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The Oswald T. Avery Collection

Title:

The Significance of Pneumococcal Types

Description:

According to Avery's colleague and biographer, Rene Dubos, Griffith's findings in this article were like "exploding a bombshell in the field of pneumococcal immunology." In it, he described his observation of an experiment in which R cells of type I pneumococcus transformed into S cells of type II in the course of his experiment. Griffith's findings here were highly influential on several members of Avery's lab, including Martin Dawson and Lionel Alloway. This article was originally published in January 1928.

Number of Image Pages:

48 (5,132,306 Bytes)

Date:

1966

Creator:

Griffith, Fred

Source:

Periodical: Griffith, Fred. "The Significance of Pneumococcal Types." Journal of Hygiene 64, 2 (1966): 129-175. Article. 48 Images.

Publisher:

Cambridge University Press

Rights:

Reproduced with the permission of Cambridge University Press. Any reproduction or copying of this material in any format, beyond single copying by an authorized person for individual use, must first receive the written consent of Cambridge University Press.

Subject:

Medical Subject Headings (MeSH):: Research; Serology; Transformation, Bacterial

Exhibit Category:

Shifting Focus: Early Work on Bacterial Transformation, 1928-1940

Relation:

The Transformation of Pneumococcal Types: I. The Conversion of R Forms of Pneumococcus into S Forms of the Homologous Type [and] II. The Interconvertibility of Type-Specific S Pneumococci (January 1, 1930)

The Transformation In Vitro of R Pneumococci into S Forms of Different Specific Types by the Use of Filtered Pneumococcus Extracts (January 1, 1932)

Box Number: 1

Folder Number: 8

Unique Identifier:

CCAAOD

Document Type:

Articles

Language:

English

Format:

application/pdf

image/tif

Physical Condition:

Good

Series: Research and Discovery of the Transforming Principle, 1912-1999

SubSeries: Preliminary Research

Folder: Scientific Articles, 1928-1937, 1966, 1980-1984

Metadata Last Modified Date:

2007-01-31

Annotation by Joshua Lederberg:

Node:  Frederick Griffith died in London Blitz April 1941, aet. 60.
See Lancet 5/3/41 (p.588-589 for obit.  Also 
U DOWNIE, AW
TI PNEUMOCOCCAL TRANSFORMATION - BACKWARD VIEW - FOURTH GRIFFITH
   MEMORIAL LECTURE
SO JOURNAL OF GENERAL MICROBIOLOGY
VL 73: 1 - & ; 1972;

more:

jl 1/26/03

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