This is a aoawwkat, belated reply to yopv letter of July 1st.

Ymk observed CPOII) reac.tiona the bscterir f'rm

the very begbmlng.
cheak for. rpeciilolty.
sive axaslinstian wax the past few yearr of thio oroaai hybridization.
'LhSs was started by 'Ilmkofrky and hse been continued by David Qillergie
in the bacteria and by Ritossa in hi@m forare.  The cenkral larue la
to aheek whether a hcrtcsrolcagow hybrid with ribosaml RM actuaUy
invollver the *~ibosd cistrons" of the CharllQnging DIOA. Ue have
be- wing the hroropBi3.u mmteriol as WQU u varlour atrains of 5,
coli which we hove found contain different &reo of the ribod
RBUI, to conlxol this.  Without thirs reset of' lnfurm@tioa, no certain
conchalone CM be dram,  Wa will probably be writing much of thir
araterlal in the netu fut;ure. The trouble 18 w have BO much because
we waited until we were certain.
aaushg (e.g, 3% btwdap1, chicken and drosolphilr),

That lr why WB usad viral and nrraarrliyll DSA to

$ubrsqumtky, w8 carried out a fairly e%ten-

-

The wxwnt of ribord hosaology is

X am sanding you a cropy of a paper which is to war in the


           I up Just In the process of fbfahing up

JMB whioh dercrlbes ouc ~bw &hod of hybrid d&ectia which ir extremely
a~~~t~, sensitivct, end convenient. I am also includfng u preprint on
our
three nore paperr on this sy8tea.  The z-eamn why this work ha8 sudden-
ly bl08sonatd forth is that we have Plmlly been able to make Infectious
$IRA ixl the test-tube in nuursivs quurtitirsc.
that we are really etu4ylng the ri@t reaction,
cover, you will receive some more raprlntr of s papsr given at ItQFseUes.

synthesizing ryoten.

mis gives us eanfidencs
  Alio, undsr separate

     X do hope to be out on the West coast In late October shce f
will be attendbg a met- of the Acedesy In Mattle,  It ir nore than
likely that I will be ia and around the B.y area the week of October l8,

With kindest regards,

linceretly yours,

SS:m

8. lilpiegelxm
.oPesror of xicroblology