A failure to begin treatment early may leave time for the patient's delusory suspicions to include medications and the health care team and lead to the patient's withdrawal and impreg- nable resistance to receiving help. DEPRESSION: For the most part, the criteria for diagnosis of the depression subtypes may be applied to the elderly as is customary for younger patients. However, in a minority of cases there are special difficulties in diagnosing depression in the elderly be- cause of masking, complication by physical illness, or presence of cognitive impairment or striking paranoid or anxiety symptoms. J The masking of depression can be minimized by routinely probing for depressed mood and associated symptoms. Furthermore, patients who have previously had a depression and are relapsing can some- times convey that their previous symptoms are returning without being able to pinpoint a depressed mood. This underlines the value of continuing aftercare of recovered patients in view of the high rate and often subtle symptoms of relapse among elderly depressives. Distinguishing between the somatic (vegetative) symptoms of depression and the physical symptoms of medical illness or the aging process is quite a common problem (Gurland and Toner 19821: The somatic symptoms of depression include those usual for adult malor depressions but more often extend to discomforts, aches and pains which may be vague or referred to a specific site such as F-13 the chest, abdomen, urinary tract or oral area. In medical ill- ness, symptoms such as loss of energy and interest, sleep distur- bance, loss of appetite and weight may resemble the symptoms of depression; and may precede the discovery of the underlying physical illness (particularly with secondary carcinomas in the brain, apathetic hyperthyroidism, carcinoma of the head of the pancreas, uremia, pernicious anemia, heavy metal poisoning, or collagen disease). Where the differential diagnosis of depression and physical illness arises it requires a proper investigation of evidence for both conditions and a detailed examination of the symptoms and their chronological sequencing. Blood level assays may identify whether there is a medication which might be precipitating the depression. The conjunction of symptoms suggesting depression and cognitive impairment calls for distinguishing depressive dementia (pseudodementia) from depression in dementia. Depressive dementia is discovered in about 4% of patients referred for investigation of presumptive dementia (Rabins 1985). These patients tend to recover their normal cognitive functioning when the depression is relieved (Bulbena and Berrios 1986); although recent work sug- gests that after an interval of wellness (which may be lengthy) a greater than chance proportion of these cases may emerge as clearcut dementia. Recognition of the reversible depressive dementia is assisted by neuropsychological testing (Caine 1981) and certain clinical features (described by Wells, 1979, and Rabins, 1985). ANXIETY: Aging produces an increased chance of anxiety being ac- companied by a physical disorder; if the latter is present it may produce symptoms that overlap with the anxiety symptoms making differential diagnosis more difficult. In cases of late onset of anxiety disorder a determined search for a possible underlying physical condition should be instituted (Lader 1982). Even where the anxiety disorder occurs alone the physician may be unduly in- fluenced by the age of the patient to interpret the symptoms as indicating a physical (e.g. cardiovascular) disorder with a con- sequently misdirected emphasis in investigation and treatment. Several physical disorders are particularly likely to be misdiag- nosed as anxiety because they produce trembling, tachycardia and hypesexcitability (eg. hypoglycemia, hyper-thyroidism); or dread, bewilderment, weakness, dizziness, resp-iratory distress and sweating (eg. silent myocardial infarct, pulmonary embolism, small stroke or cerebral ischemic attack). Other physical condi- tions mimicking the symptoms of anxiety include excess intake of caffeine, sympathomimetic medications in non-prescription drugs for colds or allergies, and the withdrawal symptoms of sedatives, hypnotics or alcohol. Probing for a depression underlying anxiety symptoms is also a high priority since the depression if present would then be the main target of intervention. Phobic anxiety cases may not be recognized when fear or avoidance of a situation is rationalized as a disability due to frailty or chronic physical disorder. Opportunities for rehabilitation may thereby be missed. F-14 2.2 THROUGH EFFECTIVE TREATMENT: Most mental health problems of the elderly offer the prospect of complete return to normality or at least substantial improvement, if treated appropriately and in a timely fashion. This is in contrast to such physical disorders as stroke, heart disease or cancer where permanent damage is usually incurred at or preceding the time of Onset of symptoms. Conditions such as maJor depression, dysthymia, paranoia, and general anxiety are for practical purposes as functional (without permanent structural damage) in the elderly as in the young; these conditions do not in general herald the onset of dementia or other declines associated with aging. However, the functional mental health disorders of the elderly often have a long duration if neglected, and may become ir- retrievably chronic if treated too late. Thus, the successful treatment of these disorders will truncate the episode, lower prevalence rates and prevent years of individual suffering and disability; as well as remove the risks to which the patient is exposed while ill (e-g of suicide). Treatment of these 'functional' conditions in the elderly is remarkably effective if applied with skill and determination; treatment of some organic disorders such as delirium is equally effective. In the case of primary dementia, effective treatments are currently directed at secondary symptoms; treatments for the the basic intellectual changes are still evolving. DEMENTIA: The treatment of a primary dementia should follow the ruling out of reversible conditions that resemble it. The specific treatment of Alzheimer's disease is not yet out of the experimental stage. Current understanding of the pathophysiology of this condition has led to the abandonment of treatments aimed at combating anoxia and has turned attention away from drugs (such as hydergine) with uncertain and marginal effects towards those which fit the rational cholinergic model. There are several variations on this latter theme: (a) Choline, a constituent of normal diet, in the concentrated form of oral lecithin; to promote production of acetylcholine. (b) An- ticholinepterase (e.g.physostigmine) parenterally (and more recently, orally) with the intention of allowing accumulation of acetylcholine at nerve endings by preventing its breakdown. Physostigmine is short acting, but newer drugs of this class are being tried (e.g. tetrahydroaminoacridine). (c) Arecoline or the longer acting oxotremorine, in an attempt to bypass the impaired neuron and stimulate post synaptic receptor sites since these remain intact. (d) Piracetam to increase the activity Of neural cells and perhaps increase the firing rate. Interventions derived from the cholinergic hypothesis of the dementia deficits have led to measurably improved cognitive functioning in some studies but not yet of a degree and duration that has clinical significance. The search will continue for an effective drug with a lasting action and tolerable side effects, which can act at specific cholinergic sites that mediate memory processes and can capitalize on the structures that retain some F-15 functional potential, at least in the earlier stages of Alzhelmer's disease. There are also treatments specific to other subtypes of dementia. Removal of plaques in the external carotid arteries and control of hypertension may be beneficial in preventing progression of the multi infarct type- Ventricular shunts or other means of aiding the flow of cerebrospinal fluid may relieve some cases of normal pressure hydrocephalus. Treatment of behavioral problems is not specific to the subtype of dementia. A superimposed complication of dementia such as delirium or depression must first be ruled out. The patient's restlessness at night may exhaust the caregivers; simple remedies are best (eg. daily activities, a soft night light) and a short acting benzodiazepine at night only if necessary until a non pharmacological routine is established. Anxiety, irritability, suspiciousness and repetitive overactivity should also be managed without resort to chemical restraints if possible, but psychotropics may be temporarily needed. The management of the dementias should concentrate on adJusting the demands on the patient to be engaging but not overwhelming, easing the introduction to new caregivers or locations, and