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I am sorry for not writing to you sooner. I think you are enjoying the best of your health and are much successful in your
The review which I promised has been published in Japanese Journal of Medical Progress and I sent it by separate mail. Bacterial
genetics is yet unfamiliar in Japan, so my review has been well received. For example, Prof. Akiba (Tokyo Univ.) and Prof.
Kikkawa (Osaka Univ.) etc. wrote to my words of praise. I'm deeply indebted to you for your kindness.
Prof. Kikkawa says to me that he will recommend me to receive Yukawa -- scholarship, if I am willing to study at his laboratory.
(You may know Prof. Yukawa who is the famous physician and has received Nobel price. Prof. Yukawa offeres a scholarship to
support promising young student in Japan.) This invitation is too much for me, but I have not answered him yet. Because, I
am responsible now for the study of Enterobacteriaceal under Dr. H Fukumi,
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Chief of Bact. Division, N.I.H. and so I can't change my position for time being. But. I will devote my life to the study
of microbial genetics, so I should like to be in close connection with you and Prof. Kikkawa. And also I hope that I may be
able to study at your laboratory someday. Expecting the coming of such an opportunity, I'm taking lessons in English conversation.
My present studies are as follows,
1) Availing conjugatable Shigella strains which I have discovered last year, I obtained some biochemical mutants. I am increasing
their markers moreover to make the detailed chromosomes-map.
2) I got some mutants of Salmonella strains I'm studying their gene-recombination. This study will support my idea that
phase variation of Salmonella H-antigens is explainable by the multiple alleles.
3) I am measuring the mutation rates of some genes of Shigella and Salmonella.
4) Study of the amino-acid metabolism of Shigella
5) Soon I am intending to start the extraction of DNA from Shigella.
6) I have almost completed the translation of the article "The Theory of Rate Processes and Gene Mutation" published
by W.D. McElroy and C.P. Swanson in the Quarterly Review of Biology 1951, 26, 348-363.
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The Section of Microbial Genetics will be organized in order to receive the subsidy from the Ministry of Education, Japan.
But I shall fail to enter my name as a member of the Section, because I am too young (I'm 28 years old). I shall be able
to receive the subsidy through my chief, Dr. H. Fukumi who will be one of the members of the said organization.
Many thanks for your reprint published in Cold Spring Harbor Symp. 1951.
I would appreciate it very much to receive your articles which will be published from now on, and I hope that your warm and
constant leadership may continue on me.
Please extend my best wishes to Mrs. Lederberg and Dr. Zinder.