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The Edward D. Freis Papers

The Veterans Administration Hospital and Georgetown University School of Medicine, 1949-1964: Documents

[Edward Freis at his desk]. September 1958.
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Metadata Record Freis, Edward D., Frank A. Finnerty Jr, and William B. Walsh. "The Treatment of Severe Essential Hypertension." The Medical Clinics of North America 34, 6 (November 1950): 1741-1750. Article. 10 Images. pdf (1,049,445 Bytes) ocr (30,024 Bytes)
"The Treatment of Severe Essential Hypertension." November 1950.
Metadata Record Finnerty, Frank A. Jr, and Edward D. Freis. "Experimental and Clinical Evaluation in Man of Hexamethonium (C6), A New Ganglionic Blocking Agent." Circulation II, 6 (December 1950): 828-836. Article. 9 Images. pdf (1,204,030 Bytes) ocr (35,858 Bytes)
"Experimental and Clinical Evaluation in Man of Hexamethonium (C6), A New Ganglionic Blocking Agent." December 1950.
Metadata Record Freis, Edward D., J. Calvin MacKay, and William F. Oliver. "The Effect of 'Sympatholytic' Drugs on the Cardiovascular Responses to Epinephrine and Norepinephrine in Man." Circulation III, 2 (February 1951): 254-259. Article. 6 Images. pdf (812,117 Bytes) ocr (26,492 Bytes)
"The Effect of 'Sympatholytic' Drugs on the Cardiovascular Responses to Epinephrine and Norepinephrine in Man." February 1951.
Metadata Record Freis, Edward D. "Veratrum Viride and Hexamethonium in the Treatment of Severe Diastolic Hypertension." The Medical Annals of the District of Columbia XX, 6 (June 1951): 297-304. Article. 8 Images. pdf (1,063,660 Bytes) ocr (31,645 Bytes)
"Veratrum Viride and Hexamethonium in the Treatment of Severe Diastolic Hypertension." June 1951.
Metadata Record Johnson, Robert L., Edward D. Freis, and Harold W. Schnaper. "Hemodynamic Changes in the Small Vessels in Man as Analyzed by Digital Plethysmography." Angiology 2, 5 (October 1951): 412-422. Article. 11 Images. pdf (1,338,853 Bytes) ocr (29,928 Bytes)
"Hemodynamic Changes in the Small Vessels in Man as Analyzed by Digital Plethysmography." October 1951.
Metadata Record Freis, Edward D., Joseph R. Stanton, Frank A. Finnerty Jr, Harold W. Schnaper, Robert L. Johnson, Charles E. Rath, and Robert W. Wilkins. "The Collapse Produced by Venous Congestion of the Extremities or by Venesection Following Certain Hypotensive Agents." The Journal of Clinical Investigation 30, (1951): 435-444. Article. 10 Images. pdf (1,439,628 Bytes) ocr (38,571 Bytes)
"The Collapse Produced by Venous Congestion of the Extremities or by Venesection Following Certain Hypotensive Agents." 1951.
Metadata Record Freis, Edward D., Frank A. Finnerty Jr, Harold W. Schnaper, and Robert L. Johnson. "The Treatment of Hypertension with Hexamethonium." Circulation V, 1 (January 1952): 20-27. Article. 8 Images. pdf (1,099,493 Bytes) ocr (33,581 Bytes)
"The Treatment of Hypertension with Hexamethonium." January 1952.
Metadata Record Freis, Edward D., Thomas F. Higgins, and Harold J. Morowitz. "Transcapillary Exchange Rates of Deuterium Oxide and Thiocyanate in the Forearm of Man." The Journal of Applied Physiology 5, 9 (March 1953): 526-532. Article. 7 Images. pdf (640,082 Bytes) ocr (18,971 Bytes)
"Transcapillary Exchange Rates of Deuterium Oxide and Thiocyanate in the Forearm of Man." March 1953.