clarifying the information the patient needs to relate to the en- vironment, other people and time through use of signs and other cues. Depending on the level of disability entailed and the capability of the family to provide the appropriate personal as- sistance, a lengthy list of special services can be invoked in the community or in congregate sites. Social services and local chapters of self help societies devoted to this condition offer advice on obtaining services. For example, respite care (e.g. sitting services, day care, or temporary admission to a hospital or. a nursing home) is available in many communities to relieve overly taxed family caregivers and reduce the risk of permanent placement of the person in an institution. Support groups for families add emotional and practical help. Modified psychotherapy, remctivation therapy, reality orientation can be valuable aspects of care; even though the measurable benefits for cognitive functioning are slight, if any, the impact on sZlf esteem and social activity can be gratifying. The underlying condition in cases of secondary dementia or delirium is either known, strongly suspected or can be discovered by careful clinical investigation. For those causes shared by secondary dementias and deliria, or peculiar to deliria, the prognosis is good for the intellectual changes if treated in a timely fashion. For some other secondary dementias there are also helpful interventions. SCHIZOPHRENIA: In elderly patients with paranoia it is essential that compliance with treatment be-obtained although this is not easy. Without treatment very few patients will recover whereas with treatment the great maJority of patients should improve. A favorable response is usually quickly evident, and more than half the treated patients will return completely to their premorbid F-16 state, Usually an abnormal personality (Post 1964). DEPRESSION: The importance of treating depression in the elderly is supported by the good initial response (which is comparable to that obtained in younger patients), the relief of distress and functional impairment, the improvement in accompanying physical illness, and the reduction in the risk of suicide that can be ob- tained. With adequate treatment of maJor depression, the prognosis for short term improvement is good where duration is short but be- comes very gloomy if the duration is over 2 years; until other- wise proved it is safest to infer that early referral and inter- vention will reduce the proportion of refractory cases. If a medication is at fault then withdrawing it should be followed by improvement in the depressive symptoms within a few weeks. Suicide is usually preceded by a clinical depression or other psychiatric disorder. In the great maJority of elderly suicides there has been a recent contact with a psychiatrist or primary care physician suggesting that better liaison between these professionals might create an opportunity for preventive inter- vention. The risk of suicide is increased by bereavement, isola- tion and concommitant physical illness. Antidepressants are indicated for treatment of maJor depressions and other severe depressions. Differences in effectiveness be- tween the commonly used antidepressants are not yet sufficiently marked or invariant in the elderly to dictate a rote choice of medication; however, the side effects characteristic of a par- ticular medication require special consideration in the elderly (Neshkes and Jarvik 1986). The benefits of pharmacological treat- ment for depression must be weighed against side effects; of most concern are excessive sedation, cardiac arrythmias and conduction defects, orthostatic hypotension ( with the risk of falling and fracturing) or anticholinergic syndromes of the peripheral (e. g. urinary retention or narrow angle glaucoma) or central (e.g. confusional) types. Lithium carbonate is used in the elderly for the relief of the manic phase of bipolar depression, for the maintenance control of relapses in unipolar depression and as an adJuvant to antidepressants in refractory depressions. .a Electroshock therapy is a safe and effective treatment for depression in the elderly. This treatment is advisable for cases otherwise refractory to treatment, rapidly progressive, severe, suicidal or losing a high proportion of body weight. The side ef- fects of confusion or memory impairment are not lagting and are negligible with unilateral administration to the non dominant hemisphere and when the total number of treatments is not more than twelve (which should be sufficient for those who are likely to respond at all). Psychotherapy, either individual or group, is widely used by psychogeriatricians for depressed patients, either as adJuvant to physical treatments or where the latter are not appropriate. Groups are well accepted by the depressed elderly. F-17 ANXIETY: Reassurance and explanations to the patient, supportive psychotherapy, strengthening the involvement of the social net- work and reducing environmental threats are the first choices for relief of generalized anxiety in the elderly. Adequate exercise, curtailment of excessive sleeping especially during the day, regular bedtime rituals, simple relaxation routines and formal behavioral strategies for reducing tension should all be con- sidered prior to and as adJuvants to pharmacological interven- tions. Psychotherapy and cognitive therapy are also helpful. Ben- zodiazepines are relatively free of dangerous side effects and are useful when used in low dosage for short periods; over longer periods their use can be troublesome in the elderly who are prone to drug accumulation and unwanted sedative or central inhibitory effects with intellectual changes. The treatment of phobic anxiety is basically the same as in younger persons (e.g. behavior therapy) but may have to be blended with the techniques of rehabilitation medicine. Similarly, for panic disorder (with or without associated agoraphobia) the approach to treatment is like that used in young adults; tricyclic antidepressants and monoamine oxidase in- hibitors are effective. 3. Prevention of relapses. Elderly patients who have suffered and recovered from a mental health problem remain at high risk of relapse. Unless preventive steps are taken or maintenance treatment is introduced, disorders like maJor depression and general anxiety are likely to show a pattern of repeated episodes; paranoia is prone to lapse back into a chronic psychotic state; delirium may recur in a life threatening manner. Yet preventive steps or maintenance treatment can dramatically change the frequency of relapse; can make the difference between a sick and dependent patient and a person who is free of distress and able to function normally or adequately. DEMENTIA AND DELIRIUM: Preventing the relapse of behavioral problems in dementia is crucial to alleviating the patient's distress, relieving the burden on family caregivers and reducing the likelihood of the patient needing admission to a long term care facility. Techniques for keeping the patient engaged in ac- tivitiw while keeping challenges within tolerable limits have been described. SCHIZOPHRENIA: The potential for relapse of paranoia is so high that maintenance treatment is the rule. Even where maintenance is attempted, about a quarter of the patients will remain in, or return to a psychotic state. This is in contrast to the aged adult schizophrenic whose symptoms have generally become so muted that they often require little in the way of medication control. When the symptoms have abated the neuroleptic should be main- tained but reduced gradually; efforts at further cautious reduc- tion should be made every few months and drug free "holidays" at- tempted twice a year. At the first sign of relapse the previous level of dosage should be reinstituted. The goal is the lowest dose necessary to assist reasonable adJustment of the patient and F-18 minimize the elderly patient's high risk of tardive dyskinesia. More general long term measures include testing the benefit of hearing aids and relieving social isolation through day care. DEPRESSION: High rates of relapse are the rule among elderly depressives. Over 70% will recover with initial treatment but about 75% of these will relapse over the long haul unless main- tained on pharmacological treatment (Post 1984). Among treated elderly depressives about equal thirds stay well, remain depressed or recover and relapse. In any event, the psychiatrist should see the patient regularly after recovery unless there is good communication through the family or primary care prac- titioner. Cognitive therapy has been systematically evaluated in the older age group with favorable results (Borson and Raskind 1986). Its success seems to prove that the elderly, contrary to the stereotype, are capable of changing their habitual modes of thinking and reacting. By learning cognitive schemata less loaded with negative evaluations