February 25, 1977 Dr. Donald S. Fredrickson Director National Institutes of Health Bethesda, Maryland 20014 Dear Don: First 9 want to tell you how pleased I am that the Secretary of HEN retained you as Director and, as re- ported in Science, made gestures of strong support for the BIE. It's a fine start. I realize that the issue of recombinant DNA research is even more troublesome than it was in June of last year when we last met in San Francisco and talked about it. I was shocked then by the ugly tone of Sinsheher's address to the ,American Society of Biological Chemists and by the warm response it received from an audience that should have been revolted by it. In the interim it has become even clearer to me that what we now must fear most, is not the remte possibility of biological warfare, but instead the war on biology. If we succumb through weakness or confusion to the forces who are attacking scientific inquiry in the G.S., I am certain that the frontiers of genetic research will develop else- where (e.g., Soviet Union, China, Israel) and will provide a refuge for American scientists. This is a lesson from history that does not need to be learned painfully still again. My best wishes for your efforts on behalf of reason and the national welfare. Sincerely, Arthur Romberg