Mr. Lloyd Shearer
140 N;>. Hanil ttsn Orlve
Beverly Hills, California 90231

Dear L I oyd:

Here are sane thoughts on a "Maonshot on Cancer."

Modlcal and biologtcol sc'lenSfsts tend to bo -arsditionalfsfs and indlvld-
ual lsts havir,!: very  1 ittle conf idencs In large scale or "big" sclsnce.
Wst arct pcrt-l'ir.it3 srientlsts spending much of their time either In teaching,

   : 36 dnlvcrs: ;y achiofstration, al I of which nseds to be dma. How-
ever, :;ifh a feti? nofaple oxceptians, having only par" Plmo available for
research crf ntccssity moans theynrnwt limit Oho scape of fhoir programs.
Targz-i-ccf i;rq-ms -fo s;.fvo mjar disacse ara 0u.f of sig;iT and aut of mind;
ixrc3vcr, thsy are als:, disapproved of %or twr, reasons:
to n3-t succead In ail efforts atteaptcd, a safe assuc+*iion sinco many
dffforent hyp3thoses 8nd leads musf be examined slrnuftaneously and many
\.rill St? found faulty; 2) It titif! succeed, In whlch case th6 targstcd big
science prog-eia prwides $03 much competition for academe and their modest
effcsr-iis are tat In the mass of data aceurnulatod.

0 tkay arc Iikoiy

?here i;re thcrofore powerfuf strongly mcraivatsd tendencies In the biomedical
scien"r+lc cannunity to limit the extent of government sponsored Targeted big
science pro$rains having sufficient scape to achieve solu*ions to problems
such eci concw, cardfovascular diseases and genetically doterminod defects  in
cf;ildhct.sd and chronic disease in old age.
rola-kivoly farge scate suppcr? of basic biomedical science, which has- achieved
WTB in prorwi-ing human heatth in the last 30 years than had been achieved in
tb provtous 1300 years, was fha resulP of.s-fron5 support. by a small  number of
inteitigcnP Cmgrecismen and Ssnatws and a few knowtcdgeebls and dedicated
faymcn.  Al.Pf,wgh grs&fy aid& by i9 few far-soclng modical sciontists and
educator; This mmarnent was no? ?he result of a ground swell suppart from the
~oncrali-ty of tiomedical Ins0itutlons, scienfists, educators 3r practftioners;
insfead a d3g-in-the-rnangor a-kfitude has prevailed ammgst many  ff no? mst
esfcbllshed scTenSisSs and educators. This unfortunate sltuatIon is'not con-
fined .tc, Phe h'cstern sctontiflc establishment; if anything, ft Is likely to
bo VJXS~ in tho USSR.

It should be quite clear that the

Enclosed is o shwt "Paint of Vlew" article for the cover fcsturo of the
Docoxber Cuilotin of the UICC (Internatfmaf Union Against Cancer); also
a preprint of my Cherry Hill presontatfon.

i enjayed my two evonings with you and our dfscusslons about almost everything.
Please give my regards 40 your wife and son.

Sincerely,

Rabert J. Huebner, M.D., Chief
Viral Carcinogenesis Branch
Nak i 3na I Cancer I nsj i *uta