of their performance and experiences, they are able to respond with greater satisfaction and mastery to daily events. ANXIETY: Some of the measures recommended for curtailing an episode of general or phobic anxiety, should also reduce the chances of a recurrence; including supportive psychotherapy, strengthening social supports and reducing environmental threats. Similarly, the routines described for improving sleep habits and reducing tension mitigate against relapses. VI. The barriers to seizinq the opportunities that may arise for intervention; and the stratenies and needed resources for enhanc- ing the chances of successful intervention. Conventional and innovative techniques of health promotion can convey to the elderly and their support network the essential facts of mental health preventive interventions which have been reviewed here: The potential for relief of suffering and impaired functioning; the importance of seeking treatment early; the in- formation,that allows participation in treatment decisions, self monitoring of the need for initiating and cooperating in treat- ment, and Judgments on the quality of treatment being received; the effects of life event stress and the value of interpersonal relations in coping at those times; the health implications of communicating intimately with significant others; the normal men- tal health standards that are achievable in old age and the snares in attributing remediable mental health problems to a deterioration brought on by aging; methods of maintaining good mental health through good physical health, rehabilitation of disability, and discretion with medications; simple measures to regulate sleep and control anxiety; and much else. In addition to arming the elderly with such facts, health promotion programs can put the elderly in a position to press for specific organiza- tional changes consistent with the interventions they select. F-19 Some of the difficulties facing health promotion (and disease prevention) interventions are: 1. There are too few professional and non-professional service providers who have special training in the mental health problems of the elderly and the means of preventing them. 2. There is a discrepancy between the sites to which the elderly in need of intervention tend to gravitate and the sites at which special skills and treatment are available. 3. There are attitudes on the part of the elderly which mitigate against their explicitly seeking help for mental health problems, on the part of the public which lead to underestimation of the effectiveness of current treatments, and on the part of service providers which tend to deny the elderly the time and attention that they need. 4. Medicare and other reimbursement mechanisms do not cover enough ambulatory psychiatric visits (including those to residents of nursing homes) to permit adequate prevention of the onset or relapse of mental health problems; nor to deliver the services at the sites which would gain optimum contact with the population at risk; much less for health promotion for high risk groups who are not yet ill. 5. The knowledge base is still patchy on the identification of high risk indicators for mental illness among the elderly: some predictors are strong (e-g of relapses) and some weak (e.g. of first onset of depression in old age). Similarly, there is variability in the specification of ef- fective interventions: some are proven effective (e. g. an- tidepressive medications) and some are very promising but as yet uncertain in management or effect (e.g. strengthening social sup- ports to buffer stress). Research can redress these gaps in knowledge. ----_--_--------------------------------------------------------- ACKNOWLEDGMENTS: With permission, this review is based upon two papers recently prepared by the same authors; the bibliography for the citations in the text of this review is contained in the two source papers and has not been repeated here because of space limitations: Gurland BJ, Mayeux R, Meyers BS: The effectiveness of interven- tion for the mental health of the elderly, in Grimley-Evans J, Kane R and Macfadyen D. (eds) Improvinq the Health of Older People a World View. Oxford University Press, London, 1988. Gurland BJ, Meyers BS: Geriatric psychiatry, Talbott JA, Hales RE, Yudofsky S (ed6): Textbook of Psychiatry. American Psychiatric Press, 1988. F-20 EEALTB PROMOTION AND AGING NUTRITION Nancy Chapman. R.D., M.P.H. N. Chapman Associates, Inc. Ann Sorenson, H.S., Ph.D. Health Scienriat Administrator, NIA "The trick fs to live to be 100. very few people die after that." George Burns Aging is inevitable. Health promotion. including good nutrition. can slov the rate of degeneration and foiter the independence and well-being of older individuals. For years, health promotion activities targeted only younger adults. Health profes,ionaLs and adults over 65 simply accepted the high rate of chronic disease and the concomitant physical and mental impairments. Elealth-promoting dietary recommendations were generally vieved as useless. Hovever, a preponderance of evidence now suggests many potential benefits of good nutrition for older persons: 1) Life expectancy after age 65 has increased in part because of an abundant food supply, which has eliminated most nutritional deficiencLes (1). 2) Reducing body weight and excess intakes of sodium, sugars, fats, and cholesterol can lover the risk of developing hypertension, diabetes, and heart disease for many individuals and improve the management of these diseases for older as well as younger individuals (2). 3) Nutritious diets that protect physical and mental health help older people to work longer and lead independent lives (1). 4) Maintaining P reasonable weight, exercising regularly, and selecting a proper diet may retard the aging process and delay certain debilitating conditions common in old age (i.e.. osterporosis, hypertension, dementia, and diabetes) (3). 5) Preventing malnutrition can reduce the need for recurrent hospitalizations and prevent the occurrence of complicating conditions, thereby, Lowering medical costs (3). 6) Selecting the best, most economical foods to meet nutrlttonal needs and using appropriate nutrition programs can maxLmize Limited financial resources and permit Lndependent Living for the older population. 7) Correcting poor dfets for healthy older persons eliminates the need for and avoids the hazards of high doses of expensive dietary supplements (4). To de,Lgn appropriate nutrition strategies for those over 65, decision-makers need to 1) consider the heterogeneous CharacteristLcs of the elderly population, 2) differentiate age-related changes from effects of degenerative diseases, and 3) recognize the Limitations of the current research base. This paper discusses these factors as veil as other related areas -- problems in determining nutritional status and nutrient requirements of older persons, emerging research issues, and the effectiveness of current nutrition interventions. Several links between nutrition and other health promotion areas are identified. The issues identified in this paper, though not exhaustive, provide a starting point for developLng the strategies that wLLL address nutrition concerns in the rapidly groving, aging population in the U.S. CHARACTERISTICS OF OLDER PERSONS , Older persons, generally defined as individuals over the age of 65, represent a very diverse group The sex and racial composition of specific cohorts change as the subgroup ages beyond 80 years. The physical and mental capabilities of elders vithin and among older subgroups also vary widely: thus the potential benefits of nutrition therapies are not uniform. Attempting to foster independence and veil-being in this heterogeneous popuLatLon vi11 require that policy makers and health care professionals examine the distinct characteristics of two to three age strata over 65 before deveLopLng broad interventions or formulating policies. The varlacions in physiological, physical, and mental functions are grearer among older persons than among any yaunger cohort. This heterogeneity reflects, in part, the diversity Ln lifestyles, economic and social conditions, food supply, culture, education, and exposure to other environmental factors experienced daring their graving and maturing years. Genetics, of course, also plays a major role in the rate of functional loss in various organs and one's susceptibility to chronic diseases (such as cancer, coronary heart disease, diabetes, and osteoporosis). A Later section describes more fully the differences in age-related functional changes and occurrence of chronic diseases. G-L PsvchosocLal and economic determinants Many psycho*ocLol factors affect the food habits and nutritional *r.atus of the old. Depression, loss of *elf-esteem, loss of *pou*e, inability to live Lndependently, and loss of a sense of purpose =nd motLvotLon adversely affect nutrLtiona1 status by decreasing