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The Edward D. Freis Papers

Further Readings

[Edward Freis at his desk]. [ca. 1990].
Web Resources

Albert and Mary Lasker Foundation. 1971 Winner Albert Lasker Award for Clinical Medical Research. The Lasker Foundation. http://www.laskerfoundation.org/awards/1971clinical.htmExit
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Manuscript Collections

The National Library of Medicine. History of Medicine Division. Finding Aid to the Edward D. Freis Papers, 1926-2004. http://oculus.nlm.nih.gov/freis550


Books

Freis, Edward D. "Clinical Pharmacology and Use of Chlorothiazide in the Treatment of Hypertension." In Hypertension. Edited by John H. Moyer. New York: W. B. Saunders Company, 1959.

Freis, Edward D. "Clinical Use of Ganglion Blocking Agents in the Treatment of Hypertension and a Comparison of Different Blocking Agents." In Hypertension. Edited by John H. Moyer. New York: W. B. Saunders Company, 1959.

Freis, Edward D. "Observations on Cardiac Output, Peripheral Blood Flow and Blood Volume in Hypertension--Before and During Treatment." In Hypertension. Edited by John H. Moyer. New York: W. B. Saunders Company, 1959.

Articles

1940s

Freis, Edward D., and Robert W. Wilkins. "Effect of Pentaquine in Patients with Hypertension." Proceedings of the Society for Experimental Biology and Medicine 64 (1947): 455-458.

Freis, Edward D., and Reginald H. Smithwick. "The Effect of Lumbodorsal Splanchnicectomy on the Blood Volume and 'Thiocyanate Space' of Patients with Essential Hypertension." American Journal of the Medical Sciences 214 (October 1947): 363-367.

Freis, Edward D. "Recent Advances in the Medical Treatment of Essential Hypertension with Particular Reference to Drugs." The Medical Clinics of North America 32, no. 5 (September 1948): 1247-1258.

Freis, Edward D., and Joseph R. Stanton. "A Clinical Evaluation of Veratrum Viride in the Treatment of Essential Hypertension." American Heart Journal 36, no. 5 (November 1948): 1-16.

Freis, Edward D., Joseph R. Stanton, Julius Litter, James W. Culbertson, Meyer H. Halperin, F. Corbin Moister, and Robert W. Wilkins. "The Hemodynamic Effects of Hypotensive Drugs in Man. II. Dihydroergocornine." Journal of Clinical Investigation XXVIII, no. 6 (November 1949): 1387-1402.

1950s

Freis, Edward D., Joseph R. Stanton, and F. Corbin Moister. "Assay in Man of the Chemical Fractions of Veratrum Viride, and Identification of the Pure Alkaloids Germitrine and Germidine as Potent Hypotensive Principles Derived from the Drug." Journal of Pharmacology and Experimental Therapeutics 98, no. 2 (February 1950): 166-173.

Freis, Edward D., Frank A. Finnerty Jr., and William B. Walsh. "The Treatment of Severe Essential Hypertension." The Medical Clinics of North America 34, no. 6 (November 1950): 1741-1750.

Finnerty, Frank A. Jr., and Edward D. Freis. "Experimental and Clinical Evaluation in Man of Hexamethonium (C6), A New Ganglionic Blocking Agent." Circulation II, no. 6 (December 1950): 828-836.

Freis, Edward D., Joseph R. Stanton, Frank A. Finnerty Jr., Harold W. Schnaper, Robert L. Johnson, Charles E. Rath, and Robert W. Wilkins. "The Collapse Produced by Venous Congestion of the Extremities or by Venesection Following Certain Hypotensive Agents." Journal of Clinical Investigation 30 (1951): 435-444.

Freis, Edward D. "Veratrum Viride and Hexamethonium in the Treatment of Severe Diastolic Hypertension." The Medical Annals of the District of Columbia XX, no. 6 (June 1951): 297-304.

Johnson, Robert L., Edward D. Freis, and Harold W. Schnaper. "Hemodynamic Changes in the Small Vessels in Man as Analyzed by Digital Plethysmography." Angiology 2, no. 5 (October 1951): 412-422.