Metadata Record Rose, John C., Saul R. Gilford, Herbert P. Broida, Anton Soler, Edward A. Partenope, and Edward D. Freis. "Clinical and Investigative Application of a New Instrument for Continuous Recording of Blood Pressure and Heart Rate." New England Journal of Medicine 249, (8 October 1953): 1-8. Article. 8 Images. pdf (793,090 Bytes) ocr (10,864 Bytes)
"Clinical and Investigative Application of a New Instrument for Continuous Recording of Blood Pressure and Heart Rate." 8 October 1953.
Metadata Record Freis, Edward D., and Recep Ari. "Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension." Annals of the New York Academy of Sciences 59, (30 April 1954): 45-53. Article. 9 Images. pdf (796,651 Bytes) ocr (14,628 Bytes)
"Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension." 30 April 1954.
Metadata Record Freis, Edward D., Edward A. Partenope, Lawrence S. Lilienfield, and John C. Rose. "A Clinical Appraisal of Pentapyrrolidinium (M&B 2050) in Hypertensive Patients." Circulation IX, 4 (April 1954): 540-546. Article. 7 Images. pdf (954,891 Bytes) ocr (29,728 Bytes)
"A Clinical Appraisal of Pentapyrrolidinium (M&B 2050) in Hypertensive Patients." April 1954.
Metadata Record Freis, Edward D. "The Discrepancy Between Home and Office Recordings of Blood Pressure in Patients under Treatment with Pentapyrrolidinium. Importance of Home Recordings in Adjusting Dosages." The Medical Annals of the District of Columbia XXIII, 7 (July 1954): 363-368. Article. 6 Images. pdf (753,515 Bytes) ocr (20,185 Bytes)
"The Discrepancy Between Home and Office Recordings of Blood Pressure in Patients under Treatment with Pentapyrrolidinium. Importance of Home Recordings in Adjusting Dosages." July 1954.
Metadata Record de Kruif, Paul. "Rauwolfia Against High Blood Pressure." Reader's Digest 65, 388 (August 1954): 31-36. Article. 6 Images. pdf (543,374 Bytes) ocr (15,584 Bytes)
"Rauwolfia Against High Blood Pressure." August 1954.
Metadata Record Freis, Edward D. "Adverse Effects of Antihypertensive Drugs." GP X, 5 (November 1954): 32-33. Article. 2 Images. pdf (201,617 Bytes) ocr (5,842 Bytes)
"Adverse Effects of Antihypertensive Drugs." November 1954.
Metadata Record Freis, Edward D. "Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine." New England Journal of Medicine 251, (16 December 1954): 1006-1008. Article. 2 Images. pdf (354,242 Bytes) ocr (14,398 Bytes)
"Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine." 16 December 1954.
Metadata Record Rose, John C., Herbert P. Broida, Charles A. Hufnagel, John F. Gillespie, Pierre J. Rabile, and Edward D. Freis. "A Method for the Study of the Circulation in the Dog Using a Mechanical Left Ventricle." The Journal of Applied Physiology 7, 5 (March 1955): 580-584. Article. 5 Images. pdf (737,282 Bytes) ocr (19,137 Bytes)
"A Method for the Study of the Circulation in the Dog Using a Mechanical Left Ventricle." March 1955.
Metadata Record Freis, Edward D., Herbert P. Broida, Charles A. Hufnagel, and John C. Rose. "Effects of Varying the Output of a Mechanical Left Ventricle on the Circulation in the Dog." The American Journal of Physiology 182, 1 (July 1955): 191-196. Article. 6 Images. pdf (642,823 Bytes) ocr (19,957 Bytes)
"Effects of Varying the Output of a Mechanical Left Ventricle on the Circulation in the Dog." July 1955.