appetite and Lnterest in eating and food preparation (5). Place of residence and economic *tatus can determine access to food s~.,,,~cQs and health care services. In 1985, the majorlcy of those over 65 were vhite, non-institutionalized women, either living in a family setting (67%) or living alone (30~). Few (5X) lived in nursing homes, and mo*t of these vere over 85. After age 80 to 85, males and blacks are more likely to survive. Although many older persons maintain households, many need help with personal care and food purchasing and preparation. Older persons tend to reside more frequently in central cities, small town*. and rural areas where acce** to social and health services, nutrition program*, and food stoxes may be limited. Because older re*Ldents Ln urban and rural areas are often less educated and poores than suburban residents, their risk of nutritional problems increase* (6). The dLetary parcerns of these rural residents Lnclude large amounts of salty snacks, heavy sweets-sugar desserts, and high fat meat (7). Older persons are more likely than younger adults to be poor or live an fixed Lncomes. Federal programs (Medicare, Medicaid. Social Security) have slowed the onset of poverty for some, but more than two out of every fLve of those over 65 are poor or economically vulnerable (8). Those over 85, nonvhltes, women, and persons LLving alone experience the hLghest rate* of poverty (8, 9, 10). As Lnflatlon increases, those 1lvLng on fixed or low incomes fLnd that a larger portion of theLr income is *pent for food. The recent low Lnflation rate has partly eased this burden. PartLcLpatlon in the food stamp program, the nutrition program for seniors, and the commodity supplemental food program has aiso Lmproved older persons access to food: but these safety-net programs provide protection for only a small proportion of poor older persons (8). The cultural and socfal influences on food habits are also important to consider In planning nucr1tion strategies (10, 11, 12, 13). DavLs and Randall (14) described trends In famLly structures and gender roles, in social LntegratLon, in employment opportunities, in education and in economic stability that affected the food habits and food choices of three subgroups of the population vho would be over 65 by the year 2000. For example, individuals born betveen 1910-1930 experienced food shortages: often Lived close to their food supply: and were less educated. They may require dLfferent food offerings and educationaL cools than persons born betveen 1940-1950. NutrLtLonaL problems of the older cohort vha ate more complex carbohydrate* and Less fat may differ from the younger cohort who were exposed to more processed foods with more fats and simple sugars. A Lover fertLLlty.rate among those barn Fn 1910-30 could Limft family support a* they age compared to those born ten to twenty years later. NutrLtLonal status The nutritional status of the older persons often reflects lifetime nutrient Lntakes and food behaviors, as well as age-related conditions and socioeconomic determinants. ExperLence vith chronic degenerative dLseases and conditions, drug regimens, drug and dLet interactions, and functLona1 *tiltus also influences health. To Lntecpret the nutrition data from surveys, caution should be taken not to confuse cross-sectional data shoving secular trends Ln dietary patterns with longLtudLna1 data showing vLthLn person change* over time (15, 16, 17). The most recent survey data from NHANES II showed alder adults selecting mO*t frequently the folloviyg foods from each specific group: whole and Lov fat milk and cheese (milk group), grapefruit* and melon (fruLt group). potatoes and tomatoes (vegetables), bread, biscuits, and muffins (breads and cereals group), and ground beef (meat group) (18). The 1977-78 National Food ConsumptLon Survey data showed that one-third of older adults used whole grain bread* and that older persons were the highest users of eggs, skim milk, vegetable*, fruit*, soups and lowest u*er* of soft drLnks (19). National survey data (20) also shov that estimated food energy Lncakes decline vLth age; the Lowest mean intakes are for those 75 years and over (about 1850 kcal for males and 1400 kcal for females). Adults generally gain weight untL1 age 50; then, relative weights decline. The variance for energy intakes of those over 65 years of age Is great, due to the small numbers in this subset. Assessments of caloric intake adequacy require data on body size and physical activity. For some older persons, having been obese and consuming inappropriate Levels of sodium and perhaps, calcium, protein, and fat earlier Ln life may have raised their chances of developing hypertension, cardiovascular disease (CVD), diabetes, and cancer. DLetary cholesterol Lntakes for many over 65 (means are 461 mg for males, 316 mg for females) rematn above recommended levels for lowering the rL*k of CVD. G-2 Intakes of most nutrlenrs except vitamin C and vitamin A also appear to decrease vlth age. Foods consumed by most older adults provided adequate levels of protein, preformed niacin, viramin C, folate, and phosphorus. Intakes of calcium iron, vitamin A, thiamin, rLboflavin, and potassium for most adults either approached or failed to meet the RDAs. In general, biochemical or clinical markers of defictency were rarely found (<5x on average) Ln the older persons (21). Of concern are older women who have hFgh rates of bone fractures and related lover intakes of calcium and vitamin D-rich milk products (22, 23). Usage of dietary supplements. drugs, and alcohol An approprLate assessment of nutritional status cannot overlook the population's use of dietary supplements, drugs, and alcohol. In turn, additional data on the nutritional status and requirements may stimulate promotfon of more dietary supplement use by older persons. [Ihe elderly as targets of health fraud are discussed later.] Usage of supplements by older persons has increased from an estimated 1 percent in 1975 (24) to estimates of 40 percent narFonvLde in 1980 (25). Analysis of n-tlonal survey results s"ggests that chose vho use supplements may not be the individuals most Ln need of them (4, 22, 26, 27). Approximately half of those who use supplemental vitamins take multivitamins, Ln particular vitamin C and E (22, 28, 29). Dietary supplementation does not appear to routinely improve nutritional status for older persons. It may even lead to nutrient imbalances, toxicities and/or interactions with drugs. especially if megadoses (10 times the RDAs) are taken (4, 22, 30). Although older AmerLcans constitute about 10 percent of the population, they use about 25 percent of all prescription drugs. This 1s not surprising since many chronic diseases are managed vith prescription drugs. Over half of older people take at least one medication daily and many take six or more a day for multiple diseases. The drug-drug and drug-nutrient interactions may affect body composition, nutrient balance, or appetite, as discussed later (31). ExcessFire alcohol intakes may also advance nutrient deficiencies (i.e., thiamin, niacin and other vacer soluble nutrients), may damage organs and tissues important to nutrient utillzacion, and may depress appetite and the desire and ability to eat. The result can be poor nutritional status. Older persons have a lower tolerance for alcohol which becomes more concentrated as body water declines with age. Approximately 30X percent of those 65 and over consume alcohol on a regular basis (at least one time/week). About 15% of this cohort are considered 1Lght drinkers, 11% moderate drinkers, and 6X heavy (32). If the older persons' drinking habits are reflective of the adult population, then the 5 percent of the population vhLch drinks most heavily, accounts for about 50 percent of the total alcohol consumption. Since alcohol is a risk factor for diabetes, hypertension, cancer, and liver disease, moderation of intake is advisable at axy age. EFFECTS OF AGING AND CHRONIC DEGENERATIVE DISEASES Normal aging changes body composition, physical performance, organ system function and condition in all individuals if they live long enough: hovever, changes occur at different rates in differenr people. Even wLthin the same Individual, degeneration of various tissues and organs occurs at different rates (33). There are some 60- or 70-year-olds with organ function tests equivalent to SOmeone 30 or 40 years younger. Conversely, there are some younger individuals vith physiological capacities in the range of an average elder (34). Age-related chanxes Physiological changes in many organ systems naturally accompany the aging process. Examples of various age-related conditions that can affect the nurritlonal status of older persons include sensory impairments, altered endocrine, gastrointestinal, and cardiovascular functions, and changes in the renal and musculo-skeletal systems (35). During the aging process, changes in dentation and in the oral cavity (recession of gums and decreased salivary flov) can occur. These conditions are exacerbated by some medications. Dental caries, periodontal disease, and trauma have Led to the Loss of natural teeth in approximately 29X of those over 65 and 50% of individuals over 80. Being toothless or having ill-fitting dentures can reduce chevfng abilFty and raise the risk of choking. Well-fitting dentures are essential for chewing high fiber, nutritionally-rich foods, such as raw fruits and vegetables, vhole grain products, and nuts. The use of fluoridated water, fluoride treatments, regular dental care, and improved diet may decrease dental problems for the next generation of older persons. Less is knovn about prevention of periodontal disease, especially the potential role of nutrients (e.g., sucrose, fluoride, and calcium). [These Lssues ~111 be consLdered in background papers prepared for other vorking groups.J Decreased organ or tissue function can be accelerated by anorexia or nutrient imbalances or deficiencies related to chronic illness, use of therapeutic regimens, or lack of proper medical care. Many age-related conditions affect the older person's ability to ingest, absorb and utilize G-3 esssntill nufrlcnts. 