Freis, Edward D., Frank A. Finnerty Jr., Harold W. Schnaper, and Robert L. Johnson. "The Treatment of Hypertension with Hexamethonium." Circulation V, no. 1 (January 1952): 20-27.

Freis, Edward D., and Frank A. Finnerty Jr. "Recent Developments in the Treatment of Severe Hypertension." GP VII, no. 3 (March 1953): 70-78.

Freis, Edward D., Thomas F. Higgins, and Harold J. Morowitz. "Transcapillary Exchange Rates of Deuterium Oxide and Thiocyanate in the Forearm of Man." The Journal of Applied Physiology 5, no. 9 (March 1953): 526-532.

Rose, John C., Saul R. Gilford, Herbert P. Broida, Anton Soler, Edward A. Partenope, and Edward D. Freis. "Clinical and Investigative Application of a New Instrument for Continuous Recording of Blood Pressure and Heart Rate." New England Journal of Medicine 249 (8 October 1953): 1-8.

Freis, Edward D., Edward A. Partenope, Lawrence S. Lilienfield, and John C. Rose. "A Clinical Appraisal of Pentapyrrolidinium (M&B 2050) in Hypertensive Patients." Circulation IX, no. 4 (April 1954): 540-546.

Freis, Edward D., and Recep Ari. "Clinical and Experimental Effects of Reserpine in Patients with Essential Hypertension." Annals of the New York Academy of Sciences 59 (30 April 1954): 45-53.

Rose, John C., Herbert P. Broida, Charles A. Hufnagel, John F. Gillespie, Pierre J. Rabile, and Edward D. Freis. "A Method for the Study of the Circulation in the Dog Using a Mechanical Left Ventricle." Journal of Applied Physiology 7, no. 5 (March 1955): 580-584.

Freis, Edward D., Herbert P. Broida, Charles A. Hufnagel, and John C. Rose. "Effects of Varying the Output of a Mechanical Left Ventricle on the Circulation in the Dog." The American Journal of Physiology 182, no. 1 (July 1955): 191-196.

Freis, Edward D., and Harold W. Schnaper. "Transcapillary Loss, Equilibrium Time, Half-Return Time of Thiocyanate and Heavy Water in the Forearm." Proceedings of the Society for Experimental Biology and Medicine 92 (1956): 188-194.

Freis, Edward D., and Ilse M. Wilson. "Mecamylamine, a New, Orally Effective, Hypotensive Agent." Archives of Internal Medicine 97 (May 1956): 1-11.

Freis, Edward D., and Ilse M. Wilson. "Results of Prolonged Treatment with Pentolinium Tartrate with Special Reference to the Addition of Rauwolfia, Hydralazine or Both." Circulation XIII, no. 6 (June 1956): 856-865.

Freis, Edward D. "Hypertension: Current Status of Therapy -- Hope for the Future." Journal of the National Medical Association 48, no. 4 (July 1956): 252-263.

Rose, John C., and Edward D. Freis. "Alterations in Systemic Vascular Volume of the Dog in Response to Hexamethonium and Norepinephrine." The American Journal of Physiology 191, no. 2 (November 1957): 283-286.

Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. "Treatment of Essential Hypertension with Chlorothiazide (Diuril): Its Use Alone and Combined with Other Antihypertensive Agents." Journal of the American Medical Association 166, no. 2 (11 January 1958): 137-140.

Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. "Chlorothiazide in Hypertensive and Normotensive Patients." Annals of the New York Academy of Sciences 71, no. 4 (3 February 1958): 450-455.

Freis, Edward D., and Harold W. Schnaper. "The Effects of a Variety of Hemodynamic Changes on the Rapid and Slow Components of the Circulation in the Human Forearm." Journal of Clinical Investigation 37, no. 6 (June 1958): 838-845.

Freis, Edward D. "Treatment of Hypertension with Chlorothiazide." Journal of the American Medical Association 169, no. 2 (10 January 1959): 105-108.

