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The Joshua Lederberg Papers

Letter from Haig Papazian to Joshua Lederberg pdf (110,988 Bytes) transcript of pdf
Letter from Haig Papazian to Joshua Lederberg
Item is handwritten.
Number of Image Pages:
2 (110,988 Bytes)
1952-05-21 (May 21, 1952)
Papazian, Haig
Lederberg, Joshua
Courtesy of Joshua Lederberg.
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Lederberg Grouping: Correspondence B
Box Number: 7
Folder Number: 234
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Papazian, Haig
21st May '52
Dear Josh,
Thanks for the Kaffert ref.--Yes I had missed it.
I have just seen Leonard Lerman who I know you met here with Nowick--he tells me he is going to marry and he is going to marry into a genetical family--Miss Lindegren!
Teaching in the college has taken up most of my time this year but I have run across something which I think should be followed up. I was operating on some dikaryons as Harden did years ago to separate the two monokaryons. My dikaryan was A'B'smt XA2B2stml
s being the morph. mutant streak and m' a uracil [ . . . ] I was looking for cytoplasmic effects or delay in gene expression and this I did not get--or rather I think I have something of the sort but in a very curious way. One of the successful operations gave use to monokaryon which was very very dwarf. This, phenotype d', crossed with wild type gave rise to wild type, streak (s), d' and two new phenotypes d and s'. I [ . . . ] to be a new single gene mutant and d' was the double mutant sd, so that all that had happened was that the outcome of the operation was a new mutant d in the nucleus of A'B' smt. But what about streak (s) which should segregate out and what about the s' mycelia? Well s' when [ . . . ] crossed with wild type segregates s and t perfectly normally, and furthermore s' actually sectors into s more or less randomly with an average of something less than 1 sector per plate. I don't think this can be regarded as a genic change of s--s' and back again but I think it must be a non-genic change, the two alternatives being rather stable through several hundred cell divisions. It is not a virus.
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