1s well PJ obtaL" and prepare fhod. AddLcional age-related changes are di,cus,sd under emcr8i"g research issues. Chronic discnse-related channes The prevalence of hypertension, diabetes, CVD, cancer, osteoporosis, and arthritis increases with age. Four out of five older persons have at leasr one chronic condition and many have multiple problems. Obesity, affeCti" approximately 28% of older persons, is also related to many chronic diseases. Hnny of these conditions require special diets, drugs. or other therapeutic regimens that could further compromlsc nutritio"ol status. nortnlity and morbidity rates for diseases differ by gender and race. This may reflect genetic differences, lifestyle habits, or differences in access to health care. Therefore, when planning nutrition strategies, special diet-related problems should be considered by race and sex. Briefly, 1982-84 data (36, 37) show that reported rates of CVD, stroke, and cancer are higher for maLes than females, with the highest incidence =mo"g black males. Hypertension and arthritis rates are highest stmong females, especially blacks. The prevalence of diabetes is comparable for vhite males and females, but about 50X higher for black females than for white females (36, 38). This may be due to the high prevalence of obesity among older black females (37). osteoporosis. generally affects more "omen than me", measured by the higher proportion (four to one) of bone fractures in "omen than me", and more vhites than blacks (36) and Mexican AmerLca"s (39) . Eigher bone density initially explains part of these differences; but the potential for obesity may explain the racial difference and should also be explored. Associated immobility ha"dicaps a" older P~*SOII'S ability to purchase and prepare food and thus Limits food selections and independent 1iVi"g. Similarly, resorption of the residual alveolar ridge (bony ridge in which teeth are positioned) reduces the retention of dentures (40, 41) and may limit food selections. MAJOR POLICY ISSUES The previous descriptions of the socioeconomic factors, nutritionaL status, usage of drugs, alcohol and dietary supplements, and specific health problems, serve as background to the major policy issues. This section highlights the following areas to explore in developing nutrition policies for the agfng: 1) Nutrition surveillance and monitoring 2) Emerging research issues 3) Nutrlrlon services for older persons 4) Technology advances 5) Food assistance and nutrition programs 6) Nutrition education and information This Listing does not order the importance of these issues, information gathering to dissemination. but rather the logical progression from For the public, the value of research is best realized when people learn the co"se"sus on the findings through the mass media or nutrition education programs. Nutrition surveLllance Several national and state surveys have been conducted on, or include, the older population. These surveys are designed to determine the amounts and types of foods consumed, the nutrient co"te"t of intakes, the existence of cLinLca1 signs of nutritional problems, biochemic?..l evidence of sub- clinical nutritional deficiencies. and the hercatologlcal or A limited number of cross-sectional population studies supplement these national data: hovever, there is almost as much variability between individuals within a" age group as betveen group averages of age decade groups (42). The NIA Baltimore Longitudinal Study of Aging provides the only data to assess individual variations Ln intake, biochemical, anthropometric, and functional parameters. Many surveys lack documentation of dietary supplement usage. There has also been minimal nutrition surveillance and monitoring among institutionalized elders (those in ambulatory care centers and Long-term care facilities), homebound, or homeless older persons. Likewise, little Is known about older persons in defined ethnic groups such as Asian Americans, recently, native Americans, and, untL1 Hispanics. of age, Nutritional data on subgroups of older persons, in vhom malnutrition may be more comma", are also missing. such as those over 80 years It is often diffLcuLt to compare nutritional surveys which include or focus on older persons because of differences in dietary methodology and standards (43). To date, the nutrition surveys of older persons in the U.S. have been very Limited in scope, have frequently excluded the oldest old age groups. and have used varying standards of comparison in presenting the frequencies of nutrient deficiencies (33). In the NHANES I and NHANES II, adults ages 65-74 years comprised approximately 6-8X of the sample. The USDA Nationvide Food Consumption Surveys (NFCS) also collects data on the food intakes of individuals ages 65-74, representing G-4 approximately 10% of the 1977-78 NFCS. ~~ Lnformarton on individuals older than 75 was gathered from eLther survey. . Comparisons of independently-living ond institutionalized older persons The nutritional status of long-term instltutionalired =nd Independently living older persoys needs to be compared. Older persons in institutions are usually subject to fixed meals vhich may not accommodate their individual food preferences, though they often adhere to specified dLetary regimens. Often, individuals in these ,etting, lose interest in foods and eat sparingly. A national survey of geriatric patientr in institutions in the U.S. and of homebound individuals would be instructive. Halor areas to research Lnclude (44): 1. 2. 3. 4. 5. Food-energy and nutrient needs of sedentary and bedridden patients: The means to best carry out nutritional screening and a~~ts+menf of geriatric patients in these facilities: The interpretation of clinical, anthropometric, hematologfcal, and biochemical indices of nutritional stat"3 in chronically sick older patients, with or without age-related conditions (i.e., skin disease, renal dysfunction, anemia, and muscle wasting): The responsiveness of patients shoving one or more indices of malnutrition to nutrient .upplementatlon: and Acceptable values for nutrit~0~~1 status indicators in nursing home patients. . Methods of nutritional assessment Dietary Fntakes documented Later in Life may not correlate vith anthropometric. biochemical measurements. or clinical evaluations taken at the same time. Often these measurements more closely describe a myriad of historical experiences and long-term food intakes. Longitudinal studies provide information that begins to explain possible relationships of intakes to other measurements. To standardize the result.3 of geriatric nutrLtiona1 studies, a core set of assessment tools needs to be identified and then used routinely (as a minimum) for all studies or surveys. Nutrient and energy intakes are determined using 24-hour recalls, food records, food frequencies and dietary hlatorles. Interpretation of the histories requires standards. Appropriate standards for various age-subgroups of older persons do not exist. ComparLsons are made to nutritional data from NEIANES I and II and the 1977-78 NECS despite limitations identified earlier. Reliability of Lnformation in these dietary histories has also been questioned. Memory, vision, and hearing may decline vith age. making it more difficult to recall accurately foods previously eaten. Likevise, arthrlcfs may impede record keeping. AnthropometrLc measurements (e.g., height, weight, and skinfolds) are affected by aging. for example, height decreases over time due to changes in the integrity of the skeletal system. Measurements are often hard to obtain because of poor posture, or the LnabLlLty of the older persons to stand erect unassisted. For these LndivLduals, recumbent