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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Bernard D. Davis pdf (58,159 Bytes) transcript of pdf
Letter from Joshua Lederberg to Bernard D. Davis
Number of Image Pages:
1 (58,159 Bytes)
Date:
1949-07-27 (July 27, 1949)
Creator:
Lederberg, Joshua
Recipient:
Davis, Bernard D.
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Methods
Research
Research Personnel
Relation:
Lederberg Grouping: Correspondence B
Box Number: 6
Folder Number: 200
Unique Identifier:
BBAADF
Accession Number:
1
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Davis, Bernard D.
Transcript:
July 27, 1949.
Dear Bernie,
Thanks for the details on broth vs. plate recombination. After examining them, I would conclude that the discrepancy in our results is that you get relatively few prototrophs on the plates. Perhaps your agar is too clean! In another connection, Cavalli has compared the two methods, and agrees with my results.
I don't think I am going to do anything on this angle, because Cavalli (in Fisher's lab at Cambridge) has discovered a derivative of 58-161 which gives very high efficiencies of recombination (nearly 100%, discounting microcolonies). In fact, I have been able to find almost 10% of fermentative recombinants by plating cell mixtures (grown together) out on complete EMB agar. This is the most important lead yet on the nature of the zygote, and it should soon be possible for Cavalli to find the fusions microscopically.
Gordon Allen is due to come here Monday next, and wasn't too definite about how long he expected to remain. He has some rather optimistic ideas on how quickly he can get through his experiments, but I am looking forward to talking with him. It's as hot as can be here, and you can imagine how much Esther and I would prefer to spend the summer at some cool, dull place like PG!
Sincerely,
Metadata Last Modified Date:
2009-06-15
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