Septamber 26, 1950

Dr. and !&I). 0. P. Cor1
Washington University School of Hsdlcina
gins's Highway
Saint Louis, Missouri

Pear Doctor and Mre. Corl:

Many thanks for your kind congratulatory marsage.
would have the opportunity of reelng you In Bethssda to tell poa persan-
ally how indebted f felt to both of yan in so numy ways.  We are looking
forward to when you may be able to eoie to efther a Study Section or an
Acardew seeti% and spen&,some pleasant $ours as we have in the paet.

I waa hoping that It

%e local excitement; concerns the appointls~nt of DCKItor Sebrell a@ D1reetor
of the EIXH to succeed Doctor Dyer who le retiring because ef age.  I fhlnlr
betor Sebrsll'e eppoiatmont will b. a favorable OM for ua.  both from the
stlsndpoint of his interest in letting people do what they enjoy doing anh
hit genuine dislike for elaborate administrative strvetnrts.

f might mention some of the labbratory derelopraent6 that dght be of Inter-
art to yon: Homcker seems to have some fairly good evidence that the
oxidation of phoaphogluooaate In yeast procsede by way of beta-keto oxi-
dation; decarboxylation to a ribulase phoaphtls whleh is In ~quillbrlum
wfth rfbose-5-phosphats.  He has sepwrated there two pentors phosphates
chromatographlaally and la now'trying to purify the enayme in order to
localize the initial reaction.

Ssegrnlllar and Herecker haw been able to work out a rynthesii of glucoae-6-
phosphate by the use of polyphoephate to a paint where wlth only a few days'
work one can obtain approximately 40 ~raaie of 84 purity or more.

Xeppal has been able to purify yeast lnorganlc: pJFophosphataae about ten-
fold beyond %he Brniley and Webb preparation.
genous at this point, but there Is hardly any a8n;~r&~1ce of that.
the important stepa in the preparation is to &e a rather alkaline extrwt
of dry yeast which is about 50 times richer in activity than the autolyzate
of frsah yeast.

The preparation pray ba homo-

One of

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