length, total arm length, knee height and arm span have been proposed as alternative methods to estimate stature (45, 46). More research on the reliability of these measurements Is needed before they can be recommended as routine clinical practice. Actual weight is less difficult to measure than height. For ambulatory people, a calibrated balance beam scale is used. For the non-ambulatory, wheel chair or bed balance beam scales are available. Beforjz weighing, the patient's hydration state should be noted, as severe edema or dehydration can distort actual velght and anthropometric measurements (47). Skinfold measurements are also affected by the age-related decrease in lean body mass that results in a larger proportion of body weight aa fat. Fat stores are also redistributed truncally. Changes in skin compressibility and elasticity hinder interpretation of sklnfold measurements (33). Biochemical parameters may be affected by an age-related decline in renal function, by shifts in fluid balance, by drug-drug or drug-nutrient interactions, by the long-term effects of chronic or coexisting disease, and by malnutrition. For example, low serum albumin levels often indicate poor nutritional status: however, kidney and Liver disease, cancer, congestive heart failure, and other diseases (common among older persons) cause marked reductions in serum albumin (37). Ruling out chcse conditions muSt be done before lov serum albumin concentration is associated vlth malnutrition alone. ~~~ accurate results, bLochemicaL analysis should use several blood and void samples (48, 49, 50). The moat effective clinical methods of nutritional assessment are based on physical examinations and observation, and reflect long-term nutritional status. Clinical evaluations must be highly 3crutlnized because of the potential for human error, especially vhen large numbers are evaluated. For example, several age-related changes In clinical appearance--dry skin, sensory loss, and sparse hair -- may appear to be representative of one or more nutrient deflcLencles (47). Other limitations in assessment methodology are discussed later. G-S EmerRinR research isSUeS Nutrition and aging research focuses on two general areas: issues related to interaction of diet and aging functions (i.e., physiological, psychological, sociological) and dietary relationships with pathological conditlon3 common to old age. More specifically, much of the current research is directed tovard the following topics: 1) 2) 3) 4) 5) 6) 7) 8) 9) The effects of aging on nutrient digestion, absorptton and utilization and the relationship between these effects and nutrient requirements. The role of dietary restriction in modifying age-related physiological changes or the role of diet in treating conditions associated vith changes in immune and endocrine functions and changes in body composition. The influence or effects of neurological, environmental, and dietary factors on senile dementia or sensory deficits in older persons. The influence of physiological, behnvloral, and environmental factors (e.g., sensory function, dental status, culture, cognition, and economics) on the quality and quantity of food eaten by older individuals, and on the relationship betveen various patterns of dietary intake and nutritional and health status. The nutritional changes including changes in food intake vhich accompany chronic diseases common In the older person. The role of nutrition and nutritional status during adult years in the etiology and prthogenesis of diseases and problems of older persons. The effect of therapeutic regimens (i.e., drugs, surgery) on nutritional status and the effects of nutritional status on the efficacy of therapeutic agents. The associetion betveen nutritional status and morbidity and mortality -- examining patterns of dietary intake and mortality. Valid methodologies for use in assessing nutritional status in older persons and in establishing age-appropriate norms. Although recent estimates suggest that 20X of the population in the year 2010 vi11 be over 60, and that one half of those will be at least 75 years of age, much of the research base on nutrition, ag*ng, and health is quite immature. An increase in the understanding of these dynamic interrelationships can improve the quality of life of the aged, provide more effective health care, and lessen the impact of aging on the health of older persons. A balance of animal experiments, epidemiologic research, and clinical trials is needed to study the nutritional status and requirements of geriatrics. To assess nutritional status Ldeally requires 1) determining daily consumption of energy and nutrients, 2) measuring tissue levels of nutrients, 3) clinical examinations including anthropometric measurements, and 4) evaluating physical and mental function. Current assessments of older persons are handicapped by a lack of appropriate age-related biomarkers and valid standards for intake and biochemical and anthropometric values to vhlch survey results can be compared. The related limitation in methodology and gaps in research knowledge were discussed under the nutrition surveillance section. Many of the gaps in our knowledge about nutrition and aging are being investigated by NIA-supported researchers and by researchers at the NIA, the USDA Human Nutrition Research Center on Aging, and other government and private research centers around the country. . Effects of aging on dietary intakes and eating patterns The need for research on socioeconomic influences on eating behaviors of older persons and the biopsycho#ocial antecedents of age-related changes in eating habits will be discussed in this section. There is a need to clearly differentiate generational patterns in selection and eating of foods from changes in eating habits which are age-specific. Since previous educational, social, economic, and cultural erperlences vary widely among various cohorts of individuals over age 65 y.ZZlrs, these influences on food use and preparation patterns need to be separated from late life modifications in eating habits that result from age-related physical changes, chronic diseases, and lifestyle changes (51). Little is knovn about the diets and nutritional status of individuals 75 years of age and older, who are part of the most rapidly graving and frailest segment of the U.S. population. Future research also needs to address the differences in dietary patterns associated with various stages in the late life cycle and with the variety of settings vithin which older persons Live (i.e., alone, with family, or institutionalized). In addition, the effects of interventions. social or nutritional, at these various stages and in these settings need to be evaluated (51). Among the socioeconomic factors, the type and level of income are particularly important. Poverty, for example, can restrict the amount and frequency of food purchases and also influence housing, cooking facilities, and overall health (3). Eating patterns and food choices are also determined by family structure, social situations, emotional statu,, cultural and religious beliefs, and living arra.ngements. Therefore, retirement, children leaving home, divorce or death of spouse, a G-6 move to an institution, P new community, or p resLdence with limited cooking facilities. or entering or ix-entering the labor force later in Life can introduce changes in the food purchases, food preparation methods, and eating environment. These change*. along with social isolation and psychological problems, may cause nnorexin or disinterest in food. Boredom can lead to over eating or snacking. LCVin'S (52) SOCial net,,ork analyses and Gifft's (53) exam*n=ti*n *f nutr*t**n. behavior, and change provide approaches to determine "hat social interactions change vith age and hov these changes effect nutritional statUs. Research that has identified food- and nutrition-related ottttudes and knovledge of older persons will be discussed Ln the last section. Age-related sensory impairments and prescriptions for special diets further affect food choices. Loss of vision may restrict ability to prepare food or obtain food. Loss of hearing may constrain socializing at mealtime or may make it dif- ficult to get information on menu items or food products. Loss of smell and taste acuity may directly affect appetite and decrease the desire to eat (54, 55). Professionally prescribed diets such as lov sodium, lov fat, and low sugar may further depress appetite and increase anorexia. -future research should investigate the effect of special diets on food intakes and nev vays to formulate appetizing foods lover in specific nutrients, yet acceptable to the target population. Answers to these questions vi11 certainly require cooperation among gerontologists, physiologists, and food scientists. . Aging, and energy and nutrient requirements The nutritional requirements of those over 65 are difficult to determine and are largely