Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Joshua Lederberg Papers

Title:
The Nutrition of Salmonella Annotation pdf (296,535 Bytes) ocr (8,614 Bytes)
The Nutrition of Salmonella
Number of Image Pages:
4 (296,535 Bytes)
Date:
1947-05 (May 1947)
Creator:
Lederberg, Joshua
Source:
Periodical: Lederberg, Joshua. "The Nutrition of Salmonella." Archives of Biochemistry 13, 2 (May 1947): 287-290. Article. 4 Images.
Lederberg UI: P8
Publisher:
Academic Press
Rights:
Reproduced with permission of Academic Press.
URL: http://www.elsevierdirect.com/imprint.jsp?iid=5Exit
   Disclaimer; please review our Privacy Policy
Single copies of the article can be downloaded and printed for the reader's personal research and study.
Subject:
Medical Subject Headings (MeSH):
Salmonella
Nutritional Physiological Phenomena
Genetics, Microbial
Mutation
Relation:
Lederberg Grouping: Published Scientific Article
Metadata Record Letter from Joshua Lederberg to M. C. Nesheim (March 16, 1996) pdf (42,624 Bytes) ocr (880 Bytes)
/ps/access/BBGMSR.pdf
Box Number: 79
Folder Number: 13
Unique Identifier:
BBABEQ
Accession Number:
3
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Writings
SubSeries: Published Scientific Articles
Folder: P8: "The Nutrition of Salmonella" (1947)
Metadata Last Modified Date:
2008-02-20
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples

Annotation by Joshua Lederberg:
KW: Salmonella auxotrophs;

work started from the start of my studies at YALE (from April 1946 on),
reflecting earliest convictions that serotypes in Salmonella bore
earmarks of genetic recombination in natuiral history.  Natural
auxotrophs would also offer easy experimental material for\crossing studies,
perhaps obviating need to seek laboratory mutants.  The footnote makes
it clear that I was already headed towards a Ph.D. credential by 
Feb '47.
Most Salmonellas were auxo-autotrophic;
tryptophane and cystine were common among the auxoheterotrophic forms .

The natural historical or ecological significance remains obscure.
Probably too little attention is paid to the accumulation of metabolically
significant intermediates in the blocked strains.  [cf also
dmesiology or self-restraint!; but there has been no test of the
impact on virulence of the natural auxotrophies.]  Reversions were readily
noted.

Latent genes, raw material for divergent evolution, are also discussed here.\

jl 1/15/99