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The Joshua Lederberg Papers

Title:
Letter from Roger Y. Stanier to Joshua Lederberg pdf (138,689 Bytes) transcript of pdf
Letter from Roger Y. Stanier to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
2 (138,689 Bytes)
Date:
1950-04-25 (April 25, 1950)
Creator:
Stanier, Roger Y.
Recipient:
Lederberg, Joshua
Rights:
Courtesy of Joshua Lederberg.
The National Library of Medicine's Profiles in Science program has made every effort to secure proper permissions for posting items on the web site. In this instance, however, it has either not been possible to identify or contact the current copyright owner. If you have information regarding the copyright owner, please contact us at profiles@nlm.nih.gov.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 64
Unique Identifier:
BBAFDM
Accession Number:
8
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Stanier, Roger Y.
Transcript:
April 25, 1950
Dear Joshua - -
First physical plans. I am teaching summer session at the University of Washington from June 19 - - July 19, and plan thereafter to spend a little time climbing in the Grand Tetons with a couple of friends. However, I should get back to Berkeley during the first week of August. This program is conditional on my still being a member of the U.C. faculty at that time, which is by no means certain. I've been well to the front of the battle with the Regents over the loyalty oath issue, and this political problem had taken a large part of my time during the post academic year. The settlement finally attained is one of which I deeply disapprove, and I haven't made up my mind whether is accept it and stay or go elsewhere. If the latter, I'll probably be busy moving at the end of the summer. So I can't promise anything definite at present.
Have you heard from our housing bureau yet? They have your name listed, and should be beginning to some through with rental possibilities. If you don't receive any information from them during the next couple of weeks let me know, and I'll see what can be done in the way of direct action (ad. in the local paper).
Are you planning to go to the SAB meetings? I'll be there, and will probably know more clearly by then about my own future.
Second, scientific matters. With reference to your query re. paper II, I suspect that rapidly-dried cells are still in large measure viable, but we have never determined this, since our interest at that time was to get cells that would not behave like living ones, and could thus be used to study the various individual step-reactions. This is something that derives systematic study but hasn't yet received it. My work has been pretty much at a standstill for the last 7-8 months as a result of heavy teaching and loyalty oath.
[END PAGE ONE]
[BEGIN PAGE TWO]
I don't know what to make of your K-12 mutant which forms a constitutive galactosidose ; particularly its substantive responses seem most prevention. On the other hand, the finding that K-12 on rich media can be "pre-adapted" in the absence of scientific substitutes doesn't frighten me too much. It could mean that precursors and available energy are present so abundantly that the adaptive bug is reduced to the point of no longer being experimentally observable. This is the orthodox explanation, of course. There is naturally the alternative that the enzymes are actually produced in the absence of the specific substrate. It might be instructive to find out whether the presence of INP has any effect on the rate of attack when added before the specific substitute. If the former explanation is correct, there might be a detectable rate-difference over a period of 60 minutes or so between treated and untreated cells. If the latter, there should be none.
Am very busy just now, so will write no more. I hope you'll be in Baltimore so that we can talk over some of these matters.
Best wishes
Roger
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2017-05-08
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