unknown. Undetected disease and use of dietary supplements or medication complicate the task of defining population samples that are representative of various strata of older persons. In addition, there are fev controlled metabolic studies in humans related to micronutrient metabolism in aging (21). An examination of long-term diets of very old people who have remained healthy until an advanced age may shed light on nutrient needs of older persons. At present, most nutrienr requirements are generally age invariant. However, RDAs for all persons over 51 are extrapolated from data collected painly on males ages 20 to 30 years of age (48, 56). Current research on the vitamin nucriture of older persons may provide data to modify the current recommendations, especially as the relationships betveen specific nutrients and chronic diseases unfold or if never RDAs optimize health and tissue function. Energy needs decline vith age because of decrease in metabolism related to a decrease in physical activity and loss of lean body mass. Since energy needs decline vhile nutrient needs remain stable or perhaps increase, recommending nutrient levels in terms of veight of the nutrient per 1000 kcal or per unit of lean body mass may be particularly useful for those over age 65 years. Conversely, energy intake restriction and exercise affect aging. This topic ~111 be addressed later. Protein synthesis appears to decline with age (44, 57), as does the synthesis of muscle tissues, organ tissue, and other protein moieties (e.g., collagen, immune system components, and enzymes) (33). Declining protein intakes do not appear to affect deleteriously older populations vho have no evidence of wasting diseases (57). Nitrogen and dietary protein requirements may, however, be increased in response to physiological stress common in older persons (i.e., infections, fractures, surgery and burns) (56). Preventing protein deficiency with attendant hypoalbuminemia is most important in older persons when protein-bound drugs are taken (44). Patients with renal or hepatic disease may require protein restrict- Lens. Hovever, the quantity and type of protein best able to meet the needs of older people has not been ascertained, even for healthy populations. Present evidenc&indicates that vitamin A and ribaflavln absorption or tissue levels do not decline vith age, despite intakes that are lover than the present RDA (17). Research on the role of carotenoids in cancer etiology may indicate advantages of increased intakes. Age does not appear to affect folate absorption and/or metabolism, except in individuals vith atrophic gastritis (58). Individuals vith hypo- and acholorhydria may compensate for the malabsorption through increased bacterial folate synthesis. Some research suggests that the RDAs for viramin D. B6, and B12 might be too Low, at least for certain groups of older persons (21). Reduced vitamin D synthesis in the skin, lack of sun exposure, lav intakes, and impaired l-a hydroxylation depress vitamin D production in older persons (59). For nav. increased sun exposure combined vith low-dose supplementation (i.e., 10 ug/day) (21) or tvice-per- year regimen of 2.5 mg vitamin D2 (60) are recommended for housebound older persons to maintain adequate serum vitamin D. Both human and animal research suggest age-related seductions in vitamin 86 absorption and metabolism (e.g. impaired pyridoxal phosphate formation or increased urinary excretion), but more conclusive data are needed to suggest changes in the RDA (21). Serum vitamin 812 levels appear to decline vith increasing age, perhaps because of pernicious anemia and/or atrophic gastritis-related malabsorption (21). Negative health consequences of these changes have not been documented (61). There is no consistent evidence for linking vitamin E, chiamin, or vitamin C requirements vith age. The effect of increasing dietary vitamin E levels on tissue lipid peroxidation and platelet G-J vit;lmin E Levels (and function) needs further exploration (21). Age-related changes in thiamin absorption vary depending on the a**es*ment method used: however, it is veil knovn that alcohol interferes vith thlamfn absorption and phosphorylation. Age-related declines in vitamin C Levels in the blood, plasma, and Leukocytes are reported in most studies: hovever, changes in tissue Levels are less canalstent (21). Smoking (62), medication (63). and environmental stress (64) combined vlth Lov intake*, can compromise vLtamLn C Status, but the health consequences of these observations are not veil-estnbilshed (34). UntLL improved method* for biochemical evaluations of vitamin K and nLacLn nutriture are available, Lt Ls difficult to determine changes in nutrient requirements for these vitamins. Incomplete food tables handicap studies on zinc, copper, chromium, and selenium *tat"* of the older persons. Fluid intake. especially vater, declines in older persons along with a age-related Loss of body vater. Adequate vater intake (e.g., 30 ml/kg of body weight) or approximately 1 ml of water for each calorie ingested) (64) Is reasonable and important to normal renal and hovel function (5, 65). Several questfons are important to consider in setting nutritional requirement* for the aging (44): 1. Can ve formulate dietary recommendations that mitigate against development of aging changes in body composition? 2. Since diseases such as o3ceoporo*is, atherosclerosis, and cancer are in part age-related and appear to have Long Latency periods, can ve offer guidelines for the diets of younger people vhich vi11 protect them from the development of these disease*? 3. What crLteria should ve use to determine the nutrient needs of elders? 4. What are the specially formulated preventive health goals for the elderly? Should they change with successLve age strata over 65 years? . Effects of energy intake and expenditures on the aging process Although some older persons seek the "fountain of youth" in dietary supplements, the ansver to deceleration of the aging process may be found in caloric deprivation or increased energy expenditure. Energy intake restriction (ER) vithout essenttal nutrient deficiency has been the only intervention in animals that extends maxLmum Lifespan in all species tested and across wide phylogenetic differences. Long-term national studies of persons on Lov calorie diets are often confounded by Low Levels of nutrients and/or poor personal health habits. UaLford et al. (66) d escribed four phases that trace the hLstory of ER in the study of aging. Initial vork shoved that ER slovs the biological aging process and favorably affects the incidence and age of onset of malignancies, arthritis, renal disease, and osteoporasis in animals. Secondly, animal studies demonstrated that ER animals had slowed age-related changes (not necessarily disease-"' related) in the immune system. Liver enzymes, age pigment*, behavioral and psychomotor pattern*. The third phase is P search for mechanisms that suggest causality that might Lnclude altered gene eXpreSSiOn, thymic hormone Levels, protection against free radical injury, and DNA repair. Descriptions of the effect of ER on cLrcuLatLng levels of in+uLLn, somatostatin, thyroxine, and other hormones are needed. Exploring energy restriction in humans is the next phase. Increasing energy expendLture through exercise also appears to influence mortality and morbidity through a number of complex physLoLagLca1 mechanisms. The effect* of inactivLty mimic the effect* of aging (67): almost 5OZ of the functional decline attributed to aging may in fact be related to inactivity (68). Combined with a calorie-appropriate diet, exercise maintains a reasonable body veight, Lean body ma** and good physical performance. This combination also helps to prevent or reduce fat cell hypertrophy, production of high density Lipoproteins (HDLs), hypertension, osteoporosis and insulin resistance. [A separate background paper explores exercise in more detail.1 With the increasing interest in the effects of peroxidation processes on aging, intervention vith various antioxidant*, including vitamins A, C, and E and selenium has been tried in both animal and human trials but the results have been mixed or inconcLusive. More research is needed in this area. . Drug and nutrient/food interactions The high use of drugs among the aging may further compromise their health. The average older person receives more than 13 prescriptions a year and may take a* many as 6 drugs at a time. Cardiac drugs (e.g., diuretics) are most videly used by the aging population, folloved by drugs to treat arthritis. psychic disorders, and respiratory and gastrointestinal conditions. Uany of these diseases are diet- related, and the use of drugs may complement, supplement, or supplant diet therapy. Long-term use of a variety of drugs (often at high doses) raises the risk of drug-nutrient interact ions. Individuals with nutrLtionaLly inadequate intakes and impaired nutritional