Letter from Shigaru Akamatu(?) to Joshua Lederberg
Item is handwritten.
Number of Image Pages:
2 (128,109 Bytes)
1951-05-19 (May 19, 1951)
Courtesy of Joshua Lederberg.
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You air letter (February 17, 1951) to Dr. Kobayashi arrived this department today. The letter was already opened. Is the
head of department, I write you this letter, because Dr. Kobayashi left this university four years ago and live now in Nagano
district as a clinical doctor. I am very glad to read that you use s-parenitrophenol nexoside[?] for carbohydrase assey[SIC].
I think also this compound is a good substrate.
Reports from this department are usually printed in the name of each researcher. They come here, work under[?] my guidance
for two of three years and go away. This is the condition of the most institutes of this country. I am sorry.
I send you some papers of studies on carbohydrase. The reports after the war are written in Japanese, because the "Journal
of Biochemistry" was not issued since the war time. But this journal has been now re-issued and I intend to write a summary
in it recently. I wish you wait for some time to let me translate the content of the papers of Dr. Kobayahi.
If you allow me to summarise[sic] in a few sentences, our studies on carbohydrase (15-neterosidase_) are as follows
[END PAGE ONE]
[BEGIN PAGE TWO]
B-Glucosidase, p-glactosidase and p-xlyrosidase are different enzymes from each other. Each enzyme can exsit[sic] in nature
in two different types, Taka- and emulsin- type. Taka type has an affinity to sugar group, emulsin type on the other hand
to 5-glycoside bond. This is the first step of enzyme-substrate combination. In the primary enzyme substrate compound occurs
the second step combination between the affinity group of enzyme and substrate each other.
[TABLE=My hypothesis for specificty of B-heterosiolase]
I send you also some papers of phosphatase etc. Reports after the war are also not in print.
Prof. P. Hundler is now in this medical school as a member of Conference of American-Japanese medical educators. You would
perhaps hear of the poor
condition of my department. I can not express my think in good words, please pardon me.