INDIANA UNIVERSITY

BLOOMINGTON, INDIANA

DEPARTMENT OF ZOOLOGY

October 19, 1946

Dr. Sol Spiegelman
Department of Bacteriology
School of Medicine
Washington University
Euclid Avenue and Kifig's tiighway
St. Louis, Missouri.

Dear Sol:

I urderstand completely the difficulties that you are having with Busch

and only hope, for your sake and for the sake of the other investigators
wrking on yeast, that you may eventually be able to clear up the difficulties
that now conflont you in sending out  cultures.
like the same circumstances as the others do want your cultures,  since we
wanted them for classroom use only.  Thanks for your kind offer to  send the
diploid adaptable strains, but I think we must pass up your offer because
our primary purpose would be to demonstrate some of the geneac phenomena
rather than adaptation.

We, of course, are in nothing

You have probably already seen the answer to your question about Preer's

mrk for it has appeared in the current issue of the Proceedings of the
National Academy.

  I was particularly happy to hear that Lindegren is revising his C.S.H.
manuscript so that much of the discussion will become unnecessary.
would seem to me a much better way of doing things and I hope that it might
be arranged that the discussors of his paper can see his revision so as to
make corresponding changes in the discussion.  I heard some comments about
the St. Louis Missouri Botanical Garden Symposium which I hope will not be
repeated about the C.S.H. Symposium.  Apparently, there were some revisions
in the manuscripts that made much of the discusston pointless, yet the dis-
cussers were not informed of the manuscript changes, and the consequence was
that part of the discussion seemed quite pointless in print.
would do a good deed all around if you could use your influence to see that
such blunders do not happen with respect to the C.S.H. papers.  I should be
glad, for example, if you would suggest to Lindegren that he and I exchange
manuscripts in order to adjust our discussions correspondingly.  I muld be
glad to make this suggestion myself,but I think that taking everything into
consideration it might be more effective if it were initiated by a third
pe r son .

That

I think you

  Our work on the killer substance has progressed with very gratifying
rapidity within the last few months,  and
discuss the matter with you at some length, perhaps in Boston i& not sooner.
As soon as I found out that we were to have a Biochemist, I mde up my midL
that the most practicable approach would. be to concentrate first on the killer
stuff itself, not kappa.  I concentrated our efforts on pushing as far as
possible our knowledge of this substance (which we now call paramecin) so
as to get the Biochemist off to as good a start as possible.
cision was a wise one because our efforts have paid off to an unexpected
degree .

I hope to have an opportunity to

I think the de-

-2-

You have certainly put your finger on the critical problems in your

own work, and, though they are tough as you well know, I think it will turn
out in the end that your plan of attack is a Wise one.

With very best wishes for success,

Cordially ,