Status are at the highest risk. Use of high-potency nutrient supplements may also affect drug efficacy. G-8 Physician, need to cxplaln carefully the potential side-effects vhen certain drugs and food./$oppLements are taken together. For some older persons, altering the drug therapy may be more appropriate than recommending dietary changes or food restrictions. Periodic assessments can ide,,tify borderline nutritionrl status that require appropriate dietary recommendations, nutrient supplementation. or change in drug regimen. Roe (44, 69) has detailed several areas of drug-nutrient interactions. Thele include 1) diet effects on drug disposition, 2) drug disposition in malnourished subjects, 3) drug induced mrlnutrition, and 4) drug-food and drug-nutrient incompatibilities. Key Lntcrnction3 relevant to the aging population are discussed belov and more detail on drug use is provided in a separate background paper. More research la needed to explain these interactions and to determine their clir,icrL Si&`nifiC-Cc in the aging Population. Foods component, and nutrients can affect drug absorption and metabolism. Heavy metals, high fat intakes and, to P Lesser extent, high protein foods delay gastric emptying and, thus, delay the passage of drugs into the small intestines. Kigh protein diets may also accelerate hepatic drug mcraboLism. A fasting state may hasten drug absorption from an empty stomach. Malnutrition also alters drug absorprLon, protein binding, drug metabolism and drug clearance. Protein-bound drugs such as varfarin and diazepam may be more toxic in patients vith hyponlbuminemlo. On the other hand, some drugs decrease absorption of nutrients or cause mineral depletion. Such drugs include Laxatives, antacids, anti-inflammatories (e.g., asptrin), diuretics, antibiotics, analgesics (e.g., Lndomethacin), and hypocholesterolemics (e.g., cholestpramine). Appetite can be enhanced by tricyclic antidepressants, reserpine, antihistamines, and anabolic steroids, vhereos amphetamines and related drugs depress the appetite. But the aging process can reverse these effects. Phenothlazine, a psychotropic agent, that usually increases food intake may decrease oppetlte in older persons whose race of drug metabolism Is slaved. Specific foods or alcoholic beverages can precipitate adverse reactions to drugs. Some reactions such as the tyrnmine rcaccions with monoamine oxidase inhibitors may be Life-threatening, while others such as the reactions caused by disulfiram and hypoglycemic agents to alcohol are extremely unpleasant. Guidelines for drug development are needed that include studies In the elderly and consideration of various drug and food/nutrient interactions. Initially, research must determine hov much drug efficacy and safety might improve with proposed guidelines (70). The quality of such research depends 1x1 part on the reltability of nutritional status assessments conducted and nutritional standards applied. Education-information transfer about drug-nutrient interactions for the public and the caregivers also needs consideration (70). . Diet and chronic degenerative conditions The prevalence of chronic conditions, such as osteoporosis, gastrointestLna1 disorders, diabetes, cardiovascular disease, and central nervous system disorders, increases with age. Questions about the role of nutrition in delaying the onset or mitigating the consequences of these conditions are the focus of NIA-sponsored research and conferences. The following examples are illustrations of aging and nutrition research topics: Osteoporosis: Osteoporosis 1s defined as an absolute decrease in the amount of bone, Leading to fracture, after minimal trauma. Although age-related bone Loss is common, certain older persons are at higher risk of developing fractures than others. Riggs (71, 72) suggests that osteoporosis may be two distinct bonethinning syndromes: I) a "postmenopausal" form (Type I), associated wLth estrogen deficiancy and 2) P "senile" form (Type II). highly correlated vlth aging. Type 1, occurring predominantly In females 15-20 years after menopause, thins trabecular bones (e.g.. vertebral bodies, ultradistal radius (forearm), and mandibles) that Lead to fractures and tooth loss. Type 11, occurring mainly in persons of both sexes over 75 years, thins both the cortical bone and trabecular bones proportionately, Leads to fractures of hip, femur, tibia, and pelvis. Definitive etiologies for either the early deficit in trabecular bones in Type I or gradual thinning in Type II need to be determined. Pharmacokinetic studies using calcitonin and dlphosphonates have begun to explain the ceLluLar mechanisms of bone resorption. Other studies (73, 74) have suggested risk factors including insufficient bone density at maturity, lov levels of endogenous estrogen and other hormones, prolonged immobility and weightlessness, Long term use of corticosteroids, family history, impaired intestinal or renal function, and diet. Prevention of osteoporosis has become a public health concern and has brought the promotion of foods high in c.alcium (e.g., milk products), calcium fortified foods (e.g., cereals, breads, and sofr drinks), high potency calcium supplements, and other nutrient supplements. NIB Consensus Conference (75) recommended calcium Lntakes at P Level of 1000 to 1500 mg, estrogen therapy, and exercise for Questions remain about 1) what Levels of calcium intakes are most protective against age-related bone Loss and do these Levels vary with age or sex of individual. 2) do calcium requirements vary with the Level and type of physical activity, 3) hov does calcfum intake/supplementation interact G-9 vith estrogen status, 4) do calcium, fluoride, and vitamin D metabolltes protect bones independently or in conjunction vlth estrogen therapy, veight-bearing exercise, or other approaches, and 5) how do vitamin D, protein, phosphorus, and even alcohol affect calcium requirements. Lastly. designing precise methods for measurement of bone mass 1s critical for dererminlng relationships becveen diet and bone loss for the population or assessing the risk of bone fractures in individuals so as to use prophylactic therapy most effectively (76). Osteoarthritis (OA) also causes great pain, Lmmobility, and loss of independence for many aging individuals. Although nutrient deficiencies or excesses have not been implicated in this disease, obesity has been found to be associated vlch OA of the knee and hip but not of the sacroiliac joint (77). Glpcation in diabetes and cardiovascular disease: Glycation or non-enzymatic glycosylation may well be involved in the etLology of a number of age-related diseases. GLycosylation describes the process whereby glucose, fructose, or galactose react vith proteins or nuclerc acids to form a Schiff base. The Schlff base undergoes further changes to form advanced glycosylation end (AGE) products. The excessive accumulation of AGE products in the tissues, especial1y in the arterial valls, acceIerates progressive stiffening or rigidity of these tissues. This rigidity may be caused by the cross-linking of proteins (e.g., collagen) and increases vith age. Elevated glucose concentrations characteristic of diabetes promote advanced glycosylation, thus accelerating stiffness of the tissues. Such rigidity may Lead to reduced elasticity in the cardiovascular system. As a result, cardiac function declines, renal blood flow decreases, and vital lung capacity and oxygen uptake also decline. Further studies on advanced glycation may elucidate the mechanisms involved in the formation of senile cataracts, aging peripheral nervous system, and etiology of atherosclerotic plaques. apochlorhydria: New research lnitlatives are studying the effects of aging on gastric secretions and the subsequent impact on nutritional stat"s of the older persons. Hypochlorhydria incidence increases with age and may affect up to one-third of those people over 60 years of age. women are more often affected than men. but the current extent of the problem and those at highest risk for disease are not knovn. Future epidemiologic studies of hypochlorhydria must be based on a common standardized case definlrion in order to assess the impact of aging on the disease. The causes of hypochlorhydria and the commonly associated atrophic gastritis are also largely unknovn, yet these disorders have far reaching implications for health maintenance in the older population. The major clinical implications of hypochlorhydrla are altered absorption of nutrients and drugs in the upper gastrointestinal tract, bacterial over grovth resulting in infections and changes in the immune response, and the predisposition to other diseases and disorders. Defective absorption of calcium, iron, folate, and vitamin B12 and the related deficiency diseases are of particular concern in hypochlorhydric patients. Reduced production of hydrochloric acid may affect the development of gastric cancer. B-vitamins