Metadata Record Freis, Edward D., and Ilse M. Wilson. "Mecamylamine, a New, Orally Effective, Hypotensive Agent." Archives of Internal Medicine 97, (May 1956): 1-11. Article. 11 Images. pdf (1,442,995 Bytes) ocr (42,285 Bytes)
"Mecamylamine, a New, Orally Effective, Hypotensive Agent." May 1956.
Metadata Record Freis, Edward D., and Ilse M. Wilson. "Results of Prolonged Treatment with Pentolinium Tartrate with Special Reference to the Addition of Rauwolfia, Hydralazine or Both." Circulation XIII, 6 (June 1956): 856-865. Article. 10 Images. pdf (1,319,636 Bytes) ocr (34,097 Bytes)
"Results of Prolonged Treatment with Pentolinium Tartrate with Special Reference to the Addition of Rauwolfia, Hydralazine or Both." June 1956.
Metadata Record Freis, Edward D. "Hypertension: Current Status of Therapy--Hope for the Future." The Journal of the National Medical Association 48, 4 (July 1956): 252-263. Article. 12 Images. pdf (1,791,361 Bytes) ocr (55,933 Bytes)
"Hypertension: Current Status of Therapy--Hope for the Future." July 1956.
Metadata Record Freis, Edward D., and Harold W. Schnaper. "Transcapillary Loss, Equilibrium Time, Half-Return Time of Thiocyanate and Heavy Water in the Forearm." Proceedings of the Society for Experimental Biology and Medicine 92, (1956): 188-194. Article. 7 Images. pdf (835,400 Bytes) ocr (24,932 Bytes)
"Transcapillary Loss, Equilibrium Time, Half-Return Time of Thiocyanate and Heavy Water in the Forearm." 1956.
Metadata Record Rose, John C., and Edward D. Freis. "Alterations in Systemic Vascular Volume of the Dog in Response to Hexamethonium and Norepinephrine." The American Journal of Physiology 191, 2 (November 1957): 283-286. Article. 4 Images. pdf (571,108 Bytes) ocr (15,914 Bytes)
"Alterations in Systemic Vascular Volume of the Dog in Response to Hexamethonium and Norepinephrine." November 1957.
Metadata Record Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. "Treatment of Essential Hypertension with Chlorothiazide (Diuril): Its Use Alone and Combined with Other Antihypertensive Agents." Journal of the American Medical Association 166, 2 (11 January 1958): 137-140. Article. 4 Images. pdf (581,708 Bytes) ocr (19,853 Bytes)
"Treatment of Essential Hypertension with Chlorothiazide (Diuril): Its Use Alone and Combined with Other Antihypertensive Agents." 11 January 1958.
Metadata Record Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. "Chlorothiazide in Hypertensive and Normotensive Patients." Annals of the New York Academy of Sciences 71, 4 (3 February 1958): 450-455. Article. 6 Images. pdf (555,409 Bytes) ocr (15,573 Bytes)
"Chlorothiazide in Hypertensive and Normotensive Patients." 3 February 1958.
Metadata Record Freis, Edward D., and Harold W. Schnaper. "The Effects of a Variety of Hemodynamic Changes on the Rapid and Slow Components of the Circulation in the Human Forearm." The Journal of Clinical Investigation 37, 6 (June 1958): 838-845. Article. 8 Images. pdf (886,109 Bytes) ocr (30,709 Bytes)
"The Effects of a Variety of Hemodynamic Changes on the Rapid and Slow Components of the Circulation in the Human Forearm." June 1958.
Metadata Record Freis, Edward D. "Chlorothiazide in Hypertension." The Heart Bulletin 7, ([November-December 1958]): 105-107. Article. 3 Images. pdf (463,495 Bytes) ocr (14,337 Bytes)
"Chlorothiazide in Hypertension." [November-December 1958].
Metadata Record Freis, Edward D. "Rationale and Methods for the Treatment of Early Essential Hypertension." The Journal of the National Medical Association 50, 6 (November 1958): 405-412. Article. 8 Images. pdf (1,025,038 Bytes) ocr (33,532 Bytes)
"Rationale and Methods for the Treatment of Early Essential Hypertension." November 1958.
