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The Joshua Lederberg Papers

Title:
Letter from Bernard D. Davis to Joshua Lederberg pdf (253,250 Bytes) transcript of pdf
Letter from Bernard D. Davis to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
2 (253,250 Bytes)
Date:
1951-08-25 (August 25, 1951)
Creator:
Davis, Bernard D.
Recipient:
Lederberg, Joshua
Rights:
Reproduced with permission of Elizabeth M. Davis.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 6
Folder Number: 200
Unique Identifier:
BBADEH
Accession Number:
5
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Davis, Bernard D.
Transcript:
Aug 25, 1951
Dear Joshua,
Thanks for the information.
I'd like to test all possible [ . . . ], single or multiple, and would welcome any contributions. Please don't send them until after Labor Day. Incidentally, did you get the Ps. fluon. mutants by the penicillin method? Somewhere I picked up the idea that this bug is very resistant to the drug. For extending our march for intermediates it would be good to use an organism not closely related to the Euterobact. we've been working with.
Unless you feel there'd be no point in testing a resistant mutant derived by multiple steps, I'll be glad to try to make one from one of your stocks when I get back. I must admit the pattern of increasing degrees of specific sulfonamide[?] resistance (not crossing with PNBA) on successive mutations makes me swallow hard in explaining it as an enzyme of increasingly altered configuration due [ . . . ] to excessive allelic culturation, for one might expect a single step also to provide a big distortion in the enzyme resulting in high resistance.
[END PAGE ONE]
[BEGIN PAGE TWO]
Yet we know so little about that[?] process that the interpretations I have advanced should hardly be given up on the basis asked[?].
Congratulations on the indirect selection of Srr, Vr, clones. I simply cannot take Harry's stuff seriously at the present time, and have been sufficiently convinced of the L and D and N evcombe[?] expts. so that I would have been annoyed at any conflicting results. But it's good to get further direct evidence, and I'm glad my fears about the small size of the clones of these rare mutants were not realized.
Sorry I won't be in Minneapolis - am on the ACS program at their Sept. jamboree and think that's enough meeting for a while. Have a good time. Since the bacteriologists learned last year that they eat at their convention, I trust you'll use appropriate discretion when the geneticists get together.
Best,
Bernie
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2017-03-27
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