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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Bruce Wallace Annotation pdf (117,824 Bytes) transcript of pdf
Letter from Joshua Lederberg to Bruce Wallace
Description:
Item is handwritten. Item is a photocopy.
Number of Image Pages:
1 (117,824 Bytes)
Date:
1982-01-03 (January 3, 1982)
Creator:
Lederberg, Joshua
Recipient:
Wallace, Bruce
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence E
Box Number: 32
Folder Number: 4
Unique Identifier:
BBADKZ
Accession Number:
5
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1978-1984
Folder: Dobzhansky, Theodosius
Transcript:
R. Bruce Wallace
Jan 3 1982
DNA as mutagen
How thoughtful of you to recall what I wrote 20 years ago! The deeper my regrets that my calendar is fully booked for the time of your meeting. If it should open up unexpectedly I will write back to you.
You may recall how Dobzhansky characterized the pneumococcus transformation as a "desired transformation" even before Avery and co. characterized DNA there.
This may seem a semantic nicety but Avery (and Harriett Ephrussi) were informed by it in such a way that they avoided doing or interpreting multi-marker recombination expts. in a single, straightforward way; and this was left to Rollin Hotchkiss some years later.
Best wishes,
Joshua Lederberg
Metadata Last Modified Date:
2008-07-18
Linked Data:
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Annotation by Joshua Lederberg:
Node: Wallace, Bruce was a graduate student at Columbia, drafted to war;

KW: DNA as mutagen -interpretation of Avery; P-81; Dobzhansky;**;

"what I wrote 20 years ago" refers to Nobel lecture (P-81)
where I remark that DNA will prove to be the only (specific) mutagen:
in effect site-direcvted mutagenesis."  He is inviting me to a
meeting.

You may recall how D' characterized the pneumococcus transformation
as a 'directed mutation' even before Avery & Co. characterized DNA there.
This may seem a semantic nicety but Avery (and Harriett Ephrussi) were
informed by it in such a way that they avoided doing or interpreting
multi-marker recombination expts. in a simple straightforward way;
and this was left to Rollin Hotchkiss some years later."
My account does not do justice to her work in the 1960's.

I don't understand the notations to CSH 5/16 and Roche 5/15/82;
I did attend the latter meeting

The reprint background is D': GATOOS, p. 49
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jl 2/28/99; 3/2/99