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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Louis Dienes Annotation pdf (101,951 Bytes) ocr (2,020 Bytes)
Letter from Joshua Lederberg to Louis Dienes
Number of Image Pages:
1 (101,951 Bytes)
Date:
1952-11-03 (November 3, 1952)
Creator:
Lederberg, Joshua
Recipient:
Dienes, Louis
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 6
Folder Number: 211
Unique Identifier:
BBADKJ
Accession Number:
5
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Dienes, Louis
Metadata Last Modified Date:
2005-05-18
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples

Annotation by Joshua Lederberg:
Keywords:  L-forms; Klieneberger-Nobel;P-70; P-25; transduction

Dienes, at MGH was doyen of L-forms.  We had seen these in phage-
lysates of Salmonella, and as in P-25 were diverted into postulating
an unwarranted role for these in phage-mediated transduction.  By
this date we had resolved that: phage was the transducing element.
Cf: P-29


Filtrability of L-form phase bacteria is still a challenge.  Sizing
has been by filtrability and flexibility of proto/spheroplasts may
play a role.

We eventually clarified that L-forms were "protoplasts" in later
experiments with penicillin.

Cf: P-70