Metadata Record Frohlich, Edward D., Frank J. Fedor, William V. C. Leahy, and Edward D. Freis. "Evaluation of I131-Labelled Diodrast Renograms with Suggestions on Improving the Technic." The Medical Annals of the District of Columbia XXVIII, 6 (June 1959): 324-329. Article. 6 Images. pdf (639,957 Bytes) ocr (16,614 Bytes)
"Evaluation of I131-Labelled Diodrast Renograms with Suggestions on Improving the Technic." June 1959.
Metadata Record Frohlich, Edward D., and Edward D. Freis. "Clinical Trial of Guanethidine, a New Type of Antihypertensive Agent." The Medical Annals of the District of Columbia XXVIII, 8 (August 1959): 419-422. Article. 4 Images. pdf (404,969 Bytes) ocr (12,209 Bytes)
"Clinical Trial of Guanethidine, a New Type of Antihypertensive Agent." August 1959.
Metadata Record Wilson, Ilse M., and Edward D. Freis. "Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide." Circulation XX, 6 (December 1959): 1028-1036. Article. 9 Images. pdf (1,081,294 Bytes) ocr (34,921 Bytes)
"Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide." December 1959.
Metadata Record Freis, Edward D. "Hemodynamics of Hypertension." Physiological Reviews 40, 1 (January 1960): 27-54. Article. 28 Images. pdf (3,349,787 Bytes) ocr (105,844 Bytes)
"Hemodynamics of Hypertension." January 1960.
Metadata Record Freis, Edward D. "The Role of Hypertension." The American Journal of Public Health and the Nation's Health 50, 3 (March 1960): 11-13. Article. 3 Images. pdf (312,820 Bytes) ocr (9,505 Bytes)
"The Role of Hypertension." March 1960.
Metadata Record Freis, Edward D. "Mechanism of the Antihypertensive Effects of Diuretics: Possible Role of Salt in Hypertension." Clinical Pharmacology and Therapeutics 1, 3 ([May-June 1960]): 337-344. Article. 8 Images. pdf (906,302 Bytes) ocr (27,702 Bytes)
"Mechanism of the Antihypertensive Effects of Diuretics: Possible Role of Salt in Hypertension." [May-June 1960].
Metadata Record Frohlich, Edward D., Harold W. Schnaper, Ilse M. Wilson, and Edward D. Freis. "Hemodynamic Alterations in Hypertensive Patients Due to Chlorothiazide." New England Journal of Medicine 262, (23 June 1960): 1-3. Article. 3 Images. pdf (310,264 Bytes) ocr (11,919 Bytes)
"Hemodynamic Alterations in Hypertensive Patients Due to Chlorothiazide." 23 June 1960.
Metadata Record Veterans Administration Cooperative Study Group on Antihypertensive Agents. "A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate." Archives of Internal Medicine 106, (July 1960): 81-96. Article. 16 Images. pdf (2,061,210 Bytes) ocr (69,365 Bytes)
"A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate." July 1960.
Metadata Record Freis, Edward D. "Bretylium & Guanethidine: Two New Drugs Producing Specific Blockade of the Sympathetic Nervous System." The Heart Bulletin 9, 5 ([September-October 1960]): 88-89. Article. 2 Images. pdf (272,514 Bytes) ocr (9,009 Bytes)
"Bretylium & Guanethidine: Two New Drugs Producing Specific Blockade of the Sympathetic Nervous System." [September-October 1960].
Metadata Record Mohler, Emile R. Jr, and Edward D. Freis. "Five-Year Survival of Patients with Malignant Hypertension Treated with Antihypertensive Agents." The American Heart Journal 60, 3 (September 1960): 329-335. Article. 7 Images. pdf (677,162 Bytes) ocr (20,503 Bytes)
"Five-Year Survival of Patients with Malignant Hypertension Treated with Antihypertensive Agents." September 1960.
