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The Joshua Lederberg Papers

Letter from Mary B. Mitchell to Joshua Lederberg pdf (96,284 Bytes) transcript of pdf
Letter from Mary B. Mitchell to Joshua Lederberg
Item is handwritten.
Number of Image Pages:
2 (96,284 Bytes)
1954-10-29 (October 29, 1954)
Mitchell, Mary B.
California Institute of Technology
Lederberg, Joshua
Courtesy of Joshua Lederberg.
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Medical Subject Headings (MeSH):
Cell Culture Techniques
Lederberg Grouping: Correspondence C
Box Number: 12
Folder Number: 112
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1953-1960
Folder: Mitchell, Mary B.
October 29, 1954
Dear Dr. Lederberg,
I am sorry to have to tell you that I cannot comply with your request for cultures of poky. We have not yet made this strain available for general distribution and have sent it to other laboratories only in a few instances when we were assured that the work planned would not duplicate ours or that of Drs. Tissieres and Gowdridge. As it happens, Dr. Gowdridge began work on the problem of the behavior of heterokaryons involving poky and not. poky strains when she was here in 1953 and has continued this work since returning to Britain. She has shown that it is a difficult problem on which to reach a conclusion and although my husband mentioned some of her results at Bellagio last year and she has I believe, presented a paper on them in England, she plans to do more work before publishing the results in full. For this reason we do not feel free to send
the strain to some one else for the same problem. I feel certain that you will understand our position on this. Perhaps by the time you have finished your observations on yeast her results with Neurospora will be available for comparison.
With regard to my trials with mixed cultures, I would most certainly not say that they gave the last word, or even the first on heterokaryons since I did not show that heterokaryons were formed. We only put that in the papers because one of the questions most frequently asked us about poky has been, "what happens when you make a heterokaryon", so we thought we should say that we didn't know.
Sincerely yours,
Mary Mitchell
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