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The Joshua Lederberg Papers

Letter from Joshua Lederberg to Edward D. Garber Annotation pdf (63,273 Bytes) transcript of pdf
Letter from Joshua Lederberg to Edward D. Garber
Number of Image Pages:
1 (63,273 Bytes)
1950-11-13 (November 13, 1950)
Lederberg, Joshua
Garber, Edward D.
This item is in the public domain. It may be used without permission.
Lederberg Grouping: Correspondence B
Box Number: 7
Folder Number: 34
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Garber, Edward D.
November 13, 1950.
Dear Ed:
I was a little surprised at the note in the last J. Bact. on use of tetrazolium for differentiating R & S "your bug"--why so coy about naming it in your letter? It would almost imply some difference either in general rH level between R and S, or else some specific metabolic difference in dehydrogenation of some substrate in your medium. Are you making similar comparisons with other species?
I doubt that I have any mimeograph material for class use that you don't already have. UW Press has approved a republication of a selected set of reprints (Luria and Delbruck; etc.) for teaching use; they should be out by next Fall. The current Methods in Medical Research (Vol. 3), just out, has a section on methods in microbial genetics. There are rumors of a text, in press, in England.
What, exactly, do you mean that a stored suspension goes avirulent? Is this a propagated change, or is it simply a matter of the immediate physiological conditon of the cells at the time they are inoculated.
How about those gigas forms?
Camphor had no effect on E. coli. I'd tried this in 1947, but thought I could do better now, but no luck.
Joshua Lederberg
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Annotation by Joshua Lederberg:
KW: tetrazolium; R/S Rough-Smooth, variation; dissociation; Yersinia pestis;

He is cryptic about naming species in correspondence, a/c security
regulations.  Paper refers to plague
 Levine HB and Garber ED J Bact 60:508 1960

  Must have been earlier letters.
jl 12/23/98