Frohlich, Edward D., Frank J. Fedor, William V. C. Leahy, and Edward D. Freis. "Evaluation of I-131-Labelled Diodrast Renograms with Suggestions on Improving the Technic." The Medical Annals of the District of Columbia XXVIII, no. 6 (June 1959): 324-329.

Frohlich, Edward D., and Edward D. Freis. "Clinical Trial of Guanethidine, a New Type of Antihypertensive Agent." Medical Annals of the District of Columbia XXVIII, no. 8 (August 1959): 419-422.

Wilson, Ilse M., and Edward D. Freis. "Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide." Circulation XX, no. 6 (December 1959): 1028-1036.

1960s

Frohlich, Edward D., Harold W. Schnaper, Ilse M. Wilson, and Edward D. Freis. "Hemodynamic Alterations in Hypertensive Patients Due to Chlorothiazide." New England Journal of Medicine 262 (23 June 1960): 1-3.

Mohler, Emile R. Jr., and Edward D. Freis. "Five-Year Survival of Patients with Malignant Hypertension Treated with Antihypertensive Agents." American Heart Journal 60, no. 3 (September 1960): 329-335.

Gilmore, Bruce L., and Edward D. Freis. "Methyldopa in the Treatment of Hypertension." The Medical Annals of the District of Columbia 34, no. 1 (January 1965): 13-18.

Daddario, Robert C., and Edward D. Freis. "Kinetocardiogram, Phonocardiogram, and Arterial Pulse Waves during Acute Hemodynamic Changes." Circulation XXXIV (September 1966): 423-436.

Kirkendall, Walter M., Alan C. Burton, Frederick H. Epstein, and Edward D. Freis. "Recommendations for Human Blood Pressure Determination by Sphygmomanometers: Report of a Subcommittee of the Postgraduate Education Committee, American Heart Association." Circulation XXXVI (December 1967): 980-988.

Freis, Edward D., and Mary C. Kyle. "Computer Analysis of Carotid and Brachial Pulse Waves: Effects of Age in Normal Subjects." The American Journal of Cardiology 22, no. 5 (November 1968): 691-695.

1970s

Franciosa, Joseph, Edward D. Freis, and James Conway. "Antihypertensive and Hemodynamic Properties of the New Beta Adrenergic Blocking Agent Timolol." Circulation XLVIII (July 1973): 118-124.

Poblete, P. F., Mary C. Kyle, H. V. Pipberger, and Edward D. Freis. "Effect of Treatment on Morbidity in Hypertension. Veterans Administration Cooperative Study on Antihypertensive Agents: Effect on the Electrocardiogram." Circulation XLVIII (September 1973): 481-490.

Shah, Shaukat, Imbrahim M. Khatri, and Edward D. Freis. "Mechanism of Antihypertensive Effect of Thiazide Diuretics." American Heart Journal 95, no. 5 (May 1978): 611-618.

1980s

Freis, Edward D. "An Interview with Edward D. Freis, MD, on Pharmacologic and Behavioral Strategies in Treating Hypertension." Behavioral Medicine 7, no. 6 (June 1980): 21, 25-26.

Papademetriou, Vasilios, Michael Price, Elizabeth Johnson, Marlene Smith, and Edward D. Freis. "Early Changes in Plasma and Urinary Potassium in Diuretic-Treated Patients with Systemic Hypertension." The American Journal of Cardiology 54 (1 November 1984): 1015-1019.

Freis, Edward D., and Vasilios Papademetriou. "Controversy in Hypertension: Are Diuretics Harmful?" Primary Cardiology 1 (January 1985): 16-26.

Papademetriou, Vasilios, Michael Price, Aldo V. Notargiacomo, John Gottdiener, Ross Fletcher, and Edward D. Freis. "Effect of Diuretic Therapy on Ventricular Arrhythmias in Hypertensive Patients With or Without Left Ventricular Hypertrophy." American Heart Journal 110, no. 3 (September 1985): 595-599.