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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Mario U. Dianzani Annotation pdf (83,777 Bytes) transcript of pdf
Letter from Joshua Lederberg to Mario U. Dianzani
Number of Image Pages:
1 (83,777 Bytes)
Date:
1950-10-15 (October 15, 1950)
Creator:
Lederberg, Joshua
Recipient:
Dianzani, Mario U.
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 6
Folder Number: 208
Unique Identifier:
BBADJY
Accession Number:
5
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Dianzani, Mario U.
Transcript:
October 15, 1950.
Dear Doctor Dianzini:
Your paper in Experimentia, "Mutation in the enzymatic equipment of Escherichia coli and Proteus OX19 directed by desoxyribonucleic acid isolated from bacteria of the same and of different species", has just come to my attention. Would you be kind enough to favor me with a reprint of this paper, and to keep me in mind for your future publications on this theme?
I would be very grateful to have the opportunity to repeat and confirm your experiments. As you may know, I have been working for some years on genetic recombination on E. coli K-12, which appears to be a somewhat different system from yours. It appears most important to compare the modalities of genetic recombination and of transformation.
A repitition of your experiments would only be meaningful with the same strains which you employed, since your own work shows, as expected, a high order of strain specificity. May I enlist your assistance therefore in supplying me with requisite cultures? The strains which I should most like to have for this purpose are "E. coli 1", UQ; SG, and a culture of an E. coli 1 type which has been induced to mutate to sucrose-oxidation. (I am especially anxious to have in hand a transformed type in order to know what to look for, especially as there may be unavoidable differences in our analytical techniques.) Your cooperation will be greatly appreciated.
Yours sincerely,
Joshua Lederberg,
Associate Professor of Genetics.
Metadata Last Modified Date:
2008-05-23
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Annotation by Joshua Lederberg:
KW: E. coli genetic transformation with DNA;
re his claim/ paper in Experientia. Mutation in the enzymatic
equipment of Escherichia coli and Proteus OX-19 directed by
desoxyribonucleic acid isolated from bacteria of the same and
of different species. 6:332-334 (1950);
Never corroborated.  Of course it could be true.;
Cf my correspondence;  I never cited it. It is cited by Kaplan,
Austrian in reviews;  He himself did not follow up with further
publications;

More: re own efforts to acquire strains and corroborate;

jl  9/12/98 ; 9/6/99