Metadata Record Freis, Edward D. "Pathogenesis of Organic Changes in Chronic Hypertension and Hemodynamic Effects of Antihypertensive Agents." Chapter 17 in Clinical Cardiopulmonary Physiology, edited by [Burgess L. Gordon]. Grune & Stratton, 1960. Pp. 295-302. Article. Excerpt. Monograph. 8 Images. pdf (1,174,923 Bytes) ocr (36,446 Bytes)
"Pathogenesis of Organic Changes in Chronic Hypertension and Hemodynamic Effects of Antihypertensive Agents." 1960.
Metadata Record Freis, Edward D. "Hemodynamic Changes in Hypertension." The Medical Clinics of North America 45, 2 (March 1961): 239-245. Article. 7 Images. pdf (655,995 Bytes) ocr (18,196 Bytes)
"Hemodynamic Changes in Hypertension." March 1961.
Metadata Record Freis, Edward D. "Current Concepts in Therapy: Antihypertensive Agents. II. Benzothiadiazine Compounds, Rauwolfia and Hydralazine." New England Journal of Medicine 266, (22 March 1962): 1-3. Article. 3 Images. pdf (429,324 Bytes) ocr (15,774 Bytes)
"Current Concepts in Therapy: Antihypertensive Agents. II. Benzothiadiazine Compounds, Rauwolfia and Hydralazine." 22 March 1962.
Metadata Record Freis, Edward D. "Current Concepts in Therapy: Antihypertensive Agents. III." New England Journal of Medicine 266, (12 April 1962): 775-777. Article. 2 Images. pdf (348,284 Bytes) ocr (13,461 Bytes)
"Current Concepts in Therapy: Antihypertensive Agents. III." 12 April 1962.
Metadata Record Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Double Blind Control Study of Antihypertensive Agents: II. Further Report on the Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglion Blocking Agents, Chlorisondamine, Mecamylamine, and Pentolinium Tartrate." Archives of Internal Medicine 110, (August 1962): 222-229. Article. 8 Images. pdf (1,046,052 Bytes) ocr (31,397 Bytes)
"Double Blind Control Study of Antihypertensive Agents: II. Further Report on the Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglion Blocking Agents, Chlorisondamine, Mecamylamine, and Pentolinium Tartrate." August 1962.
Metadata Record Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Double Blind Control Study of Antihypertensive Agents: III. Chlorothiazide Alone and in Combination with Other Agents; Preliminary Results." Archives of Internal Medicine 110, (August 1962): 230-236. Article. 7 Images. pdf (822,988 Bytes) ocr (26,216 Bytes)
"Double Blind Control Study of Antihypertensive Agents: III. Chlorothiazide Alone and in Combination with Other Agents; Preliminary Results." August 1962.
Metadata Record Veterans Administration Cooperative Study Group on Antihypertensive Agents. "An Evaluation of the Sodium Amytal Sedation Test in Male Hypertensive Patients." The American Heart Journal 64, 4 (October 1962): 473-482. Article. 10 Images. pdf (1,059,331 Bytes) ocr (32,222 Bytes)
"An Evaluation of the Sodium Amytal Sedation Test in Male Hypertensive Patients." October 1962.
Metadata Record Freis, Edward D. "Evaluation of Toxicity in Long-Term Clinical Trials." Journal of the American Medical Association 187, 5 (1 February 1964): 352-355. Article. 4 Images. pdf (684,021 Bytes) ocr (22,659 Bytes)
"Evaluation of Toxicity in Long-Term Clinical Trials." 1 February 1964.
Metadata Record Freis, Edward D. "Antihypertensive Therapy." Chapter 6 in Molecular Modification in Drug Design. [American Chemical Society], 1964. Pp. 67-76. Article. 10 Images. pdf (986,551 Bytes) ocr (28,852 Bytes)
"Antihypertensive Therapy." 1964.