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The Oswald T. Avery Collection

Title:
[Notes on the biological interpretation of Fred Griffith's finding] pdf (62,306 Bytes) transcript of pdf
[Notes on the biological interpretation of Fred Griffith's finding]
Number of Image Pages:
1 (62,306 Bytes)
Date:
1956
Creator:
Lederberg, Joshua
Source:
Periodical: Lederberg, Joshua. [Notes on the biological interpretation of Fred Griffith's finding]. American Scientist 44, 3 (1956): 268-269. Notes. 1 Image.
Publisher:
Sigma Xi, The Scientific Research Society
Rights:
Reproduced with permission of Sigma Xi, The Scientific Research Society.
Subject:
Medical Subject Headings (MeSH):
Transformation, Genetic
Exhibit Categories:
Shifting Focus: Early Work on Bacterial Transformation, 1928-1940
After the Discovery: The Transforming Principle's Reception by the Scientific Community
Relation:
Metadata Record Genetic Transduction (July 1956) (in The Joshua Lederberg Papers) pdf (1,846,664 Bytes) ocr (50,667 Bytes)
/ps/access/BBABGL.pdf
Box Number: 5
Folder Number: 4
Unique Identifier:
CCAAQX
Document Type:
Notes
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Commentary on Avery and His Work, 1944-2005
SubSeries: Inquiries on Avery
Folder: 50th Anniversary of the 1944 Article, 1993-1995
Transcript:
slides--my talk 2/94
These spectacular discoveries in biochemistry ran far ahead of the genetic study of the pneumococcus transformation, which relied on the capsule as a sole genetic marker. Until this study was broadened about 1951 with experiments on drug resistance and other markers (8, 9), a variety of opinions were forwarded (mostly on a purely speculative level) on the biological interpretation of Griffith's finding. They included the following versions of the transforming substance:
1. It was a specific mutagen with a special ability to direct a particular gene to mutate in a definite direction.
2. It was a polysaccharide autocatalyst (perhaps as a complex with DNA) that primed an enzymatic reaction for polysaccharide synthesis.
3. It was a bacterial virus, which on infecting the bacteria provoked capsular synthesis as a host reaction.
4. It was an autonomous cytoplasmic gene or a morphogenetic inducer.
5. It might be acting at a distance without penetrating the bacterium.
6. It was a fragment of the genetic make-up of the bacterium, the only one to have been tested to that time.
7. It was an element sui generis for which no general conception should be adduced.
Lederberg 1956.
Metadata Last Modified Date:
2008-09-26

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